miRTarBase - #MIRT556303


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pre-miRNA Information
pre-miRNA hsa-mir-6818   
Genomic Coordinates chr22: 30007049 - 30007113
Description Homo sapiens miR-6818 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6818-3p
Sequence 44| UUGUCUCUUGUUCCUCACACAG |65
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1325627700 2 dbSNP
rs750902684 3 dbSNP
rs756542190 6 dbSNP
rs1365035732 17 dbSNP
Putative Targets

Gene Information
Gene Symbol MAP2K4   
Synonyms JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Description mitogen-activated protein kinase kinase 4
Transcript NM_003010   
Expression
Putative miRNA Targets on MAP2K4
3'UTR of MAP2K4
(miRNA target sites are highlighted)		 
>MAP2K4|NM_003010|3'UTR
   1 TATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGT
  81 TTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAA
 161 CGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAA
 241 CATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTC
 321 AAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTAT
 401 GTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGAC
 481 AAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGT
 561 TTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACC
 641 ATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTT
 721 TCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGT
 801 GCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGAT
 881 GTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGC
 961 CATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCA
1041 AAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGT
1121 GGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAG
1201 GGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCA
1281 GCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTAC
1361 GTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGC
1441 AAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCA
1521 TTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCA
1601 CACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTC
1681 TCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATT
1761 GCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAG
1841 ACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGG
1921 GGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGG
2001 AGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAG
2081 TGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGG
2161 GTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAG
2241 AAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACA
2321 TAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGA
2401 ATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGT
2481 AATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATTACATTAAATTATCTGTGCATTTCACACC
2561 AGGGAAAATGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacacacuccUUGU-UCUCUGUu 5'
                    ||:| ||||||| 
Target 5' tgaacattaaAATATAGAGACAg 3'
 659 - 681 148.00 -11.40
2 
miRNA  3' gacacaCUCCUU------GUUCUCUGUu 5'
                |||| |      | ||||||| 
Target 5' gataaaGAGGCATCTTTTCTAGAGACAc 3'
 1296 - 1323 146.00 -10.80
3 
miRNA  3' gacACACUCCUUGUUCUCUGUu 5'
