pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FOXA1   
Synonyms HNF3A, TCF3A
Description forkhead box A1
Transcript NM_004496   
Expression
Putative miRNA Targets on FOXA1
3'UTR of FOXA1
(miRNA target sites are highlighted)
>FOXA1|NM_004496|3'UTR
   1 CTCCCGGGACTGGGGGGTTTGTCTGGCATAGCCATGCTGGTAGCAAGAGAGAAAAAATCAACAGCAAACAAAACCACACA
  81 AACCAAACCGTCAACAGCATAATAAAATCCCAACAACTATTTTTATTTCATTTTTCATGCACAACCTTTCCCCCAGTGCA
 161 AAAGACTGTTACTTTATTATTGTATTCAAAATTCATTGTGTATATTACTACAAAGACAACCCCAAACCAATTTTTTTCCT
 241 GCGAAGTTTAATGATCCACAAGTGTATATATGAAATTCTCCTCCTTCCTTGCCCCCCTCTCTTTCTTCCCTCTTTCCCCT
 321 CCAGACATTCTAGTTTGTGGAGGGTTATTTAAAAAAACAAAAAAGGAAGATGGTCAAGTTTGTAAAATATTTGTTTGTGC
 401 TTTTTCCCCCTCCTTACCTGACCCCCTACGAGTTTACAGGTCTGTGGCAATACTCTTAACCATAAGAATTGAAATGGTGA
 481 AGAAACAAGTATACACTAGAGGCTCTTAAAAGTATTGAAAGACAATACTGCTGTTATATAGCAAGACATAAACAGATTAT
 561 AAACATCAGAGCCATTTGCTTCTCAGTTTACATTTCTGATACATGCAGATAGCAGATGTCTTTAAATGAAATACATGTAT
 641 ATTGTGTATGGACTTAATTATGCACATGCTCAGATGTGTAGACATCCTCCGTATATTTACATAACATATAGAGGTAATAG
 721 ATAGGTGATATACATGATACATTCTCAAGAGTTGCTTGACCGAAAGTTACAAGGACCCCAACCCCTTTGTCCTCTCTACC
 801 CACAGATGGCCCTGGGAATCAATTCCTCAGGAATTGCCCTCAAGAACTCTGCTTCTTGCTTTGCAGAGTGCCATGGTCAT
 881 GTCATTCTGAGGTCACATAACACATAAAATTAGTTTCTATGAGTGTATACCATTTAAAGAATTTTTTTTTCAGTAAAAGG
 961 GAATATTACAATGTTGGAGGAGAGATAAGTTATAGGGAGCTGGATTTCAAAACGTGGTCCAAGATTCAAAAATCCTATTG
1041 ATAGTGGCCATTTTAATCATTGCCATCGTGTGCTTGTTTCATCCAGTGTTATGCACTTTCCACAGTTGGACATGGTGTTA
1121 GTATAGCCAGACGGGTTTCATTATTATTTCTCTTTGCTTTCTCAATGTTAATTTATTGCATGGTTTATTCTTTTTCTTTA
1201 CAGCTGAAATTGCTTTAAATGATGGTTAAAATTACAAATTAAATTGTTAATTTTTATCAATGTGATTGTAATTAAAAATA
1281 TTTTGATTTAAATAACAAAAATAATACCAGATTTTAAGCCGTGGAAAATGTTCTTGATCATTTGCAGTTAAGGACTTTAA
1361 ATAAATCAAATGTTAACAAAAGAGCATTTCTGTTATTTTTTTTCACTTAACTAAATCCGAAGTGAATATTTCTGAATACG
1441 ATATTTTTCAAATTCTAGAACTGAATATAAATGACAAAAATGAAAATAAAATTGTTTTGTCTGTTGTTATAATGAATGTG
1521 TAGCTAGTAAAAAGGAGTGAAAGAAATTCAAGTAAAGTGTATAAGTTGATTTAATATTCCAAGAGTTGAGATTTTTAAGA
1601 TTCTTTATTCCCAGTGATGTTTACTTCATTTTTTTTTTTTTTTTTGACACCGGCTTAAGCCTTCTGTGTTTCCTTTGAGC
1681 CTTTTCACTACAAAATCAAATATTAATTTAACTACCTTTCCTCCTTCCCCAATGTATCACTTTTCTTTATCTGAGAATTC
1761 TTCCAATGAAAATAAAATATCAGCTGTGGCTGATAGAATTAAGTTGTGTCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cacaCGAGAGACC--------AGUUGGUAg 5'
              | ||| |||        |:|||||| 
Target 5' tacaGGTCTGTGGCAATACTCTTAACCATa 3'
435 - 464 136.00 -14.30
2
miRNA  3' caCACGAG-AGACC-AGUUGGUAg 5'
            | |:|: |||||  :|:|||| 
Target 5' ggGGGTTTGTCTGGCATAGCCATg 3'
13 - 36 128.00 -14.30
3
miRNA  3' cacacgagagaccaGUUGGUAg 5'
                        ||||:|| 
Target 5' taataaaatcccaaCAACTATt 3'
100 - 121 124.00 -6.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31613593 1 COSMIC
COSN26253397 6 COSMIC
