miRTarBase - #MIRT547991


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pre-miRNA Information
pre-miRNA hsa-mir-103b-1   
Genomic Coordinates chr5: 168560904 - 168560965
Description Homo sapiens miR-103b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-103b-2   
Genomic Coordinates chr20: 3917502 - 3917563
Description Homo sapiens miR-103b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-103b
Sequence 1| UCAUAGCCCUGUACAAUGCUGCU |23
Evidence Experimental
Experiments ChIP-seq
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28198041 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369221403 4 dbSNP
rs1283132774 7 dbSNP
rs1222085747 10 dbSNP
rs572980521 14 dbSNP
rs748411363 15 dbSNP
rs769854452 23 dbSNP
Putative Targets

Gene Information
Gene Symbol HCFC2   
Synonyms HCF-2, HCF2
Description host cell factor C2
Transcript NM_013320   
Expression
Putative miRNA Targets on HCFC2
3'UTR of HCFC2
(miRNA target sites are highlighted)		 
>HCFC2|NM_013320|3'UTR
   1 ATTGGTTTTTTTACTGAAGCTATTGTGATGATGATTATTTATTAGTAACTGGTTATGAAGATTTGTCATTTAAAAGAGTA
  81 TTCTCTGGCTGTATTTCCAGCAGTTATGAACTTGAGTTTGTAAATTGTTCTTAAAATGTATTTGCTGAATTATAGATCCA
 161 AATAAAAGAAAAGAAGCAAAGACTCTCTGAAAATTAGTATATGAGTTCTTCCTTACAGATATAGCTCTTTTATAAAGAAA
 241 AACAGTGAAATTAAGATAAAAGCTAGAAAGCTTTATTACCCCAATATCTTTTATAAGGGCTGTGTAACCCAGTCATCCTA
 321 GAGTTATTGAGATGATTCTGGTAACTGGCTGTTGTATACTATGCTGTCTTATATAGTAAATGTTCTCTACATTGTAAATG
 401 TCCTACCTTTGAGTACTCCTTCTATCTTTATTCTATATGAGCAGTGTTCCTCTAACAACTGTCTTCTATTGGATAATATG
 481 TGTGATACTATAATAATTCTAATAGTTATTTGATTCCTTTCTTTGTTTACAGTTAGCACAGAGCTTAAGAAATTAAAAAA
 561 GAGGCAAGTTTAGAAACTGCTTTTGAACTTTTATTATTTTCCAAGAATCATGGTAAAATACAACAAGAACAATGAGTTTT
 641 CTTGATTCTTACCAGGCCAATATATTTGAATATATTTTTGGCCAAAGCACTTAACTTATCTGGCCCTCATTTTCCTCATA
 721 ACAGATGAGGGAGTTAAAGCAGTTTATCTTTTAGGTCCCTTTCAGCACTAAGGTTTTGTGTTTTTAGTAGAAGTGAAGTA
 801 TGTCCCTGAACATTTTCATCTGTCTTAATGGCTCTAATTTTGCTTTTGCTAAAATTAAAATCTTCATAATTGAATTCAAA
 881 ATTAAAGTATATGTCCTCCTATTGGAGAAAAAAACAAGCACCTTAACAGGACACAAGTTTTAAAATAGTGTTTTAAACAT
 961 TTGTAAGATTTTTGTAAATGCTCTAAATGTTTTATTTTTGCATTGTTTTTACCTTGAAATTGTATAAACTTTTTTACTAT
1041 GAAAATATAAGCATTAGACAGCTAACTCAGGTTCCATTACAACCTTAAAGATACAGATAGGCATTATAAACACTCTGCTA
1121 CAGGTAACTTGTTTTAAACCTTTTAGGAATTTCATGGTTCCACTGCCTATTTAAATCTGGAATTAATATACAGAGCAATA
1201 ATTGCAGAAAAGATATTTCAAACTAAGAGCTTCAATAACTGCAGGGGCACAGGTCTATCTTTTTTTATACCACATAACCT
1281 TATGCCAGTTTAGGTTGACTGAGTAGCTATGTCCTCAAATTTCATGTATGATACCCCCCAGCAAAGATGGATTTAATTGT
1361 GCAGAATTGATATATATGTGTGTTCCAGTTACTAATTTAAAGTGTATAGAATATTTTAATATATAATTTTTGTAAAGAAC
1441 TGGGATTTTTATACTACAGTATTTGTAATTAATGTGTCTCACTAATTAAGTTTCTCTTGAAGAAAATATGCAAATTGTTA
1521 GACACATAATGAGTGGTTTCCAAACTCTAAAGATAAAATAAATGCACTACTATGGTGTTGTTAGAATACCTTTTTTGTGG
