miRTarBase - #MIRT552550


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pre-miRNA Information
pre-miRNA hsa-mir-921   
Genomic Coordinates chr1: 166154743 - 166154798
Synonyms MIRN921, hsa-mir-921, MIR921
Description Homo sapiens miR-921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-921
Sequence 2| CUAGUGAGGGACAGAACCAGGAUUC |26
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31549221 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1464259216 3 dbSNP
rs768428855 8 dbSNP
rs746970999 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZFP36L2   
Synonyms BRF2, ERF-2, ERF2, RNF162C, TIS11D
Description ZFP36 ring finger protein like 2
Transcript NM_006887   
Expression
Putative miRNA Targets on ZFP36L2
3'UTR of ZFP36L2
(miRNA target sites are highlighted)		 
>ZFP36L2|NM_006887|3'UTR
   1 GGCAAGAGGGCGCCAGTGAGGAGGAAGGGAAGGCGGTTCAGAGATGTTGGAGGACACCCCTCGCCATCTCGCCCTTGCTG
  81 GGGGCACGGGAGTGGGGGGGGTGACATGGGCCCTAGGCAGACTGCAAGCCCGACCGAGCACTTGGACTCGAACTCTGTGC
 161 CGGGAGGGGCCCCCACCCCTCCTTTTTCGGTTTCCTCTTGTCTTTTTTTTTTTATTTTTATTACGAAGTTTCATTCTTTT
 241 TGAGCAAAAAAGTCGAACTTTTTCTGTTGAACAAAATATTCACAACAGGGCAGTTGTGATACGAATAGAACAAAAAAAAA
 321 AAAAAAACACTTAAACTTTGTTAGGACTCCGATGAGTTTGGGACTTCAGGAAAAATCAACCCAGCACCAGCAGCTACCAA
 401 CCACCATTCCATCTCTTCACTTGAACAGCATTAGTTAAGTCCAGATGTGGGAACCCTTCTCTTGGAAGAAGTTCCTAATT
 481 GTGTCTCAGACCGGTGTAAACAAACCAGCCAGCCGCCACCTTGCTAAACCTATAAGCTTTTTAAAATCCAATATATTCTG
 561 CCAAGAATATGCCTTGATAGTTAGCCCTCAGCCCATAGGTGTTTTTTGTTTTTTAACAGAATTATATATGTCTGGGGGTG
 641 AAAAAACCCTTGCATTCCAAAGGTCCATACTGGTTACTTGGTTTCATTGCCACCACTTAGTGGATGTTCAGTTTAGAACC
 721 ATTTTGTCTGCTCCCTCTGGAAGCCTTGCGCAGAGCTTACTTTGTAATTGTTGGAGAATAACTGCTGAATTTTTAGCTGT
 801 TTTGAGTTGATTCGCACCACTGCACCACAACTCAATATGAAAACTATTTAACTTATTTATTATCTTGTGAAAAGTATACA
 881 ATGAAAATTTTGTTCATACTGTATTTATCAAGTATGATGAAAAGCAATAGATATATATTCTTTTATTATGTTAAATTATG
 961 ATTGCCATTATTAATCGGCAAAATGTGGAGTGTATGTTCTTTTCACAGTAATATATGCCTTTTGTAACTTCACTTGGTTA
1041 TTTTATTGTAAATGAGTACAAAATTCTTAATTTAAGAGATTGTATGTAATATTTATTTCATTAATTTCTTTCCTTGTTTA
1121 CGTAAATTTTGAAAGATTGCATGATTTCTTGACAGAAATCGATCTTGATGCTGTGGAAGTAGTTTGAGGAACATCCTATG
1201 AGTTTTCTTAGAATGTATAAAGGTTGTAGCCCATCCAACTTCAAAGAAAAAAATGACCACATACTTTGCAATCAGGCTGA
1281 AATGTGGCATGCTTTTCTAATTCCAACTTTATAAACTAGCAAAAAAGTGTTTGCTTATTCCACCAGTTCTACTGTGACAT
1361 ACTCGAGTATAAAGACATGTAGCAATAACGGGGAGTGGGGGGGGAGTCTCACAGTGCCTTTGGAAGGGCCCGAACTTGCC
1441 TTAAATCTTCCTCAACCAAATAAGTATTTTATTAGTGCTTGAGAGAATCTGAATGTAGGATGGGTTCAACTGCACAAAAG
1521 GAAAAGATTTTTACCACTTTTTTTATATAGATATAAAGTGAAGCAACCGCCTTAGTGCTGAAATATGTAGTACATGAATA
1601 TGCCTTGTTTAATTACAGAAAATTCCAAAACTTGTACTATTTTTTTTTCCATGTAGAAAGGCAGGAATGTCTCCTAAGCT
1681 TTCCTGGACAGCAGATGAATGAGCGGTAGCTTTAGTTTGTACGTAGGTACAGTTGGAGCACTATATGTACTCTCTGGACT
1761 ACTTTGGACAGAAGTAGGTTTTTGAATGTAACAAGATAAGTCAACTTGAGTTGTAATATATTTTGGGGAATCAGCTCACT
1841 ACAAATTGTGACTGTAAACATTGTACTGTAAATGTTTTGTAGTTTTCCCCCAATAAAATTTTTGGGAAAAAAAGGTAAAA
1921 AAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUAGGACC---AAGACAGGGAGUGAUc 5'
            ||::|||    || |   ||||||| 
Target 5' atATTTTGGGGAATCAG---CTCACTAc 3'
 1818 - 1842 152.00 -14.30
2 
miRNA  3' cuuaggaccAAGACA-GGGAGUGAuc 5'
                   ||:|||  |:|||||  
Target 5' atatatgccTTTTGTAACTTCACTtg 3'
 1011 - 1036 124.00 -13.40
3 
miRNA  3' cuUAGGACCAA-GACAGGGAGUGAUc 5'
            || |||||| ||   ::|||:|: 
