pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SERP1   
Synonyms RAMP4
Description stress associated endoplasmic reticulum protein 1
Transcript NM_014445   
Expression
Putative miRNA Targets on SERP1
3'UTR of SERP1
(miRNA target sites are highlighted)
>SERP1|NM_014445|3'UTR
   1 AGTGACTGACCTTAAGATGTTTCCATTCTCCTGTGAATTTTAACTTGAACTCATTCCTGATGTTTGATACCCTGGTTGAA
  81 AACAATTCAGTAAAGCATCCTGCCTCAGAATGACTTTCCTATCATGCTTCATGTGTCATTCCAAGGTTTCTTCATGAGTC
 161 ATTCCAAGTTTTCTAGTCCATACCACAGTGCCTTGCAAAAAACACCACATGAATAAAGCAATAAAATTTGATTGTTAAGA
 241 TACAGTAGTGGACCCTACTTATTCAGTCAATTAAGAGTAAGTTTTTTTATGTGGTTATTAAAACAGTATGAACAATTAGT
 321 CTAACTCTGCATAGACAGGGTCTAGATTTTGTTAACCCAAATGTATAACTGCAGTTAGCTTAAATTACAATTTGAAGTCT
 401 TGTGGTTTTTATATAGCTAGGCACTTTATTACTCTTTTGAACTGAAAGCACACTCCCTTATAGGTTCATGTAACTGTCCT
 481 GTAATAAGGTGCTTATAAATGGAACAACTACACAGCCTAGTTTTGCCACAACCTTTAGCATCTAAAAAGTTTTAAAAGCT
 561 TCTAAATGTCTAATATAAAGGGAGATGCTTATAGCCACAACATCTATTTTACCAATATTGTTTCCATTACACTACCTTGG
 641 ATTTTGCATGAGTGAGTATAGTAACCCAAGATGCCATAAAAAAAAAACTTGATCGTTTTCTGACTTAATCAGTTACTGTG
 721 GTTTCACTAAAAGCTACCGTGGTGGAGTGAAGTCAGTCAGGGAAGGTTTGTTTATGTTACATTTATTTCACCAGAACTAT
 801 TTTAATATATCAAAGGGGTTTACTATGCCAAACAAAATTCTAGGGAAAAATACTGCTAAAAATGGATGCCTCATCAGAAC
 881 ATGCTGTTGAGTCCAATGTGCCATAAGACATTTTAGCATGTTAAATAGCACTTTTAATAGCAAAAAAAGGCACATCAACT
 961 GCGAAGTTATCCTTAGTTTGCAAATGCTTTTTCTAGATTAATGATTTTTCAATCATTAGGGTACTAGACACATCAGCCTA
1041 AAGTGGCATCTGGAATTGAATGGATTTACTGATAATGATCAGTCTTTAGTCTTCCCTTTGTTATATGACTTTATAGGTTA
1121 TGATTGATCAAATTTACGTTTTACTAATGGTAAGGGTGAGGGTCATAGGGCAGGTTTTGGGTTTTCTAGTACTGTTGAAA
1201 ACTGCAAGTATTGGCTATTTGTATACTTAGCCATAACTTGGTGAAAAAAAACCTGAGCAGTGTCTATGTATTAATGCGTT
1281 GGAAAGAAAGCTGCTTGTGTTTGCTTTGTTAATTGCCTCAGGATATTTCTTTTAAAATAAGCTGTTTTAAGAGGAACAGA
1361 AGGGAAATCTGCTACCTAGTCTATACACAGCGTGAACCTCACAGGGGGCTTCTGATACCCTCAAACATGGAGAACAGTAA
1441 GGGAGCAGAGTGGTTAAGGACTTTCAGGAACTTAACTATTCTGGAATAAGGAATGAATCAACTGACCTTGGGCCAGCAGG
1521 TTTTTAACTAAATTGTTACTTGCCTTTCTCACCCAGTTAATCAGTCTCTGTACTTGTTTCCCTTTTTGAAACAAGTGTCT
1601 TGGTTAACTAATTCTGTTTTATGGTTGTGCTAAATTCATAGCAGGTGCCTTATTCTTTGCTTTTAGTCAAACCATTCCAT
1681 ATCAGAATTTTCCTTGGTTTACTATAGATATTTGGCTTTAAGTTGTTGTTTGTGTTTTTTAATGTACAATGTTCTGATAA
1761 ATTTGACTGTTAAATTGCTATAGCTAGCAATCATTTTACATATGTAAAATTGCATTCCCTTTGTATTTCATGTGTAATTC
1841 ACCAATTAAGTGCAGTTTATATTCAGGTTGGATTATGCATGTTTAGGTAAACGAAAGCTGTGTCTTACTTGATTTATTCT
1921 TTAAAAATAAAGTTCCCTGAATATTTGATGCTTTTCTTCTAAACGGAAATGATTTTACAGTTATCTGAGTGTACCTTTTA
2001 TAGTTAGTAGAAAATGATTTTAAAGAATGTTTAGTATTGTACTTAAATGGTATGCAGAGGCACAGATGTAAGGTTTATAA
2081 CTGGAAATAGGTGGTAAGAAAAATATATAGAAAGCACAATGATTTGAATATTTTTCCACTTAGGATTTCCTAATCTCCTT
