miRTarBase - #MIRT547959


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pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HIGD1A   
Synonyms HIG1, RCF1a
Description HIG1 hypoxia inducible domain family member 1A
Transcript NM_001099668   
Other Transcripts NM_001099669 , NM_014056   
Expression
Putative miRNA Targets on HIGD1A
3'UTR of HIGD1A
(miRNA target sites are highlighted)		 
>HIGD1A|NM_001099668|3'UTR
   1 AAGAAGAGATGCTGTCTTGGTCTTGTTGGAGGAGCTTGCTTTAGTTAGATGTCTTATTATTAAAGTTACCTATTATTGTT
  81 GGAAATAAACTAATTTGTATGGGTTTAGATGGTAACATGGCATTTTGAATATTGGCTTCCTTTCTTGCAGGCTTGATTTG
 161 CTTGGTGACCGAATTACTAGTGACTAGTTTACTAACTAGGTCATTCAAGGAAGTCAAGTTAACTTAAACATGTCACCTAA
 241 ATGCACTTGATGGTGTTGAAATGTCCACCTTCTTAAATTTTTAAGATGAACTTAGTTCTAAAGAAGATAACAGGCCAATC
 321 CTGAAGGTACTCCCTGTTTGCTGCAGAATGTCAGATATTTTGGATGTTGCATAAGAGTCCTATTTGCCCCAGTTAATTCA
 401 ACTTTTGTCTGCCTGTTTTGTGGACTGGCTGGCTCTGTTAGAACTCTGTCCAAAAAGTGCATGGAATATAACTTGTAAAG
 481 CTTCCCACAATTGACAATATATATGCATGTGTTTAAACCAAATCCAGAAAGCTTAAACAATAGAGCTGCATAATAGTATT
 561 TATTAAAGAATCACAACTGTAAACATGAGAATAATTTAAGGATTCTAGTTTAGTTTTTTGTAATTGCAAATTATATTTTT
 641 GCTGCTGATATATTAGAATAATTTTTAAATGTCATCTTGAAATAGAAATATGTATTTTAAGCACTCACGCAAAGGTAAAT
 721 GAACACGTTTTAAATGTGTGTGTTGCTAATTTTTTCCATAAGAATTGTAAACATTGAACTGAACAAATTACCTATAATGG
 801 ATTTGGTTAATGACTTATGAGCAAGCTGGTTTGGCCAGACAGTATACCCAAACTTTTATATAATATACAGAAGGCTATCA
 881 CACTTGTGAAATTCTCTTGTCTAATCTGAATTTGCATTCCATGGTGTTAACATGGTATATGTATTGTTATTAAAGTAAGT
 961 GACCCATGTCAAATGTCTTTTATTTATTTCATGAGGAAAAGCTTTCTGTAGAGGAACAAATTTGAGAACAAGTTTCAGGA
1041 AATTGTCTTTTTTGTTGTTGTTCTCTAATCATGTTCTCCTTTCTGTTTCAACGATTTTAAAAATATTTTACTTTATGGTA
1121 TGTTTTATTTTTTTTCCTTTTGTGGGTAATTTTTGTTCTATTGATTATCCATATAAATTTTTTTTTTTTTTTTTTGAGAC
1201 GGAGTTATTCTCTGTCATCTTGGCTGGCGTGCAGTGGCACGATCTTGGCTCACTGCAACTTCCATCCCCCAGGTTCAAGT
1281 GATTCTCTTGCCTCAGCCTCCTGAGTAGCTGTGATTACAGGCATGCACCAACATGCCTGGCTAATTTTTGTATATTTAGT
1361 AGAGACGAGGTTTCACCATGTTGGCCAGGCTGATCTTGAATTCCTGACCTCAGGTTATCCACCTGCCTCGGCCTCCCAAA
1441 GTGCTAGGATTACAGGCGTGAGCCACCACGCCCAGCTGATTATCCATATAATTATAACACTCTTCTATTTATTTTCAGTC
1521 ACCAATAATTCCTTTTGAGCAATATTTAAGCCTAGCATATTTCTTCCTTCCCTCCTCCTCTACTAACCAGTTCTGGTCGA
1601 TATATTATTGGATTTTACTCTTATACTGTTTGTTTGTTTGTTTGTTTGTTTATTTTGAGACAGAGTCTTGCTCTGTTGCT
1681 GAGGCTGGAGTACAGTGGTGTGATCTGAGCTCACGGCACCCTCCACCTCCTAGCTTCGTGCGATTCTGATGCTTCAACCT
1761 TCCGAGTAGCTGGGATTACAGGCATGCGCCACCATGTCGGGCTAATTTTTGTGTTTTTAGTAAAGGCGAGGTTTCACCAT
1841 GTTGGATGATCTTGAACTCCTGGCTTCAAGAGATCTATCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAAGCATAATCC
1921 ACCACACCTGACCTACTTTTGTATGTTAAATGTGATTATACTTCTCTTTGACTTGTCAGCTTAGCTTTAGCTGATACACT
2001 CTGGTGCCCAACTATTATTGTATCAGTGAACTTCCACTTTCTTTTCCTTTTCTCTCAATTTTTGTTGTATCATTCCTACC
