pre-miRNA Information
pre-miRNA hsa-mir-4524a   
Genomic Coordinates chr17: 69099564 - 69099632
Description Homo sapiens miR-4524a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524a-5p
Sequence 6| AUAGCAGCAUGAACCUGUCUCA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322445998 8 dbSNP
rs1350790266 13 dbSNP
rs1263495678 21 dbSNP
Putative Targets

Gene Information
Gene Symbol GPR27   
Synonyms SREB1
Description G protein-coupled receptor 27
Transcript NM_018971   
Expression
Putative miRNA Targets on GPR27
3'UTR of GPR27
(miRNA target sites are highlighted)
>GPR27|NM_018971|3'UTR
   1 GGGAGGCCCCGCCACATAGACCCCCAACCCAGCCTTTCCCTTTGGCTCGGACGGTGACGTTGTATCTTTTCCTTCTGGCC
  81 CCTGTTTAATTTTCTAAGCTGCCTTCAAAATGACTCGAAGTGGACAGACACTTGGATTGTACTGACTCCTTTGGGGGTGG
 161 GGTGGGTGAGGAGTAGGATGCTCAGCCCACTCCAGCTCCGCACATTCGTCCTCCTAACTCGACTTTCTTCCTGACAATAG
 241 GCCCTGCAGTCTTTTTGTAGCGGTACTGACGTCTTTTATTCCATGTGTGGTTCCTTTTTTTCTTTTTCTATAAAGGCTGT
 321 ACTAATTTTCTTCATGCAACGTTTCCTAAAGACCATGGCCAGTTTTCTACAGAAGCTATTTTTGACAACCTCAAGTGGCA
 401 TTACATTTTGCAGTGAAGTAGAGGAACCTAGGGGGACTTCTTCACAAGTTAGATTTCTTGAGGATCTTCTGTTGGAAGCA
 481 GGAGAAAGTGGGGGGTGGGGGGAAGTTGTCCGAAATGCCCTCTGAATTGCCGGCTGCAGGGTCCTTGTGCTGCGCTGGTT
 561 CTTTGAAAGTCTCAGTGTTGATATTGAACTTAAAGAGCAGAGATGGAGATCAGTAGCAAGGCAGTCATTTTTTTAAAGCA
 641 GTAAGTAACAAGTAAGATTTGGTTCCCGGTTTACTTTCTGCTGCTAAAAACCACGTCAGTGACAACTGCTCTCTGTATTA
 721 TAGCAATCTTGAATGGAAACATTTCTGTCAAGTTGTAAGTTTTAAAAGAGTAAAGTGTTTTGGTTAGTAATGATGTGGAG
 801 AAAAATACAGTATTGCATGTGTTCGTGTGTATAGATTGTGGTTCGAGGATTGGGAGGGCTCTGAGAAGCAGAGTACTACA
 881 TCAAAATTGTTTTAAGTATTTTTTGCCAATAAAAAATTAATTTTATGGAAATGGCTTGTGCTTTGAGAAGCCCAGTTTTA
 961 TTCTGTCTTATGAAACTAATTTCCACTTTGAAAATTGTTCTTCTGTTGTTTATGGTATAAATGAATGGAATATAATGATA
1041 TCCTCCTTCTAGGAAACAAAGCATTTCCTTAAAATGTTTGCTAGGTTAAGCTGTGCTGTTCTACTGATGGTTGTTTTAAA
1121 TTAATAATGAGAACTATAATTTAAATAATATTTCTTTGTTAGACATTATAATGTTAAACTGAAAGACTAAATTCTGCAAG
1201 TAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acucuGUCCAAGU-----ACGACGAUa 5'
               | ||||:|     |||||||| 
Target 5' ggttcCCGGTTTACTTTCTGCTGCTAa 3'
661 - 687 157.00 -13.00
2
miRNA  3' acuCUGUCCAA----GUACGACGAua 5'
             | :|||||    ::|||||:|  
Target 5' tttGCTAGGTTAAGCTGTGCTGTTct 3'
1077 - 1102 125.00 -12.20
3
miRNA  3' acucUGUCCAAG---UACGACGaua 5'
              :|||| ||   :||||||   
Target 5' ggctGCAGGGTCCTTGTGCTGCgct 3'
532 - 556 122.00 -14.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20061792 49 COSMIC
COSN30716879 50 COSMIC
COSN25015670 200 COSMIC
COSN1960143 201 COSMIC
COSN25009471 201 COSMIC
COSN17769456 208 COSMIC
COSN32062762 470 COSMIC
COSN1960145 579 COSMIC
COSN23510404 793 COSMIC
COSN6775332 846 COSMIC
COSN23302704 1043 COSMIC
COSN1960147 1208 COSMIC
COSN26191458 1255 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs554955358 3 dbSNP
rs1189626068 7 dbSNP
rs766959288 9 dbSNP
rs947488770 12 dbSNP
rs1167961533 14 dbSNP
rs754355056 15 dbSNP
rs759679789 18 dbSNP
rs200989069 19 dbSNP
rs765168988 22 dbSNP
rs1416947263 23 dbSNP
rs1291729490 24 dbSNP
rs752972273 25 dbSNP
rs758548577 26 dbSNP
rs1253127260 28 dbSNP
rs1337474240 35 dbSNP
rs1041162489 38 dbSNP
rs1202973389 41 dbSNP
rs1273735077 43 dbSNP
rs781024959 49 dbSNP
rs375668312 50 dbSNP
rs1169345355 54 dbSNP
rs543723129 60 dbSNP
rs1213393762 61 dbSNP
rs1333711304 62 dbSNP
rs1019954773 63 dbSNP
rs901468652 63 dbSNP
rs760137767 67 dbSNP
rs768112590 69 dbSNP
rs775749172 73 dbSNP
rs888099465 74 dbSNP
rs1032678123 79 dbSNP
rs1303279094 80 dbSNP
rs1172779215 82 dbSNP
rs1364885903 82 dbSNP
rs1418892163 83 dbSNP
rs1192347240 84 dbSNP
rs1455979462 98 dbSNP
rs1251607120 99 dbSNP
rs1005601724 100 dbSNP
rs1458457286 103 dbSNP
rs1238449811 107 dbSNP
rs1403094787 114 dbSNP
rs1206178026 117 dbSNP
rs1305313353 131 dbSNP
rs1299751937 132 dbSNP
rs1219234922 143 dbSNP
rs1362433494 155 dbSNP
rs1215331535 172 dbSNP
rs1377327050 173 dbSNP
