miRTarBase - #MIRT559762


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pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ABHD5   
Synonyms CDS, CGI58, IECN2, NCIE2
Description abhydrolase domain containing 5
Transcript NM_016006   
Expression
Putative miRNA Targets on ABHD5
3'UTR of ABHD5
(miRNA target sites are highlighted)		 
>ABHD5|NM_016006|3'UTR
   1 ACACACTGAAGCTCTGATGGGAAAACCTGGTGACTGATATAGTTGTTCAGCAATAATTCATAGTCTGTGATGAAGAGTAG
  81 TGAATACAACACACAACCAGGCAGCCTTCTTGACTATACTTTGCACATGTTTTCTTTAGGAATTCACTCACACATTTAAA
 161 CCAGTTAGTGCCTTCTAGAAGAATGGCTTTCCTTTCTCCTACACAAAATTGAAATATACAAGTCTCTAAATATAATACCT
 241 TTAAATAAAAGGTTATTTGTCCCTCTGATGTACTGAAAAACTGTAATTTTTCAGCTGAAAATTTTTTAATCTAACTTTGC
 321 TAGTTATTTTTATATTGCAATCTATATTACCAATTTAGGAAGTGATTTCTGAGTCTCTTACACTGTAAAGGTGCACTTTA
 401 TTTTCTTTGTCTTCCCCATCATGTATTTATTGTGTCTTGATAACTGATATTAATCTAAATTCAATGTGTTTTTATGTAAA
 481 AATTTGTCAGTTGTTTAGAATATTTCACTTTGTTTTTGAAACGGAGTGACAAGGCAGATTTTTGGTTAGAGGACGGGAGT
 561 TGATCACTATCATTACTTTTTCTAGTTTACCTGTTTTTTATATTTAAGGCTGCTAAGCCATGTTCAGCATTTTAAATGTG
 641 GTCTATCCTGACATACAGTGTATAACAACATAACTCCTTGGAACCTCCTATGTGTGGTATAATTCTACTCTTCCAAGGAA
 721 CATGACTTCAATACTTTCAGTGATTCAGGTACTGAAAAGCCTTACCTAAAAGGCTGTTCTTTGTTTCCCCCTTTCATACT
 801 ATTCTTTTCCATGACCCAGGATGCAGCAAATGAAACAGATTTCTTCTCTTAAGGGGATATTAAGACTGTTACTTCCTAGT
 881 AAGCCAAGTAATACCATATTTTTATTAACATCTAACTTTTGTAGATGGGTGCTAAAATTGCATACATTTTAACCACTAAA
 961 ATAGAAAAACAAGTGGTGCTATTATGTCTCATGGCACCAGAAATGAGCTAGCACTTGGGTTTGTTGTTGCTGTTGTTTAT
1041 TAAGAGTATTGTGTTAATTAAATCATTACATACTTGAAGTTATATTACAAAAATTCTAGAAGGTTGATTGAACTATTTTT
1121 TTAGGAACTACCATCAAGTGTAGCATTTTCTTGCAGTTTTAAAATGAGGAAAACTTCTTTGAAACTGTGAAATGCTCCAT
1201 GTGGTAACTGGCTGCTGAGAAAACCCTTCACCAAAAAAATAAATAAAAATTGAATAGGATTGTCATCAAGAAGGCATCTT
1281 TCGCTAACGTTGCTTGTCTAGGAGAAAGGTAGCTATGTAAATAAAAACAGTGAACTAGAGCAAATAGTGGTTTAATGGTT
1361 TTGTTATTGCATTTTTAAAATGGTTAATTAGGGAATTTGTAGTTGTTAGGAAATGTAAGGTTGTGTCACTGTTGATTAAC
1441 TGCCAGAAAGACTGAATGTTCTATTTTCAACATTTCTCCCCTATAAAAGAATAGACAAATTATACTGAAGCATGATATAA
1521 ACATCTTCCCAATGAACAATTTGTCTCACTTGTCAGATTAACTAGGTTAGTGCAGGAAGCAACATGAGCGCCAAGATGTG
1601 TTGTCTGATTTCTCTACCTTAAGAACAATAATAGTCTTTTTAGTTAGTATTTTGGATGGCCAGGTTTCAAACCTGTATGT
1681 GGTACAAATAATTTGGGTAATATTTTTGTATTTTTGTTTTACACACTCTCTAATCTCAATTATCCTTTGCTGGGAGAATG
1761 ACAGGTTTCACTTATACAGGAAGGTTTTTGCACAGGAAATTTGGTCCCAGCCCTTGGAAGGAAGAAGTTCCTTCGTTTAC
1841 TTAGTGAATGGAGTTTCTGGCCGCAGATGTGCCAAGTGATTGAAGAAAGATATACCCCAATATCAAGTGATAATTTATTT
1921 TCCTACAGACTGAATTTGCTTTATTTGAAAGATGTTGTAACTCTTTTTAAAGTTAGATTTTACCCTGAGGTATAGTATAT
2001 GTAATTTTGTGAAGATTGAGCTGGAAGGGAAGTTCACAATCCTCACATTTAAAAAAATATAGTGGGTGCTAAATGTTTTC
2081 TTAAAAATCTAGTACAGCATTTGATCTTTGTTATGCACAGCATACTTTTATTTTACAGAATAAATTTTCCTGTGATAGTC
2161 ACAACAAGACAGCTGTATAGTTTCTTGAGTCTTTTGTATGGACCAGTCTCTGTATAATAGTTAACTACAGGACTGTGGAT
2241 CCAGCAAATGTTCAGTAAATGCTGCTGTTGTTCTTAGGGAAGGCTACTCTGGGTGTTGTGGCCGCCATACATGGCTTTAC
2321 CTGGGTCCATGCATTCCCTTAAGATGACTTCTGTTTTCTTCTTTTTTCTTCTGATTTTCCAAAAAAAAAAAAGCCTTGCC
2401 TAAGGTTGGTTTTAGAATATGATTTGCAGAACACTTTTGAAATGTCTTCATTCATATATGTAATATATATTTATACTTAA
2481 AGGGCCATACGCGATTTCAATAAAACAAGAAGTACTGGAAAGAATAAACAAAAATAGCCAGAAGATGCCTAGAAAAGAAC
2561 AATGTGGAAGGAGGGATAACCCTATTAAATATTATAACATAATGTTTACAATATGAGAAAGTCTAGGAATTTAGTACATG
2641 ATAAAGCATCTCATTCAGAGAAAAAGGCTTTAAAAATGGTGTTGAGAGAAGTGTGGTTAACCATTTGGAAAAAAAAATAA
2721 AATTGAATCGATTTCTCACAGGATACACAGGATAAAATCTGAATAGAACAAAGACCCAATTTTTAAAATGAAACCCTCTT
2801 TCTAACTAGAAGAAAACATAGATGAATTATTGTATAATCTGACAGTGAGAAAAACTTTCCTAGGACTGAAAATTCAGAAG
2881 CAATAAAAAGAGAAGTCTATAGAAGAATTTTCAGCCAGATGGAATGGCTCATGGCTGTAATCCCAGCATTTTGGGAGGCT
2961 GAGGCAGAAGGACTGCTTGAGACCAGGAATTCAAAACCAACCTGGGCAACCTAGTAGGACTGGCTCTACCAAAAAAAAAA
3041 AAAAAAAAAAATTAAGTACCTGGCCTGGGTTCCACCTACTTGGGAGGCTGAGGTAGGAGGACTGTGAGCCCAGGAGTTTG