2161 GTCATCCAATTCAAGCTCAAGATGAAGCACAATTCTTTGATCTCCCTTTGCCAGTTGAATTTTATAGATCATCTAATGTT
2241 GAGCACAGTATGAGAATAAATATTGGGGTTGTCAACATTACTCAGTTACTCTTTGTGGTTTAACTCTAACATTTCAACAA
2321 GTTGTCAATTAATTGTATCTGTTGGGTTGTATATAATGTTGCTCAAAATAATTAAGTGGACTTCCAAAAATAAGATTTCC
2401 ATTGTAACAGGATGCATTGTGATGGGCTTTGACTTACATTAAAGAAATGTGGATAGTCAACTGCAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agAUUG---UGGU--GUCACACCAAAc 5'
            |:||   |:||  :| |||||||| 
Target 5' tcTGACTTAATCAGTTACTGTGGTTTc 3'
699 - 725 158.00 -14.60
2
miRNA  3' agaUUGUGGU--GUC--------ACACCAAAc 5'
             ||||::|  |||        |||||||| 
Target 5' gtcAACATTACTCAGTTACTCTTTGTGGTTTa 3'
2271 - 2302 155.00 -13.20
3
miRNA  3' agAUUGU--GGUGUC---ACACCAAAc 5'
            | |||  ::: ||   |||||||| 
Target 5' aaTTACAATTTGAAGTCTTGTGGTTTt 3'
383 - 409 150.00 -8.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14040138 8 COSMIC
COSN30458702 72 COSMIC
COSN31480982 78 COSMIC
COSN510610 108 COSMIC
COSN30509011 110 COSMIC
COSN31611970 227 COSMIC
COSN31514063 283 COSMIC
COSN6736107 510 COSMIC
COSN20099221 678 COSMIC
COSN31536227 873 COSMIC
COSN31556467 941 COSMIC
COSN31590809 962 COSMIC
COSN26644531 987 COSMIC
COSN26556756 1047 COSMIC
COSN30174324 1058 COSMIC
COSN5146017 1208 COSMIC
COSN31607986 1316 COSMIC
COSN31519832 1330 COSMIC
COSN5858259 1582 COSMIC
COSN31607981 1690 COSMIC
COSN20099219 1805 COSMIC
COSN21009384 1871 COSMIC
COSN21221906 2206 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1489338941 2 dbSNP
rs1377743225 5 dbSNP
rs751569122 10 dbSNP
rs1465827079 14 dbSNP
rs1374042153 15 dbSNP
rs1400702639 16 dbSNP
rs1210155885 19 dbSNP
rs779403834 24 dbSNP
rs1430003613 30 dbSNP
rs893403326 32 dbSNP
rs370298193 33 dbSNP
rs749978281 36 dbSNP
rs764945316 48 dbSNP
rs1356810168 50 dbSNP
rs1211368257 59 dbSNP
rs761562880 60 dbSNP
rs369865086 68 dbSNP
rs1344011877 70 dbSNP
rs768053304 71 dbSNP
rs759958005 72 dbSNP
rs1305921070 74 dbSNP
rs1193828800 82 dbSNP
rs760411512 84 dbSNP
rs774962533 87 dbSNP
rs770893592 88 dbSNP
rs1050477541 90 dbSNP
rs769641131 100 dbSNP
rs1307360369 102 dbSNP
rs2140095 108 dbSNP
rs747914134 110 dbSNP
rs907403388 121 dbSNP
rs1037736218 123 dbSNP
rs948481846 130 dbSNP
rs940669318 133 dbSNP
rs1300159259 134 dbSNP
rs907827580 136 dbSNP
rs982430925 137 dbSNP
rs1353618522 140 dbSNP
rs949210318 141 dbSNP
rs1311958978 143 dbSNP
rs916380086 154 dbSNP
rs1485738670 155 dbSNP
rs990585411 161 dbSNP
rs957743926 167 dbSNP
rs1032491208 173 dbSNP
rs563202243 187 dbSNP
rs972432262 195 dbSNP
rs1484417546 198 dbSNP
rs1050091 204 dbSNP
rs965983728 216 dbSNP
rs1257490913 225 dbSNP
rs1227466017 230 dbSNP
rs977808669 233 dbSNP
rs1180188915 240 dbSNP
rs1380041810 242 dbSNP