COSN20078123 10 COSMIC
COSN30654313 11 COSMIC
COSN31613662 12 COSMIC
COSN26269441 21 COSMIC
COSN30147913 40 COSMIC
COSN31514105 49 COSMIC
COSN29757585 53 COSMIC
COSN30490802 103 COSMIC
COSN21842283 219 COSMIC
COSN29616553 220 COSMIC
COSN28485358 230 COSMIC
COSN31550662 242 COSMIC
COSN31609623 243 COSMIC
COSN31532491 271 COSMIC
COSN8549285 272 COSMIC
COSN27975335 348 COSMIC
COSN31562981 350 COSMIC
COSN26220350 351 COSMIC
COSN26565720 413 COSMIC
COSN19462368 458 COSMIC
COSN19464643 458 COSMIC
COSN31548452 466 COSMIC
COSN29674750 528 COSMIC
COSN29659166 563 COSMIC
COSN25976403 636 COSMIC
COSN27994899 692 COSMIC
COSN25837975 694 COSMIC
COSN28068774 699 COSMIC
COSN26310191 701 COSMIC
COSN31488573 711 COSMIC
COSN26172162 718 COSMIC
COSN26386095 742 COSMIC
COSN29639391 784 COSMIC
COSN30045380 872 COSMIC
COSN28484262 906 COSMIC
COSN28484295 918 COSMIC
COSN31530482 939 COSMIC
COSN29588951 942 COSMIC
COSN24454905 1072 COSMIC
COSN31543514 1074 COSMIC
COSN25836836 1090 COSMIC
COSN26200393 1092 COSMIC
COSN15956766 1133 COSMIC
COSN27927164 1140 COSMIC
COSN29645517 1157 COSMIC
COSN17076051 1229 COSMIC
COSN19568301 1243 COSMIC
COSN31565176 1255 COSMIC
COSN27870134 1266 COSMIC
COSN20757291 1269 COSMIC
COSN19535843 1300 COSMIC
COSN26231470 1331 COSMIC
COSN26403134 1355 COSMIC
COSN28135664 1372 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1292633181 2 dbSNP
rs1402717973 3 dbSNP
rs780709606 6 dbSNP
rs367849941 14 dbSNP
rs1164628893 16 dbSNP
rs768015890 17 dbSNP
rs776976444 18 dbSNP
rs746573702 26 dbSNP
rs1173104875 34 dbSNP
rs1279729910 35 dbSNP
rs780538350 36 dbSNP
rs181561875 37 dbSNP
rs1197615861 39 dbSNP
rs1490897710 40 dbSNP
rs1022566815 41 dbSNP
rs750731146 43 dbSNP
rs779274463 49 dbSNP
rs1338456355 51 dbSNP
rs2698 58 dbSNP
rs923005164 58 dbSNP
rs2699 72 dbSNP
rs1480178433 78 dbSNP
rs1010983929 80 dbSNP
rs373922372 89 dbSNP
rs1415852624 90 dbSNP
rs976211371 99 dbSNP
rs1357902309 109 dbSNP
rs540009140 110 dbSNP
rs760722682 119 dbSNP
rs35689225 125 dbSNP
rs1017695073 127 dbSNP
rs577740419 131 dbSNP
rs1172988775 135 dbSNP
rs1008561395 138 dbSNP
rs911822 143 dbSNP
rs1430066108 144 dbSNP
rs543970164 145 dbSNP
rs1047525590 146 dbSNP
rs957509140 147 dbSNP
rs1304833143 150 dbSNP
rs1296839335 154 dbSNP
rs771938444 160 dbSNP
rs1303366626 161 dbSNP
rs1368869185 163 dbSNP
rs1230777665 165 dbSNP
rs1275547080 166 dbSNP
rs370407762 167 dbSNP
rs1460081549 170 dbSNP
rs1202122176 172 dbSNP
rs761345795 180 dbSNP
rs1266967289 183 dbSNP
rs575199708 193 dbSNP
rs1001304639 196 dbSNP
rs1192932636 205 dbSNP
rs1165366532 212 dbSNP
rs1251132341 215 dbSNP
rs1450732682 216 dbSNP
rs1052935 218 dbSNP
rs1052936 219 dbSNP
rs929170662 220 dbSNP
rs1418298223 222 dbSNP
rs555361506 223 dbSNP
rs190079848 230 dbSNP
rs774003130 232 dbSNP