3121 AGGATGCAGTAAGCCACTGCACTCCAGCCTGGGTGACAGAGAAGAAAAAAGATTTTTTTGGATAGCTGAAAATATTTGCA
3201 GCATTTATCACAGAGGGCTAATTGTAGCCCTATATATGAAGAATTTTAAACTATGAGAAGAACCCGAAGAATAGGCAAAA
3281 GGATGTGAACAGACAGTTAACAGAAAATAGAATGCAAATGGTCTTTAAACATACAAGGATATGCATAAAAAGACAAATGC
3361 AAAATAAAATAAAATAATGGAAATACCTTTCTTACCTGTGAGATTGGGGAAAATCCAAGTTAGGCAATGCACTCTGTTGA
3441 GACAATAGGGAAACAGGCACTCCAAAAATTACAAATCCCTGTGGATGGTATTTGTTAACTAGCAAAGTTAAATGAGTATA
3521 TCCTTCAACCTGGCAGACCCAGTTCTAAGAATCCATATGAGATGCACTTGCAAGAATATGAAATAGTATATGCACAAAGA
3601 TCTTGATTACAGCACTGTTTCTAATAGCTACAGACTGGAAGCCAGCCAAATCTCCATTGATAGGGAATTGATGGAAGGAA
3681 CTAGGGTATATCTATACAATGGGATACTACACAGCTGTAGAAAGGACTGCGAACTATTTTTGTAGTTCTGGTCTGGAGAA
3761 ATCTCCAGAATATAGGAAATGAAAAATGTAAAGCACAGAAGAGAATGTATGGTGTGCTGTCTGTTGTATAACGAAGAGAC
3841 AAATGGAAAAAATATGTATTTGCTTTTTTTGTAAAGCAATAGAAGAATTAGTTATACCAATAACTAATAAAATGATCTCC
3921 TTGTTAGTGGTGGTAGGGAGCTAGACAAGGATGGCAACTATTTCTGTATCTTACATACCTTTTATTTTGAGGCCCTGTCA
4001 ATGTTTTATATAATAAACATTTTTTGAAAAGGCAACTCTTAAAACTAAAACAAACTTAACAGTCTGTCAAGTTGGTGATA
4081 TAACCCCACAGAAGACTTACTTCAAGTGACTTGAAAACTTAGTATTTTGTCTGTACTTTGCTAATGGAATATATCCTACA
4161 GACCAAACAACCACAAATAAATCTTAAACTGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uacaUCCGGAAAUCUAGUGAa 5'
              :||  ||  ||||||| 
Target 5' ggacGGGAGTT--GATCACTa 3'
 551 - 569 145.00 -9.70
2 
miRNA  3' uacauccGGAAAUCUAGUGAa 5'
                 |||| |||| ||| 
Target 5' tgcattcCCTTAAGATGACTt 3'
 2330 - 2350 130.00 -11.90
3 
miRNA  3' uacAUCCGGAA-AUCUAGUGAa 5'
             || | :||  ||| |||| 
Target 5' gaaTATGATTTGCAGAACACTt 3'
 2415 - 2436 122.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
345226 30 ClinVar
345227 39 ClinVar
901386 58 ClinVar
901387 97 ClinVar
345228 126 ClinVar
901388 155 ClinVar
901389 228 ClinVar
345229 282 ClinVar
345230 303 ClinVar
901942 393 ClinVar
901943 465 ClinVar
345231 708 ClinVar
901944 849 ClinVar
345232 880 ClinVar
901945 917 ClinVar
345233 1010 ClinVar
345234 1012 ClinVar
902842 1077 ClinVar
345235 1111 ClinVar
345236 1202 ClinVar
345237 1266 ClinVar
345238 1345 ClinVar
345239 1372 ClinVar
345240 1418 ClinVar
345241 1467 ClinVar
900284 1486 ClinVar
900285 1538 ClinVar
345242 1567 ClinVar
345243 1569 ClinVar
900286 1597 ClinVar
345244 1614 ClinVar
345245 1663 ClinVar
345246 1730 ClinVar
345247 1757 ClinVar
345248 1758 ClinVar
345249 1759 ClinVar
345250 1835 ClinVar
345251 1859 ClinVar
345252 1864 ClinVar
345253 1896 ClinVar
345254 1933 ClinVar
345255 1958 ClinVar
902011 2049 ClinVar
345256 2058 ClinVar
345257 2065 ClinVar
902012 2100 ClinVar
902013 2110 ClinVar
902014 2129 ClinVar
345258 2138 ClinVar
902015 2207 ClinVar
345259 2305 ClinVar
345260 2325 ClinVar
902906 2350 ClinVar
345261 2381 ClinVar
345262 2446 ClinVar
345263 2464 ClinVar
902907 2493 ClinVar
902908 2501 ClinVar
345264 2509 ClinVar
900348 2541 ClinVar
345265 2543 ClinVar
345266 2709 ClinVar
345267 2718 ClinVar
345268 2927 ClinVar
345269 2936 ClinVar
345270 2966 ClinVar
345271 3031 ClinVar
900349 3172 ClinVar
345272 3187 ClinVar
345273 3254 ClinVar
345274 3289 ClinVar
901503 3293 ClinVar
345275 3373 ClinVar
345276 3672 ClinVar
345277 3681 ClinVar
901504 3701 ClinVar
345278 3731 ClinVar
345279 3756 ClinVar
345280 3762 ClinVar
345281 3807 ClinVar
902073 3833 ClinVar
345282 3834 ClinVar
902074 3876 ClinVar
902075 3886 ClinVar
345283 3953 ClinVar
345284 4148 ClinVar
902076 4189 ClinVar
345285 4190 ClinVar
COSN28182627 9 COSMIC
COSN30112663 17 COSMIC
COSN26964529 26 COSMIC
COSN8869806 39 COSMIC
COSN31604500 60 COSMIC
COSN30467169 68 COSMIC
COSN17500967 92 COSMIC
COSN31549036 98 COSMIC
COSN31485497 146 COSMIC
COSN7762301 187 COSMIC
COSN20090807 310 COSMIC
COSN1950315 603 COSMIC
COSN22565945 925 COSMIC
COSN9551616 963 COSMIC
