pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BLMH   
Synonyms BH, BMH
Description bleomycin hydrolase
Transcript NM_000386   
Expression
Putative miRNA Targets on BLMH
3'UTR of BLMH
(miRNA target sites are highlighted)
>BLMH|NM_000386|3'UTR
   1 TACTGCCCTCCAGCTCTTTCCTCCTTCCATGGAACCTGACGTAGCTGCAAAGGACAGATCCAGGGACTGAAGCCAAAGTT
  81 ATGCAAGGGACTGTGTGTTGCCACAGGACACAGTCAGATTTCCAGTCTCCACCAGGAACCTCTTCAGAAAGTGTGCTTTA
 161 TGCTGAAACAGAATACTGTTAAAGGAAAAAAAAGAGGGGGGAAGATCAGGTCATACTATCTACTCTCCTCATCTCTAACA
 241 GCTCAGGATCTCTTAGCATTTTAATTAGATGTAATTGTTTGTCTTTAACTGTCAAAAAGTTTGGTTCTGTGTCTGTGTTT
 321 TAATAAGACGAGAGGACGAGCGATTGAGGTGTATGGAGAGAAAACAGACCTAATGCTCCTTGTTCCTAGAGTAGAGTGGA
 401 GGGAGGGTGGCCTAAGAGTTGAGCTCTCGGAACTGCATGCTGCTGGACAGTATCACTGTCTTTCCTAGATGGCAGTCACT
 481 GAATTCCATTTTTTCAAGGTAATTTCTTGTGCCTCTAATAGCCCAAGAATGGGAGGTTGATCAGATCTGACATGATTCCT
 561 TCCTGTTCTGAACTGTGGGGTGTGCACATCTCTGCTTGAGTCAGGTTTGAGTAGAGGCTTAGAGACAGTTGGGTGAGAAC
 641 AACCAAAATCTTATCATGGTCTCAGTCATAATCATTAGGGGGAACTCTAGCCAAATGGTTTAACTTCTGCCTGTGGAACT
 721 GGGGATTGGGTGGGCAGGAAAAGGTGATATCCATTCTTTCTGATAACTAGATGGTGCTGAGAAGCTTTTGAATAAAAACT
 801 TTGCTAAATGAGAATAAGCTGAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucggAGGUACUUAAGACUAc 5'
                |||||   ||||||| 
Target 5' gtgataTCCATTCTTTCTGATa 3'
744 - 765 156.00 -11.50
2
miRNA  3' gaucGGAGGUACUUAAGACUac 5'
              |||:| ||  ||||||  
Target 5' gattCCTTCCTG--TTCTGAac 3'
554 - 573 138.00 -11.50
3
miRNA  3' gaucggaGGUACUU--AAGACUac 5'
                 |:: |||  ||:|||  
Target 5' gatggtgCTGAGAAGCTTTTGAat 3'
770 - 793 113.00 -5.21
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26508667 10 COSMIC
COSN30513188 10 COSMIC
COSN6101531 13 COSMIC
COSN30454373 23 COSMIC
COSN31489056 23 COSMIC
COSN30101656 32 COSMIC
COSN21486731 41 COSMIC
COSN18741222 46 COSMIC
COSN30179416 49 COSMIC
COSN26967892 52 COSMIC
COSN30179455 60 COSMIC
COSN31508965 67 COSMIC
COSN31491932 68 COSMIC
COSN31574967 76 COSMIC
COSN18741221 159 COSMIC
COSN18740090 186 COSMIC
COSN22835223 304 COSMIC
COSN31568618 378 COSMIC
COSN31543864 423 COSMIC
COSN26557173 433 COSMIC
COSN26506141 464 COSMIC
COSN20113767 580 COSMIC
COSN7163468 722 COSMIC
COSN1716312 734 COSMIC
COSN31577605 786 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs931439401 1 dbSNP
rs766236646 2 dbSNP
rs1366036785 3 dbSNP
rs1328731439 8 dbSNP
rs369356508 10 dbSNP
rs756057721 11 dbSNP
rs376678281 13 dbSNP
rs541524896 15 dbSNP
rs1294471220 16 dbSNP
rs761422697 21 dbSNP
rs1348941309 29 dbSNP
rs773850136 35 dbSNP
rs189092759 40 dbSNP
rs368324730 41 dbSNP
rs867494709 44 dbSNP
rs1218808249 49 dbSNP
rs1039519281 59 dbSNP
rs942627818 64 dbSNP
rs1234975001 72 dbSNP
rs915608702 77 dbSNP
rs1399700886 80 dbSNP
rs1206046861 82 dbSNP
rs1232884273 86 dbSNP
rs998272726 89 dbSNP
rs992886743 91 dbSNP
rs1382333526 101 dbSNP
rs1174039784 104 dbSNP
rs986434787 109 dbSNP
rs1174875997 112 dbSNP
rs1390128787 113 dbSNP
rs1408674220 113 dbSNP
rs59446067 119 dbSNP
rs184629086 127 dbSNP
rs951092364 129 dbSNP
rs3190884 130 dbSNP
rs558853710 134 dbSNP
rs1031356068 144 dbSNP
rs768828157 162 dbSNP
rs3190885 172 dbSNP
rs3190887 175 dbSNP
rs3190888 181 dbSNP
rs3190889 182 dbSNP
rs3190890 185 dbSNP
rs3190891 187 dbSNP
rs1024242693 194 dbSNP
rs1441393191 194 dbSNP
rs1012387288 196 dbSNP
rs1216199410 196 dbSNP
rs1451909929 197 dbSNP
rs960955718 197 dbSNP
rs1035230995 200 dbSNP
rs1243004659 202 dbSNP
rs1468607327 207 dbSNP
rs747256106 209 dbSNP
