miRTarBase - #MIRT559437


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pre-miRNA Information
pre-miRNA hsa-mir-628   
Genomic Coordinates chr15: 55372940 - 55373034
Synonyms MIRN628, hsa-mir-628, MIR628
Description Homo sapiens miR-628 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-628-3p
Sequence 61| UCUAGUAAGAGUGGCAGUCGA |81
Evidence Experimental
Experiments Microarray
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 7 15 - 55372968 29233923 MiREDiBase
A-to-I 8 15 - 55372967 29233923 MiREDiBase
C-to-U 19 15 - 55372956 20591823 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26969715 1 COSMIC
COSN30123186 10 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1410255602 2 dbSNP
rs1401315366 3 dbSNP
rs1322836365 4 dbSNP
rs1158103480 8 dbSNP
rs1216611749 11 dbSNP
rs749619551 13 dbSNP
rs778157225 18 dbSNP
rs756600789 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARSJ   
Synonyms ASJ
Description arylsulfatase family member J
Transcript NM_024590   
Expression
Putative miRNA Targets on ARSJ
3'UTR of ARSJ
(miRNA target sites are highlighted)		 
>ARSJ|NM_024590|3'UTR
   1 GCACAAATATTTCCTGTTTGGTTAAACTTTAATCAGTTCTTATCTTTCATCTGTTTCCTAGGTAAACCAGCAAATTTGGC
  81 TCGATAATATCGCTGGCCTAAGCGTCAGGCTTGTTTTCATGCTGTGCCACTCCAGAGACTTCTGCCACCTGGCCGCCACA
 161 CTGAAAACTGTCCTGCTCAGTGCCAAGGTGCTACTCTTGCAAGCCACACTTAGAGAGAGTGGAGATGTTTATTTCTCTTG
 241 CTCCTTTAGAAAACGTGGTGAGTCCTGAGTTCCACTGCTGTGCTTCAGTCAACTGACCAAACACTGCTTTGAATTATAGG
 321 AGGAGAACAATAACCTACCATCCGCAAGCATGCTAATTTGATGGAAGTTACAGGGTATACCATCCGCAAGCATGCTAATT
 401 TGATGGAAGTTACAGGGTAGCATGATTAAAACTACCTTTGATAAATTACAGTCAAAGATTGTGTCACCTCAAAGGCCTTG
 481 AAGAATATATTTTCTTGGTGAATTTTTGTATGTCTGTCATATGACACTTGGGTTTTTTAATTAATTCTATTTTATATATA
 561 TATATATGTTTCTTTTCCTGTGAAAAGCTGTTTTTCTCACATGTGAACAGCTTGCACCTCATTTTACCATGCGTGAGGGA
 641 ATGGCAAATAAGAATGTTTGAGCACACTGCCCACAATGAATGTAACTATTTTCTAAACACTTTACTAGAAGAACATTTCA
 721 GTATAAAAAACCTAATTTATTTTTACAGAAAAATATTTTGTTGTTTTTATAAAAAGTTATGCAAATGACTTTATTTTATT
 801 TTTATTTCCTGCATACCATTAGAATAATTTTATTTCATTTCTTCAAATTACCAAGCACTGTAATACTATAAATTAATGTA
 881 ATACTGTGTGAATTCAGACTATAAAAAACATCATTCAGAAAACTTTATAATCGTCATTGTTCAACCAAGATTTTGAATGT
 961 AATAAGATGAATATATTCCTTACAAATTACTTGGAAATTCAATGTTTGTGCAGAGTTGAGACAACTTTATTGTTTCTATC
1041 ATAAACTATTTATGTATCTTAATTATTAAAATGATTTACTTTATGGCACTAGAAAATTTACTGTGGCTTTTCTGATCTAA
1121 CTTCTAGCTAAAATTGTATCATTGGTCCTAAAAAATAAAAATCTTTACTAATAGGCAATTGAAGGAATGGTTTGCTAACA
1201 ACCACAGTAATATAATATGATTTTACAGATAGATGCTTCCCCTTGGCTATGACATGGAGAAAGATTTTCCCATAATAATA
1281 ACTAACATTTATATTAGGTTGGTGCAAAACTAGTTGCGGTTTTTCCCATTAAAAGTAATAAACTTACTCTTATACAAAGT
1361 GGACACTGTGGGGAGATACAGAGAAATGGAAGATACGGATCCTGCCTGGAGTAGGTAACCTTGCTTGGAAACCCCACATG
1441 CAAACGTCATGAGGAGAATTAAAGGAGTATTATCAGTAATGAAGTTTATCATGGGTCATCAATGAGCATAGATTGGTGTG