COSN15680000 989 COSMIC
COSN15774523 1324 COSMIC
COSN23987607 1595 COSMIC
COSN29218182 1711 COSMIC
COSN15662486 1835 COSMIC
COSN32173443 1852 COSMIC
COSN20098356 1861 COSMIC
COSN9551617 1993 COSMIC
COSN17559968 2329 COSMIC
COSN20098357 2393 COSMIC
COSN15757880 2835 COSMIC
COSN7698638 3109 COSMIC
COSN30284805 3732 COSMIC
COSN32000180 3789 COSMIC
COSN29759497 3868 COSMIC
COSN16415850 3977 COSMIC
COSN16414721 3978 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs951479877 3 dbSNP
rs1325078182 4 dbSNP
rs1331394007 5 dbSNP
rs143080404 6 dbSNP
rs1301626037 12 dbSNP
rs769094564 27 dbSNP
rs891202021 28 dbSNP
rs376897300 30 dbSNP
rs867031642 31 dbSNP
rs1166378430 35 dbSNP
rs887472 39 dbSNP
rs770281940 41 dbSNP
rs1484923284 42 dbSNP
rs772768428 44 dbSNP
rs762430243 45 dbSNP
rs1451309280 46 dbSNP
rs1192001723 47 dbSNP
rs1392964801 49 dbSNP
rs766062556 50 dbSNP
rs1015583933 52 dbSNP
rs1159155233 53 dbSNP
rs922236119 54 dbSNP
rs1363195321 60 dbSNP
rs774086847 61 dbSNP
rs1164553766 62 dbSNP
rs955048224 71 dbSNP
rs988239819 78 dbSNP
rs913646257 82 dbSNP
rs1182206610 87 dbSNP
rs145145864 97 dbSNP
rs1247974668 99 dbSNP
rs540845485 106 dbSNP
rs1027112837 110 dbSNP
rs926471986 125 dbSNP
rs752632573 126 dbSNP
rs1023176610 128 dbSNP
rs1056367327 130 dbSNP
rs537463835 142 dbSNP
rs74367890 148 dbSNP
rs1327083305 152 dbSNP
rs896424838 155 dbSNP
rs1394903218 164 dbSNP
rs35266874 164 dbSNP
rs1163890264 169 dbSNP
rs1459697287 172 dbSNP
rs1414018456 177 dbSNP
rs924245015 178 dbSNP
rs560352118 179 dbSNP
rs1047134671 184 dbSNP
rs887149930 187 dbSNP
rs1005645148 197 dbSNP
rs532650650 206 dbSNP
rs1158908124 207 dbSNP
rs1378690344 217 dbSNP
rs868459937 228 dbSNP
rs1426789004 233 dbSNP
rs545835118 238 dbSNP
rs932504684 242 dbSNP
rs1307069548 247 dbSNP
rs1235550422 253 dbSNP
rs997446318 257 dbSNP
rs1049563301 258 dbSNP
rs1390635946 263 dbSNP
rs1318866460 270 dbSNP
rs374866960 271 dbSNP
rs138528340 272 dbSNP
rs1405744620 277 dbSNP
rs34226283 282 dbSNP
rs1454346128 288 dbSNP
rs1394035533 293 dbSNP
rs886058489 303 dbSNP
rs1291697411 310 dbSNP
rs1244239105 314 dbSNP
rs1217088750 315 dbSNP
rs1446885537 319 dbSNP
rs1375522104 324 dbSNP
rs955848631 325 dbSNP
rs1202189419 340 dbSNP
rs1348692579 345 dbSNP
rs548066391 348 dbSNP
rs1308268716 351 dbSNP
rs749957174 354 dbSNP
rs1247748784 355 dbSNP
rs762532845 363 dbSNP
rs967742442 373 dbSNP
rs568042834 381 dbSNP
rs1490035049 386 dbSNP
rs192816274 393 dbSNP
rs184361530 397 dbSNP
rs1434799205 404 dbSNP
rs1374386144 415 dbSNP
rs995723865 417 dbSNP
rs773732068 421 dbSNP
rs1235089346 422 dbSNP
rs1431290796 424 dbSNP
rs1419824316 426 dbSNP
rs926399141 437 dbSNP
rs141484969 450 dbSNP
rs1240796156 454 dbSNP
rs895401226 458 dbSNP
rs570411081 465 dbSNP
rs777718192 465 dbSNP
rs1012852767 467 dbSNP
rs1208863143 468 dbSNP
rs1446616026 477 dbSNP
rs1164481015 486 dbSNP
rs11712342 488 dbSNP
rs1344526548 489 dbSNP
rs200211956 493 dbSNP
rs992436553 497 dbSNP
rs539522541 501 dbSNP
rs1025126815 508 dbSNP
rs917841382 514 dbSNP
rs188895073 523 dbSNP
rs556338792 524 dbSNP
rs1415371565 528 dbSNP
rs1172709368 529 dbSNP
rs1356143068 532 dbSNP
rs1431123387 536 dbSNP
rs549721109 549 dbSNP
rs569237251 550 dbSNP
rs887117339 555 dbSNP
rs1409745496 560 dbSNP
rs1374426012 567 dbSNP
rs796727581 568 dbSNP
rs1315282153 570 dbSNP
rs1185825742 594 dbSNP
rs1257461958 594 dbSNP
rs1038442792 603 dbSNP
rs1031342141 609 dbSNP
rs1233664709 611 dbSNP
rs955657383 615 dbSNP
rs1305533307 626 dbSNP
rs1226109656 630 dbSNP
rs535476622 656 dbSNP
rs1274503516 660 dbSNP
rs899943632 662 dbSNP
rs1334005352 671 dbSNP
rs1308534004 682 dbSNP
rs997016343 697 dbSNP
rs1204462826 698 dbSNP
rs765950590 708 dbSNP
rs1373513930 717 dbSNP
rs1297237629 718 dbSNP
rs1439623736 723 dbSNP
rs1351288888 733 dbSNP