1601 CTGTATGAATCTTTACTCTTTAAATGTGTACTTTACAATGTTTACAAGGAGCTTCTCTGGTTTGTTATCCCAGCAATGCC
1681 CTTGGTGAGAGCTTCATTCTGCATTTGTTTAATTCATATGCTTTGCTTTTGGCATATGCTTGCTTTTTGCACTAGTAGAA
1761 TTTTAACTTACCTCATTATTATGTTTGTAATCATTTGTCTAGCTTCTGTAATGTATCTGATATAGGCTAAACAAATACTT
1841 AACCAAAGTTAAAATACATGGTAAGCAATTTTGCACATATTAAATATTAGGGTTTGTTGTGTATATGTGTATACTTAATT
1921 ATAAAAGAATATGAATGGAAAGTTATACTAAAAGTATATGTTTCAAGCCCAGTTATTTTAAAGATCTATTGCTTTAATAG
2001 AAAAAGTTTGGCTTTTAACCCTTTCTTCTCTGCATTAATTAACAACGTGCATCTTGAAGCCCTTCTCCTGATAACAAGGA
2081 ATAAGTTGATTTTAAGCAAAGGATAGAATATTTGTTTGAGTGTGCACATTTATACCTGTTTAGTATTTGATTCAGTTAAG
2161 CCTCCACTCTTCTGGATCAGGAGGTGATTCTGAACCTGTGGTTCTAACATATGACTTAACTGTTTAGAGGGAAGAGAAGT
2241 CTTTCTATACTGAGGGATTTGTTAAAATCATAAATGTTTTTGCCCTGAGACTTAGCCCAGATTCTATTTTTTTTTTTTTT
2321 TTGGCATTTGTACATTAAGCACCAGTCATATTTATCTCTGTGATAAGGGATTGCTGACTAAAAAATGCCATTAAGAAATC
2401 TCTGTGGCTTTGACATTAGTAGTTAATAAGAGATCTTAGAGCTGTGTGCTGATGAATAGAATGAATTGGAGCAAATAGCA
2481 AGAGAAGTGCATTTAGCTTCTTATGATTTGCACATTTTCTAAATGAAGATCCCTTTGTGTAGCAGTAGGCTGTATCATGC
2561 AGATATTTTTCATAGGATTTGCACTGAGTTAAATGACTTTCTTTACTCTTCCCAGTCAGGTAAGCAGTTCAAATATAACA
2641 AGACTTTGTGCCAGTCCTCTTCTGTGTTCTGCAACTCTGGCTCTCATAAGTAGTAAAAATATTTTTGATGTTGCATGCTC
2721 TCAGAATTATGTTTTCTAAAATATCATATTGGCTTCATTTTAGTTTAATAAACTTCTTTGGCAACTTAATTAGACATAGG
2801 GTATATATAAACTCAATTTTATCTGCATTTTTTAAAAAATTGAAATAATCTGATTGCATGTATGAAGGACTCCTGCCTCA
2881 TTACCCAATTACATAAATACAATTATCTATAGGAAGGTGAAATTGTTGATCTATTATTTCAAAGACTTGTAGACTAGCAA
2961 AGATTCATTCTGATTAGAAATAAGGTCTATAGCTAAAGATATTTTTATTTTAAAAAATTACAGCCCTTGTAACAAAAATC
3041 ATTTGTAACATTGGATATGAAGACATTATTAGTATTTAAAATTATTGTAGTCATTTGATCATAAATGAAGTAGCTTGCAA
3121 AATAGACTTGGTCTTTGACCCTTTAAGGTGTAACTGACTGACTGTTGTGTTTTTCAAGACTGATTTTAGGCAGTTTTATG
3201 TATCGTGTACCAATGATATGTAAAATAAAGCACCTTTTCTACTATAAACAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGUCGU--AACAUG-UCCCGAUACu 5'
            || :|  || ||: ||||||:|| 
Target 5' ccCAATATCTTTTATAAGGGCTGTGt 3'
 280 - 305 147.00 -14.50
2 
miRNA  3' ucgucGUAA-CAUGUCCCGAUACu 5'
               :||| |||   ||:|||| 
Target 5' ttattTATTAGTAACTGGTTATGa 3'
 35 - 58 138.00 -11.00
3 
miRNA  3' ucgUCGU-AACA-UGU-CCCGAUACu 5'
             | || |||| |||  || |||| 
Target 5' aaaATCATTTGTAACATTGGATATGa 3'
 3035 - 3060 128.00 -8.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31576400 6 COSMIC
COSN30635960 13 COSMIC
COSN30511471 16 COSMIC
COSN31514103 93 COSMIC
COSN7308178 370 COSMIC
COSN24927950 376 COSMIC
COSN32010010 463 COSMIC
COSN20668638 708 COSMIC
COSN16438510 1046 COSMIC
COSN15992681 1690 COSMIC
COSN5928632 1758 COSMIC
COSN20092635 1814 COSMIC
COSN20110063 1927 COSMIC
COSN27217131 2323 COSMIC
COSN4726446 2525 COSMIC