             |||   ||| |:|||||| 
Target 5' cacTGTTCTGAA-AGGAGACAt 3'
 1847 - 1867 142.00 -12.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15201838 4 COSMIC
COSN30677854 5 COSMIC
COSN32065052 28 COSMIC
COSN30645882 31 COSMIC
COSN31504262 31 COSMIC
COSN31487689 37 COSMIC
COSN13700681 40 COSMIC
COSN30751905 51 COSMIC
COSN31611911 57 COSMIC
COSN31610256 135 COSMIC
COSN30605360 148 COSMIC
COSN30505182 165 COSMIC
COSN26569892 172 COSMIC
COSN30108106 213 COSMIC
COSN26604435 215 COSMIC
COSN8831289 236 COSMIC
COSN8602349 405 COSMIC
COSN31529127 419 COSMIC
COSN28673266 432 COSMIC
COSN31591115 446 COSMIC
COSN30540989 503 COSMIC
COSN31529669 517 COSMIC
COSN8602350 535 COSMIC
COSN31557405 546 COSMIC
COSN229730 555 COSMIC
COSN31609641 625 COSMIC
COSN31541966 640 COSMIC
COSN31517214 775 COSMIC
COSN31519951 796 COSMIC
COSN26568620 895 COSMIC
COSN21669330 1274 COSMIC
COSN6650014 1329 COSMIC
COSN20188867 1662 COSMIC
COSN1713429 2064 COSMIC
COSN30172676 2068 COSMIC
COSN26508918 2124 COSMIC
COSN20243415 2250 COSMIC
COSN31479761 2314 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759895365 4 dbSNP
rs201971628 5 dbSNP
rs1160522880 8 dbSNP
rs753044476 20 dbSNP
rs189817203 22 dbSNP
rs1177317456 26 dbSNP
rs750313329 28 dbSNP
rs1440414957 29 dbSNP
rs758163020 36 dbSNP
rs1300906062 42 dbSNP
rs1328873603 43 dbSNP
rs757919548 49 dbSNP
rs1444294698 50 dbSNP
rs368292817 51 dbSNP
rs376888511 52 dbSNP
rs1376940685 66 dbSNP
rs1173871300 69 dbSNP
rs182465459 70 dbSNP
rs991391012 77 dbSNP
rs1447077528 78 dbSNP
rs1217388804 83 dbSNP
rs1471455387 86 dbSNP
rs139724158 89 dbSNP
rs565243535 92 dbSNP
rs185329765 104 dbSNP
rs977552536 111 dbSNP
rs755582365 125 dbSNP
rs754518168 126 dbSNP
rs1277957623 128 dbSNP
rs1162191662 130 dbSNP
rs1413774405 136 dbSNP
rs778639435 138 dbSNP
rs541396988 149 dbSNP
rs1401809070 151 dbSNP
rs1278849405 158 dbSNP
rs1320294154 162 dbSNP
rs933099258 163 dbSNP
rs1051435127 173 dbSNP
rs888807017 181 dbSNP
rs1373192745 188 dbSNP
rs943587891 196 dbSNP
rs190190304 202 dbSNP
rs1386400527 207 dbSNP
rs751116797 209 dbSNP
rs1243587953 211 dbSNP
rs1420115201 225 dbSNP
rs899306678 226 dbSNP
rs773452215 232 dbSNP
rs1283517036 234 dbSNP
rs1217729861 238 dbSNP
rs1447362213 241 dbSNP
rs1283547066 242 dbSNP
rs868621549 242 dbSNP
rs1206757986 243 dbSNP
rs575260150 259 dbSNP
rs1225401711 266 dbSNP
rs1232125778 269 dbSNP
rs1353218981 270 dbSNP
rs1433396058 276 dbSNP
rs1346168731 298 dbSNP
rs1317988135 304 dbSNP
rs1281475093 306 dbSNP
rs1464067275 327 dbSNP
rs993682136 336 dbSNP
rs1203885563 344 dbSNP
rs1397268930 352 dbSNP
rs530205553 357 dbSNP
rs1026780896 366 dbSNP
rs548739275 375 dbSNP
rs1411982419 383 dbSNP
rs1188492312 389 dbSNP
rs1462922916 393 dbSNP
rs1241337469 394 dbSNP
rs1049438 402 dbSNP
rs1185791242 403 dbSNP
rs1237265742 410 dbSNP
rs1470773420 419 dbSNP
rs1273702690 430 dbSNP
rs563431936 438 dbSNP
rs1160822984 439 dbSNP
rs1004076840 444 dbSNP
rs146597820 450 dbSNP
rs183470579 451 dbSNP
rs1270006924 452 dbSNP
rs1177410004 456 dbSNP
rs959395850 457 dbSNP
rs1373883498 464 dbSNP
rs570740002 475 dbSNP
rs1327162125 478 dbSNP
rs1450741872 483 dbSNP
rs991338612 498 dbSNP
rs1021515339 502 dbSNP
rs1336161499 509 dbSNP
rs1410765497 512 dbSNP