rs1328288727 736 dbSNP
rs192696923 738 dbSNP
rs751363466 739 dbSNP
rs1184661246 746 dbSNP
rs1242758841 751 dbSNP
rs1020554652 761 dbSNP
rs1163488456 764 dbSNP
rs115721641 766 dbSNP
rs979096857 781 dbSNP
rs757493547 782 dbSNP
rs1479755816 790 dbSNP
rs1255147018 796 dbSNP
rs1033428576 799 dbSNP
rs796565606 802 dbSNP
rs1271188034 810 dbSNP
rs1188302009 814 dbSNP
rs1420346284 817 dbSNP
rs991968634 830 dbSNP
rs1305624278 836 dbSNP
rs114083722 849 dbSNP
rs1398087217 864 dbSNP
rs1303700640 871 dbSNP
rs1442099343 874 dbSNP
rs554350163 879 dbSNP
rs577414446 880 dbSNP
rs931354098 894 dbSNP
rs1346334549 897 dbSNP
rs796916659 900 dbSNP
rs1158412872 909 dbSNP
rs1417413823 911 dbSNP
rs184630690 913 dbSNP
rs1339443916 919 dbSNP
rs536691447 922 dbSNP
rs909150757 924 dbSNP
rs1445373985 935 dbSNP
rs562678422 940 dbSNP
rs1250961099 944 dbSNP
rs1362076012 975 dbSNP
rs781353157 977 dbSNP
rs1038411959 982 dbSNP
rs1217522128 983 dbSNP
rs899911335 984 dbSNP
rs932729955 992 dbSNP
rs1326366465 997 dbSNP
rs1349508724 1003 dbSNP
rs1303677867 1005 dbSNP
rs781163659 1010 dbSNP
rs373123930 1012 dbSNP
rs541842732 1020 dbSNP
rs1299589038 1033 dbSNP
rs1384295063 1033 dbSNP
rs1363197142 1040 dbSNP
rs1288797874 1046 dbSNP
rs891307123 1051 dbSNP
rs1278382391 1052 dbSNP
rs1377414003 1070 dbSNP
rs1031458463 1071 dbSNP
rs189602319 1077 dbSNP
rs1194992453 1079 dbSNP
rs1218252127 1084 dbSNP
rs1260956547 1089 dbSNP
rs1011277432 1090 dbSNP
rs1486356091 1099 dbSNP
rs1280476865 1102 dbSNP
rs1021150363 1103 dbSNP
rs2191361 1111 dbSNP
rs1252710601 1115 dbSNP
rs1308513943 1116 dbSNP
rs372643079 1116 dbSNP
rs985356129 1116 dbSNP
rs1191667767 1117 dbSNP
rs1000487070 1124 dbSNP
rs1295477885 1130 dbSNP
rs1421382467 1134 dbSNP
rs1398747760 1139 dbSNP
rs912395148 1140 dbSNP
rs1313507731 1143 dbSNP
rs965277602 1157 dbSNP
rs1176814743 1160 dbSNP
rs1400256393 1167 dbSNP
rs1401256579 1174 dbSNP
rs972539241 1186 dbSNP
rs1372339323 1194 dbSNP
rs1033769146 1197 dbSNP
rs918696989 1198 dbSNP
rs1168199446 1200 dbSNP
rs886058490 1202 dbSNP
rs959121458 1212 dbSNP
rs1319844887 1213 dbSNP
rs1186527075 1218 dbSNP
rs1484405244 1233 dbSNP
rs1345465656 1235 dbSNP
rs180941201 1239 dbSNP
rs756156289 1248 dbSNP
rs1398847705 1253 dbSNP
rs931383336 1258 dbSNP
rs886058491 1266 dbSNP
rs1251146232 1272 dbSNP
rs1217218633 1275 dbSNP
rs1337511281 1276 dbSNP
rs540893921 1282 dbSNP
rs1024783436 1283 dbSNP
rs1275766813 1284 dbSNP
rs185972954 1289 dbSNP
rs777954285 1290 dbSNP
rs1392228340 1294 dbSNP
rs1274590276 1295 dbSNP
rs916560313 1303 dbSNP
rs1328990911 1325 dbSNP
rs1343273961 1331 dbSNP
rs115156029 1332 dbSNP
rs1418399214 1343 dbSNP
rs533017694 1344 dbSNP
rs1285204058 1345 dbSNP
rs58997366 1345 dbSNP
rs1365083375 1346 dbSNP
rs749830666 1347 dbSNP
rs1214453946 1348 dbSNP
rs1247996210 1357 dbSNP
rs999736862 1358 dbSNP
rs974061868 1364 dbSNP
rs921271097 1368 dbSNP
rs886058492 1372 dbSNP
rs1213672284 1399 dbSNP
rs1354296736 1402 dbSNP
rs1281311005 1405 dbSNP
rs1335342830 1414 dbSNP
rs3733156 1418 dbSNP
rs1442828879 1421 dbSNP
rs1051598252 1426 dbSNP
rs1011308442 1427 dbSNP
rs912678463 1433 dbSNP
rs1403575053 1436 dbSNP
rs1387089228 1457 dbSNP
rs1200095968 1464 dbSNP
rs886058493 1467 dbSNP
rs1378092597 1472 dbSNP
rs1476904704 1473 dbSNP
rs1042576887 1479 dbSNP
rs1455836084 1482 dbSNP
rs904076264 1484 dbSNP
rs1213489135 1485 dbSNP
rs189585954 1486 dbSNP
rs1054767312 1487 dbSNP
rs1286966429 1490 dbSNP
rs1205725787 1495 dbSNP
rs1350135603 1496 dbSNP
rs1284133666 1502 dbSNP
rs1236833415 1505 dbSNP
rs1371423647 1507 dbSNP
rs894820280 1508 dbSNP
rs965657609 1516 dbSNP
rs1013273864 1517 dbSNP
rs1025129635 1518 dbSNP
rs866306269 1519 dbSNP
rs1329918527 1520 dbSNP
rs535409380 1521 dbSNP
rs1241617632 1526 dbSNP
rs1434905463 1529 dbSNP