Target 5' ccATACTGGTTACTTGGTTTCATTGc 3'
 665 - 690 123.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30472656 16 COSMIC
COSN28844934 94 COSMIC
COSN28635949 122 COSMIC
COSN28720971 144 COSMIC
COSN28833072 175 COSMIC
COSN8609230 214 COSMIC
COSN31486499 242 COSMIC
COSN4804522 275 COSMIC
COSN21594305 289 COSMIC
COSN26575789 328 COSMIC
COSN26585936 429 COSMIC
COSN20096602 551 COSMIC
COSN32069230 562 COSMIC
COSN20096601 578 COSMIC
COSN5504254 582 COSMIC
COSN20096599 608 COSMIC
COSN25023250 735 COSMIC
COSN31523424 744 COSMIC
COSN20746047 753 COSMIC
COSN16896190 856 COSMIC
COSN1840905 862 COSMIC
COSN4624936 902 COSMIC
COSN24882730 906 COSMIC
COSN26930655 948 COSMIC
COSN21684899 1076 COSMIC
COSN21854632 1079 COSMIC
COSN27760245 1090 COSMIC
COSN9374524 1093 COSMIC
COSN1840903 1141 COSMIC
COSN22838747 1525 COSMIC
COSN7129830 1771 COSMIC
COSN24294811 1848 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746029792 2 dbSNP
rs540921240 3 dbSNP
rs1446967578 4 dbSNP
rs1402006079 5 dbSNP
rs757323833 7 dbSNP
rs373802896 9 dbSNP
rs1383723613 11 dbSNP
rs1396253639 13 dbSNP
rs530374570 19 dbSNP
rs909459987 24 dbSNP
rs1415008327 25 dbSNP
rs981053308 27 dbSNP
rs542622432 28 dbSNP
rs1315014054 32 dbSNP
rs1385235092 32 dbSNP
rs1179324898 34 dbSNP
rs758307238 42 dbSNP
rs111364621 43 dbSNP
rs375785322 46 dbSNP
rs1436962274 47 dbSNP
rs1290296843 48 dbSNP
rs1247949216 51 dbSNP
rs377227881 54 dbSNP
rs1258294521 56 dbSNP
rs1460076864 58 dbSNP
rs891551605 60 dbSNP
rs183481973 61 dbSNP
rs1000653563 70 dbSNP
rs905505909 71 dbSNP
rs1403222785 73 dbSNP
rs1222406791 78 dbSNP
rs1044358361 79 dbSNP
rs776275843 81 dbSNP
rs950000656 85 dbSNP
rs917136289 88 dbSNP
rs972563505 90 dbSNP
rs939812896 91 dbSNP
rs1234211405 92 dbSNP
rs1258030527 93 dbSNP
rs1335686592 93 dbSNP
rs903732189 94 dbSNP
rs1039585447 95 dbSNP
rs373461799 96 dbSNP
rs1028741447 97 dbSNP
rs575291671 98 dbSNP
rs146079842 99 dbSNP
rs1448305825 102 dbSNP
rs893962631 102 dbSNP
rs1050793566 111 dbSNP
rs1000348230 114 dbSNP
rs905560938 115 dbSNP
rs1044462743 116 dbSNP
rs949705182 119 dbSNP
rs1202313614 123 dbSNP
rs1250754960 124 dbSNP
rs1159203665 130 dbSNP
rs929678770 134 dbSNP
rs1192649121 139 dbSNP
rs1266519792 142 dbSNP
rs1479885599 145 dbSNP
rs1193965890 147 dbSNP
rs895752709 149 dbSNP
rs1168950725 155 dbSNP
rs1354528731 158 dbSNP
rs1458878948 159 dbSNP
rs1305296918 161 dbSNP
rs544770148 165 dbSNP
rs1344049786 166 dbSNP
rs1036921566 168 dbSNP
rs1050546 169 dbSNP
rs939865276 172 dbSNP
rs370558048 175 dbSNP
rs909698654 175 dbSNP
rs573040441 178 dbSNP
rs932723118 179 dbSNP
rs1223724206 180 dbSNP
rs377134875 180 dbSNP
rs1179424294 182 dbSNP
rs1443891599 188 dbSNP
rs1243383522 190 dbSNP
rs1202580217 194 dbSNP
rs1185372955 200 dbSNP
rs1474133759 200 dbSNP
rs552845864 200 dbSNP
rs1269549481 201 dbSNP
rs1364069680 202 dbSNP
rs977161699 204 dbSNP
rs191576047 208 dbSNP
rs567189720 210 dbSNP
rs1278238664 211 dbSNP
rs187128624 213 dbSNP
rs1269635093 214 dbSNP
rs1380014975 214 dbSNP
rs1436271627 214 dbSNP
rs3209872 214 dbSNP
rs1240676942 215 dbSNP
rs1286102313 216 dbSNP
rs1383895822 220 dbSNP
rs1214659893 223 dbSNP
rs1237528445 224 dbSNP
rs1483969039 225 dbSNP
rs1185959459 226 dbSNP
rs988332371 230 dbSNP
rs1444573842 232 dbSNP
rs1159554102 233 dbSNP
rs1410656698 234 dbSNP
rs1317968120 236 dbSNP