COSN24042174 2920 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1267831957 3 dbSNP
rs750538624 6 dbSNP
rs759703540 6 dbSNP
rs1260867456 7 dbSNP
rs767568866 9 dbSNP
rs775607693 12 dbSNP
rs1428216973 13 dbSNP
rs1290385892 21 dbSNP
rs1412379006 22 dbSNP
rs371832373 23 dbSNP
rs543945744 23 dbSNP
rs764203945 26 dbSNP
rs1359239981 27 dbSNP
rs1322211511 28 dbSNP
rs754272498 29 dbSNP
rs1362540100 31 dbSNP
rs1296910999 33 dbSNP
rs757618662 35 dbSNP
rs1401031075 45 dbSNP
rs779205414 51 dbSNP
rs955153823 55 dbSNP
rs1406930772 56 dbSNP
rs1364006415 62 dbSNP
rs1007524181 67 dbSNP
rs1019394995 80 dbSNP
rs1387262621 81 dbSNP
rs1156703336 98 dbSNP
rs965319632 110 dbSNP
rs1377929592 117 dbSNP
rs377596943 131 dbSNP
rs987699200 138 dbSNP
rs547297695 141 dbSNP
rs1402849923 164 dbSNP
rs963676235 164 dbSNP
rs867025664 184 dbSNP
rs1331186118 189 dbSNP
rs1203831946 192 dbSNP
rs148300201 194 dbSNP
rs983923544 198 dbSNP
rs1225807052 201 dbSNP
rs1343840822 214 dbSNP
rs1386836546 220 dbSNP
rs1302836759 243 dbSNP
rs1310046564 248 dbSNP
rs1222475856 264 dbSNP
rs1400029367 270 dbSNP
rs1402912413 272 dbSNP
rs534476335 279 dbSNP
rs1016651847 280 dbSNP
rs1428369529 281 dbSNP
rs1193877086 289 dbSNP
rs1319656916 293 dbSNP
rs958736251 293 dbSNP
rs919712651 295 dbSNP
rs916924620 299 dbSNP
rs1196529791 303 dbSNP
rs1280000085 311 dbSNP
rs931062406 315 dbSNP
rs983043624 324 dbSNP
rs1321807053 327 dbSNP
rs112515414 332 dbSNP
rs908346472 334 dbSNP
rs1488799519 345 dbSNP
rs758769635 349 dbSNP
rs770980433 362 dbSNP
rs1430157849 365 dbSNP
rs1192967964 376 dbSNP
rs1265405735 378 dbSNP
rs1046264444 382 dbSNP
rs1043861792 406 dbSNP
rs936114569 407 dbSNP
rs905204594 417 dbSNP
rs1055040405 419 dbSNP
rs938053207 425 dbSNP
rs1417032555 434 dbSNP
rs1166774195 436 dbSNP
rs1426055023 438 dbSNP
rs889195692 441 dbSNP
rs943486102 447 dbSNP
rs1185893784 451 dbSNP
rs1460383555 455 dbSNP
rs142012550 462 dbSNP
rs901879234 469 dbSNP
rs778155530 472 dbSNP
rs893912318 473 dbSNP
rs1009636528 474 dbSNP
rs1021559735 480 dbSNP
rs1317255104 483 dbSNP
rs993480139 489 dbSNP
rs1360879843 492 dbSNP
rs1382014497 494 dbSNP
rs1459936945 504 dbSNP
rs1292321291 517 dbSNP
rs1331782975 520 dbSNP
rs1364815628 522 dbSNP
rs1403808991 526 dbSNP
rs571860607 531 dbSNP
rs1009162594 540 dbSNP
rs146337443 551 dbSNP
rs1005335584 553 dbSNP
rs1216553888 555 dbSNP
rs1017219207 562 dbSNP
rs964958228 565 dbSNP
rs1481797590 566 dbSNP
rs1231563825 577 dbSNP
rs1204006049 589 dbSNP
rs1490577690 594 dbSNP
rs958464378 603 dbSNP
rs1243953013 604 dbSNP
rs181716294 605 dbSNP
rs1309947013 608 dbSNP
rs1225413426 611 dbSNP
rs1024072278 615 dbSNP
rs1278754109 620 dbSNP
rs971027408 620 dbSNP
rs1367125481 624 dbSNP
rs1263628145 628 dbSNP