1521 GATCCTGTAGACCCTGGTGTTTTCTTTGAAGTGCCCTCTCCTAATGCAGAGGCCTTGAAGCTTACAGTATACACTTGAAA
1601 AGTCACAGATAGCTAGAATTATGATCTTTGAAGTTATAACTGTGATCTGAAAATGTGTGTGGTGGTATGACAGCATACCA
1681 TTAAATACATTTACATCACAGCTCAAAGGACTGTGATATAATCCATTTATATCACAACTCAAAGGACTGTGATATAATCC
1761 ATTTATATCACAGCTCACAGTTTCTGAAAATGTATAAAAGAATCTATAATCTAGTACTGAAATTACTAAATTGGGTAAGA
1841 TGATTTAAATGATTTTAATTTTAACATTTTATTTCTAGAATATATGGCTCCATTTTATTTTATAGTGTAAAGTTGTATTT
1921 CCTAAAGTTTGTGTTTTGTCGACAGTATCTTTTAAATGAGTCTTAAAAATAAAGGCATATTGTTCATGTTAAAAAAAAAA
2001 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agcugacgGUGAGAAUGAUCu 5'
                  |||| ||||||| 
Target 5' tttctaaaCACT-TTACTAGa 3'
 690 - 709 152.00 -12.50
2 
miRNA  3' agcugACGGUGAGAAUGAUCu 5'
               |||:||||||:| || 
Target 5' caaggTGCTACTCTTGCAAGc 3'
 184 - 204 128.00 -17.30
3 
miRNA  3' agcUGACGGUGAGAAUGAUcu 5'
             ||||  |   ||||||  
Target 5' agtACTGAAA---TTACTAaa 3'
 1813 - 1830 127.00 -5.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14090137 13 COSMIC
COSN31505446 31 COSMIC
COSN20061882 32 COSMIC
COSN31581240 39 COSMIC
COSN15833405 89 COSMIC
COSN30476423 91 COSMIC
COSN28561364 114 COSMIC
COSN30486797 118 COSMIC
COSN30154805 122 COSMIC
COSN30458149 132 COSMIC
COSN30100511 159 COSMIC
COSN19667242 239 COSMIC
COSN28706672 243 COSMIC
COSN26297621 256 COSMIC
COSN26272779 313 COSMIC
COSN27313496 336 COSMIC
COSN20091103 377 COSMIC
COSN19073537 378 COSMIC
COSN22643490 465 COSMIC
COSN20125569 552 COSMIC
COSN20100458 561 COSMIC
COSN20091099 563 COSMIC
COSN29138738 676 COSMIC
COSN31566133 690 COSMIC
COSN20100452 790 COSMIC
COSN9899549 959 COSMIC
COSN22447979 968 COSMIC
COSN9899548 1180 COSMIC
COSN1980980 1534 COSMIC
COSN7725353 1696 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1364247640 1 dbSNP
rs375976255 4 dbSNP
rs749673314 7 dbSNP
rs1368236234 9 dbSNP
rs924333560 10 dbSNP
rs1391055823 11 dbSNP
rs777816003 19 dbSNP
rs1474188623 36 dbSNP
rs192011585 38 dbSNP
rs1193748653 40 dbSNP
rs1480100208 42 dbSNP
rs1298464020 44 dbSNP
rs866362526 48 dbSNP
rs748379395 58 dbSNP
rs781332212 65 dbSNP
rs755056687 67 dbSNP
rs1231130145 68 dbSNP
rs751520337 71 dbSNP
rs1194311693 76 dbSNP
rs766442195 79 dbSNP
rs1274823270 80 dbSNP
rs145449869 82 dbSNP
rs750248437 83 dbSNP
rs764737121 84 dbSNP
rs753501045 87 dbSNP
rs1406050507 90 dbSNP
rs1335558020 91 dbSNP
rs187853058 97 dbSNP
rs760224284 107 dbSNP
rs1421816955 110 dbSNP
rs1398163704 112 dbSNP
rs528288187 113 dbSNP
rs17620564 114 dbSNP
rs1426535211 118 dbSNP
rs528499896 119 dbSNP
rs994649662 121 dbSNP
rs1232100612 126 dbSNP
rs1179394250 127 dbSNP
rs1439836823 129 dbSNP
rs767157175 134 dbSNP
rs761640751 135 dbSNP
rs1037036289 143 dbSNP
rs868054165 150 dbSNP
rs974551039 154 dbSNP
rs546065508 155 dbSNP
rs575187161 156 dbSNP
