pre-miRNA Information
pre-miRNA hsa-mir-190b   
Genomic Coordinates chr1: 154193665 - 154193743
Description Homo sapiens miR-190b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-190b
Sequence 11| UGAUAUGUUUGAUAUUGGGUU |31
Evidence Not_experimental
Experiments
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF223   
Synonyms -
Description zinc finger protein 223
Transcript NM_013361   
Expression
Putative miRNA Targets on ZNF223
3'UTR of ZNF223
(miRNA target sites are highlighted)
>ZNF223|NM_013361|3'UTR
   1 GTGTTGTACATATTTATGGGGTACAGTGTGATATTTAAATATATGTATATGATGTATAATGATCAAATCAGTGTAATTAG
  81 CACATTTATCACCTCAATTATCTCTTTTTTGTGTTGAGAAAATTAAAAATTCATTGTTCCAGCAGTTTGAAAATAAATTG
 161 TTGTCGATGATAGTCACCTTTAGTGCTGCAGAACAGCAGAACTTCTTCCTCTTATCTACCTGTACTTTTGCATCCATTAG
 241 CCAACCTTTGGCCATCCCACCTATCCCTTACCCTTCCCTGCCTCTAGAGCCACTGTTCTCACTACTTCTAAGAAATCAGC
 321 TTTTTAAGCTTCCCCATGTGATTGAGGACAGTTTGAAGTTAGTGTTTCAGCCATAGCTCAGCATACCCCAGTGGTCGTGG
 401 GACTGTCAGAGCAGAGAATGCTGCAGGGTTTCTAACAGAAGTTTGACAATTAGTTATTATTCAGGAGACAGGTCTTAGTA
 481 TAAGAGTTTGTTCACACACTTTCAAAACACTAATGATGAACATGTCAAAATTGATGACCACTAGAATGTCAGCCACATGT
 561 GTCTTTGTATTTTTGCTGCATCCTTACATTGCTTGAGTCTGGAAGATTGAGGCTGCACTGACCTATGGTAGTGCTACTGC
 641 ACTCCAGCCAGGGCAACAGAGTGAGACCCTGTCTCCAAAAAAAAAAATTAAATAAATACCTTTCTTTGTTTCTAGAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uugGGUUAUAGUUUGUAUAGu 5'
             |:|||: ::|||||:|| 
Target 5' acaCTAATGATGAACATGTCa 3'
507 - 527 150.00 -15.50
2
miRNA  3' uuggguUAUAGUUUGUAUAGu 5'
                :|:|:: ||||||: 
Target 5' ------GTGTTGTACATATTt 3'
1 - 15 135.00 -5.90
3
miRNA  3' uugggUUAUAGUU--UGUAUAgu 5'
               |||:|||:  ||||:|  
Target 5' actagAATGTCAGCCACATGTgt 3'
540 - 562 126.00 -9.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30151603 4 COSMIC
COSN30182784 11 COSMIC
COSN28853212 27 COSMIC
COSN31566957 27 COSMIC
COSN30508856 32 COSMIC
COSN13812917 110 COSMIC
COSN30616000 111 COSMIC
COSN22515617 133 COSMIC
COSN30750378 154 COSMIC
COSN31509701 273 COSMIC
COSN30738805 295 COSMIC
COSN30508195 312 COSMIC
COSN8605932 356 COSMIC
COSN30516190 381 COSMIC
COSN31600400 412 COSMIC
COSN7446282 485 COSMIC
COSN5856476 708 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs778384237 1 dbSNP
rs761481920 4 dbSNP
rs911696005 7 dbSNP
rs779670169 11 dbSNP
rs1233240608 13 dbSNP
rs771074604 14 dbSNP
rs1162548786 18 dbSNP
rs944557838 21 dbSNP
rs1457918024 25 dbSNP
rs1038736249 26 dbSNP
rs989529055 26 dbSNP
rs767107717 27 dbSNP
rs759871250 29 dbSNP
rs1282873506 31 dbSNP
rs772171370 34 dbSNP
rs1278468984 36 dbSNP
rs776539101 38 dbSNP
rs545020976 43 dbSNP
rs1288283293 45 dbSNP
rs1321631625 46 dbSNP
rs1223977939 49 dbSNP
rs765194738 52 dbSNP
rs967144944 53 dbSNP
rs750315081 56 dbSNP
rs748722999 59 dbSNP
rs978112671 62 dbSNP
rs762451118 66 dbSNP
rs1296361440 67 dbSNP
rs765938015 68 dbSNP
rs776949601 69 dbSNP
rs1179913687 70 dbSNP
rs1412872298 73 dbSNP
rs1376185007 77 dbSNP
rs1173536779 81 dbSNP
rs1424323992 83 dbSNP
rs886142500 84 dbSNP
rs940247119 85 dbSNP
