miRTarBase - #MIRT551468


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pre-miRNA Information
pre-miRNA hsa-mir-499a   
Genomic Coordinates chr20: 34990376 - 34990497
Description Homo sapiens miR-499a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-499a-3p
Sequence 70| AACAUCACAGCAAGUCUGUGCU |91
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30512073 1 COSMIC
COSN8868602 4 COSMIC
COSN20079766 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs768246420 3 dbSNP
rs3746444 4 dbSNP
rs761417578 6 dbSNP
rs150018420 8 dbSNP
rs1406470841 9 dbSNP
rs772652105 11 dbSNP
rs1189840352 16 dbSNP
rs759966338 17 dbSNP
rs1475405341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TRIM59   
Synonyms IFT80L, MRF1, RNF104, TRIM57, TSBF1
Description tripartite motif containing 59
Transcript NM_173084   
Expression
Putative miRNA Targets on TRIM59
3'UTR of TRIM59
(miRNA target sites are highlighted)		 
>TRIM59|NM_173084|3'UTR
   1 AAATGTCAACCTGAATTGTTTAAATGGGCTTATTCTGTACATTGCTAAACAAAAAATGGGGTAGCATGGATAAAGAGCAA
  81 ACTAAGCTTTATTAGTGCTGCAACTAATATAAACAAATGTTTATATTTGTTGCTTCTTTTGGTTAGCAATGATATGTCAA
 161 AGTTATATCTGAAATAGTCAAATCTTTGGGAAACAGAATCTAGTAACAATTTGAAAAGTAATACACTATCCCATTTTTAT
 241 TGGCTTTATGATGGTTGACATAATGTTGCTGTGACATTTAAACATTCTTGTACCAATATTGTCTTTTACCATTATTATAT
 321 ACTGCAGTTAATTGGCTTTACAGTTCTTTATATATATAGCAAAATCCTGAAAGAACATATACCTTTATTTTGATGTGGCT
 401 TGAAGCTTTTGAATGGGTGAATAAGGATGATAGAAAGGTTTCAAAATCAAGCAACAAAGTCTTAAAGTGATAAGGCATGG
 481 CTTAAAGATCTTTTGATCAAACATACCTGTGTTTGAGATAGATTTAAGAGCCCTAAATGCTTATCACCATTCACTCCAAA
 561 TAAAACTATTGCTTTTGGATAACTGTTAGAGTAAAGTGGCTTTTTAAAAGAAATTTTTGAGACTGGGTCTCACCTTGTTG
 641 CCCAGGCTGGAGTGTAGTTGTCTGGTCATGACTCACTGCAGTTTCGACCACCCAGGCTCAATCGATCCTCCCGCCTCTGC
 721 CTCTGGAGCAGCTGGGACAAGGCACACACCCCCATGCCTGGCTAATTAAAAAAATTGTTTTTTGTAGAAACGAGGTTTTG
 801 CCATATTGCCCAGGTTGGTCTCAAACTTCTGGGCTCAAGAGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAG
 881 ACGTTAGCCACACTGTGCCTGGGGGCCAGCATTTTCTAATACTTGTCATATTCTATAGTTTGTGCAAATTTAAGATTGTT
 961 TTTTTTTCTGCTCGTCAGTCAAATCAGTTCTTGGATTAAAAACTCATTCTTATTAGAACAGAATCATGTTGGTAACTTGG
1041 TCTGCAACAGGTTTTGATGGCATCATGTGGACTTTATTCATCTTAACTCATTTAAATTTTCTACCACATTCCCTTAAGCT
1121 AATGCAAAAGTACCAACAACTTAATCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCA
1201 GGCTGGAGTGCAGTGGCGTGATCTCGGCTCATTGCAAGCCCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCC
1281 CGAGTAGCTGGGACTACAGGCATCTGCTACCACGCCCAGCTAATTTTCTGTATTTTTAGTAGAGATGGGGTTTCACTGTG
1361 TTAGCCAGGATGGTCTCTATCTCCTGACCTCATGATCCACTCGCCTCAGCCTCCCAAAATGCTGGGATTATAGGCGTGAG
1441 CCGCCACGCCCGGCCCAACAACTTAATCTTTTATTAGCTTTGCTTAAGAGGGCCAATTAAATCAAAGCCCTTTAGTTCCC
1521 TTTAACAGGGACTGGAGTTATGATGCATGTGTTACGACTTTTGGCCCACTGTCCATGCAACTCTAAGTGCAGGTTGATTT
1601 GCTTTCCAGAAATCCCAAAGGGGCTGCTCTTGGATCACCGAAGAGCCTTACCTATATCAAATCAAAAAGACATTCTGGGT
1681 CAGATTAGACTATGCTCCTGGCCCTACAGATTGCACATAAACTATCATAAATACAGCTTTTTCAGGGAACTAGTTCTAAA
1761 ACTCTTACCTGCTGAGAATAAGTCTTAACACTAAGATGACTGTATTATATCAATTTATTATTAGAATCAGACTTATACCT
1841 AGCACAATTAACTATTGTGTGGGCAAAGAACATTTAAAGGGCATAGTAGAGGTAAGGAGAGACACATACTCAGCTAGAGA
1921 TAAAAATACTAAGTTGCACTGATTACTTAAAATACTAGTCACACCATAAAAGTGCCCTGTAGTTTCAAAAACACGTAAGC
2001 AATGAAATGTTAGCCATTATGTGTTAAACTACTTAATCTCATTTCTGTGATGTGAATATTTTTAACCCCCTTTTTGTAGA
2081 TGAGGGAACTGACAAGTGACTTGTCCAAGGCCATATAGCTGTGAGAAAACCCATGCATTCTCTTTTCAGAGTTCATGCTA
2161 TCACTCAACTTTAAAGTAGGCCAAGATTAATGTTGGTAAGGGTTTGTAATCTGTAAGAATGCTAAAAACGTAAGTATATA
2241 TATCATTTTAGATTTGACATTTTGTATCTTGCCAGTTTTTAGGAGAACTTTTCATTTTGTTAAGTATGCATGAATATAGT