rs966775137 244 dbSNP
rs985944554 248 dbSNP
rs1415300675 255 dbSNP
rs954148254 261 dbSNP
rs1297657920 265 dbSNP
rs1303440629 267 dbSNP
rs1402899831 269 dbSNP
rs188904641 270 dbSNP
rs1306864803 275 dbSNP
rs1375853426 279 dbSNP
rs1240543240 280 dbSNP
rs146968610 289 dbSNP
rs576877785 289 dbSNP
rs772793794 293 dbSNP
rs528649174 294 dbSNP
rs1208836516 296 dbSNP
rs1256067209 306 dbSNP
rs1009068542 308 dbSNP
rs1347128535 310 dbSNP
rs1319424321 315 dbSNP
rs1484548234 316 dbSNP
rs1197276986 317 dbSNP
rs3836399 325 dbSNP
rs375888313 329 dbSNP
rs957391780 334 dbSNP
rs554283404 339 dbSNP
rs1393510923 341 dbSNP
rs16862718 345 dbSNP
rs1176968572 354 dbSNP
rs1379417824 355 dbSNP
rs996287828 357 dbSNP
rs1046321724 365 dbSNP
rs1399407260 367 dbSNP
rs1333051656 402 dbSNP
rs1365128062 414 dbSNP
rs1301419426 417 dbSNP
rs768559051 420 dbSNP
rs1397695192 424 dbSNP
rs1475817923 427 dbSNP
rs746071468 428 dbSNP
rs1038191363 431 dbSNP
rs1013059984 432 dbSNP
rs1458557400 447 dbSNP
rs1184197052 448 dbSNP
rs1245343844 453 dbSNP
rs868792217 456 dbSNP
rs35579941 458 dbSNP
rs1191973985 461 dbSNP
rs1427474104 467 dbSNP
rs894241276 469 dbSNP
rs1242301232 478 dbSNP
rs1048868220 490 dbSNP
rs1422848229 495 dbSNP
rs940737765 496 dbSNP
rs144400108 506 dbSNP
rs1467008642 513 dbSNP
rs918961796 516 dbSNP
rs141778282 524 dbSNP
rs1293783815 525 dbSNP
rs944625832 526 dbSNP
rs184011601 532 dbSNP
rs538241678 536 dbSNP
rs949259143 540 dbSNP
rs1319289948 549 dbSNP
rs953242087 551 dbSNP
rs1220971806 552 dbSNP
rs916428806 555 dbSNP
rs1321521418 558 dbSNP
rs1222728565 569 dbSNP
rs1248680396 574 dbSNP
rs191769099 576 dbSNP
rs757375586 598 dbSNP
rs753997439 600 dbSNP
rs957444056 606 dbSNP
rs925095904 610 dbSNP
rs1188225948 625 dbSNP
rs778289742 631 dbSNP
rs756584465 632 dbSNP
rs972073245 634 dbSNP
rs1165145341 654 dbSNP
rs1435982302 659 dbSNP
rs1392823806 663 dbSNP
rs774392747 670 dbSNP
rs1417475821 675 dbSNP
rs1297089714 676 dbSNP
rs1024530323 678 dbSNP
rs1401249718 681 dbSNP
rs1282976249 687 dbSNP
rs1292458038 688 dbSNP
rs1379003007 688 dbSNP
rs3836398 688 dbSNP
rs397703556 688 dbSNP
rs1351867766 689 dbSNP
rs1019658182 694 dbSNP
rs550064603 695 dbSNP
rs1284299250 699 dbSNP
rs1185421519 700 dbSNP
rs5853481 700 dbSNP
rs111852001 710 dbSNP
rs1472418210 716 dbSNP
rs1182300284 719 dbSNP
rs1167746820 720 dbSNP
rs1157700052 727 dbSNP
rs994599930 731 dbSNP
rs186776072 734 dbSNP
rs1419585723 736 dbSNP
rs1331563387 738 dbSNP
rs767761709 738 dbSNP
rs377058873 739 dbSNP
rs1286372602 745 dbSNP
rs1375171602 747 dbSNP
rs963873756 749 dbSNP
rs1239819743 753 dbSNP
rs1036457374 756 dbSNP
rs1198859435 763 dbSNP
rs911535167 765 dbSNP
rs1214032040 780 dbSNP