rs542637158 513 dbSNP
rs977289694 514 dbSNP
rs1277757102 518 dbSNP
rs924479052 521 dbSNP
rs748422493 522 dbSNP
rs1487424435 523 dbSNP
rs1234141930 525 dbSNP
rs954466763 533 dbSNP
rs1223668429 544 dbSNP
rs1306613460 551 dbSNP
rs188410287 555 dbSNP
rs1320887488 564 dbSNP
rs546555189 566 dbSNP
rs910190495 570 dbSNP
rs1255844126 571 dbSNP
rs1366046920 578 dbSNP
rs943033266 579 dbSNP
rs1037916538 585 dbSNP
rs568012626 597 dbSNP
rs535168966 598 dbSNP
rs1250331492 601 dbSNP
rs920852236 601 dbSNP
rs193245128 603 dbSNP
rs576184750 605 dbSNP
rs1047889723 612 dbSNP
rs906720725 618 dbSNP
rs1177318276 626 dbSNP
rs537272159 633 dbSNP
rs1480024657 643 dbSNP
rs1249242020 648 dbSNP
rs141440676 649 dbSNP
rs774589194 652 dbSNP
rs1055150998 655 dbSNP
rs577441740 658 dbSNP
rs541405516 664 dbSNP
rs1310996638 671 dbSNP
rs1010865686 674 dbSNP
rs1224460814 675 dbSNP
rs1349960962 676 dbSNP
rs1286457201 681 dbSNP
rs1416885311 687 dbSNP
rs1376236303 689 dbSNP
rs1021464279 698 dbSNP
rs764885646 704 dbSNP
rs1049439 706 dbSNP
rs1172239991 708 dbSNP
rs1396920620 710 dbSNP
rs968661720 713 dbSNP
rs28921113 717 dbSNP
rs1031489798 718 dbSNP
rs28921114 726 dbSNP
rs386576571 726 dbSNP
rs796558922 726 dbSNP
rs184089088 737 dbSNP
rs1284597734 738 dbSNP
rs910305030 748 dbSNP
rs1232049382 751 dbSNP
rs1475343987 753 dbSNP
rs1251569890 762 dbSNP
rs11555725 767 dbSNP
rs1482472280 771 dbSNP
rs1262803165 773 dbSNP
rs1217135857 791 dbSNP
rs563793589 796 dbSNP
rs1235193997 797 dbSNP
rs59832266 798 dbSNP
rs1048481585 804 dbSNP
rs1363833074 805 dbSNP
rs186704791 806 dbSNP
rs1271080885 814 dbSNP
rs1431564879 818 dbSNP
rs1386304211 820 dbSNP
rs201362372 821 dbSNP
rs1330387946 827 dbSNP
rs1373923998 828 dbSNP
rs1461503672 833 dbSNP
rs1476264484 842 dbSNP
rs1416789044 847 dbSNP
rs191563418 857 dbSNP
rs1429854132 861 dbSNP
rs1264333760 863 dbSNP
rs1187417045 865 dbSNP
rs1464877789 866 dbSNP
rs1266751778 868 dbSNP
rs1369749772 870 dbSNP
rs1425166109 880 dbSNP
rs1215710668 882 dbSNP
rs1055095564 896 dbSNP
rs1264885041 904 dbSNP
rs1304926393 919 dbSNP
rs1242889701 925 dbSNP
rs895242550 926 dbSNP
rs528384363 927 dbSNP
rs777910390 934 dbSNP
rs1363028104 945 dbSNP
rs183860741 955 dbSNP
rs1043689070 957 dbSNP
rs1441474446 959 dbSNP
rs1389390633 969 dbSNP
rs1160906936 978 dbSNP
rs1463216885 995 dbSNP
rs1443041330 998 dbSNP
rs902541481 999 dbSNP
rs998752463 1000 dbSNP
rs565054493 1003 dbSNP
rs1032024002 1019 dbSNP
rs954528193 1031 dbSNP
rs1266804062 1034 dbSNP
rs1208088180 1040 dbSNP
rs1481771015 1049 dbSNP
rs1252105147 1053 dbSNP
rs1227466480 1056 dbSNP
rs1008742120 1057 dbSNP
rs1305270834 1059 dbSNP
rs1295808707 1060 dbSNP
rs1341925536 1072 dbSNP
rs1330396821 1074 dbSNP
rs1017481412 1077 dbSNP
rs1392590604 1081 dbSNP
rs1396857391 1087 dbSNP
rs530627261 1089 dbSNP
rs568009724 1099 dbSNP
rs188576778 1100 dbSNP
rs1388715301 1102 dbSNP
rs1175878255 1108 dbSNP
rs544055289 1109 dbSNP
rs1209380455 1121 dbSNP
rs1377538282 1122 dbSNP
rs192717367 1123 dbSNP
rs973174439 1127 dbSNP
rs1027311137 1132 dbSNP
rs1448913832 1133 dbSNP
rs1204708462 1135 dbSNP
rs1482172052 1136 dbSNP
rs759629494 1137 dbSNP
rs1344267831 1139 dbSNP
rs1273004488 1145 dbSNP
rs568630474 1146 dbSNP
rs1335849108 1147 dbSNP
rs1389291541 1148 dbSNP
