miRTarBase - #MIRT557697


—
pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GATA6   
Synonyms -
Description GATA binding protein 6
Transcript NM_005257   
Expression
Putative miRNA Targets on GATA6
3'UTR of GATA6
(miRNA target sites are highlighted)		 
>GATA6|NM_005257|3'UTR
   1 GCCCACGCCGCCAGGAGGCAGGGAGGGCTCCGCCGCGGGCCTCACTCCACTCGTGTCTGCTTTTGTGCAGCGGTCCAGAC
  81 AGTGGCGACTGCGCTGACAGAACGTGATTCTCGTGCCTTTATTTTGAAAGAGATGTTTTTCCCAAGAGGCTTGCTGAAAG
 161 AGTGAGAGAAGATGGAAGGGAAGGGCCAGTGCAACTGGGCGCTTGGGCCACTCCAGCCAGCCCGCCTCCGGGGCGGACCC
 241 TGCTCCACTTCCAGAAGCCAGGACTAGGACCTGGGCCTTGCCTGCTATGGAATATTGAGAGAGATTTTTTAAAAAAGATT
 321 TTGCATTTTGTCCAAAATCATGTGCTTCTTCTGATCAATTTTGGTTGTTCCAGAATTTCTTCATACCTTTTCCACATCCA
 401 GATTTCATGTGCGTTCATGGAGAAGATCACTTGAGGCCATTTGGTACACATCTCTGGAGGCTGAGTCGGTTCATGAGGTC
 481 TCTTATCAAAAATATTACTCAGTTTGCAAGACTGCATTGTAACTTTAACATACACTGTGACTGACGTTTCTCAAAGTTCA
 561 TATTGTGTGGCTGATCTGAAGTCAGTCGGAATTTGTAAACAGGGTAGCAAACAAGATATTTTTCTTCCATGTATACAATA
 641 ATTTTTTTAAAAAGTGCAATTTGCGTTGCAGCAATCAGTGTTAAATCATTTGCATAAGATTTAACAGCATTTTTTATAAT
 721 GAATGTAAACATTTTAACTTAATGGTACTTAAAATAATTTAAAAGAAAAATGTTAACTTAGACATTCTTATGCTTCTTTT
 801 ACAACTACATCCCATTTTATATTTCCAATTGTTAAAGAAAAATATTTCAAGAACAAATCTTCTCTCAGGAAAATTGCCTT
 881 TCTCTATTTGTTAAGAATTTTTATACAAGAACACCAATATACCCCCTTTATTTTACTGTGGAATATGTGCTGGAAAAATT
 961 GCAACAACACTTTACTACCTAACGGATAGCATTTGTAAATACTCTAGGTATCTGTAAACACTCTGATGAAGTCTGTATAG
1041 TGTGACTAACCCACAGGCAGGTTGGTTTACATTAATTTTTTTTTTTGAATGGGATGTCCTATGGAAACCTATTTCACCAG
1121 AGTTTTAAAAATAAAAAGGGTATTGTTTTGTCTTCTGTACAGTGAGTTCCTTCCCTTTTCAAAGCTTTCTTTTTATGCTG
1201 TATGTGACTATAGATATTCATATAAAACAAGTGCACGTGAAGTTTGCAAAATGCTTTAAGGCCTTCCTTTCAAAGCATAG
1281 TCCTTTTGGAGCCGTTTTGTACCTTTTATACCTTGGCTTATTTGAAGTTGACACATGGGGTTAGTTACTACTCTCCATGT
1361 GCATTGGGGACAGTTTTTATAAGTGGGAAGGACTCAGTATTATTATATTTGAGATGATAAGCATTTTGTTTGGGAACAAT
1441 GCTTAAAAATATTCCAGAAAGTTCAGATTTTTTTTCTTTGTGAATGAAATATATTCTGGCCCACGAACAGGGCGATTTCC
1521 TTTCAGTTTTTTCCTTTTGCAACGTGCCTTGAAGTCTCAAAGCTCACCTGAGGTTGCAGACGTTACCCCCAACAGAAGAT
1601 AGGTAGAAATGATTCCAGTGGCCTCTTTGTATTTTCTTCATTGTTGAGTAGATTTCAGGAAATCAGGAGGTGTTTCACAA
1681 TACAGAATGATGGCCTTTAACTGTGAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaucggaGGUACUU----AAGACUAc 5'
                 :|||| :    ||||||| 
Target 5' tccaaaaTCATGTGCTTCTTCTGATc 3'
 331 - 356 145.00 -9.10
2 
miRNA  3' gaUCGGAGGUACU--UAAGACUAc 5'
            :|: ||::| |  | |||||| 
Target 5' taGGTATCTGTAAACACTCTGATg 3'
 1005 - 1028 126.00 -10.90
3 
miRNA  3' gaucgGAGGUACUU--AAGACUAc 5'
               :|||| |||  ||| ||| 
Target 5' aaataTTCCA-GAAAGTTCAGATt 3'
