pre-miRNA Information
pre-miRNA hsa-mir-4282   
Genomic Coordinates chr6: 72967687 - 72967753
Description Homo sapiens miR-4282 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4282
Sequence 40| UAAAAUUUGCAUCCAGGA |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN32074657 13 COSMIC
COSN6331413 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1195771339 5 dbSNP
rs755058572 6 dbSNP
rs1245753664 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol INCENP   
Synonyms -
Description inner centromere protein
Transcript NM_001040694   
Other Transcripts NM_020238   
Expression
Putative miRNA Targets on INCENP
3'UTR of INCENP
(miRNA target sites are highlighted)
>INCENP|NM_001040694|3'UTR
   1 GGCTGGCCTGCGGCCTTCTTGGCAGCCTCGCCTCCTGTCCATGTCTATCTGTCTGTCTGTCGGTCTCTGTCTTGGTCTGT
  81 TGCCCTCCTTCTTGGCATGCCATTGTGGAGGGCTTGGCCAGGTGTATATAAACGTCCTCTGTGCTGGGTGTTTCTGCTGC
 161 AGGTGGCAGGTGGCCCCAGGCCTGTTTGGAGGATGGGCTGGGTGGGTGGGTGGGGAAGAAATGGGCCCAGCCCCACATGG
 241 CCTGCAGACAGTGCTCTGTAAATAGTTGTTTTAATTTAGCTGAATGTTAGCATTTTAGTCTTTGGCATTTTAGCGTTTGG
 321 GAGGTAGATTAATAAAGTATATTCCTTCAAGCCTGCTGTTGATACCATGAAGACTGGGCGCCTCAGTCCCAGCCCTGTAG
 401 CTGTGTGTCTTGGGCCACCAGTGGCCTGCAGGACGAAGGTACTGTTCCATCACCTGCGGTGTGCCTCAGGATCACCAGGT
 481 GCAGGCCCCCACCCTCGGAGATGCTGCTGCAGTGAGTGGTTCCACTGCCTGGATAACCCTTGAGGAACACGTCAGTTACT
 561 GTCACGATGGGGCAGGTGGAGCTCCTTCCTATTTTTTGGGGTGCTCCCTGTTTGTAAAGGGGAGTTTGTTCATTGGGAAA
 641 GACCTGGGTCTTGACACGGCCCTGCCACTTAGTCCCCTACCCTCTCCATTCCCCAGGCTCCACCCGTGCTGCTCAGGTGC
 721 AAATGGACTTGAGAGCATCTATGTGCTGGTGAAGCATGAGGTCTGAGTAGAAAAGGGGTATCCCTTGAGACCACCTTGGG
 801 ACCAGTGCTTGCAAGCAGCGAGATATTTCCCCAGCAAAACCAGGCAGCTGCTAATTAAATGCTTAGAACCAATGAAAGCT
 881 GGCTGTGGTCCTGCCTGTGAGCTGCCTACTGCTGCCTTCTGAATGCATATATCTGCTACTGTAGCCCCGGGTTGTCAAAC
 961 TATGGCCTGTGGGCCAAATCCAGCCACAGTCGGTTCTTTAAAGTTTTATCGAAACACAAGCAATGGAAATGCCCATTTCC
1041 ATTGTTGTCTCCAGTTGCTCTGCTCCGAGGGCAGTGTTAAGTTGTGCAGCAGAGGCCCCTCCATGCAAAGCTGAATATGT
1121 TTACTATTTGAACTTTTTCAGAAGTTCTGCTTAAGGACAAAATAAAGCCTAAATCCAAGAACACTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agGACCUAC-GUU-UAAAAu 5'
            ||| ||| :|: ||||| 
Target 5' agCTGAATGTTAGCATTTTa 3'
278 - 297 112.00 -6.30
2
miRNA  3' agGAC----CUACGUUUAaaau 5'
            |||    |:|||||||    
Target 5' tgCTGCTCAGGTGCAAATggac 3'
707 - 728 102.00 -9.80
3
miRNA  3' aggaCCUACGUUUAAaau 5'
              ||| |:|:|||   
Target 5' tttgGGAGGTAGATTaat 3'
316 - 333 102.00 -7.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24304056 12 COSMIC
COSN30527697 13 COSMIC
COSN18735737 19 COSMIC
COSN17038280 850 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1338957159 5 dbSNP
rs767585970 10 dbSNP
rs750670344 12 dbSNP
rs756479179 13 dbSNP
rs1257900029 14 dbSNP
rs1219468172 15 dbSNP
rs762116366 16 dbSNP
rs1488596146 17 dbSNP
rs780630578 19 dbSNP
rs755587677 20 dbSNP
rs1476100447 21 dbSNP
rs777382465 23 dbSNP
rs1464076727 26 dbSNP
rs1412627494 30 dbSNP
rs1792896 31 dbSNP
rs770493259 33 dbSNP
rs1345787656 36 dbSNP
rs898402188 38 dbSNP
rs780645786 42 dbSNP
rs995215653 43 dbSNP
rs767974132 44 dbSNP
rs1432925800 48 dbSNP
rs745604678 48 dbSNP
rs1388018149 49 dbSNP
rs750802366 50 dbSNP
rs1284928957 52 dbSNP
rs756469306 52 dbSNP
rs1012361358 54 dbSNP
rs1016922578 62 dbSNP
rs1162415180 63 dbSNP
rs1473028341 64 dbSNP
rs1013359625 66 dbSNP
rs1024701153 67 dbSNP
rs1047738 68 dbSNP
rs1248097067 68 dbSNP
rs1365821092 77 dbSNP
rs994795154 80 dbSNP
rs1025898980 83 dbSNP
rs1344744226 84 dbSNP
rs958524290 88 dbSNP
rs1281254539 92 dbSNP
rs1357522676 93 dbSNP
rs552620050 114 dbSNP