rs1004290873 174 dbSNP
rs185539426 182 dbSNP
rs1375543999 183 dbSNP
rs1385234608 200 dbSNP
rs1322960824 202 dbSNP
rs1197791392 203 dbSNP
rs1468741810 210 dbSNP
rs986766794 212 dbSNP
rs1236015406 213 dbSNP
rs1286868473 213 dbSNP
rs764117609 217 dbSNP
rs1045734463 219 dbSNP
rs544212956 220 dbSNP
rs1229356235 222 dbSNP
rs948974213 224 dbSNP
rs753507267 225 dbSNP
rs916137201 226 dbSNP
rs1265971022 228 dbSNP
rs1452142965 237 dbSNP
rs2374215 239 dbSNP
rs1409632829 240 dbSNP
rs1196607406 242 dbSNP
rs1418346889 244 dbSNP
rs1159627923 254 dbSNP
rs1030657109 255 dbSNP
rs1365827552 261 dbSNP
rs977405754 263 dbSNP
rs776776954 272 dbSNP
rs967597385 275 dbSNP
rs1272317244 279 dbSNP
rs555833308 314 dbSNP
rs1406818867 317 dbSNP
rs1306757798 326 dbSNP
rs1350401630 335 dbSNP
rs1341609368 336 dbSNP
rs1410890093 342 dbSNP
rs1309530382 343 dbSNP
rs1273275548 344 dbSNP
rs1264375665 348 dbSNP
rs1356499753 349 dbSNP
rs1224032817 355 dbSNP
rs145806344 359 dbSNP
rs1482683033 364 dbSNP
rs1182652516 366 dbSNP
rs1252327845 371 dbSNP
rs1233915070 373 dbSNP
rs1369816607 373 dbSNP
rs1473015341 374 dbSNP
rs1162390803 375 dbSNP
rs1415583369 376 dbSNP
rs1326987833 377 dbSNP
rs879132373 377 dbSNP
rs374473515 378 dbSNP
rs868838277 378 dbSNP
rs1399729060 379 dbSNP
rs1389715699 380 dbSNP
rs1336459831 381 dbSNP
rs1372173291 383 dbSNP
rs924780978 385 dbSNP
rs1164403033 386 dbSNP
rs1369235476 390 dbSNP
rs1306087259 392 dbSNP
rs1445133229 394 dbSNP
rs1400258543 396 dbSNP
rs1426693385 397 dbSNP
rs1330198261 399 dbSNP
rs1166781592 400 dbSNP
rs573375268 401 dbSNP
rs1399510943 402 dbSNP
rs1430880859 406 dbSNP
rs1171637648 411 dbSNP
rs1300297285 413 dbSNP
rs1454451989 415 dbSNP
rs1377369157 416 dbSNP
rs1311621861 420 dbSNP
rs149751642 420 dbSNP
rs1396600354 421 dbSNP
rs977160852 424 dbSNP
rs1271792200 427 dbSNP
rs894247768 437 dbSNP
rs17046575 442 dbSNP
rs77948545 459 dbSNP
rs1252976057 461 dbSNP
rs1233354706 468 dbSNP
rs1181060978 473 dbSNP
rs1257193719 474 dbSNP
rs1446608185 488 dbSNP
rs1186761468 494 dbSNP
rs985840688 497 dbSNP
rs1450661209 508 dbSNP
rs906900030 513 dbSNP
rs1173225471 521 dbSNP
rs569587710 523 dbSNP
rs34797424 530 dbSNP
rs930272789 538 dbSNP
rs1303778594 550 dbSNP
rs898633786 552 dbSNP
rs1038554569 554 dbSNP
rs1210351150 555 dbSNP
rs1363886623 558 dbSNP
rs13110575 561 dbSNP
rs34933524 563 dbSNP
rs369755555 563 dbSNP
rs397732178 563 dbSNP
rs1491172842 567 dbSNP
rs1366577264 568 dbSNP
rs202201381 568 dbSNP
rs60782230 568 dbSNP
rs766488111 568 dbSNP
rs1282848333 572 dbSNP
rs1207003454 578 dbSNP
rs1247619854 580 dbSNP
rs1238396554 582 dbSNP
rs1373122163 589 dbSNP
rs1280637677 590 dbSNP
rs1445078640 592 dbSNP
rs1188355788 595 dbSNP
rs1423754988 602 dbSNP
rs911314719 610 dbSNP
rs973728798 619 dbSNP
rs1470766621 629 dbSNP
rs1318175211 631 dbSNP