rs1016358983 781 dbSNP
rs1005338575 785 dbSNP
rs1457268338 792 dbSNP
rs1380547056 807 dbSNP
rs1470953684 817 dbSNP
rs372759916 818 dbSNP
rs915109406 825 dbSNP
rs148067491 827 dbSNP
rs527427425 828 dbSNP
rs1339302248 842 dbSNP
rs886462007 845 dbSNP
rs181231704 846 dbSNP
rs1332443992 863 dbSNP
rs977837074 864 dbSNP
rs1233915418 866 dbSNP
rs1013577042 868 dbSNP
rs1231296710 872 dbSNP
rs1368975779 881 dbSNP
rs547831143 885 dbSNP
rs558411197 894 dbSNP
rs1055044923 896 dbSNP
rs531348995 897 dbSNP
rs1264934436 905 dbSNP
rs6791721 914 dbSNP
rs1197847129 917 dbSNP
rs1463952114 918 dbSNP
rs1354683115 923 dbSNP
rs546502074 927 dbSNP
rs991776986 928 dbSNP
rs958912481 929 dbSNP
rs1245725847 940 dbSNP
rs1478070278 942 dbSNP
rs1177890552 948 dbSNP
rs1027830414 949 dbSNP
rs1174734486 949 dbSNP
rs1171879230 950 dbSNP
rs994982391 960 dbSNP
rs577495849 962 dbSNP
rs149255936 963 dbSNP
rs1042141303 965 dbSNP
rs1276375645 970 dbSNP
rs1316066525 971 dbSNP
rs748393114 977 dbSNP
rs757411812 980 dbSNP
rs1217906738 986 dbSNP
rs1258524673 994 dbSNP
rs1438904836 998 dbSNP
rs1341245395 999 dbSNP
rs540726229 1006 dbSNP
rs189971277 1010 dbSNP
rs555054338 1012 dbSNP
rs912301247 1020 dbSNP
rs1201041236 1037 dbSNP
rs986454270 1038 dbSNP
rs1260367095 1042 dbSNP
rs74879358 1044 dbSNP
rs1195061142 1047 dbSNP
rs1050042057 1064 dbSNP
rs1456719790 1065 dbSNP
rs34209817 1066 dbSNP
rs1162977436 1067 dbSNP
rs931907096 1071 dbSNP
rs1426787849 1075 dbSNP
rs922224173 1076 dbSNP
rs974933839 1078 dbSNP
rs1296211014 1080 dbSNP
rs935135244 1083 dbSNP
rs1242410232 1085 dbSNP
rs185164308 1088 dbSNP
rs1283376009 1094 dbSNP
rs923754839 1097 dbSNP
rs1224223178 1099 dbSNP
rs755341599 1099 dbSNP
rs747402342 1102 dbSNP
rs1487694995 1104 dbSNP
rs1282679580 1105 dbSNP
rs963583805 1106 dbSNP
rs772721682 1112 dbSNP
rs556291055 1113 dbSNP
rs1016822459 1116 dbSNP
rs769701596 1122 dbSNP
rs950891781 1131 dbSNP
rs556163939 1137 dbSNP
rs138561075 1138 dbSNP
rs1360058604 1139 dbSNP
rs1420394334 1140 dbSNP
rs962261363 1147 dbSNP
rs1387129146 1148 dbSNP
rs1015504264 1154 dbSNP
rs752508033 1155 dbSNP
rs1383284015 1156 dbSNP
rs144677619 1159 dbSNP
rs1306636058 1163 dbSNP
rs1352456052 1164 dbSNP
rs1028619316 1165 dbSNP
rs1452596135 1173 dbSNP
rs1361902186 1177 dbSNP
rs1160945898 1180 dbSNP
rs1001150410 1188 dbSNP
rs1200367296 1192 dbSNP
rs180948296 1194 dbSNP
rs1462936747 1198 dbSNP
rs1177095912 1202 dbSNP
rs1255336021 1203 dbSNP
rs1042643462 1209 dbSNP
rs1053657937 1210 dbSNP
rs945211519 1211 dbSNP
rs1161425252 1226 dbSNP
rs1375976415 1233 dbSNP
rs935225597 1240 dbSNP
rs1406644915 1244 dbSNP
rs902381028 1244 dbSNP
rs1187342704 1246 dbSNP
rs1375777794 1252 dbSNP