2081 TTGTGAGGACATATAATATTTACATTCTGTTGTCATCCTCACATTTCTTAGTTCCACAGTTTAAATGTATTTGAAACTCA
2161 AAACATTCCCATTAATCTCTTGGTCAGCTGAAATTAATGATTTAATAGTTTCCTTAAAAAAGACTCATGGAACAATTTCC
2241 CTAAATTTTTGCCATGTCAAATATGTTTATCTGTAGCCTTTACACAGTAAAAACAATTTGGCTAGATAATACAATTCTCA
2321 GTTCATATTTTTCTTTGGAATATTAAAGTATTGCTATAGAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGACAAGGACGACUu 5'
            :| || ||||||| 
Target 5' taTTTTTGCTGCTGAt 3'
 634 - 649 150.00 -10.10
2 
miRNA  3' ucGACAAG--GACGACUu 5'
            :|| ||  :|||||| 
Target 5' tcTTGCTCTGTTGCTGAg 3'
 1666 - 1683 132.00 -11.00
3 
miRNA  3' ucGACAAG-GACGACUu 5'
            |||||: |||| || 
Target 5' ccCTGTTTGCTGCAGAa 3'
 332 - 348 126.00 -11.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26978788 9 COSMIC
COSN31608577 11 COSMIC
COSN30164941 16 COSMIC
COSN30155133 22 COSMIC
COSN30153837 29 COSMIC
COSN26978789 43 COSMIC
COSN31488718 52 COSMIC
COSN30489669 73 COSMIC
COSN19656229 92 COSMIC
COSN19656228 165 COSMIC
COSN30164986 244 COSMIC
COSN31598748 280 COSMIC
COSN18891175 332 COSMIC
COSN31540182 466 COSMIC
COSN26548705 595 COSMIC
COSN31559571 756 COSMIC
COSN30278922 775 COSMIC
COSN16586725 884 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759327231 2 dbSNP
rs773991910 9 dbSNP
rs770552158 15 dbSNP
rs1435906109 16 dbSNP
rs370956652 19 dbSNP
rs182640164 20 dbSNP
rs777191314 25 dbSNP
rs1314031149 28 dbSNP
rs878942359 29 dbSNP
rs1277348157 36 dbSNP
rs774731315 40 dbSNP
rs770590240 55 dbSNP
rs994122299 60 dbSNP
rs11555610 69 dbSNP
rs1238891159 72 dbSNP
rs772713956 78 dbSNP
rs11555611 88 dbSNP
rs1260611917 97 dbSNP
rs1005511399 101 dbSNP
rs889885186 116 dbSNP
rs1255384498 118 dbSNP
rs1482235020 136 dbSNP
rs1197692560 137 dbSNP
rs1192401122 139 dbSNP
rs1251268222 151 dbSNP
rs528460977 152 dbSNP
rs1049867145 154 dbSNP
rs1243296812 156 dbSNP
rs559786212 170 dbSNP
rs901390169 171 dbSNP
rs542700075 176 dbSNP
rs1463927601 177 dbSNP
rs934925193 179 dbSNP
rs1400343725 217 dbSNP
rs926189788 230 dbSNP
rs1328933914 233 dbSNP
rs190155115 238 dbSNP
rs185779481 246 dbSNP
rs1043804021 253 dbSNP
rs1219660408 256 dbSNP
rs1276544563 267 dbSNP
rs557208432 269 dbSNP
rs377449716 270 dbSNP
rs1251983758 292 dbSNP
rs946375840 318 dbSNP
rs916217503 334 dbSNP
rs1255199356 336 dbSNP
rs1469064561 343 dbSNP
rs1290682157 352 dbSNP
rs1190994691 364 dbSNP
rs1430842165 371 dbSNP
rs1445779472 373 dbSNP
rs1423510645 380 dbSNP
rs1464686534 381 dbSNP
rs1328685756 382 dbSNP
rs1405251842 395 dbSNP
rs180900888 402 dbSNP
rs1396301294 409 dbSNP
rs1436683724 415 dbSNP
rs1337251396 420 dbSNP
rs990590355 430 dbSNP
rs960440377 431 dbSNP
rs1278808853 437 dbSNP
rs386660535 442 dbSNP
rs1317216451 446 dbSNP
rs1216935560 452 dbSNP