2321 TGAGTATATGAGTAACTGGTTCTTATGCTGCTGTTTTGTATTTTTACCAGCAGGAAGATTGCAAAAGTTGATGTATGTAA
2401 ATCTTGAAATATTTCTAAGTTTTATGTATAACAAAATATGTATTTTAATAAACTTCTTTTGATATTTTAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgugucUGAACGACACUACAa 5'
                 |:|| ||||||||| 
Target 5' taatctcATTT-CTGTGATGTg 3'
 2034 - 2054 158.00 -12.40
2 
miRNA  3' ucGUGUCUG--AACGACACUACAa 5'
            ||:| ||  || :| |||||| 
Target 5' aaCATATACCTTTATTTTGATGTg 3'
 374 - 397 134.00 -8.20
3 
miRNA  3' ucGUGUCUGAACGACACUAcaa 5'
            || || |||   |||||   
Target 5' aaCAAAGTCTTAAAGTGATaag 3'
 453 - 474 120.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31494441 12 COSMIC
COSN31497439 34 COSMIC
COSN30147989 35 COSMIC
COSN30171942 35 COSMIC
COSN30452563 59 COSMIC
COSN30168223 69 COSMIC
COSN30467343 69 COSMIC
COSN30527769 90 COSMIC
COSN28858983 108 COSMIC
COSN30108055 196 COSMIC
COSN7624662 270 COSMIC
COSN9761506 489 COSMIC
COSN22356212 583 COSMIC
COSN24654359 860 COSMIC
COSN22297021 1089 COSMIC
COSN9140072 1221 COSMIC
COSN9140071 1332 COSMIC
COSN20090930 1496 COSMIC
COSN28630650 1503 COSMIC
COSN31522589 1583 COSMIC
COSN31603519 1639 COSMIC
COSN31568127 1640 COSMIC
COSN31609982 1640 COSMIC
COSN30173983 1663 COSMIC
rs1047210 1502 GWAS
rs6785881 1771 GWAS
rs7629 2455 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766714172 2 dbSNP
rs1212382835 5 dbSNP
rs1016395285 11 dbSNP
rs763392386 21 dbSNP
rs371119412 28 dbSNP
rs761983154 35 dbSNP
rs1402102194 40 dbSNP
rs889129911 41 dbSNP
rs1299312281 42 dbSNP
rs772676992 43 dbSNP
rs1401905500 47 dbSNP
rs1474515298 47 dbSNP
rs1168045594 50 dbSNP
rs1371862010 58 dbSNP
rs567328028 58 dbSNP
rs548808234 62 dbSNP
rs750723248 64 dbSNP
rs1172365782 66 dbSNP
rs369888415 67 dbSNP
rs1300415576 77 dbSNP
rs886471984 78 dbSNP
rs1365275678 85 dbSNP
rs1048175857 92 dbSNP
rs1392741585 98 dbSNP
rs1387446809 101 dbSNP
rs1161904432 103 dbSNP
rs1338479244 113 dbSNP
rs920748780 118 dbSNP
rs1279012249 123 dbSNP
rs1355231175 128 dbSNP
rs1243019542 132 dbSNP
rs933314107 133 dbSNP
rs1267783312 135 dbSNP
rs560382395 136 dbSNP
rs940858311 146 dbSNP
rs1195409638 154 dbSNP
rs763399002 155 dbSNP
rs943208938 159 dbSNP
rs776015791 160 dbSNP
rs1474775742 162 dbSNP
rs914404607 164 dbSNP
rs1185079876 165 dbSNP
rs927661577 167 dbSNP
rs981895247 174 dbSNP
rs763862654 179 dbSNP
rs551651216 181 dbSNP
rs1178821818 188 dbSNP
rs1480840342 196 dbSNP
rs1023337346 197 dbSNP
rs1355010660 198 dbSNP
rs924360203 200 dbSNP
rs989784443 211 dbSNP
rs1315326548 222 dbSNP
rs1341444845 224 dbSNP
rs981527906 228 dbSNP
rs1239028274 232 dbSNP
rs769909987 233 dbSNP
rs1350862456 235 dbSNP
rs957975190 236 dbSNP
rs971053875 238 dbSNP
rs1361221548 239 dbSNP
rs1198338801 240 dbSNP
rs1258086705 244 dbSNP
rs918172845 245 dbSNP
rs1424119841 251 dbSNP
rs1292017670 252 dbSNP
rs1181008304 255 dbSNP
rs1030887452 262 dbSNP
rs745943201 263 dbSNP
rs1237789338 265 dbSNP
rs999290997 273 dbSNP
rs991066197 277 dbSNP
rs1374899424 283 dbSNP
rs1464794455 290 dbSNP
rs1304798309 295 dbSNP
rs1403370777 295 dbSNP
rs959560492 299 dbSNP
rs1391112357 304 dbSNP
rs901015698 311 dbSNP
rs1309800269 322 dbSNP
rs1016429707 341 dbSNP
rs1019411347 343 dbSNP
rs1006332530 348 dbSNP
rs1311096537 352 dbSNP
rs1230628904 354 dbSNP
rs545017942 359 dbSNP
rs889097841 359 dbSNP
rs1197725029 362 dbSNP
rs1301624436 373 dbSNP
rs533243491 381 dbSNP
rs1050479115 383 dbSNP
rs930644317 387 dbSNP
rs1179178831 394 dbSNP
rs1394617973 400 dbSNP
rs201714962 402 dbSNP
rs950884813 406 dbSNP
rs200907500 411 dbSNP
rs1378380440 415 dbSNP