rs1462354280 242 dbSNP
rs1014047573 243 dbSNP
rs1437282424 250 dbSNP
rs1298452385 252 dbSNP
rs1185896845 254 dbSNP
rs941351305 258 dbSNP
rs1212995363 261 dbSNP
rs866341845 266 dbSNP
rs916552436 292 dbSNP
rs1055133461 293 dbSNP
rs573552437 295 dbSNP
rs768452041 296 dbSNP
rs1036762646 298 dbSNP
rs1466220993 298 dbSNP
rs1240987231 299 dbSNP
rs553682929 300 dbSNP
rs1467751391 303 dbSNP
rs1414145680 305 dbSNP
rs1475705560 309 dbSNP
rs928049664 310 dbSNP
rs1164663872 311 dbSNP
rs888008996 319 dbSNP
rs1459266657 322 dbSNP
rs1050692749 325 dbSNP
rs28756127 331 dbSNP
rs1428794878 335 dbSNP
rs570945930 340 dbSNP
rs1356346095 344 dbSNP
rs1337456243 348 dbSNP
rs923412470 349 dbSNP
rs966905430 350 dbSNP
rs1362677267 351 dbSNP
rs75207901 358 dbSNP
rs1331007618 360 dbSNP
rs915469963 363 dbSNP
rs1228895584 365 dbSNP
rs577328157 372 dbSNP
rs965333236 405 dbSNP
rs1211634736 406 dbSNP
rs1237624526 408 dbSNP
rs560369071 422 dbSNP
rs1185414483 425 dbSNP
rs1017247183 426 dbSNP
rs1326879724 436 dbSNP
rs1159640719 440 dbSNP
rs771564852 441 dbSNP
rs1178366008 453 dbSNP
rs1352571715 463 dbSNP
rs1169587201 469 dbSNP
rs34059222 478 dbSNP
rs1033989021 483 dbSNP
rs979965527 486 dbSNP
rs1442729502 488 dbSNP
rs1278823247 490 dbSNP
rs1348458807 491 dbSNP
rs1026044118 493 dbSNP
rs1220413619 495 dbSNP
rs1278688570 500 dbSNP
rs568122813 502 dbSNP
rs971290223 503 dbSNP
rs1024524056 505 dbSNP
rs994048587 509 dbSNP
rs1484210612 512 dbSNP
rs1191189420 514 dbSNP
rs897899940 515 dbSNP
rs1232772356 517 dbSNP
rs993288925 525 dbSNP
rs1193472974 536 dbSNP
rs1253205006 538 dbSNP
rs899033517 555 dbSNP
rs1434254993 568 dbSNP
rs1006619082 569 dbSNP
rs879158704 573 dbSNP
rs1372656921 586 dbSNP
rs1410256278 603 dbSNP
rs747595738 603 dbSNP
rs1327971726 604 dbSNP
rs1215209933 605 dbSNP
rs1037948754 609 dbSNP
rs1012799221 610 dbSNP
rs1438484163 617 dbSNP
rs1304157772 620 dbSNP
rs1470063582 623 dbSNP
rs1231458362 628 dbSNP
rs894403085 635 dbSNP
rs1055104657 645 dbSNP
rs1204354800 646 dbSNP
rs1308592979 647 dbSNP
rs1272710112 657 dbSNP
rs1201638256 670 dbSNP
rs1254239765 674 dbSNP
rs1453809382 676 dbSNP
rs939354466 677 dbSNP
rs928029959 679 dbSNP
rs1275782659 683 dbSNP
rs1232144415 696 dbSNP
rs34573592 699 dbSNP
rs548142715 699 dbSNP
rs1475876807 701 dbSNP
rs1167599493 705 dbSNP
rs1370387182 716 dbSNP
rs1042528715 721 dbSNP
rs1326431843 722 dbSNP
rs566385575 725 dbSNP
rs1438031348 726 dbSNP
rs777982092 730 dbSNP
rs1052943 734 dbSNP
rs1326558043 737 dbSNP
rs1052944 741 dbSNP
rs1226197677 742 dbSNP
rs1268112676 746 dbSNP
rs184932768 752 dbSNP
rs946276319 761 dbSNP
rs1274279473 762 dbSNP
rs1468450437 763 dbSNP
rs752512637 766 dbSNP
rs915371627 766 dbSNP
rs1447723408 769 dbSNP
rs1192729682 773 dbSNP
rs1371571954 775 dbSNP
rs1356182736 780 dbSNP
rs1171730471 781 dbSNP