rs1280508026 1530 dbSNP
rs918389489 1538 dbSNP
rs1004714723 1550 dbSNP
rs984128167 1557 dbSNP
rs554908983 1567 dbSNP
rs563435148 1569 dbSNP
rs1261178829 1572 dbSNP
rs948113438 1584 dbSNP
rs1348810074 1585 dbSNP
rs1046826697 1590 dbSNP
rs746473026 1591 dbSNP
rs746232107 1592 dbSNP
rs1052624004 1597 dbSNP
rs1166206357 1600 dbSNP
rs954173528 1604 dbSNP
rs893940566 1613 dbSNP
rs12491747 1614 dbSNP
rs534344658 1617 dbSNP
rs912646161 1629 dbSNP
rs1374396883 1631 dbSNP
rs368470132 1634 dbSNP
rs1173608034 1635 dbSNP
rs1413112553 1643 dbSNP
rs945467834 1657 dbSNP
rs1422158894 1660 dbSNP
rs117110703 1663 dbSNP
rs1261684861 1673 dbSNP
rs1190087592 1674 dbSNP
rs534505586 1676 dbSNP
rs1486042966 1679 dbSNP
rs1266568177 1680 dbSNP
rs1449801224 1682 dbSNP
rs765007173 1695 dbSNP
rs1237106483 1700 dbSNP
rs1208342403 1701 dbSNP
rs1439305654 1703 dbSNP
rs1019686280 1709 dbSNP
rs1213795376 1721 dbSNP
rs901101532 1729 dbSNP
rs139091067 1730 dbSNP
rs1233363608 1735 dbSNP
rs1354341134 1752 dbSNP
rs1300694739 1754 dbSNP
rs34048061 1757 dbSNP
rs113347419 1758 dbSNP
rs34011416 1759 dbSNP
rs895426323 1774 dbSNP
rs1465446360 1777 dbSNP
rs1013660068 1782 dbSNP
rs149517586 1794 dbSNP
rs576143123 1799 dbSNP
rs1424729318 1800 dbSNP
rs886150025 1802 dbSNP
rs1004642575 1808 dbSNP
rs541779619 1812 dbSNP
rs969858616 1813 dbSNP
rs1389118614 1816 dbSNP
rs1180222623 1821 dbSNP
rs1016075585 1833 dbSNP
rs12488350 1835 dbSNP
rs927932687 1836 dbSNP
rs1329905996 1838 dbSNP
rs996053690 1851 dbSNP
rs1214303231 1859 dbSNP
rs571429944 1859 dbSNP
rs886058494 1859 dbSNP
rs1445075972 1863 dbSNP
rs12488392 1864 dbSNP
rs1224992457 1867 dbSNP
rs1360508250 1875 dbSNP
rs1244150105 1876 dbSNP
rs954690260 1886 dbSNP
rs987168595 1888 dbSNP
rs1278595023 1892 dbSNP
rs1446503001 1894 dbSNP
rs886058495 1896 dbSNP
rs1328478968 1908 dbSNP
rs966739512 1918 dbSNP
rs1462388564 1933 dbSNP
rs886058496 1933 dbSNP
rs1197521467 1935 dbSNP
rs541306296 1935 dbSNP
rs564255323 1944 dbSNP
rs1162697577 1949 dbSNP
rs1457137931 1953 dbSNP
rs533137321 1954 dbSNP
rs1408974136 1955 dbSNP
rs936819857 1957 dbSNP
rs144021874 1958 dbSNP
rs1254705257 1963 dbSNP
rs1244592593 1964 dbSNP
rs767379534 1964 dbSNP
rs1051017019 1968 dbSNP
rs1186152642 1969 dbSNP
rs942417643 1969 dbSNP
rs916814705 1970 dbSNP
rs1463943456 1973 dbSNP
rs1171966922 1975 dbSNP
rs900806449 1977 dbSNP
rs949663639 1990 dbSNP
rs1025550986 1991 dbSNP
rs1046062726 1998 dbSNP
rs886119105 2004 dbSNP
rs1292356885 2005 dbSNP
rs1455396138 2006 dbSNP
rs1345916370 2009 dbSNP
rs1158245177 2017 dbSNP
rs878912236 2021 dbSNP
rs1005364836 2040 dbSNP
rs563333604 2049 dbSNP
rs766039497 2050 dbSNP
rs1265178866 2058 dbSNP
rs886058497 2058 dbSNP
rs1023875182 2061 dbSNP
rs1485890586 2063 dbSNP
rs148657202 2065 dbSNP
rs750672596 2066 dbSNP
rs1213852628 2067 dbSNP
rs1349524028 2068 dbSNP
rs982566458 2069 dbSNP
rs1234411440 2076 dbSNP
rs1312034620 2081 dbSNP
rs1299798087 2083 dbSNP
rs898950828 2084 dbSNP
rs751216967 2097 dbSNP
rs1297607484 2098 dbSNP
rs1398246638 2100 dbSNP
rs1310619725 2101 dbSNP
rs1035036323 2104 dbSNP
rs1328248285 2107 dbSNP
rs190545723 2110 dbSNP
rs1028830783 2117 dbSNP
rs890337726 2121 dbSNP
rs988140264 2122 dbSNP
rs915522699 2124 dbSNP
rs1008830834 2128 dbSNP
rs62253040 2129 dbSNP
rs966660632 2130 dbSNP
rs144521114 2138 dbSNP
rs1264783100 2145 dbSNP
rs1199567059 2150 dbSNP
rs1483113064 2159 dbSNP
rs370736554 2162 dbSNP
rs1254594750 2165 dbSNP
rs1230106497 2166 dbSNP
rs910686387 2170 dbSNP
rs1032378799 2173 dbSNP
rs942465762 2184 dbSNP
rs183518530 2185 dbSNP
rs1357515450 2186 dbSNP
rs991354894 2192 dbSNP
rs1335079934 2197 dbSNP
rs571081349 2202 dbSNP
rs916762006 2207 dbSNP
rs922346803 2209 dbSNP
rs1299610084 2217 dbSNP
rs1193821111 2222 dbSNP
rs949639116 2226 dbSNP