rs961847664 632 dbSNP
rs986881238 633 dbSNP
rs766569450 647 dbSNP
rs1365410002 656 dbSNP
rs528955838 666 dbSNP
rs907327407 674 dbSNP
rs72893408 688 dbSNP
rs977727616 693 dbSNP
rs1226314734 695 dbSNP
rs1408511304 708 dbSNP
rs1447785026 716 dbSNP
rs1218056817 719 dbSNP
rs1178872969 724 dbSNP
rs1471770241 731 dbSNP
rs1200723263 732 dbSNP
rs1422899622 736 dbSNP
rs1271657939 740 dbSNP
rs967333334 744 dbSNP
rs1158867877 753 dbSNP
rs1012897776 766 dbSNP
rs914366125 768 dbSNP
rs1400859019 769 dbSNP
rs894469914 789 dbSNP
rs1187334498 795 dbSNP
rs142004530 797 dbSNP
rs35790127 797 dbSNP
rs758502467 797 dbSNP
rs1303730914 798 dbSNP
rs1435096721 798 dbSNP
rs377411148 798 dbSNP
rs1347319034 803 dbSNP
rs1282716904 816 dbSNP
rs1351682018 817 dbSNP
rs989983542 817 dbSNP
rs751012881 818 dbSNP
rs1321252110 819 dbSNP
rs1223311777 820 dbSNP
rs1316695159 821 dbSNP
rs1271751212 823 dbSNP
rs4452507 825 dbSNP
rs1181910500 829 dbSNP
rs546667886 831 dbSNP
rs1225919801 842 dbSNP
rs1470320929 844 dbSNP
rs1354893196 847 dbSNP
rs528212293 850 dbSNP
rs13110620 851 dbSNP
rs1414833404 853 dbSNP
rs1356868646 854 dbSNP
rs1002661205 856 dbSNP
rs1295947165 869 dbSNP
rs944425467 873 dbSNP
rs72893406 876 dbSNP
rs1307220117 898 dbSNP
rs769233519 899 dbSNP
rs1444085327 902 dbSNP
rs376406817 903 dbSNP
rs1282686240 909 dbSNP
rs774060013 909 dbSNP
rs1345495184 910 dbSNP
rs1161034699 918 dbSNP
rs994806605 920 dbSNP
rs898752226 927 dbSNP
rs147582122 932 dbSNP
rs1007005467 933 dbSNP
rs868431800 943 dbSNP
rs2374216 945 dbSNP
rs934105364 952 dbSNP
rs1191695110 959 dbSNP
rs1235439768 959 dbSNP
rs1443573785 979 dbSNP
rs1183676178 990 dbSNP
rs1386521091 998 dbSNP
rs923907462 999 dbSNP
rs961961478 1002 dbSNP
rs1243009254 1004 dbSNP
rs192348749 1008 dbSNP
rs945914096 1013 dbSNP
rs749907782 1016 dbSNP
rs1358803196 1028 dbSNP
rs981883236 1052 dbSNP
rs1317279043 1053 dbSNP
rs1363175526 1054 dbSNP
rs914501077 1056 dbSNP
rs1227720535 1059 dbSNP
rs776814424 1064 dbSNP
rs1271353396 1066 dbSNP
rs1342071423 1068 dbSNP
rs990098268 1073 dbSNP
rs970553931 1083 dbSNP
rs529246196 1093 dbSNP
rs1203857876 1097 dbSNP
rs1336297750 1098 dbSNP
rs769096416 1103 dbSNP
rs927132450 1105 dbSNP
rs1013427409 1116 dbSNP
rs780873662 1117 dbSNP
rs981161304 1130 dbSNP
rs971190968 1136 dbSNP
rs1428279295 1141 dbSNP
rs1025694759 1148 dbSNP
rs1470102889 1149 dbSNP
rs993857179 1154 dbSNP
rs1381781887 1155 dbSNP
rs1362248139 1161 dbSNP
rs1033466528 1168 dbSNP
rs962726303 1169 dbSNP
rs1231660626 1172 dbSNP
rs903465712 1178 dbSNP
rs1017139634 1184 dbSNP
rs1324782766 1188 dbSNP
rs1042003873 1194 dbSNP
rs1264695074 1195 dbSNP
rs1326569176 1205 dbSNP
rs1204037230 1213 dbSNP
rs1261762525 1215 dbSNP
rs576554731 1216 dbSNP
rs199510995 1219 dbSNP
rs375113373 1219 dbSNP
rs540707203 1219 dbSNP
rs1050146080 1220 dbSNP