rs1461812508 416 dbSNP
rs149727410 417 dbSNP
rs1366469180 421 dbSNP
rs1158205787 426 dbSNP
rs1451740447 428 dbSNP
rs1448252131 429 dbSNP
rs1325807970 438 dbSNP
rs776896536 438 dbSNP
rs1161241872 442 dbSNP
rs1419551546 447 dbSNP
rs997933600 448 dbSNP
rs1268072268 456 dbSNP
rs1384528658 461 dbSNP
rs1207470027 467 dbSNP
rs771156752 467 dbSNP
rs1217604595 473 dbSNP
rs1036620326 474 dbSNP
rs940807555 475 dbSNP
rs544558317 476 dbSNP
rs1245984478 477 dbSNP
rs186784597 483 dbSNP
rs1487563184 489 dbSNP
rs1038967694 490 dbSNP
rs1490778869 492 dbSNP
rs1269231999 500 dbSNP
rs368318901 507 dbSNP
rs1007424429 508 dbSNP
rs928189659 513 dbSNP
rs563211429 515 dbSNP
rs540377079 516 dbSNP
rs1484608400 521 dbSNP
rs1054713373 522 dbSNP
rs1459879577 527 dbSNP
rs181316053 529 dbSNP
rs947851435 532 dbSNP
rs189730607 533 dbSNP
rs916218766 534 dbSNP
rs549590612 539 dbSNP
rs1045443311 541 dbSNP
rs1342144703 544 dbSNP
rs1218970284 548 dbSNP
rs1289084280 549 dbSNP
rs1319903388 551 dbSNP
rs747189932 552 dbSNP
rs777462680 556 dbSNP
rs949736244 559 dbSNP
rs1266181227 562 dbSNP
rs575514982 565 dbSNP
rs185419922 568 dbSNP
rs537802969 569 dbSNP
rs758238101 578 dbSNP
rs909441960 579 dbSNP
rs180803975 586 dbSNP
rs112880919 594 dbSNP
rs373051046 594 dbSNP
rs1181689196 607 dbSNP
rs1317914852 608 dbSNP
rs77247289 613 dbSNP
rs533650866 614 dbSNP
rs965175659 619 dbSNP
rs1166097219 621 dbSNP
rs1349977876 634 dbSNP
rs1289571345 635 dbSNP
rs1295992940 643 dbSNP
rs950882081 644 dbSNP
rs1400199619 645 dbSNP
rs1283419268 649 dbSNP
rs1376693922 651 dbSNP
rs566603339 657 dbSNP
rs1026820212 659 dbSNP
rs997607658 660 dbSNP
rs899174768 665 dbSNP
rs1174170781 666 dbSNP
rs1036610956 668 dbSNP
rs1005179292 674 dbSNP
rs1473947341 685 dbSNP
rs139616657 686 dbSNP
rs906674851 688 dbSNP
rs1438562700 691 dbSNP
rs966051596 696 dbSNP
rs1381590227 699 dbSNP
rs189619403 701 dbSNP
rs1007490280 703 dbSNP
rs796471427 704 dbSNP
rs1205245267 707 dbSNP
rs748089164 712 dbSNP
rs4679886 713 dbSNP
rs977975490 713 dbSNP
rs999098102 717 dbSNP
rs1354491796 719 dbSNP
rs529510992 721 dbSNP
rs1269930807 734 dbSNP
rs1276686985 735 dbSNP
rs1444527106 737 dbSNP
rs73155903 739 dbSNP
rs949767546 740 dbSNP
rs753381729 744 dbSNP
rs1055489514 749 dbSNP
rs1181043255 750 dbSNP
rs184895248 751 dbSNP
rs1470148067 753 dbSNP
rs1171643390 754 dbSNP
rs1422561579 754 dbSNP
rs954016614 754 dbSNP
rs1029046854 758 dbSNP
rs540668752 759 dbSNP
rs1399270904 761 dbSNP
rs1444553074 762 dbSNP
rs1333224900 764 dbSNP
rs572979242 766 dbSNP
rs1334610454 768 dbSNP
rs909465253 772 dbSNP
rs564274744 775 dbSNP
rs994958460 775 dbSNP
rs534788828 784 dbSNP
rs73154602 789 dbSNP
rs1005123488 791 dbSNP
rs1201086837 792 dbSNP
rs879238756 794 dbSNP
rs1374503150 801 dbSNP
rs1437935497 808 dbSNP
rs1197607080 809 dbSNP
rs150601031 812 dbSNP
rs1478845079 820 dbSNP
rs1443494389 828 dbSNP
rs1422676938 829 dbSNP
rs919426352 834 dbSNP
rs976603036 837 dbSNP
rs1404670729 839 dbSNP
rs1185989917 845 dbSNP
rs966115876 846 dbSNP
rs1017613755 847 dbSNP
rs986102594 852 dbSNP
rs957328419 855 dbSNP
rs1405838965 857 dbSNP
rs560992095 863 dbSNP
rs1053460537 864 dbSNP
rs373051193 869 dbSNP
rs1341898360 871 dbSNP
rs1252128383 882 dbSNP
rs542151283 883 dbSNP
rs748683741 887 dbSNP
rs936462166 896 dbSNP
rs1317182431 898 dbSNP
rs1453439990 899 dbSNP
rs540778656 905 dbSNP
rs1195635070 906 dbSNP
rs1373396224 922 dbSNP
rs555043178 935 dbSNP
rs1161375829 936 dbSNP
rs1042007690 940 dbSNP
rs1425303838 942 dbSNP
rs1398288867 948 dbSNP
rs1297854022 949 dbSNP
rs1168872243 955 dbSNP