rs1423529246 2228 dbSNP
rs186484499 2240 dbSNP
rs1477129343 2245 dbSNP
rs982378887 2246 dbSNP
rs1421641344 2250 dbSNP
rs1252251412 2266 dbSNP
rs1197857168 2267 dbSNP
rs908153833 2268 dbSNP
rs1178975410 2269 dbSNP
rs1337624803 2276 dbSNP
rs940331510 2278 dbSNP
rs1244173816 2280 dbSNP
rs1360143854 2280 dbSNP
rs1338854392 2285 dbSNP
rs1037412061 2286 dbSNP
rs1465893084 2290 dbSNP
rs539609211 2304 dbSNP
rs886058498 2305 dbSNP
rs556346785 2307 dbSNP
rs375122733 2308 dbSNP
rs1462916480 2315 dbSNP
rs1387492636 2319 dbSNP
rs1391396654 2320 dbSNP
rs931759021 2321 dbSNP
rs17075919 2325 dbSNP
rs890315770 2326 dbSNP
rs1008706767 2328 dbSNP
rs1440679259 2329 dbSNP
rs1237997318 2330 dbSNP
rs1177182426 2333 dbSNP
rs535550939 2340 dbSNP
rs1209312391 2354 dbSNP
rs1291222474 2354 dbSNP
rs956759601 2356 dbSNP
rs903140341 2361 dbSNP
rs1009602610 2362 dbSNP
rs1376482616 2362 dbSNP
rs999478963 2367 dbSNP
rs1284917498 2369 dbSNP
rs1312524164 2377 dbSNP
rs1232317487 2379 dbSNP
rs1306750932 2380 dbSNP
rs1277831023 2381 dbSNP
rs1331546943 2381 dbSNP
rs767567435 2381 dbSNP
rs886058499 2381 dbSNP
rs555617596 2393 dbSNP
rs1386564679 2394 dbSNP
rs1158846275 2395 dbSNP
rs1022278027 2398 dbSNP
rs968310240 2401 dbSNP
rs555017968 2404 dbSNP
rs1479246748 2416 dbSNP
rs1486679248 2418 dbSNP
rs1198833379 2427 dbSNP
rs1032306562 2428 dbSNP
rs572387719 2446 dbSNP
rs1217469489 2450 dbSNP
rs1353186730 2455 dbSNP
rs756061412 2456 dbSNP
rs966642202 2460 dbSNP
rs76200032 2464 dbSNP
rs1274157153 2469 dbSNP
rs1024200110 2471 dbSNP
rs970906942 2472 dbSNP
rs1298210278 2485 dbSNP
rs753966054 2488 dbSNP
rs982311926 2490 dbSNP
rs192172748 2491 dbSNP
rs962293407 2493 dbSNP
rs1365687870 2494 dbSNP
rs973032054 2501 dbSNP
rs1420554953 2506 dbSNP
rs75590382 2509 dbSNP
rs1358735145 2513 dbSNP
rs779175770 2521 dbSNP
rs1488044546 2522 dbSNP
rs1050167074 2525 dbSNP
rs1212572503 2527 dbSNP
rs1442758975 2531 dbSNP
rs543597397 2533 dbSNP
rs1045421655 2536 dbSNP
rs911656338 2537 dbSNP
rs1003813049 2538 dbSNP
rs1341302707 2540 dbSNP
rs746117389 2541 dbSNP
rs886058500 2543 dbSNP
rs1386001935 2548 dbSNP
rs1298923516 2550 dbSNP
rs1041571107 2551 dbSNP
rs903068215 2554 dbSNP
rs563472893 2563 dbSNP
rs1448245721 2565 dbSNP
rs892568627 2570 dbSNP
rs1333860224 2577 dbSNP
rs529144741 2582 dbSNP
rs1403086142 2596 dbSNP
rs1054166837 2598 dbSNP
rs1240466277 2606 dbSNP
rs772371727 2609 dbSNP
rs1172092643 2611 dbSNP
rs893824718 2625 dbSNP
rs1012685351 2626 dbSNP
rs1421629692 2639 dbSNP
rs1022305857 2642 dbSNP
rs1473221466 2645 dbSNP
rs1237123722 2647 dbSNP
rs1284921043 2649 dbSNP
rs1207749715 2663 dbSNP
rs1350838897 2664 dbSNP
rs1458970160 2668 dbSNP
rs1258607566 2670 dbSNP
rs1197975667 2671 dbSNP
rs968417714 2672 dbSNP
rs1007548666 2673 dbSNP
rs1228412327 2677 dbSNP
rs1377910047 2678 dbSNP
rs1282140689 2682 dbSNP
rs1018310725 2689 dbSNP
rs1379640027 2691 dbSNP
rs1247798330 2695 dbSNP
rs1488443940 2697 dbSNP
rs1332595316 2701 dbSNP
rs1189784924 2703 dbSNP
rs1023713382 2704 dbSNP
rs201589254 2709 dbSNP
rs534161371 2709 dbSNP
rs886058501 2709 dbSNP
rs542691381 2710 dbSNP
rs1253128018 2714 dbSNP
rs951151993 2714 dbSNP
rs886058502 2718 dbSNP
rs1238514097 2724 dbSNP
rs982463074 2725 dbSNP
rs1456339145 2726 dbSNP
rs970842397 2728 dbSNP
rs1440508861 2730 dbSNP
rs1003674709 2731 dbSNP
rs1221661965 2740 dbSNP
rs1320656980 2747 dbSNP
rs1015110172 2750 dbSNP
rs1287280948 2752 dbSNP
rs1241922444 2758 dbSNP
rs1354011991 2759 dbSNP
rs1310390297 2776 dbSNP
rs1375319960 2780 dbSNP
rs1446528396 2780 dbSNP
rs1295860602 2790 dbSNP
rs1437253320 2792 dbSNP
rs780224696 2796 dbSNP
rs1162803048 2797 dbSNP
rs1421696732 2802 dbSNP
rs1381162325 2805 dbSNP
rs1157753590 2807 dbSNP
rs1426607851 2815 dbSNP
rs1437668790 2819 dbSNP
rs1165649621 2828 dbSNP