rs117392689 122 dbSNP
rs1226470646 125 dbSNP
rs533731756 134 dbSNP
rs1290791230 135 dbSNP
rs933301319 140 dbSNP
rs1322850260 142 dbSNP
rs1405693461 145 dbSNP
rs1392618435 149 dbSNP
rs987530926 151 dbSNP
rs879590106 182 dbSNP
rs907923807 183 dbSNP
rs1169904226 193 dbSNP
rs1223842264 199 dbSNP
rs1483606859 199 dbSNP
rs939906716 201 dbSNP
rs1411505177 204 dbSNP
rs1198791254 208 dbSNP
rs952006565 208 dbSNP
rs1231729581 209 dbSNP
rs985045545 212 dbSNP
rs12793557 223 dbSNP
rs12786326 224 dbSNP
rs1176126682 226 dbSNP
rs964409295 229 dbSNP
rs1426185473 236 dbSNP
rs1341701362 237 dbSNP
rs898438549 238 dbSNP
rs931205146 239 dbSNP
rs1047739 246 dbSNP
rs567173232 252 dbSNP
rs1410389903 254 dbSNP
rs1330799986 259 dbSNP
rs1352703490 266 dbSNP
rs1437098349 280 dbSNP
rs1441485739 283 dbSNP
rs1332816790 284 dbSNP
rs894825102 288 dbSNP
rs1315863747 306 dbSNP
rs1385204855 315 dbSNP
rs536148207 316 dbSNP
rs1042658296 320 dbSNP
rs1244007519 325 dbSNP
rs555849511 331 dbSNP
rs1488269370 332 dbSNP
rs1370745602 336 dbSNP
rs1170118014 338 dbSNP
rs1013224153 339 dbSNP
rs1046183168 340 dbSNP
rs902262231 349 dbSNP
rs1478636662 351 dbSNP
rs368338686 357 dbSNP
rs1180437128 366 dbSNP
rs762515806 367 dbSNP
rs999733441 368 dbSNP
rs1440971143 379 dbSNP
rs764561361 380 dbSNP
rs939298116 381 dbSNP
rs1056292836 387 dbSNP
rs371496462 395 dbSNP
rs1012310440 399 dbSNP
rs1350898379 401 dbSNP
rs996852480 402 dbSNP
rs1029173988 414 dbSNP
rs954718713 424 dbSNP
rs1038472997 430 dbSNP
rs1415724945 434 dbSNP
rs1408892017 435 dbSNP
rs1157622587 443 dbSNP
rs1181355470 444 dbSNP
rs558604489 445 dbSNP
rs867534047 446 dbSNP
rs561278017 448 dbSNP
rs987429410 450 dbSNP
rs907997427 451 dbSNP
rs962423540 456 dbSNP
rs972613450 458 dbSNP
rs1266104474 459 dbSNP
rs538193634 462 dbSNP
rs751988733 464 dbSNP
rs919771610 470 dbSNP
rs898452865 474 dbSNP
rs1329851428 479 dbSNP
rs572210706 480 dbSNP
rs541640563 482 dbSNP
rs994181067 484 dbSNP
rs1409332396 485 dbSNP
rs1284460998 486 dbSNP
rs1449525158 487 dbSNP
rs1385826517 494 dbSNP
rs757790970 495 dbSNP
rs561475682 497 dbSNP
rs1319056423 498 dbSNP
rs1390077593 504 dbSNP
rs1337351132 520 dbSNP
rs575151981 526 dbSNP
rs557731981 530 dbSNP
rs1413280457 533 dbSNP
rs916461379 537 dbSNP
rs1446451686 549 dbSNP
rs949072642 551 dbSNP
rs1008916778 552 dbSNP
rs1327263958 556 dbSNP
rs1230012494 559 dbSNP
rs1465274066 561 dbSNP
rs1262464034 566 dbSNP
rs1018372202 567 dbSNP
rs544118343 571 dbSNP
rs376262439 572 dbSNP
rs974429107 579 dbSNP
rs563856718 584 dbSNP
rs1362652479 585 dbSNP
rs902289197 591 dbSNP
rs1363219787 592 dbSNP
rs1435234867 592 dbSNP
rs1224640306 598 dbSNP
rs1265604606 599 dbSNP
rs1291166154 600 dbSNP
rs1462266513 604 dbSNP
rs914993356 607 dbSNP
rs999666042 610 dbSNP
rs866599005 624 dbSNP
rs1388603661 625 dbSNP
rs1168006580 627 dbSNP
rs968241650 629 dbSNP
rs1447240327 634 dbSNP
rs977777543 638 dbSNP
rs1263706160 641 dbSNP
rs1189416944 642 dbSNP
rs1195009020 645 dbSNP
rs1487999762 648 dbSNP
rs923627009 658 dbSNP
rs879134516 659 dbSNP
rs12793280 669 dbSNP
rs1224504914 673 dbSNP
rs893981141 694 dbSNP
rs1056409794 695 dbSNP
rs1431364369 696 dbSNP
rs996269052 704 dbSNP
rs916384991 706 dbSNP
rs145594862 707 dbSNP
rs1038251006 708 dbSNP
rs1304110300 710 dbSNP
rs1407189186 712 dbSNP
rs1368908824 715 dbSNP
rs1307684580 717 dbSNP
rs1462511754 724 dbSNP
rs1374871498 726 dbSNP
rs559796895 729 dbSNP
rs1675066 736 dbSNP
rs1047038432 738 dbSNP
rs1201261969 739 dbSNP
rs749890442 740 dbSNP
rs1250536306 745 dbSNP
rs1205433021 746 dbSNP
rs547146991 756 dbSNP