rs1423508521 630 dbSNP
rs975111861 654 dbSNP
rs977087028 655 dbSNP
rs924823356 656 dbSNP
rs1406162169 659 dbSNP
rs771168592 661 dbSNP
rs1476995037 665 dbSNP
rs1186265384 668 dbSNP
rs952585987 683 dbSNP
rs936271492 685 dbSNP
rs776759958 690 dbSNP
rs1490192649 720 dbSNP
rs1261419455 723 dbSNP
rs1414931269 735 dbSNP
rs1407456918 742 dbSNP
rs1217787859 767 dbSNP
rs187588902 769 dbSNP
rs908378700 771 dbSNP
rs910732225 772 dbSNP
rs1219631227 777 dbSNP
rs1346984229 780 dbSNP
rs776744047 798 dbSNP
rs1349810649 804 dbSNP
rs749229722 812 dbSNP
rs536320027 818 dbSNP
rs949182099 821 dbSNP
rs981907446 824 dbSNP
rs1290126393 833 dbSNP
rs1455789642 835 dbSNP
rs1344013338 849 dbSNP
rs1158793543 851 dbSNP
rs546619157 874 dbSNP
rs1470534280 880 dbSNP
rs1431931590 881 dbSNP
rs926575320 888 dbSNP
rs1298339169 892 dbSNP
rs1362039352 902 dbSNP
rs866497707 906 dbSNP
rs1484835876 916 dbSNP
rs1241497807 918 dbSNP
rs937917541 922 dbSNP
rs1053739085 923 dbSNP
rs768622261 932 dbSNP
rs1269259958 934 dbSNP
rs929276880 947 dbSNP
rs1222454696 948 dbSNP
rs1307776661 951 dbSNP
rs1297098296 955 dbSNP
rs1379553055 982 dbSNP
rs1229825650 983 dbSNP
rs1310481798 988 dbSNP
rs1047757269 1018 dbSNP
rs887026096 1027 dbSNP
rs1454014858 1029 dbSNP
rs893785100 1031 dbSNP
rs945466938 1040 dbSNP
rs1469477469 1042 dbSNP
rs1373895970 1045 dbSNP
rs566843059 1051 dbSNP
rs1172591721 1052 dbSNP
rs1005906203 1054 dbSNP
rs1288302405 1063 dbSNP
rs1042442079 1071 dbSNP
rs890624002 1082 dbSNP
rs539194238 1084 dbSNP
rs1017781309 1097 dbSNP
rs1241029359 1099 dbSNP
rs1238278900 1107 dbSNP
rs1012771545 1108 dbSNP
rs1480738573 1114 dbSNP
rs900776063 1117 dbSNP
rs190977382 1152 dbSNP
rs1224818321 1157 dbSNP
rs1306375223 1166 dbSNP
rs1315146935 1167 dbSNP
rs1024434349 1170 dbSNP
rs577817233 1172 dbSNP
rs971143797 1189 dbSNP
rs998513933 1190 dbSNP
rs1180542416 1192 dbSNP
rs761597784 1197 dbSNP
rs534629824 1201 dbSNP
rs1031378362 1231 dbSNP
rs1460660765 1232 dbSNP
rs957587794 1236 dbSNP
rs1164354279 1243 dbSNP
rs1383354636 1244 dbSNP
rs1446370941 1244 dbSNP
rs537254618 1247 dbSNP
rs995062499 1256 dbSNP
rs1440899832 1258 dbSNP
rs1158690917 1260 dbSNP
rs1381582854 1268 dbSNP
rs1193651720 1272 dbSNP
rs1398465526 1279 dbSNP
rs1317116331 1281 dbSNP
rs183267808 1284 dbSNP
rs186802610 1285 dbSNP
rs990834511 1289 dbSNP
rs1244738117 1297 dbSNP
rs767241019 1304 dbSNP
rs772872823 1307 dbSNP
rs910816418 1308 dbSNP
rs3765111 1319 dbSNP
rs1389871521 1329 dbSNP
rs559421954 1330 dbSNP
rs1240740603 1335 dbSNP
rs1311405412 1362 dbSNP
rs1351522311 1364 dbSNP
rs1363817073 1370 dbSNP
rs1162810287 1380 dbSNP
rs923352384 1393 dbSNP
rs970442580 1401 dbSNP
rs1179468633 1402 dbSNP
rs1223293166 1406 dbSNP
rs981938872 1407 dbSNP