rs1423553143 958 dbSNP
rs1382983518 959 dbSNP
rs571978684 960 dbSNP
rs1164978810 961 dbSNP
rs535037015 962 dbSNP
rs193204537 967 dbSNP
rs1286405103 968 dbSNP
rs1361016078 968 dbSNP
rs537311590 968 dbSNP
rs750050412 973 dbSNP
rs114321715 974 dbSNP
rs1262234457 981 dbSNP
rs932495155 982 dbSNP
rs1185335299 987 dbSNP
rs190017693 998 dbSNP
rs1445340501 1001 dbSNP
rs973468829 1007 dbSNP
rs4679885 1013 dbSNP
rs1289609493 1015 dbSNP
rs1401953514 1015 dbSNP
rs774874039 1016 dbSNP
rs941011542 1017 dbSNP
rs1336749137 1024 dbSNP
rs1384251868 1027 dbSNP
rs1015026874 1031 dbSNP
rs569080397 1039 dbSNP
rs550790432 1041 dbSNP
rs983426553 1050 dbSNP
rs565637817 1052 dbSNP
rs185135968 1058 dbSNP
rs1246888068 1061 dbSNP
rs1461765882 1063 dbSNP
rs1012945916 1065 dbSNP
rs1236450427 1066 dbSNP
rs79811452 1069 dbSNP
rs1160150906 1071 dbSNP
rs1032496342 1076 dbSNP
rs1001001921 1079 dbSNP
rs1407289257 1079 dbSNP
rs114692699 1080 dbSNP
rs1329834594 1082 dbSNP
rs976233399 1087 dbSNP
rs944840691 1088 dbSNP
rs1337335657 1091 dbSNP
rs147263297 1096 dbSNP
rs1392584652 1099 dbSNP
rs1307287097 1101 dbSNP
rs1311301637 1104 dbSNP
rs192753299 1113 dbSNP
rs1363404252 1115 dbSNP
rs530953446 1116 dbSNP
rs1304570200 1126 dbSNP
rs73154600 1133 dbSNP
rs1481672964 1137 dbSNP
rs1177907525 1139 dbSNP
rs1406528593 1140 dbSNP
rs13081619 1141 dbSNP
rs957634059 1143 dbSNP
rs1471412631 1144 dbSNP
rs1201258953 1145 dbSNP
rs890822090 1145 dbSNP
rs1033001193 1146 dbSNP
rs1169201467 1147 dbSNP
rs1199192534 1147 dbSNP
rs977763818 1147 dbSNP
rs1403021127 1148 dbSNP
rs1462924438 1148 dbSNP
rs1489959821 1150 dbSNP
rs967338104 1152 dbSNP
rs1366275353 1158 dbSNP
rs1384730002 1160 dbSNP
rs13081607 1161 dbSNP
rs1345947487 1163 dbSNP
rs1271391220 1171 dbSNP
rs1222511329 1172 dbSNP
rs1446504280 1173 dbSNP
rs1282183126 1174 dbSNP
rs1164622811 1175 dbSNP
rs1192012657 1175 dbSNP
rs1205136249 1175 dbSNP
rs1217740512 1175 dbSNP
rs1225007717 1175 dbSNP
rs1248199708 1175 dbSNP
rs1264993440 1175 dbSNP
rs1276046794 1175 dbSNP
rs1304608542 1175 dbSNP
rs1309232961 1175 dbSNP
rs1320030548 1175 dbSNP
rs1348801164 1175 dbSNP
rs1422055696 1175 dbSNP
rs1429697303 1175 dbSNP
rs1451823245 1175 dbSNP
rs1455901498 1175 dbSNP
rs1477710627 1175 dbSNP
rs1487511691 1175 dbSNP
rs751543768 1175 dbSNP
rs1292559953 1176 dbSNP
rs1488109006 1176 dbSNP
rs1225519715 1179 dbSNP
rs76622004 1179 dbSNP
rs1331193551 1180 dbSNP
rs1214719254 1182 dbSNP
rs113061399 1186 dbSNP
rs1014105215 1187 dbSNP
rs1222734215 1188 dbSNP
rs1343349920 1193 dbSNP
rs1412200877 1193 dbSNP
rs866625107 1195 dbSNP
rs894275500 1196 dbSNP
rs1436704416 1199 dbSNP
rs1344110529 1200 dbSNP
rs1315665798 1201 dbSNP
rs1034142023 1202 dbSNP
rs932586733 1208 dbSNP
rs1401904604 1218 dbSNP
rs575018511 1220 dbSNP
rs1315904265 1223 dbSNP
rs1176317447 1225 dbSNP
rs1479668145 1226 dbSNP
rs35376916 1228 dbSNP
rs919746750 1228 dbSNP
rs553647543 1230 dbSNP
rs1046711069 1232 dbSNP
rs1184742754 1233 dbSNP
rs781442999 1243 dbSNP
rs541034976 1249 dbSNP
rs1438467430 1250 dbSNP
rs1218123618 1261 dbSNP
rs898083436 1263 dbSNP
rs369677420 1277 dbSNP
rs138419611 1281 dbSNP
rs549984884 1286 dbSNP
rs1175139816 1287 dbSNP
rs970745066 1291 dbSNP
rs910712254 1293 dbSNP
rs1470948643 1296 dbSNP
rs539529137 1301 dbSNP
rs1337235270 1303 dbSNP
rs186932550 1306 dbSNP
rs991069080 1313 dbSNP
rs936080851 1314 dbSNP
rs1374385953 1316 dbSNP
rs1218864580 1319 dbSNP
rs1360882690 1322 dbSNP
rs959918851 1324 dbSNP
rs1204865669 1331 dbSNP
rs1257928955 1332 dbSNP
rs1456945434 1333 dbSNP
rs111310836 1345 dbSNP