rs1418597754 89 dbSNP
rs751016247 94 dbSNP
rs754705207 96 dbSNP
rs780676398 98 dbSNP
rs768677464 101 dbSNP
rs991040300 101 dbSNP
rs1191120014 105 dbSNP
rs765468655 105 dbSNP
rs1280498588 112 dbSNP
rs1474898235 126 dbSNP
rs1274781385 133 dbSNP
rs1378958065 133 dbSNP
rs1247317025 134 dbSNP
rs753136109 140 dbSNP
rs1351545630 141 dbSNP
rs1214961351 148 dbSNP
rs1215989501 159 dbSNP
rs1037697649 163 dbSNP
rs1276506142 164 dbSNP
rs1049317476 166 dbSNP
rs139461616 167 dbSNP
rs527811978 171 dbSNP
rs113378479 172 dbSNP
rs1446391890 174 dbSNP
rs753267356 178 dbSNP
rs1438609958 187 dbSNP
rs1011440602 193 dbSNP
rs1022257705 212 dbSNP
rs1168083699 214 dbSNP
rs967123322 218 dbSNP
rs1238082585 220 dbSNP
rs1257529021 221 dbSNP
rs1180784263 223 dbSNP
rs777622994 226 dbSNP
rs892978302 227 dbSNP
rs1436992333 231 dbSNP
rs1011354467 240 dbSNP
rs184621820 246 dbSNP
rs965958706 247 dbSNP
rs867227918 254 dbSNP
rs974535408 261 dbSNP
rs187627728 267 dbSNP
rs1226714236 270 dbSNP
rs1033410871 271 dbSNP
rs1035041025 283 dbSNP
rs960673405 286 dbSNP
rs192485563 296 dbSNP
rs1398555990 298 dbSNP
rs984948637 309 dbSNP
rs916827339 316 dbSNP
rs952230134 317 dbSNP
rs1251886703 321 dbSNP
rs370283219 329 dbSNP
rs1180146909 331 dbSNP
rs1260105394 335 dbSNP
rs1421507455 343 dbSNP
rs1409586763 356 dbSNP
rs1457313100 361 dbSNP
rs1236061603 364 dbSNP
rs1215361628 379 dbSNP
rs1469045601 380 dbSNP
rs940363455 384 dbSNP
rs1219706322 387 dbSNP
rs907647032 388 dbSNP
rs374510943 389 dbSNP
rs1307885816 391 dbSNP
rs1223655587 395 dbSNP
rs1375349416 396 dbSNP
rs940466105 397 dbSNP
rs140718832 398 dbSNP
rs758833837 429 dbSNP
rs1416522357 437 dbSNP
rs1292556371 442 dbSNP
rs1456119527 450 dbSNP
rs1346452227 457 dbSNP
rs867767034 466 dbSNP
rs1159199261 468 dbSNP
rs1438944068 472 dbSNP
rs1459421389 473 dbSNP
rs922945097 475 dbSNP
rs1454533971 480 dbSNP
rs1266487862 482 dbSNP
rs906762618 494 dbSNP
rs1397159798 497 dbSNP
rs531306579 498 dbSNP
rs939609733 502 dbSNP
rs1216010235 518 dbSNP
rs1283047384 532 dbSNP
rs1352093133 532 dbSNP
rs957517942 533 dbSNP
rs1055291500 548 dbSNP
rs143013996 553 dbSNP
rs1041537483 561 dbSNP
rs1357194670 579 dbSNP
rs1363652779 583 dbSNP
rs902986044 584 dbSNP
rs1415619816 588 dbSNP
rs1358129866 589 dbSNP
rs1010959554 593 dbSNP
rs1022816605 601 dbSNP
rs571350061 608 dbSNP
rs1196500890 609 dbSNP
rs1430475114 616 dbSNP
rs1262730009 618 dbSNP
rs4299256 619 dbSNP
rs999916287 625 dbSNP
rs554072945 630 dbSNP
rs1212219815 631 dbSNP
rs567803493 631 dbSNP
rs1252363639 639 dbSNP
rs1018930959 643 dbSNP
rs965927606 651 dbSNP
rs974670953 653 dbSNP
rs148198486 664 dbSNP
rs1230100863 666 dbSNP
rs1308489827 668 dbSNP
rs1194639369 673 dbSNP
rs1314185710 677 dbSNP
rs1337774111 677 dbSNP
rs1399073737 677 dbSNP
rs75146506 678 dbSNP
rs185097042 679 dbSNP
rs960704632 685 dbSNP
rs1401441678 689 dbSNP
rs1282897833 696 dbSNP
rs758903041 700 dbSNP
rs576355593 709 dbSNP
rs369873089 722 dbSNP
rs1170219478 723 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuggguUAUAGUUUGUAUAGu 5'
                ||| :|| |||||| 