rs1433517777 790 dbSNP
rs1417017947 797 dbSNP
rs373474344 805 dbSNP
rs1322518284 808 dbSNP
rs1395182751 809 dbSNP
rs990072602 822 dbSNP
rs912954726 823 dbSNP
rs758743734 826 dbSNP
rs910823869 838 dbSNP
rs560042202 841 dbSNP
rs1334666030 844 dbSNP
rs1231994564 858 dbSNP
rs1263077024 868 dbSNP
rs935770503 873 dbSNP
rs1204636893 874 dbSNP
rs926922028 875 dbSNP
rs954418524 876 dbSNP
rs1486790850 878 dbSNP
rs533134621 879 dbSNP
rs1188986238 881 dbSNP
rs1176970211 882 dbSNP
rs1256506954 901 dbSNP
rs1481189129 903 dbSNP
rs1277351848 906 dbSNP
rs1161261042 911 dbSNP
rs993173645 923 dbSNP
rs1364321876 930 dbSNP
rs1449748095 930 dbSNP
rs963462166 933 dbSNP
rs971278975 945 dbSNP
rs1403840673 948 dbSNP
rs200907205 951 dbSNP
rs917211545 951 dbSNP
rs972958210 951 dbSNP
rs1347175129 958 dbSNP
rs1016076838 959 dbSNP
rs1013179941 960 dbSNP
rs546482156 961 dbSNP
rs1236679262 963 dbSNP
rs1017189793 965 dbSNP
rs1315338109 966 dbSNP
rs1259019018 973 dbSNP
rs1350201900 977 dbSNP
rs1211869545 987 dbSNP
rs894382647 989 dbSNP
rs1306617167 992 dbSNP
rs1391726655 994 dbSNP
rs1484533028 995 dbSNP
rs533201781 1008 dbSNP
rs1003535488 1014 dbSNP
rs557581544 1022 dbSNP
rs1042414622 1024 dbSNP
rs1179635378 1027 dbSNP
rs1396330149 1037 dbSNP
rs1310942625 1046 dbSNP
rs544306206 1057 dbSNP
rs575217894 1062 dbSNP
rs1375446511 1068 dbSNP
rs753902272 1092 dbSNP
rs893894669 1097 dbSNP
rs755203424 1101 dbSNP
rs1433205203 1103 dbSNP
rs1053945503 1106 dbSNP
rs561691292 1111 dbSNP
rs1374573531 1112 dbSNP
rs1391294725 1115 dbSNP
rs1305583964 1119 dbSNP
rs1373264820 1124 dbSNP
rs943556628 1132 dbSNP
rs541876694 1134 dbSNP
rs910802129 1135 dbSNP
rs1346028781 1143 dbSNP
rs572862727 1156 dbSNP
rs1206291458 1167 dbSNP
rs1251649692 1176 dbSNP
rs987718164 1181 dbSNP
rs765156464 1190 dbSNP
rs933583465 1195 dbSNP
rs151046850 1197 dbSNP
rs1454281695 1199 dbSNP
rs1192501635 1200 dbSNP
rs1392827581 1201 dbSNP
rs555691163 1221 dbSNP
rs1429907444 1234 dbSNP
rs1355478318 1260 dbSNP
rs918885620 1261 dbSNP
rs1420002664 1265 dbSNP
rs1397325643 1271 dbSNP
rs1441676127 1274 dbSNP
rs1302794086 1285 dbSNP
rs1254438631 1296 dbSNP
rs891938847 1304 dbSNP
rs1172799257 1320 dbSNP
rs972160017 1321 dbSNP
rs963134024 1328 dbSNP
rs553741854 1332 dbSNP
rs1016458262 1335 dbSNP
rs1258901305 1336 dbSNP
rs1468879646 1339 dbSNP
rs935717918 1348 dbSNP
rs927078332 1358 dbSNP
rs1202228377 1372 dbSNP
rs1186734601 1379 dbSNP
rs1484955888 1390 dbSNP
rs1418362428 1392 dbSNP
rs1428216051 1393 dbSNP
rs1169022312 1404 dbSNP
rs1260318777 1404 dbSNP
rs991332674 1417 dbSNP
rs753898649 1418 dbSNP
rs1325871902 1419 dbSNP
rs1240052014 1422 dbSNP
rs1348199219 1423 dbSNP
rs1044035925 1426 dbSNP
rs1289599630 1428 dbSNP
rs958819424 1439 dbSNP
rs10130205 1440 dbSNP
rs1380264712 1441 dbSNP