rs1287089839 1157 dbSNP
rs1407647100 1160 dbSNP
rs761285228 1164 dbSNP
rs35163626 1166 dbSNP
rs1445060167 1167 dbSNP
rs1165389249 1171 dbSNP
rs928209569 1172 dbSNP
rs539172755 1175 dbSNP
rs1171349870 1179 dbSNP
rs990939743 1185 dbSNP
rs373075028 1187 dbSNP
rs1386539830 1192 dbSNP
rs1259832318 1193 dbSNP
rs1188074227 1203 dbSNP
rs570995174 1205 dbSNP
rs1049441 1216 dbSNP
rs1049442 1227 dbSNP
rs1441621558 1230 dbSNP
rs1276178698 1233 dbSNP
rs1432379329 1244 dbSNP
rs1319532533 1247 dbSNP
rs1266966506 1251 dbSNP
rs946789596 1260 dbSNP
rs377467531 1263 dbSNP
rs1317766247 1265 dbSNP
rs1446758718 1267 dbSNP
rs1340253930 1269 dbSNP
rs1332562342 1273 dbSNP
rs1049443 1282 dbSNP
rs1402972204 1284 dbSNP
rs1320385884 1285 dbSNP
rs1158570722 1286 dbSNP
rs902487359 1290 dbSNP
rs1420373118 1292 dbSNP
rs935329976 1299 dbSNP
rs1053006065 1308 dbSNP
rs1352990895 1325 dbSNP
rs890359018 1326 dbSNP
rs4792219 1329 dbSNP
rs1465328146 1332 dbSNP
rs140706208 1339 dbSNP
rs1185139556 1340 dbSNP
rs1336323354 1343 dbSNP
rs1289886706 1344 dbSNP
rs1227417275 1345 dbSNP
rs542266426 1349 dbSNP
rs1423135285 1350 dbSNP
rs1282839382 1353 dbSNP
rs1433283338 1357 dbSNP
rs900368453 1361 dbSNP
rs1433459464 1362 dbSNP
rs557420020 1371 dbSNP
rs575793095 1385 dbSNP
rs867970900 1386 dbSNP
rs1169468093 1388 dbSNP
rs1449844751 1392 dbSNP
rs1389542979 1393 dbSNP
rs1272207826 1399 dbSNP
rs546021188 1409 dbSNP
rs1316292529 1424 dbSNP
rs150125305 1433 dbSNP
rs1198462744 1436 dbSNP
rs185127839 1442 dbSNP
rs1449551534 1450 dbSNP
rs1157958844 1451 dbSNP
rs1343339167 1460 dbSNP
rs138715568 1460 dbSNP
rs1297243446 1461 dbSNP
rs1226887500 1462 dbSNP
rs991060540 1464 dbSNP
rs1454261804 1465 dbSNP
rs561848490 1466 dbSNP
rs1331118504 1474 dbSNP
rs916718655 1486 dbSNP
rs1389352561 1487 dbSNP
rs1166430649 1489 dbSNP
rs1304915457 1490 dbSNP
rs1377457996 1491 dbSNP
rs1455569997 1492 dbSNP
rs1425743763 1493 dbSNP
rs528827767 1494 dbSNP
rs1476747022 1499 dbSNP
rs550147826 1505 dbSNP
rs1205437959 1510 dbSNP
rs979445489 1511 dbSNP
rs1274404237 1512 dbSNP
rs190166554 1513 dbSNP
rs1331317306 1525 dbSNP
rs1226713597 1530 dbSNP
rs1267596512 1532 dbSNP
rs1324454535 1540 dbSNP
rs1365600685 1546 dbSNP
rs935461626 1556 dbSNP
rs1410688903 1564 dbSNP
rs182288643 1566 dbSNP
rs891149587 1572 dbSNP
rs944594322 1577 dbSNP
rs1359729229 1584 dbSNP
rs1038984510 1590 dbSNP
rs35027510 1598 dbSNP
rs1409568600 1603 dbSNP
rs1182214518 1607 dbSNP
rs1252669600 1627 dbSNP
rs1472090457 1628 dbSNP
rs1249123975 1636 dbSNP
rs1471318987 1638 dbSNP
rs1484435890 1644 dbSNP
rs1180759126 1645 dbSNP
rs1256898851 1651 dbSNP
rs1210067401 1656 dbSNP
rs548929345 1661 dbSNP
rs994677092 1662 dbSNP
rs751434207 1668 dbSNP
rs886181583 1669 dbSNP
rs142822302 1677 dbSNP
rs1299229349 1679 dbSNP
rs1286663558 1683 dbSNP
rs1004674744 1684 dbSNP
rs1302007012 1688 dbSNP
rs1445768108 1693 dbSNP
rs1408539515 1696 dbSNP
rs1035080828 1698 dbSNP
rs1456244991 1711 dbSNP
rs1166665669 1716 dbSNP
rs753340576 1716 dbSNP
rs553603101 1718 dbSNP
rs1221134145 1725 dbSNP
rs568748222 1730 dbSNP
rs1023843732 1732 dbSNP
rs1482585604 1758 dbSNP
rs536188976 1761 dbSNP
rs189374285 1772 dbSNP
rs980000346 1776 dbSNP
rs1266242857 1780 dbSNP
rs1247302010 1781 dbSNP
