pre-miRNA Information
pre-miRNA hsa-mir-6818   
Genomic Coordinates chr22: 30007049 - 30007113
Description Homo sapiens miR-6818 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6818-5p
Sequence 6| UUGUGUGAGUACAGAGAGCAUC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs763248242 2 dbSNP
rs186621048 3 dbSNP
rs1455267770 12 dbSNP
rs1170462641 19 dbSNP
rs1435853423 22 dbSNP
Putative Targets

Gene Information
Gene Symbol RHOC   
Synonyms ARH9, ARHC, H9, RHOH9
Description ras homolog family member C
Transcript NM_001042678   
Other Transcripts NM_001042679 , NM_175744   
Expression
Putative miRNA Targets on RHOC
3'UTR of RHOC
(miRNA target sites are highlighted)
>RHOC|NM_001042678|3'UTR
   1 GATCCCCAAGGCCTTTCCTACATGCCCCCTCCCTTCACAGGGGTACAGAAATTATCCCCCTACAACCCCAGCCTCCTGAG
  81 GGCTCCATGCTGAAGGCTCCCATTTTCAGTTCCCTCCTGCCCAGGACTGCATTGTTTTCTAGCCCCGAGGTGGTGGCACG
 161 GGCCCTCCCTCCCAGCGCTCTGGGAGCCACGCCTATGCCCTGCCCTTCCTCAGGGCCCCTGGGGATCTTGCCCCCTTTGA
 241 CCTTCCCCAAAGGATGGTCACACACCAGCACTTTATACACTTCTGGCTCACAGGAAAGTGTCTGCAGTAGGGGACCCAGA
 321 GTCCCAGGCCCCTGGAGTTGTTTTCGGCAGGGGCCTTGTCTCTCACTGCATTTGGTCAGGGGGGCATGAATAAAGGCTAC
 401 AGGCTCCAACGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuacgagagacAUGAGUGUGUu 5'
                     |: ||||||| 
Target 5' tccccaaaggaTGGTCACACAc 3'
244 - 265 143.00 -9.30
2
miRNA  3' cuacGAGAGACAUGAGUGUguu 5'
              || |||| :||||||   
Target 5' tacaCT-TCTG-GCTCACAgga 3'
276 - 295 120.00 -14.70
3
miRNA  3' cuACGAGAGACAUGAGUGUguu 5'
            ||| | ||   :|||||   
Target 5' caTGCCCCCTCCCTTCACAggg 3'
21 - 42 116.00 -10.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN4892301 18 COSMIC
COSN30125773 58 COSMIC
COSN30140590 77 COSMIC
COSN31492559 83 COSMIC
COSN31491166 92 COSMIC
COSN31522746 96 COSMIC
COSN31546169 146 COSMIC
COSN30540189 260 COSMIC
COSN29468816 261 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs113093065 2 dbSNP
rs1427956507 3 dbSNP
rs1480599776 4 dbSNP
rs116729270 7 dbSNP
rs1443953840 8 dbSNP
rs763859296 9 dbSNP
rs757975795 11 dbSNP
rs868412438 14 dbSNP
rs752324572 18 dbSNP
rs1382244887 20 dbSNP
rs764951682 21 dbSNP
rs1174148638 22 dbSNP
rs558533932 23 dbSNP
rs75601992 25 dbSNP
rs776576925 26 dbSNP
rs1176645269 27 dbSNP
rs766271845 28 dbSNP
rs1016623954 31 dbSNP
rs1195474590 36 dbSNP
rs1233986452 45 dbSNP
rs760792564 46 dbSNP
rs956328993 48 dbSNP
rs773150755 54 dbSNP
rs748324494 56 dbSNP
rs530153735 57 dbSNP
rs768925209 60 dbSNP
rs1201443823 61 dbSNP
rs1059340 63 dbSNP
rs749634907 72 dbSNP
rs1195856901 77 dbSNP
rs780751103 79 dbSNP
rs758874251 83 dbSNP
rs1267632653 89 dbSNP
rs756669632 90 dbSNP
rs1340782251 91 dbSNP
rs746578969 94 dbSNP
rs777150290 95 dbSNP
rs1028500786 96 dbSNP
rs1335770147 97 dbSNP
rs1233051967 99 dbSNP
rs757863771 100 dbSNP
rs1359588192 109 dbSNP
rs752311555 112 dbSNP
rs1361734281 115 dbSNP
rs1421389827 117 dbSNP
rs764899240 118 dbSNP
rs1158399666 121 dbSNP
rs750535130 123 dbSNP
rs1471843006 124 dbSNP
rs997897983 126 dbSNP
rs754807808 128 dbSNP
rs753607543 129 dbSNP
rs1301851009 130 dbSNP
rs869165355 139 dbSNP
rs902053407 143 dbSNP
rs1040549559 146 dbSNP
rs1272585515 147 dbSNP
rs999800238 151 dbSNP
rs902781532 152 dbSNP
rs1043952998 159 dbSNP
rs1318900093 160 dbSNP
rs1305316666 162 dbSNP