rs1018487083 758 dbSNP
rs1231952253 760 dbSNP
rs1221098508 775 dbSNP
rs148899711 778 dbSNP
rs990650762 779 dbSNP
rs1225682315 792 dbSNP
rs1206499944 795 dbSNP
rs1259316169 797 dbSNP
rs1011696472 800 dbSNP
rs1021782531 801 dbSNP
rs1287894816 807 dbSNP
rs1392181322 813 dbSNP
rs916536320 819 dbSNP
rs116837523 820 dbSNP
rs1199900906 821 dbSNP
rs1270900401 827 dbSNP
rs1479434793 841 dbSNP
rs779561893 842 dbSNP
rs1182706656 843 dbSNP
rs1198656397 844 dbSNP
rs978263933 845 dbSNP
rs1364434655 850 dbSNP
rs761577197 864 dbSNP
rs1046120385 873 dbSNP
rs1483304458 877 dbSNP
rs1157042278 894 dbSNP
rs923622360 908 dbSNP
rs934986342 914 dbSNP
rs1180988425 920 dbSNP
rs766788827 926 dbSNP
rs1053955357 928 dbSNP
rs550025700 930 dbSNP
rs1337711746 932 dbSNP
rs1310871264 939 dbSNP
rs369275203 941 dbSNP
rs1383619644 946 dbSNP
rs1338857071 947 dbSNP
rs538618888 949 dbSNP
rs1387880099 950 dbSNP
rs181220991 953 dbSNP
rs749034505 959 dbSNP
rs1366302700 963 dbSNP
rs973890502 964 dbSNP
rs1404842624 965 dbSNP
rs1414031149 976 dbSNP
rs890728523 983 dbSNP
rs1244443654 988 dbSNP
rs919776289 989 dbSNP
rs186207807 992 dbSNP
rs145268581 993 dbSNP
rs1047601308 994 dbSNP
rs897828542 995 dbSNP
rs1353302373 997 dbSNP
rs555173510 997 dbSNP
rs891092439 1003 dbSNP
rs1244325760 1006 dbSNP
rs944043663 1011 dbSNP
rs79555490 1012 dbSNP
rs1028193199 1018 dbSNP
rs900086626 1019 dbSNP
rs1318917838 1031 dbSNP
rs958809951 1042 dbSNP
rs1011812354 1045 dbSNP
rs1021772035 1056 dbSNP
rs1190538948 1059 dbSNP
rs1162507159 1063 dbSNP
rs1251242391 1067 dbSNP
rs1420888651 1068 dbSNP
rs990681876 1070 dbSNP
rs1023455450 1074 dbSNP
rs1194520299 1080 dbSNP
rs1363389054 1090 dbSNP
rs1445500439 1097 dbSNP
rs903362633 1104 dbSNP
rs999250846 1116 dbSNP
rs982040640 1124 dbSNP
rs1364075587 1133 dbSNP
rs1031171776 1138 dbSNP
rs1341562838 1140 dbSNP
rs923848425 1145 dbSNP
rs960486096 1153 dbSNP
rs543691950 1157 dbSNP
rs1329333237 1162 dbSNP
rs1424488305 1174 dbSNP
rs991817654 1178 dbSNP
rs1023337664 1182 dbSNP
rs557625860 1190 dbSNP
rs1305808169 1191 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3619.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000394818.3 | 3UTR | AAAAAUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000394818.3 | 3UTR | UAAAAAAAAAAUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000394818.3 | 3UTR | GCAAUUCAAAUUUUUUUCCCUAUAUUCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
280 hsa-miR-4282 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057628 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT060732 RPS3 ribosomal protein S3 2 2
MIRT063371 ETNK1 ethanolamine kinase 1 2 2
MIRT066257 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT070774 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT070871 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT078056 PCTP phosphatidylcholine transfer protein 2 2
MIRT078408 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT084059 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT093537 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096072 SFXN1 sideroflexin 1 2 2
MIRT098316 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT100493 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT102254 HBP1 HMG-box transcription factor 1 2 4
MIRT105318 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT114143 MZT1 mitotic spindle organizing protein 1 2 4
MIRT114873 DICER1 dicer 1, ribonuclease III 2 2
MIRT134683 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT137640 RCOR1 REST corepressor 1 2 2