rs180737708 1783 dbSNP
rs956984930 1793 dbSNP
rs1049444 1799 dbSNP
rs1049445 1800 dbSNP
rs1432148263 1801 dbSNP
rs752444743 1802 dbSNP
rs1394042006 1805 dbSNP
rs539873890 1811 dbSNP
rs1268948453 1812 dbSNP
rs557978166 1816 dbSNP
rs1481152731 1817 dbSNP
rs912540518 1821 dbSNP
rs572955852 1824 dbSNP
rs532604526 1825 dbSNP
rs1458138986 1828 dbSNP
rs1367499450 1829 dbSNP
rs1164597690 1830 dbSNP
rs1038932037 1833 dbSNP
rs1392347369 1843 dbSNP
rs921854614 1849 dbSNP
rs1464808450 1852 dbSNP
rs561571491 1855 dbSNP
rs1488954694 1857 dbSNP
rs930582226 1864 dbSNP
rs747382916 1866 dbSNP
rs1344058810 1875 dbSNP
rs1049365757 1879 dbSNP
rs886298488 1880 dbSNP
rs1005010123 1883 dbSNP
rs1056235463 1886 dbSNP
rs896115338 1887 dbSNP
rs570349832 1889 dbSNP
rs1011874766 1911 dbSNP
rs1023290482 1914 dbSNP
rs968266822 1917 dbSNP
rs1449446024 1919 dbSNP
rs1428329995 1920 dbSNP
rs1201183255 1923 dbSNP
rs1001146096 1927 dbSNP
rs1031572420 1928 dbSNP
rs1438784557 1930 dbSNP
rs1193268392 1933 dbSNP
rs1484137312 1937 dbSNP
rs956909924 1939 dbSNP
rs1275146136 1947 dbSNP
rs987269021 1954 dbSNP
rs1803981 1956 dbSNP
rs374613560 1958 dbSNP
rs1276530509 1966 dbSNP
rs771371631 1972 dbSNP
rs1330002178 1974 dbSNP
rs912655032 1987 dbSNP
rs1309066008 1988 dbSNP
rs1215388789 1989 dbSNP
rs1429511984 2000 dbSNP
rs1395044798 2004 dbSNP
rs1174841059 2009 dbSNP
rs975405184 2032 dbSNP
rs1377173527 2039 dbSNP
rs1197306206 2040 dbSNP
rs573591463 2041 dbSNP
rs1049001581 2042 dbSNP
rs185090127 2047 dbSNP
rs1280385534 2049 dbSNP
rs940538048 2064 dbSNP
rs1056106567 2065 dbSNP
rs1253785833 2070 dbSNP
rs896230052 2073 dbSNP
rs1245630122 2083 dbSNP
rs1287314201 2085 dbSNP
rs1485966651 2086 dbSNP
rs1011989097 2090 dbSNP
rs562100258 2096 dbSNP
rs1044691395 2097 dbSNP
rs532801531 2098 dbSNP
rs1336514202 2100 dbSNP
rs1397148940 2106 dbSNP
rs1402078729 2108 dbSNP
rs1187924346 2114 dbSNP
rs1392393675 2120 dbSNP
rs1458876055 2124 dbSNP
rs1412724964 2132 dbSNP
rs377631607 2138 dbSNP
rs748132714 2142 dbSNP
rs903555542 2142 dbSNP
rs1239008513 2144 dbSNP
rs1001497643 2150 dbSNP
rs1407592410 2151 dbSNP
rs1441813123 2154 dbSNP
rs1031272395 2155 dbSNP
rs1321599710 2155 dbSNP
rs575309080 2162 dbSNP
rs993299076 2168 dbSNP
rs560013150 2178 dbSNP
rs892592198 2180 dbSNP
rs1266865781 2181 dbSNP
rs146989618 2183 dbSNP
rs1357967186 2191 dbSNP
rs546863393 2200 dbSNP
rs568709937 2203 dbSNP
rs964122032 2205 dbSNP
rs1389911014 2213 dbSNP
rs1382916760 2214 dbSNP
rs1335329990 2219 dbSNP
rs975519554 2230 dbSNP
rs1389507585 2235 dbSNP
rs1319914134 2237 dbSNP
rs1399223938 2238 dbSNP
rs775548386 2247 dbSNP
rs1416187277 2248 dbSNP
rs1163694710 2250 dbSNP
rs1358296663 2253 dbSNP
rs1383091869 2261 dbSNP
rs1190442821 2273 dbSNP
rs1026975007 2275 dbSNP
rs1465263417 2281 dbSNP
rs952760609 2283 dbSNP
rs1213013577 2285 dbSNP
rs1226565951 2288 dbSNP
rs985072606 2291 dbSNP
rs1317041176 2299 dbSNP
rs907792847 2300 dbSNP
rs940637164 2312 dbSNP
rs28921115 2315 dbSNP
rs1245885530 2320 dbSNP
rs1231285529 2321 dbSNP
rs1366528672 2323 dbSNP
rs1338784947 2330 dbSNP
rs1463815434 2336 dbSNP
rs538194763 2356 dbSNP
rs1188266269 2357 dbSNP
rs917770650 2359 dbSNP
rs1351896335 2361 dbSNP
rs1324471491 2371 dbSNP
rs947792171 2377 dbSNP