rs1294879238 1457 dbSNP
rs1335284129 1461 dbSNP
rs1002749626 1468 dbSNP
rs1271263392 1475 dbSNP
rs550344205 1484 dbSNP
rs1355995452 1486 dbSNP
rs755974803 1491 dbSNP
rs972646052 1494 dbSNP
rs1484700077 1496 dbSNP
rs1189687174 1509 dbSNP
rs1260009420 1510 dbSNP
rs1379989436 1530 dbSNP
rs1383648260 1535 dbSNP
rs1412268047 1538 dbSNP
rs1402483434 1542 dbSNP
rs1020937973 1545 dbSNP
rs1344737573 1549 dbSNP
rs1289028523 1557 dbSNP
rs1010010615 1559 dbSNP
rs961611881 1559 dbSNP
rs983964170 1561 dbSNP
rs1029122887 1566 dbSNP
rs996162369 1570 dbSNP
rs1223804284 1575 dbSNP
rs1314655076 1579 dbSNP
rs140611600 1583 dbSNP
rs1280671251 1588 dbSNP
rs1486169977 1594 dbSNP
rs1187717193 1596 dbSNP
rs1163212575 1602 dbSNP
rs1471430063 1610 dbSNP
rs1178327030 1614 dbSNP
rs1054318743 1618 dbSNP
rs1475115267 1619 dbSNP
rs894246708 1623 dbSNP
rs1190258407 1624 dbSNP
rs1445301870 1625 dbSNP
rs867308401 1628 dbSNP
rs397977776 1629 dbSNP
rs1491159591 1630 dbSNP
rs1466419509 1642 dbSNP
rs76800176 1644 dbSNP
rs1212813569 1645 dbSNP
rs11335498 1646 dbSNP
rs1376302092 1646 dbSNP
rs1379712296 1646 dbSNP
rs1433820057 1646 dbSNP
rs199587039 1646 dbSNP
rs34291630 1646 dbSNP
rs528948946 1646 dbSNP
rs553808810 1646 dbSNP
rs61178380 1646 dbSNP
rs776231441 1646 dbSNP
rs1208346064 1647 dbSNP
rs1276499512 1647 dbSNP
rs753717075 1650 dbSNP
rs1019376967 1668 dbSNP
rs372446825 1669 dbSNP
rs1439989135 1677 dbSNP
rs557231016 1680 dbSNP
rs889249876 1681 dbSNP
rs1033132285 1687 dbSNP
rs537567765 1690 dbSNP
rs933552755 1708 dbSNP
rs1225170490 1714 dbSNP
rs1000358414 1715 dbSNP
rs1171081349 1720 dbSNP
rs1295672647 1721 dbSNP
rs1398363130 1725 dbSNP
rs919525194 1729 dbSNP
rs1044152204 1732 dbSNP
rs1442405339 1734 dbSNP
rs1325968167 1749 dbSNP
rs971745680 1753 dbSNP
rs1461212495 1756 dbSNP
rs1395695803 1760 dbSNP
rs1341834122 1763 dbSNP
rs1215523139 1769 dbSNP
rs1257928689 1777 dbSNP
rs1456844520 1780 dbSNP
rs115714853 1791 dbSNP
rs1253674016 1792 dbSNP
rs908952139 1794 dbSNP
rs991610682 1795 dbSNP
rs1197012329 1798 dbSNP
rs368999230 1803 dbSNP
rs796903203 1804 dbSNP
rs1199773393 1806 dbSNP
rs767377268 1812 dbSNP
rs1167131134 1813 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3169.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cacaCGAGAGACC--------AGUUGGUAg 5'
              | ||| |||        |:|||||| 
Target 5' ---aGGUCUGUGGCAAUACUCUUAACCAUa 3'
1 - 27
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A PAR-CLIP data was present in SRX1760597. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000250448.2 | 3UTR | AGUUUACAGGUCUGUGGCAAUACUCUUAACCAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000250448.2 | 3UTR | AGGUCUGUGGCAAUACUCUUAACCAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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