rs537519977 177 dbSNP
rs1295095869 182 dbSNP
rs1306020106 184 dbSNP
rs577497203 187 dbSNP
rs896856156 188 dbSNP
rs746210533 191 dbSNP
rs554185038 192 dbSNP
rs541597275 194 dbSNP
rs377209199 199 dbSNP
rs1034850494 200 dbSNP
rs1393832428 201 dbSNP
rs1173528187 211 dbSNP
rs760830519 213 dbSNP
rs1253085066 222 dbSNP
rs1175787174 224 dbSNP
rs1479455060 231 dbSNP
rs1231910765 233 dbSNP
rs1211001232 234 dbSNP
rs1486351862 235 dbSNP
rs990724599 243 dbSNP
rs1022194636 244 dbSNP
rs968766509 245 dbSNP
rs764432624 247 dbSNP
rs373947289 252 dbSNP
rs930737019 263 dbSNP
rs1372913529 271 dbSNP
rs754666812 274 dbSNP
rs934735031 282 dbSNP
rs1416754571 284 dbSNP
rs1312865689 285 dbSNP
rs1373705997 285 dbSNP
rs1420851108 286 dbSNP
rs976926757 288 dbSNP
rs1365987974 291 dbSNP
rs1157412851 295 dbSNP
rs1418809880 296 dbSNP
rs1406850335 301 dbSNP
rs1446156276 303 dbSNP
rs926631811 306 dbSNP
rs1384090608 309 dbSNP
rs922754033 311 dbSNP
rs780857132 313 dbSNP
rs1254762310 316 dbSNP
rs1209460598 317 dbSNP
rs938279750 321 dbSNP
rs1262380175 327 dbSNP
rs932933499 331 dbSNP
rs1316095863 332 dbSNP
rs1049979857 338 dbSNP
rs1235352564 340 dbSNP
rs1353731949 352 dbSNP
rs559561850 356 dbSNP
rs1345762571 358 dbSNP
rs1400645973 359 dbSNP
rs577458389 361 dbSNP
rs1287605824 371 dbSNP
rs1453541689 379 dbSNP
rs945516759 391 dbSNP
rs1165274371 399 dbSNP
rs1286968699 403 dbSNP
rs1415128413 414 dbSNP
rs188959203 424 dbSNP
rs902972973 425 dbSNP
rs1263831078 428 dbSNP
rs1360117051 438 dbSNP
rs941037404 449 dbSNP
rs1184676884 474 dbSNP
rs1215257614 490 dbSNP
rs1273593678 490 dbSNP
rs560509201 490 dbSNP
rs896936061 491 dbSNP
rs999928781 492 dbSNP
rs1272724873 496 dbSNP
rs1228302888 497 dbSNP
rs1315737529 497 dbSNP
rs1294147999 498 dbSNP
rs1003278129 507 dbSNP
rs757433782 518 dbSNP
rs1460166308 524 dbSNP
rs1056343060 530 dbSNP
rs894996573 531 dbSNP
rs1012065805 533 dbSNP
rs1167631334 547 dbSNP
rs1018834112 548 dbSNP
rs965874950 552 dbSNP
rs1215518580 554 dbSNP
rs546307171 555 dbSNP
rs1252649725 566 dbSNP
rs968337249 575 dbSNP
rs1000236470 576 dbSNP
rs1032087576 583 dbSNP
rs956171060 585 dbSNP
rs193256309 590 dbSNP
rs56845303 603 dbSNP
rs769205233 606 dbSNP
rs1306211230 612 dbSNP
rs954229875 612 dbSNP
rs1178471027 618 dbSNP
rs1198116758 620 dbSNP
rs1408618598 626 dbSNP
rs985551802 629 dbSNP
rs1370677300 649 dbSNP
rs769919261 650 dbSNP
rs1156594906 654 dbSNP
rs992380292 656 dbSNP
rs918204623 663 dbSNP
rs74736165 669 dbSNP
rs1460998158 682 dbSNP
rs941598215 686 dbSNP
rs1175399596 692 dbSNP
rs754958295 706 dbSNP
rs1452412451 712 dbSNP
rs571522957 714 dbSNP
rs1182192222 718 dbSNP
rs575320618 719 dbSNP
rs2594111 720 dbSNP
rs904005070 726 dbSNP
rs1486028467 727 dbSNP
rs938971803 741 dbSNP
rs1232738102 742 dbSNP
rs1347721073 752 dbSNP
rs1382371397 754 dbSNP
rs1450506859 774 dbSNP
rs561064654 790 dbSNP
rs1281415329 791 dbSNP
rs1337185364 802 dbSNP
rs1056246264 817 dbSNP
rs894857751 819 dbSNP
rs865979325 825 dbSNP
rs115243350 837 dbSNP
rs74707992 852 dbSNP
rs888785497 858 dbSNP
rs1007197987 859 dbSNP
rs565883589 862 dbSNP
rs1282517738 866 dbSNP
rs1326126970 869 dbSNP
rs1374707975 871 dbSNP
rs1018613278 880 dbSNP
rs1043943761 885 dbSNP
rs903809736 890 dbSNP
rs1362329908 894 dbSNP
rs140322920 911 dbSNP
rs999830017 911 dbSNP
rs79146308 917 dbSNP
rs1208734318 918 dbSNP
rs1485648884 919 dbSNP
rs1285510362 923 dbSNP
rs755568472 926 dbSNP
rs998117556 927 dbSNP
rs1029701828 935 dbSNP
rs373577461 948 dbSNP
rs1033736119 954 dbSNP
rs959443166 960 dbSNP
rs954092673 969 dbSNP
rs1318866765 976 dbSNP
rs1402274726 989 dbSNP
rs777283944 1006 dbSNP
rs1158781308 1007 dbSNP
rs1469505200 1013 dbSNP
rs1462166662 1015 dbSNP
rs555115911 1016 dbSNP
rs910036920 1018 dbSNP
rs758466345 1019 dbSNP
rs1474907940 1031 dbSNP
rs1243236495 1032 dbSNP
rs1431094782 1032 dbSNP
rs1195945671 1035 dbSNP
rs1480628550 1038 dbSNP
rs917901413 1039 dbSNP
rs1175494045 1041 dbSNP