rs1051217328 1230 dbSNP
rs1178305060 1233 dbSNP
rs1410052068 1249 dbSNP
rs998653365 1250 dbSNP
rs1168455811 1254 dbSNP
rs369470990 1257 dbSNP
rs1387171077 1260 dbSNP
rs1428100938 1263 dbSNP
rs1385137099 1273 dbSNP
rs1303126029 1276 dbSNP
rs4299668 1286 dbSNP
rs1037803428 1288 dbSNP
rs940375863 1290 dbSNP
rs1326670679 1291 dbSNP
rs536764255 1293 dbSNP
rs1042744490 1297 dbSNP
rs946729372 1298 dbSNP
rs1487702078 1300 dbSNP
rs1352265456 1301 dbSNP
rs763731122 1302 dbSNP
rs907774086 1309 dbSNP
rs558296785 1310 dbSNP
rs915265651 1317 dbSNP
rs758370349 1318 dbSNP
rs145138081 1319 dbSNP
rs1470228779 1328 dbSNP
rs1255544055 1335 dbSNP
rs2374217 1342 dbSNP
rs1366734130 1346 dbSNP
rs916434240 1348 dbSNP
rs1306585137 1352 dbSNP
rs1392298442 1353 dbSNP
rs981277775 1356 dbSNP
rs79516949 1357 dbSNP
rs918335747 1373 dbSNP
rs1313654690 1381 dbSNP
rs1360111935 1388 dbSNP
rs959066127 1390 dbSNP
rs1272363913 1392 dbSNP
rs1480212157 1394 dbSNP
rs972933855 1396 dbSNP
rs866271737 1397 dbSNP
rs967387484 1398 dbSNP
rs1020506317 1404 dbSNP
rs536197327 1409 dbSNP
rs1369890172 1417 dbSNP
rs139869988 1419 dbSNP
rs1167304777 1420 dbSNP
rs1442952712 1437 dbSNP
rs890619003 1437 dbSNP
rs1398065020 1445 dbSNP
rs1297580998 1446 dbSNP
rs6845664 1450 dbSNP
rs954312181 1453 dbSNP
rs1029745855 1456 dbSNP
rs1172795683 1457 dbSNP
rs898884221 1461 dbSNP
rs1293433530 1464 dbSNP
rs1306837543 1466 dbSNP
rs1452812341 1470 dbSNP
rs1252806719 1485 dbSNP
rs1037433215 1489 dbSNP
rs998372598 1491 dbSNP
rs1203326166 1495 dbSNP
rs902711507 1497 dbSNP
rs1194675817 1502 dbSNP
rs1021033728 1506 dbSNP
rs376518243 1507 dbSNP
rs868505224 1514 dbSNP
rs773402042 1517 dbSNP
rs1186738842 1519 dbSNP
rs1419440470 1521 dbSNP
rs1046292292 1526 dbSNP
rs1236848691 1527 dbSNP
rs949344213 1536 dbSNP
rs916397274 1555 dbSNP
rs1011429432 1556 dbSNP
rs893797146 1564 dbSNP
rs1406354930 1567 dbSNP
rs1055150397 1573 dbSNP
rs767873503 1574 dbSNP
rs777461912 1582 dbSNP
rs1252561314 1585 dbSNP
rs534684290 1589 dbSNP
rs570467437 1590 dbSNP
rs1286555145 1592 dbSNP
rs1361195643 1597 dbSNP
rs1382660182 1603 dbSNP
rs551910625 1615 dbSNP
rs1297603937 1619 dbSNP
rs762083972 1622 dbSNP
rs1264049287 1624 dbSNP
rs905789239 1631 dbSNP
rs1325857084 1640 dbSNP
rs1045713871 1642 dbSNP
rs187685647 1644 dbSNP
rs1486493013 1645 dbSNP
rs1280733733 1646 dbSNP
rs918440015 1653 dbSNP
rs774780649 1657 dbSNP
rs371793837 1660 dbSNP
rs1374448584 1666 dbSNP
rs1177587863 1668 dbSNP
rs1429578352 1671 dbSNP
rs941118983 1673 dbSNP
rs575425274 1678 dbSNP
rs909527743 1682 dbSNP
rs1374062541 1683 dbSNP
rs1299982884 1688 dbSNP
rs1020329495 1695 dbSNP
rs569563448 1703 dbSNP
rs768841259 1704 dbSNP
rs749647705 1709 dbSNP
rs1174536699 1714 dbSNP
rs1343549424 1718 dbSNP
rs1404123475 1719 dbSNP
rs955160379 1723 dbSNP