rs1247726947 213 dbSNP
rs902549192 216 dbSNP
rs1043718462 218 dbSNP
rs191353216 225 dbSNP
rs775298332 226 dbSNP
rs1445424490 237 dbSNP
rs572997601 241 dbSNP
rs1420361860 244 dbSNP
rs1404813442 250 dbSNP
rs771768459 253 dbSNP
rs1021413663 269 dbSNP
rs1211935256 270 dbSNP
rs1347215066 283 dbSNP
rs1278334342 285 dbSNP
rs1231930765 295 dbSNP
rs900558689 297 dbSNP
rs187648374 305 dbSNP
rs996807702 309 dbSNP
rs745747679 314 dbSNP
rs1270489754 321 dbSNP
rs1429766493 323 dbSNP
rs1039953500 329 dbSNP
rs1207694316 330 dbSNP
rs1267966052 330 dbSNP
rs942511255 332 dbSNP
rs1041074184 335 dbSNP
rs536758876 337 dbSNP
rs563396961 338 dbSNP
rs141376601 340 dbSNP
rs778706323 341 dbSNP
rs929883988 342 dbSNP
rs918276807 353 dbSNP
rs757316321 354 dbSNP
rs1420851377 359 dbSNP
rs1382563806 367 dbSNP
rs1402211841 376 dbSNP
rs1318674320 404 dbSNP
rs973741213 405 dbSNP
rs868529344 406 dbSNP
rs1474622340 408 dbSNP
rs962790897 409 dbSNP
rs916298962 421 dbSNP
rs1314194887 426 dbSNP
rs533032846 428 dbSNP
rs541591373 437 dbSNP
rs1277382405 450 dbSNP
rs1352326843 460 dbSNP
rs571540016 476 dbSNP
rs138913009 483 dbSNP
rs1255418994 487 dbSNP
rs1035178446 488 dbSNP
rs1442361308 489 dbSNP
rs1209336493 493 dbSNP
rs1259783109 497 dbSNP
rs999806661 501 dbSNP
rs1181790447 506 dbSNP
rs1308224691 511 dbSNP
rs948354470 512 dbSNP
rs918140563 513 dbSNP
rs1471260216 519 dbSNP
rs992520715 521 dbSNP
rs1424139051 530 dbSNP
rs1432855931 531 dbSNP
rs545349096 544 dbSNP
rs183236751 552 dbSNP
rs924368935 553 dbSNP
rs1408708708 557 dbSNP
rs528729337 565 dbSNP
rs1442407379 571 dbSNP
rs1294940994 577 dbSNP
rs968433907 580 dbSNP
rs77151652 581 dbSNP
rs10556098 582 dbSNP
rs567538949 582 dbSNP
rs1349169369 585 dbSNP
rs201658968 585 dbSNP
rs3830317 585 dbSNP
rs1021485416 588 dbSNP
rs199786493 589 dbSNP
rs1439794248 595 dbSNP
rs1310467714 598 dbSNP
rs1443731105 600 dbSNP
rs1452314719 603 dbSNP
rs1175224377 614 dbSNP
rs929914949 616 dbSNP
rs975631177 631 dbSNP
rs1165664399 651 dbSNP
rs1354668815 654 dbSNP
rs549140504 656 dbSNP
rs1170330383 659 dbSNP
rs879867298 661 dbSNP
rs1370788777 668 dbSNP
rs1416357524 676 dbSNP
rs1166121316 685 dbSNP
rs1439188429 686 dbSNP
rs1474965254 691 dbSNP
rs752407378 694 dbSNP
rs1019920065 695 dbSNP
rs1227267486 699 dbSNP
rs1038452315 704 dbSNP
rs1184684749 713 dbSNP
rs1341519855 719 dbSNP
rs1008235334 725 dbSNP
rs887067640 750 dbSNP
rs1232417826 752 dbSNP
rs1025646681 753 dbSNP
rs1467276464 756 dbSNP
rs916230210 765 dbSNP
rs530988945 767 dbSNP
rs75153554 772 dbSNP
rs1274748612 773 dbSNP
rs1448849719 775 dbSNP
rs879444721 778 dbSNP
rs1190930507 785 dbSNP
rs1233675521 802 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 642.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaucggAGGUACUUAAGACUAc 5'
                |||||   ||||||| 
Target 5' --gauaUCCAUUCUUUCUGAUa 3'
1 - 20
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000261714.6 | 3UTR | GAUAUCCAUUCUUUCUGAUAACUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.706 0 0.824 0 14 Click to see details
BRCA -0.394 0.01 -0.252 0.09 31 Click to see details
LUSC 0.357 0.1 0.571 0.01 15 Click to see details
UCEC -0.914 0.13 -1.000 0.5 3 Click to see details
LIHC 0.665 0.17 0.400 0.3 4 Click to see details
STAD 0.849 0.18 1.000 0.5 3 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
BLCA -0.119 0.41 0.200 0.35 6 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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