rs535673789 1354 dbSNP
rs1432350385 1357 dbSNP
rs1000949481 1359 dbSNP
rs977463196 1361 dbSNP
rs529789751 1362 dbSNP
rs1177096906 1370 dbSNP
rs1399524321 1379 dbSNP
rs967749744 1380 dbSNP
rs1020654528 1381 dbSNP
rs917174025 1385 dbSNP
rs1355177192 1394 dbSNP
rs992741918 1396 dbSNP
rs1273228353 1397 dbSNP
rs1224455606 1402 dbSNP
rs1347820517 1402 dbSNP
rs1277941222 1403 dbSNP
rs1341169021 1403 dbSNP
rs958563703 1403 dbSNP
rs1272153568 1404 dbSNP
rs1034173069 1408 dbSNP
rs1274574341 1418 dbSNP
rs1409746768 1418 dbSNP
rs1417711640 1421 dbSNP
rs994394310 1424 dbSNP
rs568230261 1427 dbSNP
rs1129400 1428 dbSNP
rs1188448892 1431 dbSNP
rs1437848698 1435 dbSNP
rs1450176625 1435 dbSNP
rs1266263669 1436 dbSNP
rs1242571323 1437 dbSNP
rs1005331401 1438 dbSNP
rs952513354 1440 dbSNP
rs1459960996 1442 dbSNP
rs898390127 1442 dbSNP
rs765019271 1443 dbSNP
rs115630852 1447 dbSNP
rs1306689880 1448 dbSNP
rs1420315969 1448 dbSNP
rs1404802790 1449 dbSNP
rs1270461332 1450 dbSNP
rs993849190 1451 dbSNP
rs1367746502 1452 dbSNP
rs1420771109 1452 dbSNP
rs1230070674 1456 dbSNP
rs1365333715 1467 dbSNP
rs1405750009 1467 dbSNP
rs900829278 1469 dbSNP
rs564812170 1473 dbSNP
rs1230279019 1475 dbSNP
rs949523491 1476 dbSNP
rs768725310 1480 dbSNP
rs1339507788 1483 dbSNP
rs1303923580 1486 dbSNP
rs1288918732 1490 dbSNP
rs565015674 1493 dbSNP
rs528428770 1496 dbSNP
rs749167583 1498 dbSNP
rs1047210 1502 dbSNP
rs1444996286 1508 dbSNP
rs1430594297 1510 dbSNP
rs1373527828 1514 dbSNP
rs1161799437 1515 dbSNP
rs1384825738 1519 dbSNP
rs574136471 1520 dbSNP
rs925506023 1521 dbSNP
rs1161790939 1527 dbSNP
rs1158215504 1528 dbSNP
rs1050571018 1529 dbSNP
rs149415727 1541 dbSNP
rs1319364124 1544 dbSNP
rs1340441580 1545 dbSNP
rs1451089292 1546 dbSNP
rs182320805 1547 dbSNP
rs563841494 1548 dbSNP
rs1360899206 1552 dbSNP
rs1007966978 1555 dbSNP
rs542026412 1555 dbSNP
rs138943976 1556 dbSNP
rs1230922933 1559 dbSNP
rs1028089672 1565 dbSNP
rs996873736 1571 dbSNP
rs946107939 1575 dbSNP
rs1441839182 1576 dbSNP
rs1342484278 1580 dbSNP
rs1245058467 1583 dbSNP
rs1290574535 1585 dbSNP
rs1178293104 1587 dbSNP
rs917248549 1588 dbSNP
rs992774774 1590 dbSNP
rs1455513402 1592 dbSNP
rs755599975 1594 dbSNP
rs958594746 1609 dbSNP
rs750091709 1616 dbSNP
rs886921787 1623 dbSNP
rs1384397398 1625 dbSNP
rs559747167 1629 dbSNP
rs1046005622 1630 dbSNP
rs1305650720 1634 dbSNP
rs541752181 1639 dbSNP
rs577650384 1640 dbSNP
rs1261156105 1643 dbSNP
rs949927271 1650 dbSNP
rs564066287 1654 dbSNP
rs1264882455 1656 dbSNP
rs1461694694 1659 dbSNP
rs952612197 1669 dbSNP
rs1371665165 1677 dbSNP
rs1248501157 1679 dbSNP
rs1421165276 1682 dbSNP
rs1310297097 1683 dbSNP
rs1410785302 1685 dbSNP
rs1377425728 1686 dbSNP
rs1479636181 1688 dbSNP
rs1365255619 1692 dbSNP
rs1301505611 1697 dbSNP
rs114025250 1700 dbSNP
rs1393680754 1707 dbSNP
rs62272247 1714 dbSNP
rs758748123 1716 dbSNP
rs1019220388 1717 dbSNP
rs1006487379 1721 dbSNP
rs987352699 1723 dbSNP
rs955567972 1724 dbSNP
rs1418378854 1734 dbSNP
rs371116374 1736 dbSNP
rs889377200 1737 dbSNP
rs1324275114 1740 dbSNP
rs1050603851 1747 dbSNP
rs1405672955 1749 dbSNP
rs1481618790 1753 dbSNP
rs753074985 1756 dbSNP
rs904687802 1765 dbSNP
rs62272246 1766 dbSNP
rs996630515 1766 dbSNP
rs1041839700 1767 dbSNP
rs6785881 1771 dbSNP
rs767243355 1773 dbSNP
rs1004119503 1774 dbSNP
rs1477815936 1779 dbSNP
rs796971812 1779 dbSNP
rs886996235 1779 dbSNP
rs560042511 1780 dbSNP
rs1463035650 1782 dbSNP
rs1024229197 1783 dbSNP
rs1364615910 1789 dbSNP
rs1057174886 1791 dbSNP
rs1014470778 1807 dbSNP