rs1347653410 1736 dbSNP
rs1029262832 1737 dbSNP
rs954260944 1741 dbSNP
rs775905770 1754 dbSNP
rs1218037417 1758 dbSNP
rs548071867 1760 dbSNP
rs1181641461 1761 dbSNP
rs1420221979 1764 dbSNP
rs1290294018 1766 dbSNP
rs770267608 1771 dbSNP
rs1200612314 1773 dbSNP
rs1015932506 1780 dbSNP
rs966883761 1795 dbSNP
rs745946884 1800 dbSNP
rs780644354 1801 dbSNP
rs1046071371 1815 dbSNP
rs1400839218 1816 dbSNP
rs1160577479 1817 dbSNP
rs529978976 1824 dbSNP
rs1257753989 1826 dbSNP
rs893899839 1828 dbSNP
rs895026620 1830 dbSNP
rs562086506 1831 dbSNP
rs1367270140 1834 dbSNP
rs1055068271 1837 dbSNP
rs533928093 1843 dbSNP
rs936460726 1865 dbSNP
rs925113097 1880 dbSNP
rs978831886 1887 dbSNP
rs1259930472 1904 dbSNP
rs151101766 1906 dbSNP
rs1223943897 1911 dbSNP
rs1294544062 1917 dbSNP
rs1436497312 1921 dbSNP
rs1204248231 1923 dbSNP
rs1231966748 1924 dbSNP
rs913224371 1933 dbSNP
rs528545001 1934 dbSNP
rs954753826 1939 dbSNP
rs564425099 1940 dbSNP
rs546364350 1941 dbSNP
rs1164177422 1945 dbSNP
rs1387011040 1970 dbSNP
rs758043896 1974 dbSNP
rs963871952 1975 dbSNP
rs1045632836 1984 dbSNP
rs1383187800 1989 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 79642.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agcugacgGUGAGAAUGAUCu 5'
                  |||| ||||||| 
Target 5' uuucuaaaCACU-UUACUAG- 3'
 		16 - 34
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_024590 | 3UTR | CAUGUGAACAGCUUGCACCUCAUUUUACCAUGCGUGAGGGAAUGGCAAAUAAGAAUGUUUGAGCACACUGCCCACAAUGAAUGUAACUAUUUUCUAAACACUUUACUAGAAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_024590 | 3UTR | GCUUGCACCUCAUUUUACCAUGCGUGAGGGAAUGGCAAAUAAGAAUGUUUGAGCACACUGCCCACAAUGAAUGUAACUAUUUUCUAAACACUUUACUAGAAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_024590 | 3UTR | ACCUCAUUUUACCAUGCGUGAGGGAAUGGCAAAUAAGAAUGUUUGAGCACACUGCCCACAAUGAAUGUAACUAUUUUCUAAACACUUUACUAGAAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_024590 | 3UTR | CUCACAUGUGAACAGCUUGCACCUCAUUUUACCAUGCGUGAGGGAAUGGCAAAUAAGAAUGUUUGAGCACACUGCCCACAAUGAAUGUAACUAUUUUCUAAACACUUUACUAGAAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000315366.7 | 3UTR | AAUGAAUGUAACUAUUUUCUAAACACUUUACUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.386 3.1e-2 0.379 3.4e-2 24 Click to see details
GSE28260 Renal cortex and medulla 0.522 3.4e-2 0.599 1.5e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.35 4.7e-2 0.269 1.0e-1 24 Click to see details
GSE19783 ER+ ER+ breast cancer 0.349 6.6e-2 0.239 1.6e-1 20 Click to see details
GSE21687 Ependynoma primary tumors -0.173 8.6e-2 -0.161 1.0e-1 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.216 1.6e-1 -0.292 8.8e-2 23 Click to see details
GSE27834 Pluripotent stem cells 0.236 1.9e-1 0.100 3.6e-1 16 Click to see details