 1447 - 1469 126.00 -8.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1186597 42 ClinVar
COSN30449684 9 COSMIC
COSN13761755 10 COSMIC
COSN13761756 11 COSMIC
COSN31512276 11 COSMIC
COSN30103372 12 COSMIC
COSN30103364 13 COSMIC
COSN17165566 23 COSMIC
COSN30180873 28 COSMIC
COSN28855151 32 COSMIC
COSN30104444 37 COSMIC
COSN31504245 39 COSMIC
COSN17078437 58 COSMIC
COSN18741505 73 COSMIC
COSN18741506 78 COSMIC
COSN31588476 87 COSMIC
COSN31534661 93 COSMIC
COSN31555931 97 COSMIC
COSN31557786 114 COSMIC
COSN22628911 127 COSMIC
COSN31514053 133 COSMIC
COSN31545572 238 COSMIC
COSN30542508 271 COSMIC
COSN31541044 272 COSMIC
COSN30172286 553 COSMIC
COSN31572193 589 COSMIC
COSN4771243 649 COSMIC
COSN28777904 650 COSMIC
COSN8604419 699 COSMIC
COSN27906589 749 COSMIC
COSN31548481 755 COSMIC
COSN31577613 875 COSMIC
COSN31517510 896 COSMIC
COSN26565808 962 COSMIC
COSN32062813 999 COSMIC
COSN17076458 1003 COSMIC
COSN28986646 1087 COSMIC
COSN29008534 1087 COSMIC
COSN7460995 1107 COSMIC
COSN21098403 1306 COSMIC
COSN23526802 1338 COSMIC
COSN6549783 1449 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776725091 3 dbSNP
rs867525939 4 dbSNP
rs1198887969 7 dbSNP
rs759379761 8 dbSNP
rs1459688319 11 dbSNP
rs764841744 16 dbSNP
rs752123736 23 dbSNP
rs990219292 24 dbSNP
rs553826721 27 dbSNP
rs551874745 30 dbSNP
rs1422689550 32 dbSNP
rs1168792572 36 dbSNP
rs763766695 37 dbSNP
rs751142370 40 dbSNP
rs1427549089 41 dbSNP
rs115585611 42 dbSNP
rs1303548369 45 dbSNP
rs1404384125 46 dbSNP
rs1381055999 47 dbSNP
rs1298055020 48 dbSNP
rs781520905 50 dbSNP
rs746451159 53 dbSNP
rs538967383 56 dbSNP
rs978000495 60 dbSNP
rs1256634518 61 dbSNP
rs767451992 62 dbSNP
rs1941084 73 dbSNP
rs1484049523 76 dbSNP
rs1941083 78 dbSNP
rs369787804 84 dbSNP
rs910484250 85 dbSNP
rs1337675212 86 dbSNP
rs1306488968 91 dbSNP
rs1267519298 94 dbSNP
rs193273091 99 dbSNP
rs944593725 102 dbSNP
rs1355235789 104 dbSNP
rs868348062 105 dbSNP
rs991826166 113 dbSNP
rs1308087487 129 dbSNP
rs1283704140 131 dbSNP
rs554623543 135 dbSNP
rs1393872927 139 dbSNP
rs916272117 141 dbSNP
rs947719964 144 dbSNP
rs1040188389 149 dbSNP
rs1048813271 159 dbSNP
rs897658017 161 dbSNP
rs574625456 162 dbSNP
rs940493870 162 dbSNP
rs1181161263 163 dbSNP
rs1436222080 165 dbSNP
rs1048788648 169 dbSNP
rs887462596 170 dbSNP
rs758354146 171 dbSNP
rs1341718391 174 dbSNP
rs1204187877 183 dbSNP
rs564477642 202 dbSNP
rs1271624116 204 dbSNP
rs1230674304 205 dbSNP
rs1330410354 217 dbSNP
rs1050369331 220 dbSNP
rs1440746401 223 dbSNP
rs745903281 224 dbSNP
rs76974536 230 dbSNP
rs1387026409 236 dbSNP
rs1393329219 237 dbSNP
rs1003086938 238 dbSNP