rs1359785031 237 dbSNP
rs1454714008 238 dbSNP
rs1334594907 239 dbSNP
rs1381878573 240 dbSNP
rs1447431574 241 dbSNP
rs1281022495 242 dbSNP
rs1348336247 245 dbSNP
rs1336333946 252 dbSNP
rs200331054 255 dbSNP
rs1325052470 257 dbSNP
rs1201167395 261 dbSNP
rs112754298 262 dbSNP
rs556814964 264 dbSNP
rs1241988599 267 dbSNP
rs564039437 270 dbSNP
rs1179845534 271 dbSNP
rs1234943778 272 dbSNP
rs569148453 273 dbSNP
rs199657841 274 dbSNP
rs1426212776 276 dbSNP
rs1471087273 279 dbSNP
rs1159975709 285 dbSNP
rs1400141737 286 dbSNP
rs1174282775 288 dbSNP
rs1032462172 290 dbSNP
rs1447397230 293 dbSNP
rs1330858650 296 dbSNP
rs1407209232 300 dbSNP
rs1441282796 302 dbSNP
rs1156676066 303 dbSNP
rs1275232670 304 dbSNP
rs1446242200 304 dbSNP
rs1385699629 306 dbSNP
rs1221332539 307 dbSNP
rs1182749721 308 dbSNP
rs73923539 311 dbSNP
rs1002342417 312 dbSNP
rs1243470816 312 dbSNP
rs1275804941 314 dbSNP
rs541238158 314 dbSNP
rs1215907271 315 dbSNP
rs532451286 315 dbSNP
rs1445874391 316 dbSNP
rs1282771684 317 dbSNP
rs868803928 322 dbSNP
rs1014351430 323 dbSNP
rs1197596267 324 dbSNP
rs1428645673 325 dbSNP
rs1466268160 326 dbSNP
rs1169565015 327 dbSNP
rs1282289826 328 dbSNP
rs1323920654 328 dbSNP
rs1394172040 328 dbSNP
rs59794453 328 dbSNP
rs60089722 328 dbSNP
rs796750056 328 dbSNP
rs1340597026 329 dbSNP
rs1360775183 329 dbSNP
rs1161187016 330 dbSNP
rs1229055291 331 dbSNP
rs866320508 331 dbSNP
rs1267912203 333 dbSNP
rs1314870039 333 dbSNP
rs1337944338 333 dbSNP
rs1195765804 334 dbSNP
rs1292901305 334 dbSNP
rs1244198108 335 dbSNP
rs1490954023 335 dbSNP
rs1367681947 339 dbSNP
rs1268520720 342 dbSNP
rs1429350319 346 dbSNP
rs1195331306 349 dbSNP
rs1371434156 350 dbSNP
rs1475013350 351 dbSNP
rs1163818084 353 dbSNP
rs1386829460 360 dbSNP
rs1422590161 361 dbSNP
rs113541137 364 dbSNP
rs181214548 367 dbSNP
rs1315561645 368 dbSNP
rs1325371353 376 dbSNP
rs1227314930 377 dbSNP
rs942167144 379 dbSNP
rs909408935 383 dbSNP
rs1343450528 384 dbSNP
rs1244165551 385 dbSNP
rs1291506030 386 dbSNP
rs1486291479 388 dbSNP
rs1207140755 392 dbSNP
rs1036973890 393 dbSNP
rs770644553 395 dbSNP
rs981001028 395 dbSNP
rs1446544029 396 dbSNP
rs1325597121 399 dbSNP
rs1184128836 400 dbSNP
rs190204637 402 dbSNP
rs530437382 405 dbSNP
rs1442722229 409 dbSNP
rs75275902 411 dbSNP
rs1290236912 413 dbSNP
rs72788874 415 dbSNP
rs1454979760 421 dbSNP
rs956962008 423 dbSNP
rs1156497929 424 dbSNP
rs932464397 427 dbSNP
rs1396163072 433 dbSNP
rs1338148851 437 dbSNP
rs865788123 437 dbSNP
rs921369078 441 dbSNP
rs1451131240 444 dbSNP
rs1314735627 448 dbSNP
rs868680531 452 dbSNP
rs779063772 464 dbSNP
rs1241411035 469 dbSNP
rs1259258378 471 dbSNP
rs979513625 481 dbSNP
rs1204324993 483 dbSNP
rs1245052467 489 dbSNP
rs913899828 491 dbSNP
rs530564591 493 dbSNP
rs1250948054 494 dbSNP
rs564726529 495 dbSNP
rs1179205960 496 dbSNP
rs1362800102 498 dbSNP
rs1469998674 498 dbSNP
rs545090525 510 dbSNP
rs753743152 512 dbSNP
rs764112808 515 dbSNP
rs1468676113 526 dbSNP
rs572811033 532 dbSNP
rs1224064752 533 dbSNP
rs112977451 534 dbSNP
rs756170970 537 dbSNP
rs1335332326 548 dbSNP
rs113934028 552 dbSNP
rs34146845 553 dbSNP
rs553149293 554 dbSNP
rs981365213 555 dbSNP
rs200907999 556 dbSNP
rs3042140 557 dbSNP
rs551965350 557 dbSNP
rs71737208 557 dbSNP
rs891054775 561 dbSNP
rs1029706057 562 dbSNP
rs1251875689 575 dbSNP