MIRT155449 CCNT2 cyclin T2 2 4
MIRT165656 DCTN4 dynactin subunit 4 2 2
MIRT177570 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT188514 E2F7 E2F transcription factor 7 2 10
MIRT193019 TMOD3 tropomodulin 3 2 4
MIRT195823 GADD45A growth arrest and DNA damage inducible alpha 2 2
MIRT195885 DEPDC1 DEP domain containing 1 2 6
MIRT206029 NUP50 nucleoporin 50 2 6
MIRT212148 CLCN3 chloride voltage-gated channel 3 2 2
MIRT213999 DCP2 decapping mRNA 2 2 2
MIRT214650 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT221568 CBX3 chromobox 3 2 2
MIRT224544 ZNF623 zinc finger protein 623 2 2
MIRT227654 SET SET nuclear proto-oncogene 2 2
MIRT229992 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT238968 QKI QKI, KH domain containing RNA binding 2 2
MIRT239825 ACTB actin beta 2 2
MIRT241084 ZXDA zinc finger, X-linked, duplicated A 2 4
MIRT244852 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT264534 TARDBP TAR DNA binding protein 2 2
MIRT271438 SKI SKI proto-oncogene 2 2
MIRT271597 ENAH ENAH, actin regulator 2 2
MIRT294332 ZNF264 zinc finger protein 264 2 2
MIRT296341 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT301715 TEF TEF, PAR bZIP transcription factor 2 2
MIRT308549 ZNF654 zinc finger protein 654 2 2
MIRT313866 DEPDC1B DEP domain containing 1B 2 2
MIRT315529 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT321066 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT343777 NUTF2 nuclear transport factor 2 2 2
MIRT359109 MAP1B microtubule associated protein 1B 2 2
MIRT397393 GOLGA3 golgin A3 2 4
MIRT400822 CPEB2 cytoplasmic polyadenylation element binding protein 2 2 2
MIRT442171 DSEL dermatan sulfate epimerase-like 2 2
MIRT442777 JAG1 jagged 1 2 2
MIRT442862 SCARF1 scavenger receptor class F member 1 2 4
MIRT442919 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT444567 TRA2B transformer 2 beta homolog 2 2
MIRT444718 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT445018 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT445853 LRRC1 leucine rich repeat containing 1 2 2
MIRT446242 HELZ helicase with zinc finger 2 2
MIRT446542 GOLGA8B golgin A8 family member B 2 2
MIRT446643 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT446948 ZMAT3 zinc finger matrin-type 3 2 4
MIRT447061 KCNAB1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 2 2
MIRT447327 ZSCAN21 zinc finger and SCAN domain containing 21 2 2
MIRT447995 CDX1 caudal type homeobox 1 2 2
MIRT448543 RHEBP1 RHEB pseudogene 1 2 6
MIRT448752 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT448772 GOLGA8A golgin A8 family member A 2 2
MIRT449342 WDR26 WD repeat domain 26 2 2
MIRT450011 SLC16A6 solute carrier family 16 member 6 2 4
MIRT450229 PCNX pecanex homolog 1 2 2
MIRT450340 MRPL17 mitochondrial ribosomal protein L17 2 4
MIRT450381 MSI2 musashi RNA binding protein 2 2 2
MIRT450759 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT450809 NRCAM neuronal cell adhesion molecule 2 2
MIRT450947 ATAD2 ATPase family, AAA domain containing 2 2 2
MIRT459095 CCPG1 cell cycle progression 1 2 2
MIRT462428 TWISTNB TWIST neighbor 2 2
MIRT465200 TROVE2 TROVE domain family member 2 2 4
MIRT467382 SON SON DNA binding protein 2 4
MIRT468546 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT471506 PDE4D phosphodiesterase 4D 2 2
MIRT471981 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT474478 KLHL11 kelch like family member 11 2 8
MIRT475011 KANSL1 KAT8 regulatory NSL complex subunit 1 2 8
MIRT480341 C5orf51 chromosome 5 open reading frame 51 2 2