rs927813777 467 dbSNP
rs1470837769 470 dbSNP
rs575115261 474 dbSNP
rs746462774 484 dbSNP
rs1487083274 489 dbSNP
rs1187442084 491 dbSNP
rs1263186097 497 dbSNP
rs1477122100 498 dbSNP
rs558394285 499 dbSNP
rs1167937660 500 dbSNP
rs1419310826 503 dbSNP
rs747788042 504 dbSNP
rs1163690921 507 dbSNP
rs1179604762 511 dbSNP
rs1482596028 515 dbSNP
rs1005978132 517 dbSNP
rs576139579 518 dbSNP
rs1298567735 520 dbSNP
rs1028739910 525 dbSNP
rs1397997017 530 dbSNP
rs1295233556 531 dbSNP
rs1379924782 540 dbSNP
rs998259568 542 dbSNP
rs1256502464 545 dbSNP
rs1288042052 551 dbSNP
rs1318953896 553 dbSNP
rs901234632 555 dbSNP
rs1053221332 562 dbSNP
rs1297895865 565 dbSNP
rs538553545 581 dbSNP
rs1190652401 583 dbSNP
rs4682855 595 dbSNP
rs1180763587 596 dbSNP
rs1411251920 601 dbSNP
rs1043341879 610 dbSNP
rs948965605 615 dbSNP
rs1359615266 622 dbSNP
rs552932510 650 dbSNP
rs1454464971 652 dbSNP
rs1314713663 656 dbSNP
rs1359648750 656 dbSNP
rs191947252 670 dbSNP
rs916285912 675 dbSNP
rs1054786065 682 dbSNP
rs141157981 684 dbSNP
rs1309010246 688 dbSNP
rs1462236621 691 dbSNP
rs927659759 703 dbSNP
rs1162190992 709 dbSNP
rs1280025962 710 dbSNP
rs1442349324 720 dbSNP
rs6865 722 dbSNP
rs148369079 726 dbSNP
rs1441187358 727 dbSNP
rs749760145 740 dbSNP
rs796809336 744 dbSNP
rs984095138 744 dbSNP
rs954091841 746 dbSNP
rs1446948144 748 dbSNP
rs1175267389 749 dbSNP
rs1236772303 756 dbSNP
rs1425866486 758 dbSNP
rs1413770210 759 dbSNP
rs1332285515 771 dbSNP
rs1356301119 773 dbSNP
rs1028289096 774 dbSNP
rs1330995833 775 dbSNP
rs1127544 776 dbSNP
rs976683651 795 dbSNP
rs1275745684 798 dbSNP
rs1350854879 799 dbSNP
rs1217928794 809 dbSNP
rs1253304919 813 dbSNP
rs1219601233 822 dbSNP
rs187640672 823 dbSNP
rs552056132 824 dbSNP
rs1198700460 828 dbSNP
rs1031689820 837 dbSNP
rs528790066 842 dbSNP
rs999333939 847 dbSNP
rs181543348 856 dbSNP
rs1477668099 859 dbSNP
rs1374568451 860 dbSNP
rs1425640691 871 dbSNP
rs1466265762 876 dbSNP
rs1306097477 877 dbSNP
rs1398386697 879 dbSNP
rs1391773003 892 dbSNP
rs1375170305 916 dbSNP
rs71323168 918 dbSNP
rs866836598 920 dbSNP
rs1324644811 921 dbSNP
rs1022207122 926 dbSNP
rs1434726324 927 dbSNP
rs1404135070 956 dbSNP
rs35838080 962 dbSNP
rs1291461355 968 dbSNP
rs1218780888 969 dbSNP
rs1256793685 974 dbSNP
rs1315693948 977 dbSNP
rs1013200044 981 dbSNP
rs1267825849 982 dbSNP
rs894682705 987 dbSNP
rs1054798026 992 dbSNP
rs1265335971 994 dbSNP
rs1423550690 997 dbSNP
rs1365709184 1001 dbSNP
rs36020781 1002 dbSNP
rs897228291 1003 dbSNP
rs1193059607 1008 dbSNP
rs1427177970 1022 dbSNP
rs746634555 1025 dbSNP
rs1036811188 1042 dbSNP
rs777606876 1051 dbSNP
rs542991678 1052 dbSNP
rs749785212 1063 dbSNP
rs939764566 1063 dbSNP
rs1404010122 1067 dbSNP