rs1474038251 2378 dbSNP
rs1162005562 2380 dbSNP
rs1044803816 2390 dbSNP
rs28921116 2392 dbSNP
rs771988128 2393 dbSNP
rs551297905 2397 dbSNP
rs1401423730 2404 dbSNP
rs569233824 2405 dbSNP
rs936355059 2419 dbSNP
rs1053083628 2427 dbSNP
rs892713513 2430 dbSNP
rs1272909578 2446 dbSNP
rs1213267304 2447 dbSNP
rs773074624 2461 dbSNP
rs537682530 2479 dbSNP
rs1337104125 2492 dbSNP
rs1008936178 2494 dbSNP
rs1391598759 2501 dbSNP
rs1342063571 2502 dbSNP
rs1309667915 2506 dbSNP
rs539463944 2506 dbSNP
rs1283569342 2507 dbSNP
rs558202320 2510 dbSNP
rs76996718 2512 dbSNP
rs1019775986 2518 dbSNP
rs1373426420 2521 dbSNP
rs1168234794 2527 dbSNP
rs191257357 2530 dbSNP
rs183170582 2531 dbSNP
rs1190100164 2536 dbSNP
rs1027073111 2540 dbSNP
rs952786535 2541 dbSNP
rs1052139112 2542 dbSNP
rs982794513 2544 dbSNP
rs1016048078 2548 dbSNP
rs1232599444 2552 dbSNP
rs777773191 2559 dbSNP
rs1203072758 2562 dbSNP
rs1314410484 2568 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6416.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacacuccuUGUUCUCUGUu 5'
                     | |:|||: | 
Target 5' ----------cAAAGGAGGAAu 3'
 		1 - 12
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000415385.3 | 3UTR | CAAAGGAGGAAUUUACUUUCUUCACCAAGUGCAAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
150 hsa-miR-6818-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112122 TIMM17A translocase of inner mitochondrial membrane 17A 2 6
MIRT262243 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT446689 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT449923 TPST2 tyrosylprotein sulfotransferase 2 2 2
MIRT464356 USP12P1 ubiquitin specific peptidase 12 pseudogene 1 2 2
MIRT485703 CBX7 chromobox 7 2 2
MIRT497478 XPR1 xenotropic and polytropic retrovirus receptor 1 2 4
MIRT499435 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT514246 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT515032 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515065 PLA2G2C phospholipase A2 group IIC 2 2
MIRT520235 USP9X ubiquitin specific peptidase 9, X-linked 2 4
MIRT523685 FHL2 four and a half LIM domains 2 2 4
MIRT525524 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT525838 FAR2 fatty acyl-CoA reductase 2 2 2
MIRT528583 PTGER3 prostaglandin E receptor 3 2 2
MIRT530404 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530703 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT535118 PLSCR4 phospholipid scramblase 4 2 2
MIRT539880 IRGQ immunity related GTPase Q 2 2
MIRT540195 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540938 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541501 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT542544 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542559 ZNF280B zinc finger protein 280B 2 2
MIRT542689 RPS15A ribosomal protein S15a 2 2
MIRT548759 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT549735 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT553060 ULK1 unc-51 like autophagy activating kinase 1 2 2
MIRT556303 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT560816 DIP2A disco interacting protein 2 homolog A 2 2
MIRT567455 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT575143 Cd93 CD93 antigen 2 2