Target 5' -----cAUAAUAAUCAUAUCa 3'
1 - 16
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7766.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000434772.3 | 3UTR | CAUAAUAAUCAUAUCAGGGUAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000434772.3 | 3UTR | CAUAAUAAUCAUAUCAGGGUAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000434772.3 | 3UTR | CAUAAUAAUCAUAUCAGGGUAAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis -0.528 6.9e-3 -0.465 1.7e-2 21 Click to see details
GSE19783 ER- ER- breast cancer 0.252 1.3e-2 0.327 1.6e-3 79 Click to see details
GSE28544 Breast cancer 0.437 1.6e-2 0.515 5.0e-3 24 Click to see details
GSE19350 CNS germ cell tumors -0.522 4.1e-2 -0.128 3.5e-1 12 Click to see details
GSE26953 Aortic valvular endothelial cells -0.322 6.2e-2 -0.323 6.2e-2 24 Click to see details
GSE19536 Breast cancer 0.143 7.8e-2 0.171 4.4e-2 100 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.279 8.8e-2 -0.162 2.2e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.23 1.0e-1 -0.069 3.5e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.144 1.3e-1 -0.081 2.6e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.18 1.9e-1 -0.166 2.1e-1 25 Click to see details
GSE17498 Multiple myeloma -0.107 2.6e-1 -0.091 2.9e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.14 2.8e-1 -0.708 2.4e-4 20 Click to see details
GSE28260 Renal cortex and medulla -0.13 3.4e-1 -0.060 4.2e-1 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.034 4.4e-1 0.223 1.5e-1 23 Click to see details
GSE19783 ER+ ER+ breast cancer -0.029 4.5e-1 -0.086 3.6e-1 20 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.015 4.9e-1 0.071 4.4e-1 7 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD 0.837 0 0.714 0.02 8 Click to see details
BRCA 0.273 0.01 0.239 0.02 72 Click to see details
PRAD -0.474 0.01 -0.390 0.03 23 Click to see details
KIRC -0.371 0.11 -0.379 0.1 13 Click to see details
KIRP 0.504 0.12 0.321 0.24 7 Click to see details
HNSC -0.241 0.13 -0.161 0.23 23 Click to see details
UCEC -0.284 0.15 -0.189 0.25 15 Click to see details
LIHC -0.191 0.22 -0.269 0.14 18 Click to see details
STAD 0.381 0.26 0.400 0.25 5 Click to see details
THCA -0.112 0.3 -0.183 0.2 24 Click to see details
CHOL 0.324 0.34 0.000 0.5 4 Click to see details
LUSC 0.098 0.34 0.247 0.15 19 Click to see details
ESCA -0.101 0.45 0.400 0.3 4 Click to see details
KICH -0.047 0.47 -0.200 0.37 5 Click to see details
KICH -0.047 0.47 -0.200 0.37 5 Click to see details
KICH -0.047 0.47 -0.200 0.37 5 Click to see details
KICH -0.047 0.47 -0.200 0.37 5 Click to see details
KICH -0.047 0.47 -0.200 0.37 5 Click to see details
KICH -0.047 0.47 -0.200 0.37 5 Click to see details
60 hsa-miR-190b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054581 IGF1 insulin like growth factor 1 4 1
MIRT066966 ATXN7L3B ataxin 7 like 3B 2 2
MIRT192449 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT250414 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT306294 KLHL24 kelch like family member 24 2 2