rs1481581928 578 dbSNP
rs1023166582 581 dbSNP
rs1249593409 584 dbSNP
rs201597359 585 dbSNP
rs993847569 585 dbSNP
rs896859814 587 dbSNP
rs1344676621 589 dbSNP
rs1426548062 593 dbSNP
rs1015260871 595 dbSNP
rs1175965502 596 dbSNP
rs1355568310 601 dbSNP
rs190907744 607 dbSNP
rs1463987142 608 dbSNP
rs187823280 608 dbSNP
rs1405757724 612 dbSNP
rs148471515 615 dbSNP
rs184080911 615 dbSNP
rs57945316 615 dbSNP
rs941113218 619 dbSNP
rs1214263532 625 dbSNP
rs1048285517 626 dbSNP
rs1309143524 629 dbSNP
rs1276725831 632 dbSNP
rs1405603822 633 dbSNP
rs997098787 634 dbSNP
rs1250524705 635 dbSNP
rs899645299 638 dbSNP
rs887922221 645 dbSNP
rs1302431475 647 dbSNP
rs1266406505 653 dbSNP
rs1422523262 659 dbSNP
rs1356005427 660 dbSNP
rs1045244001 664 dbSNP
rs1421070499 665 dbSNP
rs76516022 667 dbSNP
rs918172331 673 dbSNP
rs1052389246 674 dbSNP
rs573484079 677 dbSNP
rs1268803487 679 dbSNP
rs1305352017 681 dbSNP
rs935332262 685 dbSNP
rs1197821154 687 dbSNP
rs923965112 692 dbSNP
rs979460258 693 dbSNP
rs968115209 699 dbSNP
rs1296867790 700 dbSNP
rs1359865935 701 dbSNP
rs918088993 706 dbSNP
rs1204225918 709 dbSNP
rs1490073900 714 dbSNP
rs1018030693 718 dbSNP
rs992612703 719 dbSNP
rs1306029530 721 dbSNP
rs1243324619 724 dbSNP
rs1484630451 731 dbSNP
rs1185284678 736 dbSNP
rs1248014648 737 dbSNP
rs556876578 739 dbSNP
rs1445767537 742 dbSNP
rs536944783 749 dbSNP
rs199648732 750 dbSNP
rs982465488 753 dbSNP
rs952386195 763 dbSNP
rs1428787952 770 dbSNP
rs1344894850 773 dbSNP
rs757353928 774 dbSNP
rs1383356438 775 dbSNP
rs955426307 776 dbSNP
rs575597572 778 dbSNP
rs1029573383 780 dbSNP
rs1027337368 785 dbSNP
rs996770448 788 dbSNP
rs899696795 794 dbSNP
rs180896921 798 dbSNP
rs896807371 802 dbSNP
rs1182344039 804 dbSNP
rs892567404 809 dbSNP
rs1462117078 812 dbSNP
rs539137008 813 dbSNP
rs1441182162 814 dbSNP
rs1005277383 817 dbSNP
rs905614211 819 dbSNP
rs1044577416 823 dbSNP
rs1241648080 827 dbSNP
rs1352424480 828 dbSNP
rs758554156 836 dbSNP
rs948237513 842 dbSNP
rs1178061022 862 dbSNP
rs1177981591 864 dbSNP
rs1469879484 867 dbSNP
rs138371172 874 dbSNP
rs1056699338 881 dbSNP
rs1470905837 885 dbSNP
rs903834505 887 dbSNP
rs1045766491 895 dbSNP
rs1442733131 897 dbSNP
rs1281087144 899 dbSNP
rs948323472 901 dbSNP
rs1421437745 909 dbSNP
rs1251838455 910 dbSNP
rs878900712 912 dbSNP
rs1263193963 914 dbSNP
rs935601923 915 dbSNP
rs565874850 921 dbSNP
rs1177006205 922 dbSNP
rs1479837101 923 dbSNP
rs923912747 924 dbSNP
rs774342060 927 dbSNP
rs547095498 930 dbSNP
rs189164031 933 dbSNP
rs1277188729 934 dbSNP
rs1303338859 934 dbSNP
rs918130515 939 dbSNP
rs536884002 940 dbSNP
rs992332102 940 dbSNP
rs1323077350 943 dbSNP
rs1181796812 945 dbSNP
rs1430038570 946 dbSNP
rs1261417528 948 dbSNP
rs185562775 949 dbSNP
rs1318710949 950 dbSNP
rs1410493232 961 dbSNP
rs1330581153 970 dbSNP
rs1352595595 973 dbSNP
rs1307562147 974 dbSNP
rs551346729 976 dbSNP
rs908307661 976 dbSNP
rs982517791 976 dbSNP
rs1223032657 977 dbSNP
rs911306430 981 dbSNP
rs1338439706 988 dbSNP
rs1215694377 989 dbSNP
rs1275532118 999 dbSNP
rs767752786 999 dbSNP
rs1204697437 1002 dbSNP
rs760049552 1002 dbSNP
rs1269944688 1004 dbSNP
rs1453001319 1006 dbSNP
rs1490906318 1014 dbSNP
rs955222587 1018 dbSNP
rs975449739 1028 dbSNP
rs922452117 1033 dbSNP
rs1475686250 1034 dbSNP
rs963995327 1036 dbSNP
rs1334175430 1043 dbSNP