rs1418118357 1408 dbSNP
rs569292509 1415 dbSNP
rs1269213167 1419 dbSNP
rs926439553 1420 dbSNP
rs1489614494 1422 dbSNP
rs34650898 1427 dbSNP
rs959301616 1427 dbSNP
rs765368419 1443 dbSNP
rs1209703971 1452 dbSNP
rs1262855993 1462 dbSNP
rs1237391387 1465 dbSNP
rs1279593217 1473 dbSNP
rs1444401654 1474 dbSNP
rs989384622 1478 dbSNP
rs546114350 1483 dbSNP
rs557514833 1487 dbSNP
rs189683606 1491 dbSNP
rs1322989920 1500 dbSNP
rs565575712 1512 dbSNP
rs1042772394 1515 dbSNP
rs554690860 1518 dbSNP
rs1038670819 1523 dbSNP
rs1429772850 1546 dbSNP
rs1178057382 1548 dbSNP
rs1479257899 1551 dbSNP
rs1267536237 1553 dbSNP
rs1193356099 1555 dbSNP
rs912017986 1557 dbSNP
rs1264545153 1563 dbSNP
rs944752762 1573 dbSNP
rs1039234712 1576 dbSNP
rs1328866274 1576 dbSNP
rs1468153257 1580 dbSNP
rs1264151216 1591 dbSNP
rs1225522425 1592 dbSNP
rs1321743697 1627 dbSNP
rs183428768 1629 dbSNP
rs995092162 1632 dbSNP
rs1267002706 1639 dbSNP
rs1425407139 1643 dbSNP
rs1049283752 1652 dbSNP
rs1328298558 1665 dbSNP
rs886683828 1677 dbSNP
rs1434284782 1685 dbSNP
rs1406468129 1697 dbSNP
rs1003922182 1704 dbSNP
rs763018246 1718 dbSNP
rs1015657920 1720 dbSNP
rs1424074260 1756 dbSNP
rs970480157 1757 dbSNP
rs1003218039 1762 dbSNP
rs1415864860 1765 dbSNP
rs753376974 1766 dbSNP
rs1173855560 1777 dbSNP
rs1167971639 1782 dbSNP
rs1476083400 1784 dbSNP
rs998626667 1787 dbSNP
rs1031327291 1798 dbSNP
rs1244119851 1799 dbSNP
rs755504923 1802 dbSNP
rs765779004 1803 dbSNP
rs1447267969 1807 dbSNP
rs915194747 1812 dbSNP
rs572881512 1814 dbSNP
rs1341476894 1819 dbSNP
rs1268503337 1824 dbSNP
rs1227554463 1832 dbSNP
rs1441544247 1833 dbSNP
rs1383517867 1837 dbSNP
rs1275564421 1846 dbSNP
rs1450249308 1862 dbSNP
rs1358390079 1864 dbSNP
rs1329072897 1866 dbSNP
rs1347355033 1876 dbSNP
rs1393623136 1878 dbSNP
rs1167481104 1880 dbSNP
rs746287495 1893 dbSNP
rs1449390818 1897 dbSNP
rs1217648184 1898 dbSNP
rs978138757 1902 dbSNP
rs1318958947 1910 dbSNP
rs144862055 1923 dbSNP
rs976656692 1928 dbSNP
rs1437811293 1933 dbSNP
rs1237267127 1948 dbSNP
rs1205413875 1949 dbSNP
rs758859676 1955 dbSNP
rs1270964027 1973 dbSNP
rs1204571776 1976 dbSNP
rs950790024 1986 dbSNP
rs1317018411 1989 dbSNP
rs1243729574 2005 dbSNP
rs1378092153 2006 dbSNP
rs1279940211 2009 dbSNP
rs1246745064 2020 dbSNP
rs983471941 2021 dbSNP
rs1306841641 2023 dbSNP
rs715664 2027 dbSNP
rs187965063 2029 dbSNP
rs1366930958 2040 dbSNP
rs1165947147 2043 dbSNP
rs944793596 2047 dbSNP
rs1055139517 2050 dbSNP
rs1039101160 2053 dbSNP
rs577086554 2065 dbSNP
rs1394217183 2069 dbSNP
rs139680755 2082 dbSNP
rs1471260365 2111 dbSNP
rs1409342498 2115 dbSNP
rs922104443 2120 dbSNP
rs1490523896 2145 dbSNP
rs747278055 2152 dbSNP
rs1220091288 2161 dbSNP
rs930862997 2168 dbSNP