rs1484761591 1252 dbSNP
rs779232455 1255 dbSNP
rs1308583922 1256 dbSNP
rs1309960232 1259 dbSNP
rs1050794285 1266 dbSNP
rs1231843231 1267 dbSNP
rs932329236 1270 dbSNP
rs920892278 1272 dbSNP
rs118038447 1277 dbSNP
rs1197212833 1278 dbSNP
rs780600970 1291 dbSNP
rs1046649304 1304 dbSNP
rs1481110089 1308 dbSNP
rs963937159 1311 dbSNP
rs950168412 1316 dbSNP
rs1265483526 1318 dbSNP
rs1432676023 1338 dbSNP
rs917318173 1341 dbSNP
rs1429978409 1345 dbSNP
rs909452749 1352 dbSNP
rs991502648 1353 dbSNP
rs1399251885 1354 dbSNP
rs567778615 1360 dbSNP
rs1259354266 1373 dbSNP
rs1299561662 1374 dbSNP
rs1364977486 1378 dbSNP
rs1283357568 1381 dbSNP
rs937356720 1383 dbSNP
rs1241542980 1388 dbSNP
rs10272 1392 dbSNP
rs879146070 1403 dbSNP
rs1206979819 1405 dbSNP
rs189397829 1408 dbSNP
rs749314488 1409 dbSNP
rs1488272343 1412 dbSNP
rs962601382 1427 dbSNP
rs908043243 1428 dbSNP
rs765726020 1430 dbSNP
rs753336565 1444 dbSNP
rs1191451609 1446 dbSNP
rs988005404 1466 dbSNP
rs1410330623 1473 dbSNP
rs1231962257 1480 dbSNP
rs1025096203 1483 dbSNP
rs992209676 1489 dbSNP
rs1347824803 1490 dbSNP
rs1457065973 1493 dbSNP
rs1303280579 1495 dbSNP
rs1381314075 1499 dbSNP
rs1382238963 1501 dbSNP
rs1290442892 1505 dbSNP
rs1454075603 1507 dbSNP
rs1416870809 1510 dbSNP
rs959362513 1512 dbSNP
rs1216749662 1518 dbSNP
rs1033655560 1529 dbSNP
rs1028670343 1537 dbSNP
rs1321394159 1542 dbSNP
rs1223475714 1548 dbSNP
rs1476144367 1552 dbSNP
rs185722519 1555 dbSNP
rs1294164815 1569 dbSNP
rs1000861731 1575 dbSNP
rs777711715 1581 dbSNP
rs1420186740 1582 dbSNP
rs1188681183 1588 dbSNP
rs1215906066 1588 dbSNP
rs1446645683 1596 dbSNP
rs1259869592 1598 dbSNP
rs1207286880 1603 dbSNP
rs1486419214 1609 dbSNP
rs903793913 1612 dbSNP
rs535058739 1614 dbSNP
rs957722083 1624 dbSNP
rs1417333920 1636 dbSNP
rs140650864 1638 dbSNP
rs560770092 1641 dbSNP
rs753124920 1647 dbSNP
rs1346378729 1648 dbSNP
rs1433469521 1666 dbSNP
rs890927274 1677 dbSNP
rs1050807226 1678 dbSNP
rs932381386 1687 dbSNP
rs899523846 1704 dbSNP
rs1247125950 1705 dbSNP
rs1293377472 1708 dbSNP
rs1031964596 1711 dbSNP
rs1351714101 1716 dbSNP
rs866563131 1725 dbSNP
rs1239595746 1727 dbSNP
rs1285002806 1730 dbSNP
rs1217886809 1731 dbSNP
rs1447559304 1731 dbSNP
rs999481522 1732 dbSNP
rs1460707289 1734 dbSNP
rs1226008021 1742 dbSNP
rs1183908555 1746 dbSNP
rs1038471780 1747 dbSNP
rs1437429649 1748 dbSNP
rs941017682 1751 dbSNP
rs909491397 1756 dbSNP
rs1401891832 1757 dbSNP
rs540787825 1761 dbSNP
rs1174616365 1773 dbSNP
rs1013810875 1775 dbSNP
rs1453858843 1776 dbSNP
rs568055447 1777 dbSNP
rs549795123 1792 dbSNP
rs1375001821 1793 dbSNP
rs766669338 1794 dbSNP
rs929467987 1800 dbSNP