rs1304790379 1809 dbSNP
rs1345847109 1813 dbSNP
rs191253727 1814 dbSNP
rs1309352927 1817 dbSNP
rs1228302969 1818 dbSNP
rs1237679561 1820 dbSNP
rs1291097842 1820 dbSNP
rs938123566 1823 dbSNP
rs903851698 1824 dbSNP
rs1290746161 1825 dbSNP
rs1229456136 1836 dbSNP
rs1345206036 1837 dbSNP
rs1281616609 1841 dbSNP
rs574585666 1846 dbSNP
rs1264413586 1847 dbSNP
rs1429607470 1854 dbSNP
rs754296456 1859 dbSNP
rs1384060741 1866 dbSNP
rs1043681016 1883 dbSNP
rs1388699808 1884 dbSNP
rs187944293 1890 dbSNP
rs927196126 1892 dbSNP
rs1286873650 1893 dbSNP
rs573087967 1894 dbSNP
rs1382710560 1895 dbSNP
rs984440818 1899 dbSNP
rs1357303983 1900 dbSNP
rs914098388 1901 dbSNP
rs934144157 1903 dbSNP
rs987076849 1903 dbSNP
rs1214156164 1907 dbSNP
rs761565005 1907 dbSNP
rs1288414093 1909 dbSNP
rs1262859399 1910 dbSNP
rs921480599 1911 dbSNP
rs1486512689 1912 dbSNP
rs1183454759 1917 dbSNP
rs931194468 1929 dbSNP
rs1442194881 1931 dbSNP
rs975141007 1933 dbSNP
rs534602878 1934 dbSNP
rs1451683621 1935 dbSNP
rs1185074266 1940 dbSNP
rs1386434796 1948 dbSNP
rs1161214126 1950 dbSNP
rs570443312 1954 dbSNP
rs1346737392 1956 dbSNP
rs1016706021 1958 dbSNP
rs918400531 1962 dbSNP
rs972533147 1966 dbSNP
rs552139192 1967 dbSNP
rs537471564 1968 dbSNP
rs150286135 1972 dbSNP
rs766421400 1974 dbSNP
rs1372923393 1977 dbSNP
rs1222267057 1980 dbSNP
rs1019293137 1994 dbSNP
rs1196869897 1995 dbSNP
rs1261758716 1996 dbSNP
rs1463028332 1999 dbSNP
rs1205056103 2002 dbSNP
rs1237543706 2005 dbSNP
rs575005945 2020 dbSNP
rs753621526 2021 dbSNP
rs1409897829 2026 dbSNP
rs1477293881 2031 dbSNP
rs1014212460 2034 dbSNP
rs985099351 2035 dbSNP
rs1189346567 2036 dbSNP
rs1421908548 2037 dbSNP
rs1255350686 2041 dbSNP
rs894281939 2044 dbSNP
rs1034176801 2046 dbSNP
rs953676363 2052 dbSNP
rs769588633 2056 dbSNP
rs1353951540 2064 dbSNP
rs1188834938 2066 dbSNP
rs200962955 2070 dbSNP
rs747635739 2071 dbSNP
rs141142462 2072 dbSNP
rs1198167560 2076 dbSNP
rs1335739438 2081 dbSNP
rs776318079 2089 dbSNP
rs1243063196 2093 dbSNP
rs760781733 2100 dbSNP
rs1308311333 2101 dbSNP
rs1223330174 2102 dbSNP
rs1281734007 2103 dbSNP
rs1449692996 2104 dbSNP
rs1378391206 2106 dbSNP
rs1328706033 2111 dbSNP
rs1464702651 2114 dbSNP
rs374616889 2116 dbSNP
rs1224652301 2118 dbSNP
rs1000847757 2123 dbSNP
rs1164678983 2131 dbSNP
rs1456182224 2132 dbSNP
rs1260094236 2134 dbSNP
rs570027023 2137 dbSNP
rs1211829471 2140 dbSNP
rs1367705267 2144 dbSNP
rs1234208833 2147 dbSNP
rs1179130683 2148 dbSNP
rs1043794417 2156 dbSNP
rs3180411 2159 dbSNP
rs1426938325 2164 dbSNP
rs1481384922 2167 dbSNP
rs1331941213 2168 dbSNP
rs530190765 2179 dbSNP
rs1173024041 2180 dbSNP
rs559885713 2184 dbSNP
rs1408227907 2192 dbSNP
rs1330947221 2198 dbSNP
rs1380617419 2199 dbSNP
rs773369775 2213 dbSNP
rs1322500997 2215 dbSNP
rs1457655292 2220 dbSNP
rs555551195 2229 dbSNP
rs895917934 2229 dbSNP
rs1057196927 2230 dbSNP
rs1347713724 2230 dbSNP
rs941528571 2231 dbSNP
rs1221200765 2232 dbSNP
rs1274462924 2232 dbSNP
rs752734045 2232 dbSNP
rs937363250 2236 dbSNP
rs905853091 2240 dbSNP
rs140759771 2244 dbSNP
rs1490767820 2244 dbSNP
rs532831283 2247 dbSNP
rs1474365435 2251 dbSNP
rs931205141 2259 dbSNP
rs578057616 2261 dbSNP
rs15470 2264 dbSNP
rs769125009 2265 dbSNP
rs1390848275 2266 dbSNP
rs972990815 2267 dbSNP
rs993142106 2269 dbSNP
rs958622123 2273 dbSNP
rs1387661945 2276 dbSNP
rs1318049386 2277 dbSNP
rs1325240511 2281 dbSNP
rs1433501577 2286 dbSNP
rs943839070 2291 dbSNP
rs1365199824 2293 dbSNP
rs1244828414 2296 dbSNP
rs1289077628 2299 dbSNP
rs1361121764 2315 dbSNP