rs373863359 162 dbSNP
rs1355572577 165 dbSNP
rs946715433 167 dbSNP
rs916545592 169 dbSNP
rs878927338 170 dbSNP
rs1290948524 174 dbSNP
rs1211131898 175 dbSNP
rs761361568 175 dbSNP
rs1190519939 176 dbSNP
rs939430029 177 dbSNP
rs1436903082 179 dbSNP
rs1059411 180 dbSNP
rs1022939745 182 dbSNP
rs1239230764 184 dbSNP
rs927830778 190 dbSNP
rs1162014947 191 dbSNP
rs561023978 192 dbSNP
rs1391686545 195 dbSNP
rs1385184798 203 dbSNP
rs972521258 205 dbSNP
rs1162071245 208 dbSNP
rs887825672 212 dbSNP
rs1365109249 214 dbSNP
rs543440941 216 dbSNP
rs1450217352 224 dbSNP
rs931128837 230 dbSNP
rs1322305339 232 dbSNP
rs897105769 234 dbSNP
rs1249182216 235 dbSNP
rs909803848 239 dbSNP
rs1338165401 240 dbSNP
rs1198654783 244 dbSNP
rs984022922 245 dbSNP
rs1395660874 249 dbSNP
rs1459664480 265 dbSNP
rs1037339394 269 dbSNP
rs1059479 270 dbSNP
rs1059482 283 dbSNP
rs1255872779 286 dbSNP
rs953847837 288 dbSNP
rs1195460570 292 dbSNP
rs1467047243 293 dbSNP
rs1266780443 295 dbSNP
rs1190210436 298 dbSNP
rs1371790570 304 dbSNP
rs943946061 309 dbSNP
rs1205723224 313 dbSNP
rs1171419734 315 dbSNP
rs1402756285 317 dbSNP
rs912228249 318 dbSNP
rs1059512 319 dbSNP
rs1027992485 322 dbSNP
rs530803333 329 dbSNP
rs565485066 332 dbSNP
rs1379615499 339 dbSNP
rs985108987 345 dbSNP
rs932395328 346 dbSNP
rs1349008698 348 dbSNP
rs997971478 349 dbSNP
rs1218733531 353 dbSNP
rs1279517877 358 dbSNP
rs1321024904 365 dbSNP
rs776061300 365 dbSNP
rs914319620 367 dbSNP
rs1483793206 377 dbSNP
rs1202478429 379 dbSNP
rs965104245 379 dbSNP
rs1232765962 380 dbSNP
rs1425828567 381 dbSNP
rs1031399479 384 dbSNP
rs1175610906 385 dbSNP
rs1359902153 388 dbSNP
rs768415443 389 dbSNP
rs1467420319 402 dbSNP
rs1000114216 403 dbSNP
rs1031905859 404 dbSNP
rs1382288617 405 dbSNP
rs1400502680 410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 389.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuacgagagacaugAGUGUGUu 5'
                        ||||||| 
Target 5' --------------UCACACAc 3'
1 - 8
2
miRNA  3' cuacGAGAGACAUGAGUGUguu 5'
              || |||| :||||||   
Target 5' uacaCU-UCUG-GCUCACAg-- 3'
19 - 36
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000339083.7 | 3UTR | UCACACACCAGCACUUUAUACACUUCUGGCUCACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
140 hsa-miR-6818-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071796 RNF11 ring finger protein 11 2 2
MIRT077120 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 4
MIRT079951 RNF138 ring finger protein 138 2 2
MIRT102968 EN2 engrailed homeobox 2 2 4
MIRT115694 MGRN1 mahogunin ring finger 1 2 2
MIRT121074 FGFRL1 fibroblast growth factor receptor like 1 2 2
MIRT143171 GLYR1 glyoxylate reductase 1 homolog 2 2
MIRT145635 LASP1 LIM and SH3 protein 1 2 2
MIRT282026 ARID3B AT-rich interaction domain 3B 2 6
MIRT301684 EP300 E1A binding protein p300 2 2
MIRT328627 AKIRIN1 akirin 1 2 2
MIRT340977 IPO5 importin 5 2 2
MIRT371401 STC2 stanniocalcin 2 2 2
MIRT378008 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT445185 CCDC88C coiled-coil domain containing 88C 2 2
MIRT447120 DUSP16 dual specificity phosphatase 16 2 2
MIRT449153 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT450200 ABHD15 abhydrolase domain containing 15 2 2