rs1332857100 2171 dbSNP
rs1403195252 2176 dbSNP
rs1282879703 2184 dbSNP
rs1370697631 2194 dbSNP
rs530169151 2195 dbSNP
rs1341426264 2197 dbSNP
rs1049693854 2202 dbSNP
rs1256606376 2210 dbSNP
rs1434935473 2211 dbSNP
rs1349847655 2235 dbSNP
rs1160257444 2247 dbSNP
rs1402749633 2248 dbSNP
rs1410261129 2252 dbSNP
rs1158626790 2254 dbSNP
rs1045571769 2258 dbSNP
rs907061994 2271 dbSNP
rs193180090 2273 dbSNP
rs1292664518 2274 dbSNP
rs1217893343 2302 dbSNP
rs1326728990 2305 dbSNP
rs201086031 2305 dbSNP
rs763632297 2306 dbSNP
rs1160250125 2307 dbSNP
rs1216719904 2307 dbSNP
rs1289926382 2307 dbSNP
rs1362065382 2307 dbSNP
rs34448146 2307 dbSNP
rs398039969 2307 dbSNP
rs777483326 2307 dbSNP
rs1452771992 2308 dbSNP
rs566800505 2311 dbSNP
rs1386839633 2313 dbSNP
rs892895759 2321 dbSNP
rs79514952 2322 dbSNP
rs75700062 2323 dbSNP
rs1267713387 2324 dbSNP
rs1477969600 2325 dbSNP
rs61939186 2325 dbSNP
rs1195533945 2326 dbSNP
rs1371086828 2331 dbSNP
rs1474972984 2332 dbSNP
rs1163710431 2333 dbSNP
rs1011652986 2335 dbSNP
rs1422808603 2338 dbSNP
rs539028529 2345 dbSNP
rs1432618926 2346 dbSNP
rs1420320579 2349 dbSNP
rs1361378823 2361 dbSNP
rs1402038941 2399 dbSNP
rs1005533020 2405 dbSNP
rs879400921 2409 dbSNP
rs906184573 2410 dbSNP
rs552250731 2415 dbSNP
rs866900130 2418 dbSNP
rs997752904 2420 dbSNP
rs1232112799 2427 dbSNP
rs1245997317 2428 dbSNP
rs1307502231 2429 dbSNP
rs1030554830 2430 dbSNP
rs950863306 2434 dbSNP
rs1363734676 2439 dbSNP
rs983588138 2452 dbSNP
rs1286460093 2458 dbSNP
rs541205149 2466 dbSNP
rs1003249522 2471 dbSNP
rs2723874 2475 dbSNP
rs1016726375 2477 dbSNP
rs963527694 2498 dbSNP
rs1033355540 2499 dbSNP
rs548154627 2503 dbSNP
rs1219590723 2505 dbSNP
rs1447547432 2515 dbSNP
rs991225388 2521 dbSNP
rs1184153669 2522 dbSNP
rs757533623 2524 dbSNP
rs2956460 2529 dbSNP
rs142988999 2554 dbSNP
rs948628955 2557 dbSNP
rs2731020 2563 dbSNP
rs1199472567 2564 dbSNP
rs537311460 2565 dbSNP
rs1480790444 2568 dbSNP
rs781183803 2574 dbSNP
rs1488348621 2591 dbSNP
rs1202461476 2604 dbSNP
rs1340632245 2628 dbSNP
rs1274490501 2633 dbSNP
rs981325257 2634 dbSNP
rs1342575898 2648 dbSNP
rs745953703 2662 dbSNP
rs769692211 2664 dbSNP
rs1395667365 2669 dbSNP
rs1374382101 2671 dbSNP
rs1218276470 2686 dbSNP
rs978393054 2692 dbSNP
rs774355999 2698 dbSNP
rs557220183 2699 dbSNP
rs934441042 2705 dbSNP
rs1164052818 2709 dbSNP
rs1259249173 2714 dbSNP
rs1426492445 2715 dbSNP
rs1018961653 2718 dbSNP
rs1366486824 2746 dbSNP
rs1186663166 2758 dbSNP
rs544351709 2770 dbSNP
rs966002206 2788 dbSNP
rs1179597035 2791 dbSNP
rs767979234 2797 dbSNP
rs974735251 2801 dbSNP
rs1291877665 2804 dbSNP
rs573861648 2807 dbSNP
rs1188069086 2809 dbSNP
rs536390467 2813 dbSNP
rs553028759 2814 dbSNP