rs184748745 1042 dbSNP
rs1274613514 1046 dbSNP
rs1413041781 1046 dbSNP
rs1230980683 1051 dbSNP
rs973410893 1054 dbSNP
rs1330913402 1076 dbSNP
rs1270772118 1083 dbSNP
rs918823048 1088 dbSNP
rs1355194603 1097 dbSNP
rs1442068364 1103 dbSNP
rs1278268200 1104 dbSNP
rs14826 1111 dbSNP
rs1441302241 1113 dbSNP
rs1347975916 1127 dbSNP
rs1163014913 1129 dbSNP
rs1404903996 1136 dbSNP
rs1224501144 1137 dbSNP
rs939001185 1142 dbSNP
rs1320899091 1144 dbSNP
rs539890126 1144 dbSNP
rs35680019 1151 dbSNP
rs978336987 1151 dbSNP
rs991791626 1153 dbSNP
rs925460547 1155 dbSNP
rs559708058 1164 dbSNP
rs1273114365 1171 dbSNP
rs1320654004 1171 dbSNP
rs1273048797 1174 dbSNP
rs1215773729 1181 dbSNP
rs1436745663 1187 dbSNP
rs1296750482 1190 dbSNP
rs1201886097 1197 dbSNP
rs1270921782 1199 dbSNP
rs1490512970 1200 dbSNP
rs1234801770 1206 dbSNP
rs1372898381 1208 dbSNP
rs947784993 1214 dbSNP
rs1436040767 1218 dbSNP
rs1355262934 1223 dbSNP
rs1198408162 1236 dbSNP
rs779191116 1249 dbSNP
rs189130320 1255 dbSNP
rs1408231463 1261 dbSNP
rs1054620169 1268 dbSNP
rs1174783841 1272 dbSNP
rs1426962418 1273 dbSNP
rs1455905521 1288 dbSNP
rs1477127176 1291 dbSNP
rs1487957861 1292 dbSNP
rs1169904584 1297 dbSNP
rs746201060 1300 dbSNP
rs1206067630 1305 dbSNP
rs1435534440 1307 dbSNP
rs1273914851 1319 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2850.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000304411.2 | 3UTR | ACUUUCUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000304411.2 | 3UTR | UUACUUUCUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000304411.2 | 3UTR | UUACUUUCUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000304411.2 | 3UTR | UUACUUUCUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000304411.2 | 3UTR | UUCCCGGUUUACUUUCUGCUGCUAAAAACCACG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
180 hsa-miR-4524a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055251 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT055826 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT060573 CCND1 cyclin D1 2 2
MIRT061013 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT064694 CCND2 cyclin D2 2 4
MIRT075268 SNTB2 syntrophin beta 2 2 4
MIRT079668 NAPG NSF attachment protein gamma 2 12
MIRT081651 CCNE1 cyclin E1 2 4
MIRT082996 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083463 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT085755 RIF1 replication timing regulatory factor 1 2 2
MIRT086022 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087431 ZNRF3 zinc and ring finger 3 2 2
MIRT088786 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT089221 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT093696 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT095090 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT096249 CANX calnexin 2 2
MIRT100215 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100746 VEGFA vascular endothelial growth factor A 2 12
MIRT100904 CD2AP CD2 associated protein 2 2
MIRT102647 UBN2 ubinuclein 2 2 10
MIRT103882 FOXK1 forkhead box K1 2 2
MIRT104246 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106310 ZFHX4 zinc finger homeobox 4 2 6
MIRT107696 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT114943 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117671 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT133799 SKI SKI proto-oncogene 2 2
MIRT140167 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142279 DCTN5 dynactin subunit 5 2 8
MIRT143288 N4BP1 NEDD4 binding protein 1 2 2
MIRT165939 CREBRF CREB3 regulatory factor 2 2
MIRT175251 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT186381 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT191470 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT196480 TAOK1 TAO kinase 1 2 2