GSE17306 Multiple myeloma -0.119 2.1e-1 -0.054 3.6e-1 49 Click to see details
GSE19350 CNS germ cell tumors 0.203 2.6e-1 0.308 1.7e-1 12 Click to see details
GSE17498 Multiple myeloma -0.092 2.9e-1 -0.055 3.7e-1 40 Click to see details
GSE32688 Pancreatic cancer 0.069 3.5e-1 0.054 3.8e-1 32 Click to see details
GSE19783 ER- ER- breast cancer -0.033 3.9e-1 0.007 4.8e-1 79 Click to see details
GSE38226 Liver fibrosis 0.066 3.9e-1 0.068 3.8e-1 21 Click to see details
GSE19536 Breast cancer -0.009 4.6e-1 -0.014 4.5e-1 100 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.015 4.7e-1 0.023 4.6e-1 25 Click to see details
GSE14794 Lymphoblastoid cells 0.007 4.7e-1 0.079 2.3e-1 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.003 4.9e-1 0.128 3.0e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.003 4.9e-1 0.128 3.0e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.003 4.9e-1 0.128 3.0e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.003 4.9e-1 0.128 3.0e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP -0.539 0 -0.475 0 29 Click to see details
STAD -0.429 0.01 -0.464 0.01 28 Click to see details
PRAD -0.349 0.02 -0.237 0.08 36 Click to see details
KICH 0.257 0.12 0.233 0.15 22 Click to see details
UCEC 0.223 0.19 0.255 0.15 18 Click to see details
PCPG -0.78 0.22 -1.000 0.5 3 Click to see details
PAAD -0.563 0.22 -0.200 0.4 4 Click to see details
KIRC -0.111 0.25 -0.160 0.16 40 Click to see details
LUSC -0.117 0.25 -0.162 0.18 35 Click to see details
LUAD -0.238 0.25 -0.200 0.29 10 Click to see details
BRCA -0.113 0.26 -0.270 0.06 34 Click to see details
LIHC -0.092 0.26 -0.070 0.32 49 Click to see details
ESCA 0.172 0.31 0.409 0.11 11 Click to see details
CESC -0.513 0.33 -0.500 0.33 3 Click to see details
BLCA -0.09 0.37 -0.287 0.13 17 Click to see details
CHOL 0.132 0.39 -0.036 0.47 7 Click to see details
THCA 0.035 0.4 0.080 0.28 58 Click to see details
HNSC -0.018 0.46 0.033 0.43 35 Click to see details
HNSC -0.018 0.46 0.033 0.43 35 Click to see details
27 hsa-miR-628-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT039584 CDC14A cell division cycle 14A 1 1
MIRT039585 AGO1 argonaute 1, RISC catalytic component 2 3
MIRT039586 TGFBRAP1 transforming growth factor beta receptor associated protein 1 1 1
MIRT039587 LRP6 LDL receptor related protein 6 1 1
MIRT071876 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT097443 JMY junction mediating and regulatory protein, p53 cofactor 2 4
MIRT100100 ABT1 activator of basal transcription 1 2 8
MIRT147692 CBX4 chromobox 4 2 2
MIRT408248 PURA purine rich element binding protein A 2 2
MIRT442047 LRAT lecithin retinol acyltransferase 2 2
MIRT444412 RAB3IP RAB3A interacting protein 2 2
MIRT452599 REPIN1 replication initiator 1 2 2