rs1417117808 1044 dbSNP
rs1428937024 1046 dbSNP
rs1454845522 1048 dbSNP
rs972652875 1049 dbSNP
rs1303547585 1052 dbSNP
rs1019466065 1054 dbSNP
rs1364908453 1062 dbSNP
rs1322253239 1067 dbSNP
rs1326556419 1069 dbSNP
rs1158927852 1076 dbSNP
rs1272501169 1076 dbSNP
rs1340469030 1079 dbSNP
rs1008027868 1080 dbSNP
rs1417723754 1083 dbSNP
rs1387541055 1084 dbSNP
rs1266717580 1089 dbSNP
rs200587724 1089 dbSNP
rs961297415 1099 dbSNP
rs552096322 1101 dbSNP
rs1246053855 1103 dbSNP
rs1448794791 1107 dbSNP
rs768340906 1108 dbSNP
rs1461072604 1111 dbSNP
rs1386886528 1112 dbSNP
rs74412224 1112 dbSNP
rs754265959 1113 dbSNP
rs1383477434 1116 dbSNP
rs1385045894 1116 dbSNP
rs969744547 1122 dbSNP
rs1363565346 1123 dbSNP
rs1206997680 1126 dbSNP
rs1022699130 1135 dbSNP
rs1486212867 1137 dbSNP
rs1261253519 1140 dbSNP
rs537585024 1141 dbSNP
rs1014443064 1151 dbSNP
rs1385485339 1154 dbSNP
rs866959118 1156 dbSNP
rs1351412772 1157 dbSNP
rs1316945544 1160 dbSNP
rs896626402 1161 dbSNP
rs1206904518 1162 dbSNP
rs182566530 1164 dbSNP
rs1464351296 1165 dbSNP
rs1184188316 1167 dbSNP
rs1244714952 1171 dbSNP
rs1381609624 1172 dbSNP
rs1421907005 1178 dbSNP
rs1310081942 1184 dbSNP
rs999696484 1185 dbSNP
rs896755258 1196 dbSNP
rs1056705053 1198 dbSNP
rs1387334201 1200 dbSNP
rs1457143942 1201 dbSNP
rs1338033563 1202 dbSNP
rs940871242 1207 dbSNP
rs1383414084 1209 dbSNP
rs1312462858 1210 dbSNP
rs528213407 1213 dbSNP
rs1336535801 1218 dbSNP
rs1241475838 1219 dbSNP
rs908036650 1220 dbSNP
rs902778742 1224 dbSNP
rs1043997417 1225 dbSNP
rs1204217398 1228 dbSNP
rs1264992815 1229 dbSNP
rs1482246228 1230 dbSNP
rs1046878827 1231 dbSNP
rs946712939 1233 dbSNP
rs1384984725 1239 dbSNP
rs189929900 1242 dbSNP
rs975124222 1249 dbSNP
rs1361338392 1253 dbSNP
rs1465010450 1255 dbSNP
rs1049818554 1263 dbSNP
rs185397136 1264 dbSNP
rs1397723374 1267 dbSNP
rs1240380415 1268 dbSNP
rs922432850 1270 dbSNP
rs1306480514 1271 dbSNP
rs972569949 1273 dbSNP
rs961239412 1274 dbSNP
rs912508793 1278 dbSNP
rs1287772264 1279 dbSNP
rs1285281124 1286 dbSNP
rs986660753 1292 dbSNP
rs1232473911 1299 dbSNP
rs956578031 1303 dbSNP
rs749054876 1306 dbSNP
rs573545563 1307 dbSNP
rs1481530109 1310 dbSNP
rs1030784069 1311 dbSNP
rs1250534357 1314 dbSNP
rs563095544 1315 dbSNP
rs9170 1320 dbSNP
rs1164670914 1327 dbSNP
rs1200908648 1327 dbSNP
rs1422471686 1334 dbSNP
rs984066584 1335 dbSNP
rs1444342504 1337 dbSNP
rs577825515 1338 dbSNP
rs1373991844 1344 dbSNP
rs968163914 1344 dbSNP
rs1432079144 1346 dbSNP
rs1167114971 1348 dbSNP
rs1370120415 1349 dbSNP
rs1405819471 1360 dbSNP
rs969693487 1361 dbSNP
rs1023070242 1362 dbSNP
rs1296279022 1364 dbSNP
rs1012264360 1365 dbSNP
rs1225813864 1367 dbSNP
rs1273687076 1369 dbSNP
rs1359647505 1375 dbSNP
rs1429323300 1379 dbSNP
rs34992054 1384 dbSNP
rs896478362 1389 dbSNP
rs1056760264 1390 dbSNP
rs370328898 1391 dbSNP
rs112154077 1395 dbSNP
rs766780498 1395 dbSNP
rs191683459 1397 dbSNP
rs763583180 1398 dbSNP
rs1035153570 1399 dbSNP
rs999647769 1400 dbSNP
rs1263323262 1402 dbSNP
rs538684695 1403 dbSNP
rs1289523901 1404 dbSNP
rs554991520 1405 dbSNP
rs930781096 1405 dbSNP
rs902724933 1413 dbSNP
rs1320758039 1416 dbSNP
rs1215800715 1421 dbSNP
rs1262011668 1431 dbSNP
rs1039846615 1432 dbSNP
rs1326655687 1433 dbSNP
rs942404985 1435 dbSNP
rs1022492128 1439 dbSNP
rs1247765779 1443 dbSNP
rs1011137404 1444 dbSNP