rs1039099048 2821 dbSNP
rs1264015296 2834 dbSNP
rs900138103 2834 dbSNP
rs185097647 2835 dbSNP
rs75460630 2841 dbSNP
rs886700789 2855 dbSNP
rs1349888785 2857 dbSNP
rs908006785 2860 dbSNP
rs1303900753 2865 dbSNP
rs1004998198 2871 dbSNP
rs750886294 2873 dbSNP
rs1380946577 2874 dbSNP
rs1388546917 2880 dbSNP
rs940970173 2886 dbSNP
rs80080991 2900 dbSNP
rs150692603 2901 dbSNP
rs1421610150 2903 dbSNP
rs1454076880 2918 dbSNP
rs1287268407 2921 dbSNP
rs1045921471 2922 dbSNP
rs1156417233 2925 dbSNP
rs906215604 2930 dbSNP
rs1396955029 2934 dbSNP
rs939053702 2948 dbSNP
rs1054715609 2954 dbSNP
rs1336607903 2967 dbSNP
rs1265821988 2968 dbSNP
rs1024149695 2970 dbSNP
rs894916342 2976 dbSNP
rs1486358022 2982 dbSNP
rs1270431248 2985 dbSNP
rs1011057786 2987 dbSNP
rs1022139605 3003 dbSNP
rs1245829520 3012 dbSNP
rs188517893 3013 dbSNP
rs902307671 3025 dbSNP
rs1329441200 3028 dbSNP
rs982109450 3047 dbSNP
rs1382716181 3060 dbSNP
rs1390492442 3063 dbSNP
rs1318369834 3079 dbSNP
rs117873850 3089 dbSNP
rs756632234 3093 dbSNP
rs771882654 3099 dbSNP
rs1200790761 3101 dbSNP
rs1376576304 3103 dbSNP
rs1198704283 3118 dbSNP
rs1448133798 3123 dbSNP
rs778232136 3128 dbSNP
rs1250286903 3130 dbSNP
rs1207274702 3134 dbSNP
rs1464598239 3137 dbSNP
rs974764956 3141 dbSNP
rs1028985267 3143 dbSNP
rs1274351799 3148 dbSNP
rs952175881 3151 dbSNP
rs1228059062 3152 dbSNP
rs985256848 3154 dbSNP
rs544489731 3160 dbSNP
rs1295100290 3164 dbSNP
rs940819934 3166 dbSNP
rs1434025222 3170 dbSNP
rs1238722278 3179 dbSNP
rs981566745 3187 dbSNP
rs928928201 3196 dbSNP
rs900253140 3200 dbSNP
rs937574109 3206 dbSNP
rs1400850638 3210 dbSNP
rs1168062401 3220 dbSNP
rs1054745372 3236 dbSNP
rs1363413144 3246 dbSNP
rs1367033762 3246 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgucguaacauguccCGAUACu 5'
                          |||||| 
Target 5' aauuacaaacaaugcuGCUAUG- 3'
 		2 - 23
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 29915.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000229330.4 | 3UTR | CAAUUACAAACAAUGCUGCUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000229330.4 | 3UTR | CAAUUACAAACAAUGCUGCUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000229330.4 | 3UTR | CAAUUACAAACAAUGCUGCUAUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000229330.4 | 3UTR | CAAUUACAAACAAUGCUGCUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.731 2.3e-3 0.703 3.7e-3 13 Click to see details
GSE28544 Breast cancer 0.18 2.0e-1 0.328 5.9e-2 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-103b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT218386 E2F3 E2F transcription factor 3 2 2
MIRT404221 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT441502 SPG20 spartin 2 6