MIRT482696 TEX9 testis expressed 9 2 6
MIRT483462 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 6
MIRT485623 FAM217B family with sequence similarity 217 member B 2 2
MIRT485714 CASP16 caspase 16, pseudogene 2 8
MIRT486279 SEC23A Sec23 homolog A, coat complex II component 2 2
MIRT491000 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT492594 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT493365 KIF5B kinesin family member 5B 2 2
MIRT494316 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT495208 EDN3 endothelin 3 2 2
MIRT497011 TCF15 transcription factor 15 2 2
MIRT498512 FRK fyn related Src family tyrosine kinase 2 2
MIRT498778 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT501045 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 6
MIRT502939 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504806 VHL von Hippel-Lindau tumor suppressor 2 6
MIRT505656 SHMT1 serine hydroxymethyltransferase 1 2 6
MIRT505964 RAB5C RAB5C, member RAS oncogene family 2 6
MIRT506322 OTUD4 OTU deubiquitinase 4 2 4
MIRT506803 KLHL15 kelch like family member 15 2 6
MIRT506917 KBTBD8 kelch repeat and BTB domain containing 8 2 4
MIRT507400 EMC7 ER membrane protein complex subunit 7 2 8
MIRT507471 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 6
MIRT508058 ATP13A3 ATPase 13A3 2 4
MIRT508135 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT509895 RPS23 ribosomal protein S23 2 4
MIRT510881 RAN RAN, member RAS oncogene family 2 8
MIRT513766 PEX5L peroxisomal biogenesis factor 5 like 2 4
MIRT516898 COPS8 COP9 signalosome subunit 8 2 2
MIRT518703 TIMD4 T-cell immunoglobulin and mucin domain containing 4 2 4
MIRT520429 TTPAL alpha tocopherol transfer protein like 2 6
MIRT521843 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT522116 NUDT3 nudix hydrolase 3 2 4
MIRT525467 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT525583 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT525906 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT526072 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT526232 MTRNR2L5 MT-RNR2-like 5 2 4
MIRT526455 FAM71F2 family with sequence similarity 71 member F2 2 4
MIRT526515 POU5F1B POU class 5 homeobox 1B 2 2
MIRT528032 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT528422 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT528995 ISLR2 immunoglobulin superfamily containing leucine rich repeat 2 2 4
MIRT529311 ATRNL1 attractin like 1 2 2
MIRT529376 SKP1 S-phase kinase associated protein 1 2 4
MIRT530015 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT530089 FMN2 formin 2 2 2
MIRT530942 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 2
MIRT531229 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT533088 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT533299 USP46 ubiquitin specific peptidase 46 2 2
MIRT533318 UNKL unkempt family like zinc finger 2 2
MIRT533721 TMEM30A transmembrane protein 30A 2 2
MIRT534096 AZF1 azoospermia factor 1 2 2
MIRT534188 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534493 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT536077 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT536242 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT537524 FAM104A family with sequence similarity 104 member A 2 2
MIRT538088 DGKH diacylglycerol kinase eta 2 2
MIRT538475 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT538853 BTG1 BTG anti-proliferation factor 1 2 4