rs1011547307 240 dbSNP
rs1032296269 243 dbSNP
rs1021632376 245 dbSNP
rs967869225 249 dbSNP
rs1236806941 250 dbSNP
rs1199720674 258 dbSNP
rs1471555708 263 dbSNP
rs1468184254 273 dbSNP
rs1251431748 283 dbSNP
rs576236856 284 dbSNP
rs1183088010 287 dbSNP
rs999025294 291 dbSNP
rs1036296999 296 dbSNP
rs1385477325 297 dbSNP
rs956219984 311 dbSNP
rs1276077482 325 dbSNP
rs185025662 326 dbSNP
rs9965366 327 dbSNP
rs1410852146 330 dbSNP
rs1323561195 334 dbSNP
rs1436931587 341 dbSNP
rs954100957 342 dbSNP
rs1357914781 343 dbSNP
rs545102362 345 dbSNP
rs756428094 348 dbSNP
rs1364756685 349 dbSNP
rs985435709 371 dbSNP
rs1393426567 374 dbSNP
rs912526712 379 dbSNP
rs1465589958 380 dbSNP
rs944667346 387 dbSNP
rs1214144086 397 dbSNP
rs780463246 401 dbSNP
rs908957782 402 dbSNP
rs1210977520 406 dbSNP
rs1346530202 408 dbSNP
rs919111119 409 dbSNP
rs749498961 412 dbSNP
rs1362268822 413 dbSNP
rs940471750 421 dbSNP
rs1428448601 431 dbSNP
rs527490115 431 dbSNP
rs1049344206 446 dbSNP
rs887546448 462 dbSNP
rs1313411562 469 dbSNP
rs1012637427 483 dbSNP
rs576673668 483 dbSNP
rs1044086995 492 dbSNP
rs1373731455 503 dbSNP
rs1170674740 506 dbSNP
rs1450292228 511 dbSNP
rs1419138760 516 dbSNP
rs1211634472 525 dbSNP
rs923122549 531 dbSNP
rs1474018458 532 dbSNP
rs1238493036 533 dbSNP
rs1187887950 537 dbSNP
rs140220180 563 dbSNP
rs1464184466 575 dbSNP
rs560932418 579 dbSNP
rs1307701142 583 dbSNP
rs1271927862 588 dbSNP
rs1050276876 589 dbSNP
rs1381087953 599 dbSNP
rs766917077 600 dbSNP
rs1414125792 603 dbSNP
rs529838347 608 dbSNP
rs1391610075 613 dbSNP
rs1475980382 615 dbSNP
rs889040700 616 dbSNP
rs372507351 617 dbSNP
rs1172355538 618 dbSNP
rs145348592 627 dbSNP
rs1416602259 628 dbSNP
rs1011493645 632 dbSNP
rs1419064496 636 dbSNP
rs549751610 639 dbSNP
rs956466280 641 dbSNP
rs1474497500 642 dbSNP
rs1254660850 644 dbSNP
rs1480675269 649 dbSNP
rs569560409 649 dbSNP
rs1022179266 656 dbSNP
rs1202032169 665 dbSNP
rs1337500423 666 dbSNP
rs1323244828 669 dbSNP
rs377023636 670 dbSNP
rs1273548566 695 dbSNP
rs1387951925 700 dbSNP
rs1391973798 710 dbSNP
rs1432954663 710 dbSNP
rs1372719336 718 dbSNP
rs954133516 725 dbSNP
rs1438920701 732 dbSNP
rs903253621 733 dbSNP
rs1327243564 737 dbSNP
rs1460265063 742 dbSNP
rs1227887059 743 dbSNP
rs1414745858 777 dbSNP
rs1160483583 792 dbSNP
rs1419099135 793 dbSNP
rs1406646879 795 dbSNP
rs544084882 807 dbSNP
rs538671890 809 dbSNP
rs985509280 810 dbSNP
rs1342812049 822 dbSNP
rs1225222653 827 dbSNP
rs1469516206 827 dbSNP
rs1263645896 829 dbSNP
rs1212835062 850 dbSNP
rs562192054 854 dbSNP
rs530271242 858 dbSNP
rs754341327 867 dbSNP
rs769199634 873 dbSNP