rs1445675343 1446 dbSNP
rs889770650 1450 dbSNP
rs1050204047 1460 dbSNP
rs1304242007 1462 dbSNP
rs1424427896 1466 dbSNP
rs1388953433 1471 dbSNP
rs1159861545 1487 dbSNP
rs573176855 1489 dbSNP
rs879175219 1492 dbSNP
rs934057074 1495 dbSNP
rs901250751 1504 dbSNP
rs1037151949 1514 dbSNP
rs1372696341 1517 dbSNP
rs939821250 1519 dbSNP
rs553546619 1520 dbSNP
rs984012862 1526 dbSNP
rs1270961318 1534 dbSNP
rs1289657554 1543 dbSNP
rs948655704 1544 dbSNP
rs1207370023 1545 dbSNP
rs1267987977 1545 dbSNP
rs979309289 1545 dbSNP
rs1212633206 1549 dbSNP
rs1236107165 1551 dbSNP
rs968258207 1552 dbSNP
rs915541823 1554 dbSNP
rs536653253 1556 dbSNP
rs1012729098 1558 dbSNP
rs375184491 1566 dbSNP
rs536741216 1568 dbSNP
rs1031832885 1571 dbSNP
rs1331900995 1577 dbSNP
rs1197303692 1580 dbSNP
rs1339723106 1581 dbSNP
rs1250366619 1583 dbSNP
rs977171164 1584 dbSNP
rs1004847005 1585 dbSNP
rs966832840 1586 dbSNP
rs1022438477 1592 dbSNP
rs1049748453 1593 dbSNP
rs1283398940 1601 dbSNP
rs567862237 1602 dbSNP
rs1346262355 1603 dbSNP
rs995043866 1605 dbSNP
rs1011086325 1607 dbSNP
rs1442272096 1612 dbSNP
rs900649230 1614 dbSNP
rs1254177994 1624 dbSNP
rs1039494710 1631 dbSNP
rs1324984830 1633 dbSNP
rs1181501306 1635 dbSNP
rs1269727351 1638 dbSNP
rs76017755 1648 dbSNP
rs1478958305 1649 dbSNP
rs942446385 1649 dbSNP
rs1410263393 1651 dbSNP
rs890842244 1651 dbSNP
rs1050722515 1652 dbSNP
rs1284500955 1653 dbSNP
rs1404951132 1657 dbSNP
rs1303204794 1664 dbSNP
rs749014951 1666 dbSNP
rs1439214690 1669 dbSNP
rs1329824744 1670 dbSNP
rs551158188 1671 dbSNP
rs1229512282 1673 dbSNP
rs771317865 1674 dbSNP
rs1331348616 1675 dbSNP
rs1340243940 1676 dbSNP
rs934975965 1676 dbSNP
rs1268113713 1683 dbSNP
rs890043176 1690 dbSNP
rs1245984363 1692 dbSNP
rs1392279373 1693 dbSNP
rs923874251 1698 dbSNP
rs1028286080 1700 dbSNP
rs773715814 1704 dbSNP
rs979747480 1705 dbSNP
rs1388139355 1711 dbSNP
rs1428669328 1716 dbSNP
rs998586117 1722 dbSNP
rs1168708572 1723 dbSNP
rs946596766 1724 dbSNP
rs537766376 1725 dbSNP
rs1037099577 1741 dbSNP
rs768097238 1745 dbSNP
rs1330990676 1750 dbSNP
rs1436496245 1752 dbSNP
rs1227943739 1756 dbSNP
rs1231905530 1756 dbSNP
rs550489432 1756 dbSNP
rs1266323476 1757 dbSNP
rs1358740625 1758 dbSNP
rs940104599 1762 dbSNP
rs1289268297 1764 dbSNP
rs888251020 1765 dbSNP
rs1048263875 1774 dbSNP
rs916399696 1779 dbSNP
rs948623081 1783 dbSNP
rs1188014737 1789 dbSNP
rs571822234 1796 dbSNP
rs569815375 1801 dbSNP
rs552030716 1806 dbSNP
rs528112946 1808 dbSNP
rs1458204110 1811 dbSNP
rs755561776 1817 dbSNP
rs1386898121 1819 dbSNP
rs750022299 1822 dbSNP
rs565991157 1826 dbSNP
rs1342432881 1829 dbSNP
rs1242941528 1831 dbSNP
rs1035078699 1833 dbSNP
rs938335694 1837 dbSNP
rs1230135778 1850 dbSNP
rs1266104381 1854 dbSNP
rs1464389400 1856 dbSNP
rs1200781073 1857 dbSNP
rs1258037923 1859 dbSNP
rs924305386 1860 dbSNP
rs950682127 1861 dbSNP
rs1027929372 1862 dbSNP
rs1473322417 1863 dbSNP
rs558918021 1865 dbSNP
rs746495930 1868 dbSNP
rs1462368675 1873 dbSNP
rs879889934 1879 dbSNP
rs1303765703 1881 dbSNP
rs1404847718 1882 dbSNP
rs977118566 1897 dbSNP
rs900702826 1898 dbSNP
rs1263264100 1899 dbSNP
rs1222349589 1904 dbSNP
rs1018198148 1906 dbSNP
rs1008981830 1907 dbSNP
rs1343519363 1907 dbSNP
rs1230233243 1908 dbSNP
rs968453683 1914 dbSNP
rs1328329842 1915 dbSNP
rs1233944796 1916 dbSNP