MIRT539075 GDNF glial cell derived neurotrophic factor 2 2
MIRT539480 ACVR2B activin A receptor type 2B 2 4
MIRT540210 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT541940 TSPAN2 tetraspanin 2 2 2
MIRT543812 COCH cochlin 2 2
MIRT545120 PDZRN4 PDZ domain containing ring finger 4 2 2
MIRT545571 GIMAP4 GTPase, IMAP family member 4 2 2
MIRT545989 XKR4 XK related 4 2 2
MIRT547213 PANK3 pantothenate kinase 3 2 4
MIRT547740 KIAA1468 KIAA1468 2 2
MIRT548022 GRB2 growth factor receptor bound protein 2 2 4
MIRT548032 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548102 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT548217 FKBP1A FK506 binding protein 1A 2 2
MIRT548588 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT548953 CDC27 cell division cycle 27 2 2
MIRT549072 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT550368 INCENP inner centromere protein 2 6
MIRT550546 MYZAP myocardial zonula adherens protein 2 2
MIRT551491 TMEM192 transmembrane protein 192 2 4
MIRT553078 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT554104 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555127 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT555477 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT555978 NPTN neuroplastin 2 2
MIRT557011 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT557706 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT558333 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558488 DBN1 drebrin 1 2 2
MIRT559942 ZNF567 zinc finger protein 567 2 2
MIRT561127 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT561791 PAWR pro-apoptotic WT1 regulator 2 2
MIRT562438 EEF2 eukaryotic translation elongation factor 2 2 2
MIRT563102 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT563212 ZNF813 zinc finger protein 813 2 2
MIRT563426 KIF3A kinesin family member 3A 2 2
MIRT563473 SPIN4 spindlin family member 4 2 2
MIRT564015 HSPA4 heat shock protein family A (Hsp70) member 4 2 4
MIRT564117 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT564223 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT564503 CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1 2 2
MIRT564515 DUSP3 dual specificity phosphatase 3 2 2
MIRT564811 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT565265 TPD52 tumor protein D52 2 2
MIRT566012 RHOB ras homolog family member B 2 2
MIRT566216 PTMA prothymosin, alpha 2 2
MIRT566638 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT566821 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT566948 LEPROT leptin receptor overlapping transcript 2 2
MIRT567290 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT567895 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT568731 MTRNR2L3 MT-RNR2-like 3 2 2
MIRT571263 ZNF239 zinc finger protein 239 2 2
MIRT572593 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2 2
MIRT573827 TGOLN2 trans-golgi network protein 2 2 2
MIRT576391 Fhl2 four and a half LIM domains 2 2 2
MIRT609901 SMS spermine synthase 2 2
MIRT613710 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT614406 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT615042 DCX doublecortin 2 2
MIRT617514 C5orf45 MRN complex interacting protein 2 2
MIRT619476 PRDM10 PR/SET domain 10 2 2
MIRT620349 TLN1 talin 1 2 2
MIRT620910 PLA2G7 phospholipase A2 group VII 2 2
MIRT622131 SP4 Sp4 transcription factor 2 2
MIRT622955 OTUD7B OTU deubiquitinase 7B 2 2
MIRT623351 MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2 2
MIRT623619 INTU inturned planar cell polarity protein 2 2