rs1002682347 1076 dbSNP
rs909752253 1080 dbSNP
rs529296744 1093 dbSNP
rs547749340 1098 dbSNP
rs1277042241 1099 dbSNP
rs1181641245 1104 dbSNP
rs1420088274 1111 dbSNP
rs189179668 1112 dbSNP
rs1044669632 1113 dbSNP
rs1355209572 1114 dbSNP
rs1197599954 1124 dbSNP
rs947326838 1126 dbSNP
rs1490239216 1127 dbSNP
rs1269776101 1128 dbSNP
rs575052359 1131 dbSNP
rs1215760543 1132 dbSNP
rs1260896666 1136 dbSNP
rs1425686307 1142 dbSNP
rs1188316858 1144 dbSNP
rs932588679 1146 dbSNP
rs921158934 1154 dbSNP
rs1160836176 1158 dbSNP
rs976735843 1160 dbSNP
rs965380968 1167 dbSNP
rs1296927407 1168 dbSNP
rs1404947336 1171 dbSNP
rs1351526464 1172 dbSNP
rs1397341936 1176 dbSNP
rs1312731090 1177 dbSNP
rs1031612997 1178 dbSNP
rs1339524074 1178 dbSNP
rs1283869223 1196 dbSNP
rs1311226820 1196 dbSNP
rs397989344 1196 dbSNP
rs5848628 1196 dbSNP
rs764214373 1196 dbSNP
rs768292648 1196 dbSNP
rs1260079192 1197 dbSNP
rs869238932 1197 dbSNP
rs1201112944 1200 dbSNP
rs977571361 1201 dbSNP
rs1440929443 1206 dbSNP
rs1318525946 1207 dbSNP
rs1180698484 1213 dbSNP
rs1381116644 1217 dbSNP
rs1439518785 1222 dbSNP
rs914513273 1224 dbSNP
rs558336294 1228 dbSNP
rs934351858 1229 dbSNP
rs1302945806 1232 dbSNP
rs544851746 1234 dbSNP
rs1333011603 1235 dbSNP
rs376728513 1237 dbSNP
rs1304515454 1238 dbSNP
rs144392185 1240 dbSNP
rs965896842 1241 dbSNP
rs1343007750 1247 dbSNP
rs1200577253 1248 dbSNP
rs1239076364 1255 dbSNP
rs894748115 1257 dbSNP
rs911400086 1258 dbSNP
rs1383571602 1266 dbSNP
rs1158521151 1267 dbSNP
rs1269856004 1272 dbSNP
rs1454745152 1279 dbSNP
rs747903125 1281 dbSNP
rs1159329407 1298 dbSNP
rs1434287471 1300 dbSNP
rs778585672 1304 dbSNP
rs986073949 1306 dbSNP
rs1035914410 1307 dbSNP
rs371337604 1312 dbSNP
rs1376408687 1321 dbSNP
rs1467828497 1322 dbSNP
rs1172187395 1327 dbSNP
rs952982808 1352 dbSNP
rs1445507529 1361 dbSNP
rs1296260840 1366 dbSNP
rs149603457 1367 dbSNP
rs1387101414 1370 dbSNP
rs191120291 1375 dbSNP
rs1300562307 1380 dbSNP
rs994148706 1387 dbSNP
rs1480265740 1412 dbSNP
rs1220613440 1416 dbSNP
rs1258733635 1420 dbSNP
rs1317547389 1421 dbSNP
rs1267426901 1422 dbSNP
rs567172711 1423 dbSNP
rs1269886859 1427 dbSNP
rs754878897 1429 dbSNP
rs780326839 1430 dbSNP
rs1445381782 1435 dbSNP
rs1479050359 1437 dbSNP
rs1195230305 1443 dbSNP
rs556985732 1446 dbSNP
rs537154745 1457 dbSNP
rs1035747693 1458 dbSNP
rs1486787824 1461 dbSNP
rs753785409 1467 dbSNP
rs1254091379 1469 dbSNP
rs1222655609 1470 dbSNP
rs1323914281 1483 dbSNP
rs571413763 1486 dbSNP
rs905653284 1493 dbSNP
rs780171718 1495 dbSNP
rs1339995198 1498 dbSNP
rs1212859802 1501 dbSNP
rs1216362283 1504 dbSNP
rs939795144 1514 dbSNP
rs1011854101 1516 dbSNP
rs1221301890 1518 dbSNP
rs1289972440 1525 dbSNP
rs893034823 1541 dbSNP