rs1050774672 1917 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuaggaccaagacaggGAGUGAUc 5'
                           ||||||| 
Target 5' -----------------CUCACUAc 3'
 		1 - 8
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 678.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_006887 | 3UTR | UGGACAGAAGUAGGUUUUUGAAUGUAACAAGAUAAGUCAACUUGAGUUGUAAUAUAUUUUGGGGAAUCAGCUCACUACAAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_006887 | 3UTR | AAUCAGCUCACUACAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_006887 | 3UTR | AGAUAAGUCAACUUGAGUUGUAAUAUAUUUUGGGGAAUCAGCUCACUACAAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_006887 | 3UTR | GGACUACUUUGGACAGAAGUAGGUUUUUGAAUGUAACAAGAUAAGUCAACUUGAGUUGUAAUAUAUUUUGGGGAAUCAGCUCACUACAAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000282388.3 | 3UTR | CUCACUACAAAUUGUGACUGUAAACAUUGUACUGUAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000282388.3 | 3UTR | UAAUAUAUUUUGGGGAAUCAGCUCACUACAAAUUGUGACUGUAAACAUUGUACUGUAAAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE17498 Multiple myeloma -0.421 3.4e-3 -0.447 1.9e-3 40 Click to see details
GSE28544 Breast cancer -0.465 1.1e-2 -0.458 1.2e-2 24 Click to see details
GSE38226 Liver fibrosis 0.493 1.2e-2 0.463 1.7e-2 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.422 2.2e-2 0.436 1.9e-2 23 Click to see details
GSE19350 CNS germ cell tumors 0.332 1.5e-1 0.448 7.2e-2 12 Click to see details
GSE19783 ER+ ER+ breast cancer 0.134 2.9e-1 0.030 4.5e-1 20 Click to see details
GSE19536 Breast cancer 0.055 2.9e-1 -0.029 3.9e-1 100 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.104 3.1e-1 -0.128 2.7e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.073 3.5e-1 -0.095 3.0e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells -0.072 3.7e-1 -0.071 3.7e-1 24 Click to see details
GSE28260 Renal cortex and medulla 0.1 3.7e-1 0.209 2.5e-1 13 Click to see details
GSE19783 ER- ER- breast cancer -0.022 4.2e-1 -0.088 2.2e-1 79 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.034 4.4e-1 0.358 6.1e-2 20 Click to see details
GSE21687 Ependynoma primary tumors -0.008 4.7e-1 0.085 2.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.008 4.7e-1 0.085 2.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.008 4.7e-1 0.085 2.5e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054764 ANGPTL1 angiopoietin like 1 3 1
MIRT066171 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT069409 ZFYVE21 zinc finger FYVE-type containing 21 2 8
MIRT102284 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 4
MIRT107595 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 6
MIRT178618 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT182407 TIPRL TOR signaling pathway regulator 2 4
MIRT186552 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT273662 HOXC8 homeobox C8 2 2
MIRT283191 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT284890 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT347670 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT400222 SLC35F6 solute carrier family 35 member F6 2 2
MIRT403517 ASPH aspartate beta-hydroxylase 2 2
MIRT442251 DCTN5 dynactin subunit 5 2 2
MIRT443023 SDR39U1 short chain dehydrogenase/reductase family 39U member 1 2 2
MIRT443097 RNF20 ring finger protein 20 2 2