MIRT607217 ACSM2A acyl-CoA synthetase medium chain family member 2A 2 4
MIRT607286 CD300E CD300e molecule 2 6
MIRT607302 RREB1 ras responsive element binding protein 1 2 6
MIRT608645 ABCF3 ATP binding cassette subfamily F member 3 2 4
MIRT611095 MYO1F myosin IF 2 4
MIRT611576 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT614271 WSCD2 WSC domain containing 2 2 2
MIRT614855 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT617114 KANK2 KN motif and ankyrin repeat domains 2 2 2
MIRT618002 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618028 CTU1 cytosolic thiouridylase subunit 1 2 2
MIRT619062 BSND barttin CLCNK type accessory beta subunit 2 4
MIRT619289 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619356 CFHR5 complement factor H related 5 2 2
MIRT620725 CCL16 C-C motif chemokine ligand 16 2 2
MIRT620913 LRRTM2 leucine rich repeat transmembrane neuronal 2 2 2
MIRT621902 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT622025 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT622556 PTPN3 protein tyrosine phosphatase, non-receptor type 3 2 2
MIRT623137 NCKAP1 NCK associated protein 1 2 2
MIRT623140 NAV2 neuron navigator 2 2 2
MIRT623701 HHAT hedgehog acyltransferase 2 2
MIRT624602 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT625944 OLIG3 oligodendrocyte transcription factor 3 2 2
MIRT625988 SPATA17 spermatogenesis associated 17 2 2
MIRT628028 LSAMP limbic system-associated membrane protein 2 2
MIRT635521 MC2R melanocortin 2 receptor 2 2
MIRT638916 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT639796 EPX eosinophil peroxidase 2 2
MIRT640344 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT644806 VLDLR very low density lipoprotein receptor 2 2
MIRT645303 AGTRAP angiotensin II receptor associated protein 2 2
MIRT645629 SYTL4 synaptotagmin like 4 2 2
MIRT645683 TBC1D13 TBC1 domain family member 13 2 2
MIRT646216 DUSP10 dual specificity phosphatase 10 2 2
MIRT648505 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT649748 UTP20 UTP20, small subunit processome component 2 2
MIRT649797 CLEC2D C-type lectin domain family 2 member D 2 2
MIRT650482 UFM1 ubiquitin fold modifier 1 2 2
MIRT653199 SP9 Sp9 transcription factor 2 2
MIRT655741 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT659978 C2CD2L C2CD2 like 2 2
MIRT660350 BAG4 BCL2 associated athanogene 4 2 2
MIRT662185 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663290 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT666817 PRCP prolylcarboxypeptidase 2 2
MIRT671665 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT671838 PDE3A phosphodiesterase 3A 2 2
MIRT672193 F2 coagulation factor II, thrombin 2 2
MIRT673870 KLF2 Kruppel like factor 2 2 2
MIRT683563 CARD8 caspase recruitment domain family member 8 2 2
MIRT684545 ZNF708 zinc finger protein 708 2 2
MIRT685140 TACR3 tachykinin receptor 3 2 2
MIRT685413 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT686039 SLC5A5 solute carrier family 5 member 5 2 2
MIRT686126 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT687473 NHLRC2 NHL repeat containing 2 2 2
MIRT687946 HHIP hedgehog interacting protein 2 2
MIRT688171 FRRS1 ferric chelate reductase 1 2 2