rs1462963881 1803 dbSNP
rs1280306136 1809 dbSNP
rs10650924 1810 dbSNP
rs3086794 1810 dbSNP
rs918050467 1814 dbSNP
rs1276432306 1819 dbSNP
rs1163942231 1823 dbSNP
rs1322713003 1829 dbSNP
rs920629303 1830 dbSNP
rs992261655 1840 dbSNP
rs1244714739 1844 dbSNP
rs570293063 1845 dbSNP
rs1033746992 1847 dbSNP
rs1233061623 1848 dbSNP
rs1038073228 1850 dbSNP
rs1170238351 1852 dbSNP
rs773035972 1854 dbSNP
rs1429279566 1862 dbSNP
rs1470569569 1864 dbSNP
rs530333613 1877 dbSNP
rs751942266 1880 dbSNP
rs1409706744 1886 dbSNP
rs1021299871 1889 dbSNP
rs560208259 1892 dbSNP
rs890978879 1893 dbSNP
rs1434476450 1900 dbSNP
rs1274331714 1907 dbSNP
rs1344851017 1914 dbSNP
rs1224021210 1929 dbSNP
rs1029423667 1937 dbSNP
rs1315872091 1950 dbSNP
rs762594809 1964 dbSNP
rs996624169 1965 dbSNP
rs974501116 1971 dbSNP
rs544721655 1978 dbSNP
rs1196219758 1984 dbSNP
rs1267524500 1985 dbSNP
rs1480448771 1987 dbSNP
rs1202262173 1988 dbSNP
rs1422025216 1999 dbSNP
rs1475298503 2004 dbSNP
rs575535045 2023 dbSNP
rs1168838836 2034 dbSNP
rs1274298288 2042 dbSNP
rs1403785175 2049 dbSNP
rs372531156 2050 dbSNP
rs1366300036 2052 dbSNP
rs750152831 2057 dbSNP
rs1406805981 2063 dbSNP
rs1285123361 2068 dbSNP
rs1324559044 2069 dbSNP
rs899613965 2086 dbSNP
rs1336929490 2089 dbSNP
rs1270552269 2091 dbSNP
rs551988529 2094 dbSNP
rs796082221 2096 dbSNP
rs1207719584 2099 dbSNP
rs941055097 2109 dbSNP
rs1490370957 2115 dbSNP
rs1050087 2116 dbSNP
rs1227780743 2124 dbSNP
rs886741776 2125 dbSNP
rs1048449972 2138 dbSNP
rs929520267 2144 dbSNP
rs1300994353 2160 dbSNP
rs527500722 2165 dbSNP
rs1194393736 2181 dbSNP
rs1375117662 2187 dbSNP
rs545690787 2199 dbSNP
rs761432914 2204 dbSNP
rs1471986942 2208 dbSNP
rs1163213065 2211 dbSNP
rs1442783629 2212 dbSNP
rs918102291 2217 dbSNP
rs35119235 2222 dbSNP
rs966666700 2223 dbSNP
rs146853225 2227 dbSNP
rs150254686 2230 dbSNP
rs559560943 2231 dbSNP
rs1243410644 2242 dbSNP
rs1313940100 2255 dbSNP
rs1359690606 2256 dbSNP
rs926735019 2263 dbSNP
rs1247619745 2273 dbSNP
rs1283224418 2276 dbSNP
rs540289084 2277 dbSNP
rs895019788 2285 dbSNP
rs979506981 2291 dbSNP
rs1169664088 2295 dbSNP
rs1054958003 2297 dbSNP
rs1183312758 2302 dbSNP
rs8052 2303 dbSNP
rs1446671580 2304 dbSNP
rs1156978049 2311 dbSNP
rs913882698 2315 dbSNP
rs1037724695 2317 dbSNP
rs940658462 2328 dbSNP
rs1159076118 2335 dbSNP
rs1386973434 2335 dbSNP
rs907856816 2342 dbSNP
rs1192174398 2344 dbSNP
rs1455890352 2347 dbSNP
rs1383123413 2356 dbSNP
rs988478283 2356 dbSNP
rs1407224382 2376 dbSNP
rs760489226 2378 dbSNP
rs1181807684 2387 dbSNP
rs554385893 2389 dbSNP
rs1239059053 2391 dbSNP
rs775430274 2403 dbSNP
rs933569271 2409 dbSNP
rs922136129 2418 dbSNP
rs1462866191 2420 dbSNP