rs1210250246 2324 dbSNP
rs1283283382 2328 dbSNP
rs1445267391 2329 dbSNP
rs1195164581 2330 dbSNP
rs1248732557 2335 dbSNP
rs1444047413 2337 dbSNP
rs137894412 2339 dbSNP
rs999948339 2341 dbSNP
rs968528122 2346 dbSNP
rs912315858 2351 dbSNP
rs1202620187 2356 dbSNP
rs1158422344 2360 dbSNP
rs1383245713 2362 dbSNP
rs1402956355 2363 dbSNP
rs1009692427 2385 dbSNP
rs796291674 2388 dbSNP
rs892441790 2388 dbSNP
rs985174003 2393 dbSNP
rs1346081210 2395 dbSNP
rs762073538 2396 dbSNP
rs900061100 2400 dbSNP
rs1032410852 2409 dbSNP
rs1278750538 2412 dbSNP
rs554826264 2412 dbSNP
rs1348198045 2413 dbSNP
rs941502402 2414 dbSNP
rs1225464305 2415 dbSNP
rs1344433726 2419 dbSNP
rs979063674 2424 dbSNP
rs969397419 2425 dbSNP
rs367845022 2428 dbSNP
rs1010418701 2430 dbSNP
rs1046830530 2433 dbSNP
rs1424676981 2434 dbSNP
rs1181288549 2435 dbSNP
rs774295442 2437 dbSNP
rs1471332680 2439 dbSNP
rs768533424 2440 dbSNP
rs917000264 2440 dbSNP
rs1468693168 2444 dbSNP
rs958619719 2444 dbSNP
rs1403643721 2445 dbSNP
rs145272486 2447 dbSNP
rs140278536 2449 dbSNP
rs7629 2455 dbSNP
rs1288717933 2456 dbSNP
rs183890816 2457 dbSNP
rs1020096623 2459 dbSNP
rs1166999094 2462 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 286827.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgugucUGAACGACACUACaa 5'
                 |:|| ||||||||  
Target 5' uaaucucAUUU-CUGUGAUG-- 3'
 		11 - 29
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000309784.4 | 3UTR | UUAAACUACUUAAUCUCAUUUCUGUGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE26953 Aortic valvular endothelial cells -0.442 1.5e-2 -0.492 7.3e-3 24 Click to see details
GSE28260 Renal cortex and medulla 0.574 2.0e-2 0.581 1.9e-2 13 Click to see details
GSE19350 CNS germ cell tumors -0.369 1.2e-1 0.026 4.7e-1 12 Click to see details
GSE32688 Pancreatic cancer -0.203 1.3e-1 -0.240 9.3e-2 32 Click to see details
GSE28544 Breast cancer -0.223 1.5e-1 -0.140 2.6e-1 24 Click to see details
GSE38226 Liver fibrosis 0.235 1.5e-1 0.081 3.6e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.109 3.2e-1 -0.156 2.6e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.039 4.3e-1 0.129 2.7e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.038 4.3e-1 -0.042 4.2e-1 23 Click to see details
GSE21687 Ependynoma primary tumors -0.002 4.9e-1 0.048 3.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.002 4.9e-1 0.048 3.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.002 4.9e-1 0.048 3.5e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD -0.57 0.02 -0.051 0.43 14 Click to see details
KIRP -0.558 0.06 -0.683 0.02 9 Click to see details
KICH -0.294 0.2 -0.127 0.36 10 Click to see details
BRCA 0.785 0.21 0.500 0.33 3 Click to see details
KIRC -0.177 0.23 -0.109 0.33 19 Click to see details
LUSC -0.361 0.32 -0.400 0.3 4 Click to see details
HNSC -0.113 0.39 -0.067 0.43 9 Click to see details
THCA -0.056 0.39 -0.079 0.34 29 Click to see details
LIHC 0.065 0.4 -0.392 0.06 17 Click to see details
UCEC -0.041 0.47 0.000 0.5 7 Click to see details
STAD 0.027 0.48 0.100 0.44 5 Click to see details
STAD 0.027 0.48 0.100 0.44 5 Click to see details
STAD 0.027 0.48 0.100 0.44 5 Click to see details
STAD 0.027 0.48 0.100 0.44 5 Click to see details
STAD 0.027 0.48 0.100 0.44 5 Click to see details
59 hsa-miR-499a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130131 TXNIP thioredoxin interacting protein 2 2
MIRT133678 ETNK1 ethanolamine kinase 1 2 2
MIRT252103 NAPG NSF attachment protein gamma 2 2