MIRT688295 FAM208A family with sequence similarity 208 member A 2 2
MIRT689044 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT689194 ZNF574 zinc finger protein 574 2 2
MIRT691253 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT695358 PHAX phosphorylated adaptor for RNA export 2 2
MIRT696674 APOC3 apolipoprotein C3 2 2
MIRT697358 ZNF394 zinc finger protein 394 2 2
MIRT697604 XIAP X-linked inhibitor of apoptosis 2 2
MIRT697726 USP6NL USP6 N-terminal like 2 2
MIRT697776 UBXN7 UBX domain protein 7 2 2
MIRT698478 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT698984 SPAG9 sperm associated antigen 9 2 2
MIRT699851 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT700172 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT704339 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT704589 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT705836 AHCY adenosylhomocysteinase 2 2
MIRT707085 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT707132 TRA2B transformer 2 beta homolog 2 2
MIRT707145 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT707234 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT707347 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT707445 PPFIBP1 PPFIA binding protein 1 2 2
MIRT707494 AXL AXL receptor tyrosine kinase 2 2
MIRT707638 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT707690 FAM118A family with sequence similarity 118 member A 2 2
MIRT707706 CDC6 cell division cycle 6 2 2
MIRT707817 TMEM170A transmembrane protein 170A 2 2
MIRT707957 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT707996 NUDT4 nudix hydrolase 4 2 2
MIRT708026 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT708058 LIX1L limb and CNS expressed 1 like 2 2
MIRT708089 KIAA1671 KIAA1671 2 2
MIRT708125 GK5 glycerol kinase 5 (putative) 2 2
MIRT708194 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT708201 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT710503 BSDC1 BSD domain containing 1 2 2
MIRT711308 IFNGR2 interferon gamma receptor 2 2 2
MIRT711740 DTX1 deltex E3 ubiquitin ligase 1 2 2
MIRT713202 SOCS6 suppressor of cytokine signaling 6 2 2
MIRT714380 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT715210 NPVF neuropeptide VF precursor 2 2
MIRT715559 EPHB4 EPH receptor B4 2 2
MIRT715835 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT716680 HLA-B major histocompatibility complex, class I, B 2 2
MIRT717660 THBS2 thrombospondin 2 2 2
MIRT718132 PALM paralemmin 2 2
MIRT718322 METTL7A methyltransferase like 7A 2 2
MIRT720693 RNF217 ring finger protein 217 2 2
MIRT720727 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT721376 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721983 FAM214B family with sequence similarity 214 member B 2 2
MIRT722163 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT722881 MOB3A MOB kinase activator 3A 2 2
MIRT723218 FMNL3 formin like 3 2 2
MIRT723788 MUC17 mucin 17, cell surface associated 2 2
MIRT724093 TMEM199 transmembrane protein 199 2 2
MIRT725265 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6818-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)

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