MIRT624409 CCDC171 coiled-coil domain containing 171 2 2
MIRT625171 CCS copper chaperone for superoxide dismutase 2 2
MIRT625685 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT625875 ALDH18A1 aldehyde dehydrogenase 18 family member A1 2 2
MIRT626002 FAM107A family with sequence similarity 107 member A 2 2
MIRT626872 HRH4 histamine receptor H4 2 4
MIRT628220 FKBP9 FK506 binding protein 9 2 2
MIRT628265 DIO2 iodothyronine deiodinase 2 2 2
MIRT628402 C8orf37 chromosome 8 open reading frame 37 2 2
MIRT630564 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT631577 RASSF9 Ras association domain family member 9 2 2
MIRT635730 CCDC58 coiled-coil domain containing 58 2 2
MIRT636224 SLC8A1 solute carrier family 8 member A1 2 2
MIRT636613 CLIC5 chloride intracellular channel 5 2 2
MIRT638899 CDK9 cyclin dependent kinase 9 2 2
MIRT640167 ATXN7L1 ataxin 7 like 1 2 2
MIRT642070 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT643034 CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2 2
MIRT644572 SPOP speckle type BTB/POZ protein 2 2
MIRT644954 IFNB1 interferon beta 1 2 2
MIRT645948 TTF2 transcription termination factor 2 2 2
MIRT646440 XRCC2 X-ray repair cross complementing 2 2 2
MIRT647896 EPN2 epsin 2 2 2
MIRT648276 ZNF582 zinc finger protein 582 2 2
MIRT649381 NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2 2
MIRT650254 CD68 CD68 molecule 2 2
MIRT650333 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT651707 VMP1 vacuole membrane protein 1 2 2
MIRT651774 VASP vasodilator stimulated phosphoprotein 2 2
MIRT653144 SRPK2 SRSF protein kinase 2 2 2
MIRT654112 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654161 RORB RAR related orphan receptor B 2 2
MIRT655716 MLF2 myeloid leukemia factor 2 2 2
MIRT657476 HDAC4 histone deacetylase 4 2 2
MIRT658095 FOXO1 forkhead box O1 2 2
MIRT658860 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT658988 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 2
MIRT660767 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT661622 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661694 TFDP2 transcription factor Dp-2 2 2
MIRT662208 PLA2G4E phospholipase A2 group IVE 2 2
MIRT662443 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664422 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT687505 NECAB1 N-terminal EF-hand calcium binding protein 1 2 2
MIRT689910 SOD2 superoxide dismutase 2 2 2
MIRT690781 PLA2G2C phospholipase A2 group IIC 2 2
MIRT698488 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT699685 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT700926 PDS5A PDS5 cohesin associated factor A 2 2
MIRT702258 LMNB1 lamin B1 2 2
MIRT703166 GPR137C G protein-coupled receptor 137C 2 2
MIRT703242 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT704737 CENPQ centromere protein Q 2 2
MIRT707310 GLRX2 glutaredoxin 2 2 2
MIRT710021 KCNQ5 potassium voltage-gated channel subfamily Q member 5 2 2
MIRT712212 SCOC short coiled-coil protein 2 2
MIRT714742 SETBP1 SET binding protein 1 2 2
MIRT718268 ZNF749 zinc finger protein 749 2 2
MIRT720553 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT722248 RBM41 RNA binding motif protein 41 2 2
MIRT723767 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT723977 KIAA0146 scaffolding protein involved in DNA repair 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4282 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)

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