MIRT201470 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204615 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204646 MOB4 MOB family member 4, phocein 2 8
MIRT204749 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206031 NUP50 nucleoporin 50 2 6
MIRT211196 FGF2 fibroblast growth factor 2 2 4
MIRT229353 ZNF449 zinc finger protein 449 2 2
MIRT247138 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT249461 ZNF691 zinc finger protein 691 2 4
MIRT256314 CDC42SE2 CDC42 small effector 2 2 2
MIRT258419 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265083 CHEK1 checkpoint kinase 1 2 2
MIRT270561 SETD1B SET domain containing 1B 2 2
MIRT274749 RAB3IP RAB3A interacting protein 2 2
MIRT277515 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT289642 CBX2 chromobox 2 2 2
MIRT301001 MTMR3 myotubularin related protein 3 2 2
MIRT307149 CTDSPL CTD small phosphatase like 2 4
MIRT309021 USP53 ubiquitin specific peptidase 53 2 2
MIRT314100 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT319338 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320619 ZNRF2 zinc and ring finger 2 2 2
MIRT324285 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT446498 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT448437 TLL1 tolloid like 1 2 2
MIRT461537 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463162 ZNF367 zinc finger protein 367 2 10
MIRT463493 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT465154 TSC22D2 TSC22 domain family member 2 2 2
MIRT466418 TFAP2A transcription factor AP-2 alpha 2 8
MIRT468278 SFT2D2 SFT2 domain containing 2 2 2
MIRT469399 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471941 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT473688 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT479618 CDC25A cell division cycle 25A 2 2
MIRT482098 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483995 ATAD5 ATPase family, AAA domain containing 5 2 12
MIRT485205 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT498763 C3orf38 chromosome 3 open reading frame 38 2 8
MIRT498961 ORC4 origin recognition complex subunit 4 2 8
MIRT499440 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500080 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500305 ZNF622 zinc finger protein 622 2 8
MIRT500410 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500789 TLK1 tousled like kinase 1 2 6
MIRT500930 SRPR SRP receptor alpha subunit 2 6
MIRT500943 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501068 SMAD7 SMAD family member 7 2 8
MIRT501711 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT502627 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502910 CDCA4 cell division cycle associated 4 2 8
MIRT502935 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504531 ZNF620 zinc finger protein 620 2 6
MIRT505106 YTHDC1 YTH domain containing 1 2 6
MIRT505337 TMEM245 transmembrane protein 245 2 6
MIRT505383 TMEM100 transmembrane protein 100 2 2
MIRT505678 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506157 PLAG1 PLAG1 zinc finger 2 8
MIRT506183 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506475 MYO5A myosin VA 2 6
MIRT506826 KIF23 kinesin family member 23 2 6
MIRT507160 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT507511 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT507845 CCNE2 cyclin E2 2 6
MIRT510403 ZNF507 zinc finger protein 507 2 2
MIRT518078 TRIM35 tripartite motif containing 35 2 2
MIRT518982 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521045 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521190 SBNO1 strawberry notch homolog 1 2 6
MIRT522088 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT524846 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT527787 TMEM44 transmembrane protein 44 2 4
MIRT537803 EFNB2 ephrin B2 2 4
MIRT540830 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541140 PISD phosphatidylserine decarboxylase 2 2