MIRT453853 ZNF12 zinc finger protein 12 2 2
MIRT459077 LSM1 LSM1 homolog, mRNA degradation associated 2 2
MIRT461304 MRPS27 mitochondrial ribosomal protein S27 2 2
MIRT464137 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT468114 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT471401 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT478220 DDX52 DExD-box helicase 52 2 2
MIRT479695 CCNT1 cyclin T1 2 2
MIRT479779 CCND1 cyclin D1 2 2
MIRT484980 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485016 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485034 TMEM189 transmembrane protein 189 2 8
MIRT485221 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490143 TERF2IP TERF2 interacting protein 2 6
MIRT508908 DOK6 docking protein 6 2 6
MIRT513877 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT515966 C9orf156 tRNA methyltransferase O 2 4
MIRT517892 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT518660 CLVS2 clavesin 2 2 4
MIRT520027 YOD1 YOD1 deubiquitinase 2 6
MIRT523884 EPHA5 EPH receptor A5 2 4
MIRT529237 PORCN porcupine O-acyltransferase 2 2
MIRT535337 PFN1 profilin 1 2 2
MIRT537532 EZR ezrin 2 2
MIRT537695 ELOVL6 ELOVL fatty acid elongase 6 2 2
MIRT538494 CLOCK clock circadian regulator 2 2
MIRT539140 ARHGAP35 Rho GTPase activating protein 35 2 2
MIRT541380 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT545018 PLP1 proteolipid protein 1 2 2
MIRT547732 KIF23 kinesin family member 23 2 4
MIRT548257 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT550372 MYLK3 myosin light chain kinase 3 2 2
MIRT551867 TMEM47 transmembrane protein 47 2 2
MIRT552289 SNAP29 synaptosome associated protein 29 2 2
MIRT552902 VSNL1 visinin like 1 2 8
MIRT552990 VAMP4 vesicle associated membrane protein 4 2 4
MIRT554729 RHOC ras homolog family member C 2 2
MIRT555301 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT556832 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT557523 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT558238 EDA2R ectodysplasin A2 receptor 2 2
MIRT558920 CBX1 chromobox 1 2 2
MIRT559198 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT559611 AMER1 APC membrane recruitment protein 1 2 2
MIRT559769 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT564648 ZNF487P zinc finger protein 487 1 1
MIRT565856 NHS NHS actin remodeling regulator 2 2
MIRT569044 ZNF655 zinc finger protein 655 2 2
MIRT569154 SIGMAR1 sigma non-opioid intracellular receptor 1 2 2
MIRT569166 DMD dystrophin 2 2
MIRT569205 CASZ1 castor zinc finger 1 2 2
MIRT569264 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT569431 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT569476 CTSE cathepsin E 2 2
MIRT570232 NCAN neurocan 2 2
MIRT570519 SHH sonic hedgehog 2 2
MIRT570680 FZD5 frizzled class receptor 5 2 2
MIRT572161 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT575142 Cd93 CD93 antigen 2 3
MIRT575644 Mitf microphthalmia-associated transcription factor 2 3
MIRT575653 Synpo synaptopodin 2 4
MIRT576375 Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2 2
MIRT576388 Fhl2 four and a half LIM domains 2 2 3
MIRT576413 Pla2g16 phospholipase A2, group XVI 2 2
MIRT576697 Hps3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 3