rs551993054 1551 dbSNP
rs888155281 1559 dbSNP
rs1184243651 1567 dbSNP
rs1415591837 1570 dbSNP
rs1318373966 1576 dbSNP
rs934300039 1577 dbSNP
rs1163840980 1582 dbSNP
rs1363444686 1586 dbSNP
rs1421259141 1596 dbSNP
rs922949989 1598 dbSNP
rs527334032 1599 dbSNP
rs932450763 1603 dbSNP
rs943132541 1611 dbSNP
rs921085180 1619 dbSNP
rs756469637 1623 dbSNP
rs756237504 1624 dbSNP
rs985631229 1630 dbSNP
rs953014140 1640 dbSNP
rs527955520 1644 dbSNP
rs6442067 1648 dbSNP
rs1238656327 1652 dbSNP
rs201602754 1652 dbSNP
rs540327155 1652 dbSNP
rs752657060 1652 dbSNP
rs914617546 1652 dbSNP
rs961333399 1652 dbSNP
rs977788366 1652 dbSNP
rs374359510 1656 dbSNP
rs750185228 1656 dbSNP
rs1379621982 1657 dbSNP
rs1248293833 1673 dbSNP
rs1219245536 1680 dbSNP
rs991685820 1688 dbSNP
rs1359770968 1693 dbSNP
rs1035694014 1694 dbSNP
rs1447347231 1695 dbSNP
rs1335028034 1700 dbSNP
rs534523658 1703 dbSNP
rs1003324653 1710 dbSNP
rs77746108 1714 dbSNP
rs566340760 1715 dbSNP
rs1349174360 1716 dbSNP
rs1221400608 1721 dbSNP
rs1279918748 1722 dbSNP
rs1202918329 1724 dbSNP
rs767688830 1726 dbSNP
rs1003162006 1727 dbSNP
rs1461625030 1732 dbSNP
rs77133911 1732 dbSNP
rs962255964 1734 dbSNP
rs1023495448 1738 dbSNP
rs1468563004 1741 dbSNP
rs74684864 1742 dbSNP
rs762049665 1757 dbSNP
rs75505649 1759 dbSNP
rs368097352 1764 dbSNP
rs371181580 1769 dbSNP
rs1004262868 1783 dbSNP
rs184621775 1783 dbSNP
rs563539695 1787 dbSNP
rs901809230 1788 dbSNP
rs1331138317 1790 dbSNP
rs1040034579 1794 dbSNP
rs1270329014 1795 dbSNP
rs866353603 1798 dbSNP
rs549814919 1804 dbSNP
rs757340428 1811 dbSNP
rs781341059 1811 dbSNP
rs567784381 1815 dbSNP
rs1260643481 1820 dbSNP
rs533250982 1827 dbSNP
rs1313592281 1833 dbSNP
rs996536201 1839 dbSNP
rs564283031 1845 dbSNP
rs1049302647 1856 dbSNP
rs931467712 1859 dbSNP
rs1339069402 1868 dbSNP
rs181141803 1872 dbSNP
rs920097689 1875 dbSNP
rs138502715 1877 dbSNP
rs1396020196 1878 dbSNP
rs986891081 1882 dbSNP
rs1480028443 1889 dbSNP
rs764429166 1904 dbSNP
rs940253227 1909 dbSNP
rs1197375995 1919 dbSNP
rs1040847584 1933 dbSNP
rs928905034 1943 dbSNP
rs1394594926 1949 dbSNP
rs1407506464 1963 dbSNP
rs924489779 1966 dbSNP
rs567081972 1976 dbSNP
rs1349823118 1983 dbSNP
rs1403587750 1985 dbSNP
rs981448574 1991 dbSNP
rs970481486 1997 dbSNP
rs1341876831 1999 dbSNP
rs751706993 2000 dbSNP
rs1218686128 2003 dbSNP
rs1023021676 2007 dbSNP
rs189888521 2015 dbSNP
rs947346694 2018 dbSNP
rs369942147 2022 dbSNP
rs1445138902 2029 dbSNP
rs1290251017 2036 dbSNP
rs992006508 2038 dbSNP
rs1220219555 2041 dbSNP
rs1265220631 2044 dbSNP
rs1478224872 2051 dbSNP
rs958771968 2054 dbSNP
rs1031465533 2058 dbSNP
rs928796902 2067 dbSNP
rs998681696 2075 dbSNP
rs1179381719 2078 dbSNP
rs901756852 2082 dbSNP