rs552594645 875 dbSNP
rs1304927170 887 dbSNP
rs1447151842 890 dbSNP
rs566392100 904 dbSNP
rs1221068120 917 dbSNP
rs960454516 920 dbSNP
rs1325479977 922 dbSNP
rs1439086409 923 dbSNP
rs1013096791 924 dbSNP
rs1289921096 925 dbSNP
rs1198617802 927 dbSNP
rs1362617086 927 dbSNP
rs1245300845 944 dbSNP
rs1156298389 952 dbSNP
rs1479310031 953 dbSNP
rs1455247582 954 dbSNP
rs1395242694 955 dbSNP
rs1177842234 956 dbSNP
rs1411852091 962 dbSNP
rs1023181030 968 dbSNP
rs1263627704 970 dbSNP
rs879151830 971 dbSNP
rs137914072 972 dbSNP
rs976425934 984 dbSNP
rs554756242 985 dbSNP
rs1485492960 998 dbSNP
rs919197380 999 dbSNP
rs1258957305 1000 dbSNP
rs984446245 1004 dbSNP
rs929183591 1007 dbSNP
rs1348700805 1009 dbSNP
rs908901277 1015 dbSNP
rs984647804 1017 dbSNP
rs369346950 1019 dbSNP
rs1386378155 1021 dbSNP
rs1367669781 1024 dbSNP
rs909005527 1028 dbSNP
rs948490286 1032 dbSNP
rs1382073255 1033 dbSNP
rs111636900 1038 dbSNP
rs961804416 1039 dbSNP
rs1435981158 1044 dbSNP
rs574562576 1048 dbSNP
rs906891704 1066 dbSNP
rs1432449885 1067 dbSNP
rs933121420 1071 dbSNP
rs1427703725 1076 dbSNP
rs910467998 1076 dbSNP
rs985928996 1076 dbSNP
rs1190005896 1080 dbSNP
rs938346416 1093 dbSNP
rs1279661952 1099 dbSNP
rs1053171029 1100 dbSNP
rs1341719425 1105 dbSNP
rs892053766 1109 dbSNP
rs1283915131 1110 dbSNP
rs1328388869 1118 dbSNP
rs1226044827 1121 dbSNP
rs1227067355 1122 dbSNP
rs1043019891 1123 dbSNP
rs529486891 1132 dbSNP
rs1350977640 1141 dbSNP
rs753444314 1152 dbSNP
rs903159514 1155 dbSNP
rs1311727351 1157 dbSNP
rs1398099861 1159 dbSNP
rs1168146743 1160 dbSNP
rs1461250490 1161 dbSNP
rs1012201467 1172 dbSNP
rs1166869999 1174 dbSNP
rs113511738 1176 dbSNP
rs1256734794 1178 dbSNP
rs1185811196 1185 dbSNP
rs1021832358 1189 dbSNP
rs537149276 1199 dbSNP
rs188999183 1201 dbSNP
rs181762297 1202 dbSNP
rs1337816134 1224 dbSNP
rs141065612 1226 dbSNP
rs774770753 1237 dbSNP
rs1013086138 1238 dbSNP
rs1364414851 1268 dbSNP
rs866561565 1283 dbSNP
rs1457442280 1285 dbSNP
rs1161727148 1289 dbSNP
rs111924382 1294 dbSNP
rs1329084419 1295 dbSNP
rs1390423605 1298 dbSNP
rs184146092 1302 dbSNP
rs1393909045 1309 dbSNP
rs1327601617 1313 dbSNP
rs1426389395 1318 dbSNP
rs748604440 1322 dbSNP
rs546224217 1328 dbSNP
rs888689336 1336 dbSNP
rs1349811646 1337 dbSNP
rs1407871331 1338 dbSNP
rs1308558557 1339 dbSNP
rs1335877095 1351 dbSNP
rs985111567 1361 dbSNP
rs1468367467 1364 dbSNP
rs1005831454 1365 dbSNP
rs1015868338 1375 dbSNP
rs1243407903 1380 dbSNP
rs1282133710 1383 dbSNP
rs1237721986 1392 dbSNP
rs961988097 1393 dbSNP
rs1305261275 1398 dbSNP
rs1441348673 1399 dbSNP
rs971765110 1406 dbSNP