MIRT260160 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT388009 DR1 down-regulator of transcription 1 2 2
MIRT441692 ABLIM1 actin binding LIM protein 1 2 6
MIRT447799 EPC2 enhancer of polycomb homolog 2 2 2
MIRT450657 STYX serine/threonine/tyrosine interacting protein 2 4
MIRT456843 ZNF460 zinc finger protein 460 2 2
MIRT464134 VPS35 VPS35, retromer complex component 2 2
MIRT465101 TSC22D3 TSC22 domain family member 3 2 4
MIRT470051 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT474146 LIMA1 LIM domain and actin binding 1 2 6
MIRT474153 LIFR LIF receptor alpha 2 2
MIRT485327 MYO1D myosin ID 2 2
MIRT496403 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT497280 MAF MAF bZIP transcription factor 2 2
MIRT500970 SPTSSA serine palmitoyltransferase small subunit A 2 2
MIRT501536 POM121C POM121 transmembrane nucleoporin C 2 6
MIRT505174 WDR76 WD repeat domain 76 2 4
MIRT505203 UQCRB ubiquinol-cytochrome c reductase binding protein 2 4
MIRT506745 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT506799 KLHL15 kelch like family member 15 2 6
MIRT525718 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT530014 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT531457 PROSER2 proline and serine rich 2 2 2
MIRT532272 CD93 CD93 molecule 2 2
MIRT538715 CAPRIN2 caprin family member 2 2 4
MIRT547356 NAT8L N-acetyltransferase 8 like 2 2
MIRT551468 TRIM59 tripartite motif containing 59 2 2
MIRT555444 NT5C3A 5'-nucleotidase, cytosolic IIIA 2 2
MIRT555674 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT557816 FOXO1 forkhead box O1 2 2
MIRT557853 FIGN fidgetin, microtubule severing factor 2 2
MIRT557880 FEM1B fem-1 homolog B 2 4
MIRT562299 GLO1 glyoxalase I 2 2
MIRT563245 QRFPR pyroglutamylated RFamide peptide receptor 2 2
MIRT565571 SLC7A2 solute carrier family 7 member 2 2 2
MIRT566214 PTMA prothymosin, alpha 2 2
MIRT575544 Map4 microtubule-associated protein 4 2 2
MIRT609316 FXYD6 FXYD domain containing ion transport regulator 6 2 2
MIRT609362 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT611163 BTLA B and T lymphocyte associated 2 4
MIRT611749 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT615019 ELK4 ELK4, ETS transcription factor 2 2
MIRT623317 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT624550 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT633934 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT635691 BMP10 bone morphogenetic protein 10 2 2
MIRT646438 DNAH8 dynein axonemal heavy chain 8 2 2
MIRT651940 UBN1 ubinuclein 1 2 2
MIRT663605 TBC1D22A TBC1 domain family member 22A 2 2
MIRT689759 PRR13 proline rich 13 2 2
MIRT691916 SRXN1 sulfiredoxin 1 2 2
MIRT698678 TEF TEF, PAR bZIP transcription factor 2 2
MIRT700924 PDS5A PDS5 cohesin associated factor A 2 2
MIRT707970 PDE12 phosphodiesterase 12 2 2
MIRT715290 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT722414 RARS2 arginyl-tRNA synthetase 2, mitochondrial 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-499a Erlotinib 176870 NSC718781 approved sensitive Low Osteosarcoma cell line (CD166)
hsa-mir-499a Cisplatin 5460033 NSC119875 approved resistant Low Cervical Cancer cell line (GH329, Hela, CaSki, Siha)
hsa-miR-499a-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-499a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-499a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-499a-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-499a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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