MIRT355845 SGMS2 sphingomyelin synthase 2 2 4
MIRT437770 MTMR6 myotubularin related protein 6 1 1
MIRT437771 MTMR6 myotubularin related protein 6 1 1
MIRT437772 Mtmr6 myotubularin related protein 6 1 1
MIRT444672 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446389 PCDHB11 protocadherin beta 11 2 2
MIRT446634 SDC3 syndecan 3 2 2
MIRT449410 TRIM5 tripartite motif containing 5 2 2
MIRT449560 GPC5 glypican 5 2 2
MIRT469928 PTPRJ protein tyrosine phosphatase, receptor type J 2 6
MIRT473736 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT474210 LDHA lactate dehydrogenase A 2 2
MIRT474583 KLF6 Kruppel like factor 6 2 2
MIRT476732 FOXN2 forkhead box N2 2 2
MIRT478455 DAB2 DAB2, clathrin adaptor protein 2 2
MIRT495327 ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 2 4
MIRT498615 MTRNR2L10 MT-RNR2-like 10 2 12
MIRT501734 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT501849 MTRNR2L8 MT-RNR2-like 8 2 14
MIRT504678 CYGB cytoglobin 2 4
MIRT506517 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT507984 BCL2L13 BCL2 like 13 2 4
MIRT508444 ZNF608 zinc finger protein 608 2 4
MIRT511366 IL6ST interleukin 6 signal transducer 2 4
MIRT520515 TRA2B transformer 2 beta homolog 2 2
MIRT524571 CALML4 calmodulin like 4 2 4
MIRT531896 INVS inversin 2 4
MIRT533916 TATDN2 TatD DNase domain containing 2 2 2
MIRT537503 FAM13B family with sequence similarity 13 member B 2 2
MIRT541689 CCDC160 coiled-coil domain containing 160 2 8
MIRT544419 ZNF460 zinc finger protein 460 2 4
MIRT544615 CSDE1 cold shock domain containing E1 2 2
MIRT545076 IL7R interleukin 7 receptor 2 2
MIRT545849 ZNF264 zinc finger protein 264 2 4
MIRT547436 MED4 mediator complex subunit 4 2 2
MIRT550157 ZNF223 zinc finger protein 223 2 4
MIRT553948 STAMBP STAM binding protein 2 2
MIRT554395 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT555667 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT564193 PM20D2 peptidase M20 domain containing 2 2 2
MIRT566792 MKL2 MKL1/myocardin like 2 2 2
MIRT566843 LRRC58 leucine rich repeat containing 58 2 2
MIRT572516 KIAA0232 KIAA0232 2 2
MIRT607428 NOTCH2NL notch 2 N-terminal like 2 10
MIRT627779 RAB30 RAB30, member RAS oncogene family 2 2
MIRT635159 ENO4 enolase family member 4 2 2
MIRT642159 ADCYAP1R1 ADCYAP receptor type I 3 2
MIRT646205 DUSP10 dual specificity phosphatase 10 2 2
MIRT657007 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT665817 TMEM161B transmembrane protein 161B 2 2
MIRT667488 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT707098 ZNF850 zinc finger protein 850 2 2
MIRT708719 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT735521 HUS1 HUS1 checkpoint clamp component 3 0
MIRT736644 AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-190b Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-190b Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-190b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)

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