rs559212263 2835 dbSNP
rs941063129 2848 dbSNP
rs559324746 2851 dbSNP
rs1291535557 2856 dbSNP
rs1378799127 2865 dbSNP
rs1487855770 2866 dbSNP
rs528060949 2868 dbSNP
rs569103879 2870 dbSNP
rs986232748 2881 dbSNP
rs571083712 2885 dbSNP
rs769145015 2896 dbSNP
rs533447323 2900 dbSNP
rs1321593183 2904 dbSNP
rs1041496822 2908 dbSNP
rs182573852 2919 dbSNP
rs1056331745 2920 dbSNP
rs924460134 2923 dbSNP
rs935896729 2925 dbSNP
rs187702555 2927 dbSNP
rs1361409821 2929 dbSNP
rs894417530 2930 dbSNP
rs1178474075 2935 dbSNP
rs10433606 2936 dbSNP
rs1379197821 2938 dbSNP
rs192781060 2943 dbSNP
rs1446673643 2945 dbSNP
rs1007994137 2955 dbSNP
rs1182459807 2960 dbSNP
rs1413191108 2964 dbSNP
rs1432477569 2965 dbSNP
rs886058503 2966 dbSNP
rs555806468 2967 dbSNP
rs1403720057 2972 dbSNP
rs1045475704 2975 dbSNP
rs1017591160 2978 dbSNP
rs566061103 2987 dbSNP
rs1214049991 2993 dbSNP
rs906580497 2994 dbSNP
rs902104834 2995 dbSNP
rs1211277111 3002 dbSNP
rs534980794 3003 dbSNP
rs1282002800 3007 dbSNP
rs1220532247 3011 dbSNP
rs556437160 3020 dbSNP
rs1341265823 3029 dbSNP
rs1172790721 3031 dbSNP
rs1192389052 3031 dbSNP
rs1277777913 3031 dbSNP
rs1357343852 3031 dbSNP
rs1422234568 3031 dbSNP
rs1465365106 3031 dbSNP
rs529300680 3031 dbSNP
rs754848146 3031 dbSNP
rs886058504 3031 dbSNP
rs1190900535 3033 dbSNP
rs997699073 3036 dbSNP
rs1015075678 3042 dbSNP
rs1026449393 3049 dbSNP
rs1256424158 3052 dbSNP
rs1402451071 3053 dbSNP
rs1465947169 3054 dbSNP
rs950920215 3056 dbSNP
rs1261794372 3057 dbSNP
rs897974841 3058 dbSNP
rs995440647 3060 dbSNP
rs147840032 3063 dbSNP
rs1027900235 3065 dbSNP
rs1397606327 3068 dbSNP
rs1342420995 3077 dbSNP
rs1449807919 3088 dbSNP
rs953800239 3091 dbSNP
rs1313788837 3093 dbSNP
rs985776837 3098 dbSNP
rs1284230877 3101 dbSNP
rs1019036187 3123 dbSNP
rs770384574 3129 dbSNP
rs1333156732 3136 dbSNP
rs182509513 3137 dbSNP
rs926286635 3140 dbSNP
rs1280630275 3142 dbSNP
rs1399470164 3144 dbSNP
rs939270082 3150 dbSNP
rs992040699 3154 dbSNP
rs1163698912 3158 dbSNP
rs1319293029 3163 dbSNP
rs1423571107 3165 dbSNP
rs1241646957 3166 dbSNP
rs1180924688 3167 dbSNP
rs1458560122 3172 dbSNP
rs1238109348 3173 dbSNP
rs913811179 3173 dbSNP
rs965740561 3182 dbSNP
rs557330587 3183 dbSNP
rs886058505 3187 dbSNP
rs1256573162 3196 dbSNP
rs1266226820 3199 dbSNP
rs1244282246 3202 dbSNP
rs773938714 3204 dbSNP
rs573859349 3214 dbSNP
rs1447244914 3226 dbSNP
rs945228272 3235 dbSNP
rs1326836825 3237 dbSNP
rs1423702011 3242 dbSNP
rs977159705 3244 dbSNP
rs34247270 3249 dbSNP
rs1387988795 3250 dbSNP
rs1211051002 3251 dbSNP
rs10433548 3254 dbSNP
rs1162163476 3255 dbSNP
rs1471844489 3264 dbSNP
rs1188427192 3266 dbSNP
rs1160759221 3273 dbSNP
rs935823294 3279 dbSNP
rs1380214692 3284 dbSNP
rs1425609567 3285 dbSNP
rs542283317 3289 dbSNP
rs886058506 3289 dbSNP
rs776275000 3293 dbSNP
rs1169640855 3294 dbSNP
rs1268082541 3302 dbSNP
rs368870978 3304 dbSNP
rs1209328093 3310 dbSNP
rs1489901784 3311 dbSNP
rs1288505771 3319 dbSNP
rs1240584658 3322 dbSNP
rs903963743 3332 dbSNP
rs187478578 3335 dbSNP
rs528182279 3341 dbSNP
rs1344947706 3342 dbSNP
rs544940801 3344 dbSNP
rs192037837 3348 dbSNP
rs1402567037 3350 dbSNP
rs1445162109 3361 dbSNP
rs1045042596 3368 dbSNP
rs1298497101 3372 dbSNP
rs564535027 3373 dbSNP
rs1341614875 3379 dbSNP
rs1157210581 3387 dbSNP
rs1479254856 3405 dbSNP
rs1378723805 3426 dbSNP
rs939354589 3428 dbSNP
rs1479529965 3434 dbSNP
rs1265578568 3441 dbSNP
rs1036431987 3448 dbSNP
rs1006374495 3455 dbSNP
rs1281823784 3459 dbSNP
rs760617748 3462 dbSNP
rs1455894631 3468 dbSNP
rs1201976530 3473 dbSNP
rs1345552867 3488 dbSNP
rs530463544 3490 dbSNP
rs878876933 3495 dbSNP
rs1274257590 3499 dbSNP
rs1016406398 3517 dbSNP
rs897943679 3518 dbSNP
rs1278309081 3522 dbSNP
rs1276653291 3534 dbSNP