rs537908965 2425 dbSNP
rs1029515081 2426 dbSNP
rs1184060981 2434 dbSNP
rs936445491 2442 dbSNP
rs996673248 2445 dbSNP
rs924996668 2447 dbSNP
rs1195806416 2448 dbSNP
rs977857820 2460 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 27230.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauuguggugucacACCAAAc 5'
                         |||||| 
Target 5' uaucagaauuuuccuUGGUUUa 3'
14 - 35
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000239944.2 | 3UTR | UCAAACCAUUCCAUAUCAGAAUUUUCCUUGGUUUACUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors -0.321 4.9e-3 -0.340 3.0e-3 64 Click to see details
GSE26953 Aortic valvular endothelial cells 0.395 2.8e-2 0.317 6.6e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.353 4.9e-2 0.193 1.9e-1 23 Click to see details
GSE38226 Liver fibrosis 0.317 8.1e-2 0.306 8.9e-2 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.25 1.1e-1 -0.224 1.4e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.189 1.5e-1 -0.224 1.1e-1 32 Click to see details
GSE28544 Breast cancer 0.206 1.7e-1 0.230 1.4e-1 24 Click to see details
GSE17498 Multiple myeloma 0.147 1.8e-1 0.174 1.4e-1 40 Click to see details
GSE28260 Renal cortex and medulla -0.193 2.6e-1 -0.018 4.8e-1 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.117 3.1e-1 -0.337 7.3e-2 20 Click to see details
GSE19350 CNS germ cell tumors 0.114 3.6e-1 0.203 2.6e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.114 3.6e-1 0.203 2.6e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.114 3.6e-1 0.203 2.6e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.305 0.02 0.397 0 42 Click to see details
CHOL -0.492 0.16 -0.371 0.23 6 Click to see details
PAAD 0.665 0.17 0.400 0.3 4 Click to see details
UCEC -0.256 0.17 -0.312 0.12 16 Click to see details
PRAD 0.128 0.2 0.152 0.16 46 Click to see details
STAD 0.149 0.26 0.149 0.26 21 Click to see details
THCA 0.095 0.27 0.127 0.2 45 Click to see details
BLCA 0.332 0.33 0.800 0.1 4 Click to see details
LUAD -0.331 0.33 -0.400 0.3 4 Click to see details
KIRP -0.064 0.39 -0.105 0.33 21 Click to see details
KICH -0.072 0.4 -0.032 0.45 15 Click to see details
LUSC 0.046 0.4 0.115 0.27 30 Click to see details
LIHC 0.037 0.42 -0.200 0.14 30 Click to see details
HNSC -0.044 0.43 -0.195 0.22 18 Click to see details
KIRC 0.02 0.45 0.052 0.37 43 Click to see details
ESCA 0.02 0.48 -0.200 0.29 10 Click to see details
ESCA 0.02 0.48 -0.200 0.29 10 Click to see details
ESCA 0.02 0.48 -0.200 0.29 10 Click to see details
ESCA 0.02 0.48 -0.200 0.29 10 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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