MIRT444124 ZNRF3 zinc and ring finger 3 2 2
MIRT454236 OSBPL10 oxysterol binding protein like 10 2 4
MIRT457919 ZNF212 zinc finger protein 212 2 2
MIRT462254 LAMA4 laminin subunit alpha 4 2 2
MIRT463176 ZNF281 zinc finger protein 281 2 2
MIRT472355 TSPAN1 tetraspanin 1 2 2
MIRT474133 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT494946 IFFO2 intermediate filament family orphan 2 2 2
MIRT497403 NPY4R neuropeptide Y receptor Y4 2 2
MIRT497641 GLDN gliomedin 2 2
MIRT505340 TMEM245 transmembrane protein 245 2 6
MIRT505680 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT510706 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT512198 C1orf43 chromosome 1 open reading frame 43 2 2
MIRT522089 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT525074 FRK fyn related Src family tyrosine kinase 2 2
MIRT531276 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT535119 PLXNA2 plexin A2 2 2
MIRT540836 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541018 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT545752 CA12 carbonic anhydrase 12 2 4
MIRT546404 SRP9 signal recognition particle 9 2 2
MIRT547991 HCFC2 host cell factor C2 2 4
MIRT554502 SAE1 SUMO1 activating enzyme subunit 1 2 2
MIRT558360 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT558863 CD2AP CD2 associated protein 2 2
MIRT559939 ZNF567 zinc finger protein 567 2 2
MIRT566300 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT567490 FOXK1 forkhead box K1 2 2
MIRT617139 ZNF556 zinc finger protein 556 2 2
MIRT625400 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT626491 CEP89 centrosomal protein 89 2 2
MIRT629487 GSN gelsolin 2 4
MIRT638456 PLXDC2 plexin domain containing 2 2 2
MIRT648498 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT654845 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT664587 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664977 TDRD1 tudor domain containing 1 2 2
MIRT665028 ELK1 ELK1, ETS transcription factor 2 2
MIRT666043 STON2 stonin 2 2 2
MIRT668863 CRY2 cryptochrome circadian clock 2 2 2
MIRT669297 C17orf85 nuclear cap binding subunit 3 2 2
MIRT680975 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682267 RS1 retinoschisin 1 2 2
MIRT685283 KIAA1143 KIAA1143 2 2
MIRT693375 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT701785 MSL1 male specific lethal 1 homolog 2 2
MIRT709373 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT715154 IL12B interleukin 12B 2 2
MIRT734499 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-103b Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-103b Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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