rs1398949537 3557 dbSNP
rs550043330 3562 dbSNP
rs1220235898 3566 dbSNP
rs1316591235 3572 dbSNP
rs1416582234 3579 dbSNP
rs1403518107 3583 dbSNP
rs1001923632 3587 dbSNP
rs1028242424 3589 dbSNP
rs889341202 3591 dbSNP
rs764115269 3594 dbSNP
rs1440914998 3604 dbSNP
rs1008239222 3606 dbSNP
rs184227734 3616 dbSNP
rs1264028456 3629 dbSNP
rs1488555108 3630 dbSNP
rs529460122 3631 dbSNP
rs1475175810 3636 dbSNP
rs965665149 3641 dbSNP
rs1189361217 3646 dbSNP
rs960392745 3650 dbSNP
rs1421447621 3661 dbSNP
rs1201644633 3669 dbSNP
rs977085859 3671 dbSNP
rs886058507 3672 dbSNP
rs1359423821 3673 dbSNP
rs1173009311 3677 dbSNP
rs1285651851 3678 dbSNP
rs1450604206 3679 dbSNP
rs549324985 3681 dbSNP
rs957351119 3684 dbSNP
rs566119632 3689 dbSNP
rs1412413069 3691 dbSNP
rs989964897 3692 dbSNP
rs913842071 3698 dbSNP
rs966602796 3700 dbSNP
rs1159879784 3701 dbSNP
rs1409528596 3709 dbSNP
rs979687304 3711 dbSNP
rs1322796594 3715 dbSNP
rs1472987471 3717 dbSNP
rs1242251697 3728 dbSNP
rs925117149 3730 dbSNP
rs886058508 3731 dbSNP
rs1333401875 3732 dbSNP
rs1203191191 3737 dbSNP
rs948639552 3741 dbSNP
rs1291538757 3745 dbSNP
rs534807288 3747 dbSNP
rs1228495438 3749 dbSNP
rs551893817 3756 dbSNP
rs886058509 3762 dbSNP
rs745510267 3764 dbSNP
rs1450921652 3770 dbSNP
rs563162123 3771 dbSNP
rs933347066 3774 dbSNP
rs1332703051 3779 dbSNP
rs1441540951 3784 dbSNP
rs560573785 3789 dbSNP
rs939323337 3792 dbSNP
rs1036405692 3796 dbSNP
rs528104363 3807 dbSNP
rs1161432440 3811 dbSNP
rs930732048 3813 dbSNP
rs1287062010 3817 dbSNP
rs1049202667 3823 dbSNP
rs571655685 3827 dbSNP
rs1214614482 3829 dbSNP
rs140754839 3833 dbSNP
rs539827619 3834 dbSNP
rs1199232534 3847 dbSNP
rs1490065321 3853 dbSNP
rs1289232776 3856 dbSNP
rs750529617 3863 dbSNP
rs905999888 3876 dbSNP
rs1308301892 3877 dbSNP
rs1223681129 3881 dbSNP
rs1371826272 3883 dbSNP
rs1002099708 3896 dbSNP
rs1040591762 3903 dbSNP
rs548845414 3913 dbSNP
rs1180088773 3915 dbSNP
rs1421255437 3918 dbSNP
rs1360884729 3919 dbSNP
rs1380593166 3922 dbSNP
rs1417174742 3925 dbSNP
rs574000256 3927 dbSNP
rs1191264074 3930 dbSNP
rs1479857870 3933 dbSNP
rs1156311129 3941 dbSNP
rs1218392699 3952 dbSNP
rs758729 3953 dbSNP
rs144617930 3956 dbSNP
rs1215523004 3961 dbSNP
rs112903046 3966 dbSNP
rs1020602802 3967 dbSNP
rs1323267234 3967 dbSNP
rs1304122665 3971 dbSNP
rs1329683051 3972 dbSNP
rs1449530756 3976 dbSNP
rs1224175962 3992 dbSNP
rs1345011303 3993 dbSNP
rs1281487816 3995 dbSNP
rs374838083 3999 dbSNP
rs1341378403 4002 dbSNP
rs1310243972 4011 dbSNP
rs573038669 4020 dbSNP
rs957114521 4036 dbSNP
rs1011759258 4039 dbSNP
rs1022735308 4046 dbSNP
rs1237959843 4056 dbSNP
rs1468808865 4061 dbSNP
rs532302934 4072 dbSNP
rs190485367 4082 dbSNP
rs1260683840 4083 dbSNP
rs1186275816 4113 dbSNP
rs1210388540 4114 dbSNP
rs1289107984 4120 dbSNP
rs1466962338 4122 dbSNP
rs1258252681 4132 dbSNP
rs1180350948 4135 dbSNP
rs758728 4148 dbSNP
rs1220549731 4154 dbSNP
rs928532192 4162 dbSNP
rs1308299063 4165 dbSNP
rs961289213 4173 dbSNP
rs972026352 4184 dbSNP
rs919273821 4189 dbSNP
rs113711457 4190 dbSNP
rs543824159 4194 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51099.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000458276.2 | 3UTR | AUCACUAUCAUUACUUUUUCUAGUUUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC 0.996 0.03 1.000 0.5 3 Click to see details
BLCA 0.994 0.03 1.000 0.5 3 Click to see details
HNSC 0.653 0.06 0.821 0.01 7 Click to see details
BRCA -0.398 0.37 -0.500 0.33 3 Click to see details
BRCA -0.398 0.37 -0.500 0.33 3 Click to see details
BRCA -0.398 0.37 -0.500 0.33 3 Click to see details
BRCA -0.398 0.37 -0.500 0.33 3 Click to see details
BRCA -0.398 0.37 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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