MIRT444560 TRA2B transformer 2 beta homolog 2 2
MIRT445696 PRKG1 protein kinase, cGMP-dependent, type I 2 2
MIRT454084 TMEM209 transmembrane protein 209 2 2
MIRT455463 LYPLA2 lysophospholipase II 2 2
MIRT456653 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT458147 LYRM4 LYR motif containing 4 2 6
MIRT467073 SRRD SRR1 domain containing 2 4
MIRT467245 SPPL2A signal peptide peptidase like 2A 2 2
MIRT468246 SFXN4 sideroflexin 4 2 2
MIRT471589 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT476639 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT482433 ADM adrenomedullin 2 10
MIRT486848 PERP PERP, TP53 apoptosis effector 2 6
MIRT489656 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT493441 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT493841 FOXN3 forkhead box N3 2 4
MIRT501378 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT509679 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510280 MED28 mediator complex subunit 28 2 2
MIRT512221 ATXN3 ataxin 3 2 6
MIRT514030 BNIP2 BCL2 interacting protein 2 2 2
MIRT521375 RDX radixin 2 4
MIRT521444 RAD51 RAD51 recombinase 2 2
MIRT526055 CBR1 carbonyl reductase 1 2 2
MIRT528658 FUNDC2 FUN14 domain containing 2 2 2
MIRT529975 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT544098 IPMK inositol polyphosphate multikinase 2 2
MIRT545579 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT547424 MED4 mediator complex subunit 4 2 2
MIRT548955 CD2AP CD2 associated protein 2 2
MIRT549537 NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 2 4
MIRT552550 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554640 ROBO1 roundabout guidance receptor 1 2 2
MIRT564904 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT565578 SLC6A8 solute carrier family 6 member 8 2 2
MIRT568312 BAG4 BCL2 associated athanogene 4 2 2
MIRT617891 PTCHD3 patched domain containing 3 2 2
MIRT621892 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT642850 RNF135 ring finger protein 135 2 2
MIRT665395 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT697879 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT698492 THOC2 THO complex 2 2 2
MIRT701227 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT701872 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT707045 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT715216 NPVF neuropeptide VF precursor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-921 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miR-921 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-921 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-921 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-921 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-921 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-miR-921 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-921 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-921 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-921 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-921 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-921 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-921 Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-921 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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