MIRT606872 CHST11 carbohydrate sulfotransferase 11 2 4
MIRT606940 GFRA1 GDNF family receptor alpha 1 2 6
MIRT607025 ZEB1 zinc finger E-box binding homeobox 1 2 2
MIRT607028 PPY pancreatic polypeptide 2 4
MIRT607081 MITF melanogenesis associated transcription factor 2 3
MIRT607769 HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2 6
MIRT607881 SATB1 SATB homeobox 1 2 2
MIRT607996 BTBD9 BTB domain containing 9 2 2
MIRT608124 TSC22D2 TSC22 domain family member 2 2 2
MIRT608132 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT608209 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT608337 SPN sialophorin 2 2
MIRT608416 SYNPO synaptopodin 2 5
MIRT608459 CD93 CD93 molecule 2 3
MIRT608555 SBK1 SH3 domain binding kinase 1 2 6
MIRT608585 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 4
MIRT608785 JAKMIP2 janus kinase and microtubule interacting protein 2 2 4
MIRT608791 CDH12 cadherin 12 2 2
MIRT608816 ONECUT3 one cut homeobox 3 2 6
MIRT608876 CNTF ciliary neurotrophic factor 2 6
MIRT608881 CLIC6 chloride intracellular channel 6 2 2
MIRT608894 ZNF860 zinc finger protein 860 2 2
MIRT608954 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609007 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 3
MIRT609045 INVS inversin 2 4
MIRT619037 CASS4 Cas scaffolding protein family member 4 2 2
MIRT625226 RPSAP58 ribosomal protein SA pseudogene 58 2 4
MIRT625545 GABRB2 gamma-aminobutyric acid type A receptor beta2 subunit 2 2
MIRT627333 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT627954 NLK nemo like kinase 2 2
MIRT629280 UNC13A unc-13 homolog A 2 2
MIRT634982 TNFAIP8 TNF alpha induced protein 8 2 2
MIRT646129 C1orf147 chromosome 1 open reading frame 147 2 2
MIRT646370 SLC22A6 solute carrier family 22 member 6 2 2
MIRT652743 TGFA transforming growth factor alpha 2 4
MIRT653984 SEMA6A semaphorin 6A 2 2
MIRT660038 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT663504 NKAPL NFKB activating protein like 2 4
MIRT667117 OCIAD2 OCIA domain containing 2 2 2
MIRT683747 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT683922 SLC43A3 solute carrier family 43 member 3 2 2
MIRT684101 LHFP LHFPL tetraspan subfamily member 6 2 2
MIRT684224 FGF14 fibroblast growth factor 14 2 2
MIRT685560 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687408 NRXN1 neurexin 1 2 2
MIRT687467 NHSL2 NHS like 2 2 2
MIRT687695 LEPREL1 prolyl 3-hydroxylase 2 1 1
MIRT688094 GLRA3 glycine receptor alpha 3 2 2
MIRT688255 FHL2 four and a half LIM domains 2 2 3
MIRT688851 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT700293 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT704679 CHST2 carbohydrate sulfotransferase 2 2 2
MIRT706392 PPID peptidylprolyl isomerase D 2 2
MIRT707388 SLC35F6 solute carrier family 35 member F6 2 2
MIRT707509 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT709808 AR androgen receptor 2 2
MIRT715491 MAZ MYC associated zinc finger protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6818-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6818-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6818-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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