rs1361718578 2088 dbSNP
rs1015564729 2090 dbSNP
rs1316930990 2094 dbSNP
rs1324332357 2099 dbSNP
rs1246469330 2100 dbSNP
rs1284595936 2103 dbSNP
rs763500242 2104 dbSNP
rs1197138406 2109 dbSNP
rs1007200666 2121 dbSNP
rs1288162663 2125 dbSNP
rs1290367556 2145 dbSNP
rs775908097 2146 dbSNP
rs770440473 2148 dbSNP
rs1048767010 2160 dbSNP
rs573542630 2161 dbSNP
rs147062284 2165 dbSNP
rs1026649926 2166 dbSNP
rs1188559210 2170 dbSNP
rs897616787 2185 dbSNP
rs1384819355 2193 dbSNP
rs1443229923 2195 dbSNP
rs762848005 2200 dbSNP
rs1160818562 2214 dbSNP
rs1317677157 2216 dbSNP
rs1453598048 2221 dbSNP
rs1440478851 2229 dbSNP
rs1335473596 2233 dbSNP
rs1329822827 2238 dbSNP
rs1411849701 2250 dbSNP
rs996583921 2254 dbSNP
rs1382088474 2255 dbSNP
rs1397251274 2258 dbSNP
rs879530714 2260 dbSNP
rs1040857409 2269 dbSNP
rs1163006649 2286 dbSNP
rs1007990316 2294 dbSNP
rs537082087 2297 dbSNP
rs1258862364 2303 dbSNP
rs1387031571 2310 dbSNP
rs1347277595 2312 dbSNP
rs1156675847 2313 dbSNP
rs903112986 2316 dbSNP
rs928879587 2317 dbSNP
rs1239115191 2318 dbSNP
rs1233193846 2319 dbSNP
rs1183598834 2323 dbSNP
rs1379870243 2324 dbSNP
rs868493979 2325 dbSNP
rs1489701196 2330 dbSNP
rs947305388 2349 dbSNP
rs866758090 2355 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucGACAAGGACGACuu 5'
            :| || ||||||  
Target 5' uaUUUUUGCUGCUG-- 3'
 		8 - 21
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 25994.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001099668 | 3UTR | AAGGAUUCUAGUUUAGUUUUUUGUAAUUGCAAAUUAUAUUUUUGCUGCUGAUAUAUUAGAAUAAUUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001099668 | 3UTR | GAUUCUAGUUUAGUUUUUUGUAAUUGCAAAUUAUAUUUUUGCUGCUGAUAUAUUAGAAUAAUUUUUAAAUGUCAUCUUGAAAUAGAAAUAUGUAUUUUAAGCACUCACGCAAAGGUAAAUGAACACGUUUUAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001099668 | 3UTR | AUUCUAGUUUAGUUUUUUGUAAUUGCAAAUUAUAUUUUUGCUGCUGAUAUAUUAGAAUAAUUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001099668 | 3UTR | AAGGAUUCUAGUUUAGUUUUUUGUAAUUGCAAAUUAUAUUUUUGCUGCUGAUAUAUUAGAAUAAUUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001099668 | 3UTR | GAUUCUAGUUUAGUUUUUUGUAAUUGCAAAUUAUAUUUUUGCUGCUGAUAUAUUAGAAUAAUUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001099668 | 3UTR | UUCUAGUUUAGUUUUUUGUAAUUGCAAAUUAUAUUUUUGCUGCUGAUAUAUUAGAAUAAUUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000321331.7 | 3UTR | CAAAUUAUAUUUUUGCUGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000321331.7 | 3UTR | CAAAUUAUAUUUUUGCUGCUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000321331.7 | 3UTR | CAAAUUAUAUUUUUGCUGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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