MIRT541419 CBX4 chromobox 4 2 2
MIRT543517 PRSS21 protease, serine 21 2 2
MIRT543824 GSG1 germ cell associated 1 2 2
MIRT544959 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545179 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545335 CCDC83 coiled-coil domain containing 83 2 2
MIRT545518 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT545670 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545931 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546102 USP48 ubiquitin specific peptidase 48 2 4
MIRT546598 SALL1 spalt like transcription factor 1 2 4
MIRT546626 RTN4 reticulon 4 2 2
MIRT547651 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547987 HCFC2 host cell factor C2 2 4
MIRT548717 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548931 CDK17 cyclin dependent kinase 17 2 2
MIRT549067 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549266 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550460 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550806 FAM229B family with sequence similarity 229 member B 2 2
MIRT552024 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552334 ZNF704 zinc finger protein 704 2 2
MIRT552732 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553795 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554694 RNF149 ring finger protein 149 2 2
MIRT555133 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555264 PRDM4 PR/SET domain 4 2 2
MIRT556848 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557474 GPR27 G protein-coupled receptor 27 2 4
MIRT558018 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558498 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558579 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558610 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT558650 CNKSR3 CNKSR family member 3 2 2
MIRT558986 CA8 carbonic anhydrase 8 2 2
MIRT559141 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559327 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT562021 LANCL1 LanC like 1 2 2
MIRT562869 KIAA1456 KIAA1456 2 2
MIRT563074 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563496 DLGAP3 DLG associated protein 3 2 2
MIRT563890 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564311 CCNT1 cyclin T1 2 2
MIRT564942 XKR7 XK related 7 2 2
MIRT564979 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565423 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566824 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571961 KIF5B kinesin family member 5B 2 2
MIRT575877 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT576523 Txlna taxilin alpha 2 2
MIRT614693 TRAK1 trafficking kinesin protein 1 2 2
MIRT616065 ZC3H14 zinc finger CCCH-type containing 14 2 2
MIRT618838 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT624626 ATXN2 ataxin 2 2 2
MIRT624652 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT640314 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT659248 CUL3 cullin 3 2 2
MIRT680972 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682261 RS1 retinoschisin 1 2 2
MIRT682505 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693904 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT699214 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT699373 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699451 SLC16A9 solute carrier family 16 member 9 2 2
MIRT701230 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702849 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT706163 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT718990 UTP15 UTP15, small subunit processome component 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4524a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4524a-5p Cetuximab resistant tissue (colorectal carcinoma)

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