rs1409453666 1408 dbSNP
rs1030455899 1416 dbSNP
rs1385605480 1419 dbSNP
rs909080552 1422 dbSNP
rs1468667356 1427 dbSNP
rs772569691 1434 dbSNP
rs565010940 1440 dbSNP
rs1194560628 1442 dbSNP
rs1198121569 1450 dbSNP
rs928381622 1461 dbSNP
rs1251482749 1462 dbSNP
rs572322336 1467 dbSNP
rs1218414061 1468 dbSNP
rs1448023982 1468 dbSNP
rs577304993 1469 dbSNP
rs954501894 1471 dbSNP
rs772615848 1472 dbSNP
rs1350938372 1477 dbSNP
rs1305144247 1489 dbSNP
rs561067070 1490 dbSNP
rs1369826694 1492 dbSNP
rs1272805943 1500 dbSNP
rs760188112 1505 dbSNP
rs1185503892 1506 dbSNP
rs1326880417 1510 dbSNP
rs188721277 1514 dbSNP
rs891451246 1515 dbSNP
rs979057024 1519 dbSNP
rs1164004863 1526 dbSNP
rs924559185 1527 dbSNP
rs1313779783 1544 dbSNP
rs947694780 1545 dbSNP
rs1191728439 1548 dbSNP
rs1487003573 1554 dbSNP
rs1281792276 1555 dbSNP
rs1057171227 1557 dbSNP
rs1346628702 1559 dbSNP
rs1276069180 1563 dbSNP
rs1216099949 1566 dbSNP
rs35257471 1567 dbSNP
rs868390220 1574 dbSNP
rs111786565 1582 dbSNP
rs889978985 1583 dbSNP
rs1398030759 1590 dbSNP
rs1309885122 1594 dbSNP
rs776318710 1596 dbSNP
rs1019714265 1599 dbSNP
rs1357641034 1601 dbSNP
rs1172881369 1603 dbSNP
rs138957832 1606 dbSNP
rs1419298638 1613 dbSNP
rs80191140 1626 dbSNP
rs1025684330 1627 dbSNP
rs952814798 1631 dbSNP
rs759178126 1632 dbSNP
rs1258839901 1636 dbSNP
rs1187962013 1642 dbSNP
rs1230051589 1643 dbSNP
rs180688081 1644 dbSNP
rs1483172632 1645 dbSNP
rs1005739851 1646 dbSNP
rs1016229106 1647 dbSNP
rs1271967213 1647 dbSNP
rs1216585119 1650 dbSNP
rs1244994482 1664 dbSNP
rs1336776456 1665 dbSNP
rs969933036 1670 dbSNP
rs186176517 1671 dbSNP
rs1377132539 1672 dbSNP
rs1030034089 1673 dbSNP
rs928412791 1678 dbSNP
rs566206652 1680 dbSNP
rs1388532040 1685 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2627.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaucggaGGUACUU----AAGACuac 5'
                 :|||| :    |||||   
Target 5' uccaaaaUCAUGUGCUUCUUCUG--- 3'
 		14 - 36
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000269216.3 | 3UTR | AUUUUGCAUUUUGUCCAAAAUCAUGUGCUUCUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.628 0.01 -0.607 0.01 15 Click to see details
LIHC -0.825 0.09 -0.400 0.3 4 Click to see details
HNSC -0.279 0.17 -0.200 0.25 14 Click to see details
UCEC -0.627 0.28 -0.500 0.33 3 Click to see details
STAD -0.461 0.35 -0.500 0.33 3 Click to see details
BRCA 0.048 0.4 0.062 0.37 31 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
BLCA -0.117 0.41 -0.029 0.48 6 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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