MIRT469515 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT498192 AKR1B10 aldo-keto reductase family 1 member B10 2 2
MIRT500151 CREBBP CREB binding protein 2 2
MIRT507319 FAM60A SIN3-HDAC complex associated factor 2 6
MIRT508343 ZNF273 zinc finger protein 273 2 6
MIRT520480 TRIM13 tripartite motif containing 13 2 2
MIRT522461 MMP16 matrix metallopeptidase 16 2 4
MIRT547116 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT548675 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT553756 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 4
MIRT559437 ARSJ arylsulfatase family member J 2 2
MIRT610490 GPC4 glypican 4 2 2
MIRT644682 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT658214 FBXO21 F-box protein 21 2 2
MIRT756083 TP53 tumor protein p53 4 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-628 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-628-3p Cisplatin 5460033 NSC119875 approved resistant High Tongue Squamous Cell Carcinoma cell line (Tca8113)
hsa-miR-628-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7, LY2)
hsa-miR-628-3p Erlotinib 176870 NSC718781 approved sensitive High Epithelial Cancer cell line (A549, UKY-29, H460, H1975, H1650, H3255, PC-9, H358)
hsa-miR-628-3p Siop Treatment Protocol sensitive High Nephroblastoma tissue
hsa-miR-628-3p Sunitinib 5329102 NSC750690 approved resistant High Metastatic Renal Cell Carcinoma tissue and cell line (Caki-2)
hsa-miR-628-3p Chemotherapy sensitive High Epithelial Ovarian Cancer tissue
hsa-miR-628-3p Platinum-based doublet chemotherapy resistant Low Lung Adenocarcinoma tissue
hsa-miR-628-3p Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-628-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (TAMR8)
hsa-miR-628-3p Aromatase Inhibitor sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-628-3p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-628-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-628-3p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-628-3p Platinum 23939 sensitive High High-Grade Serous Ovarian Cancer tissue
hsa-miR-628-3p Cisplatin 5460033 NSC119875 approved sensitive High Bladder Cancer cell line (CDDP-R-BOY, CDDP-R-T24)
hsa-miR-628-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-628-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-628-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-628-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-628-3p Tamoxifen 2733525 NSC180973 approved resistant cell line (TamR8)
hsa-miR-628-3p Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-628-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-628-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-628-3p Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)

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