pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-3911 |
Genomic Coordinates | chr9: 127690687 - 127690795 |
Description | Homo sapiens miR-3911 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-3911 | |||||||||||||||||||||||||||
Sequence | 12| UGUGUGGAUCCUGGAGGAGGCA |33 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Illumina | DRVs in miRNA |
|
|||||||||||||||||||||||||
SNPs in miRNA |
|
|||||||||||||||||||||||||||
Putative Targets |
miRNA Expression profile | |
---|---|
Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
|
Circulating MicroRNA Expression Profiling |
Gene Information | |
---|---|
Gene Symbol | URGCP-MRPS24 |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
|
Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
|
CLIP-seq Support 1 for dataset GSM1048187 | |
---|---|
Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_control |
Location of target site | ENST00000603700.1 | 3UTR | ugccgugguccugaggcaguugucucca |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM545217 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-7 transfection |
Location of target site | ENST00000603700.1 | 3UTR | ucuccacacaaguacuacuuccucg |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||
---|---|---|---|---|---|---|---|
|
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
![]() |
![]() |
|||||||
Strong evidence | Less strong evidence | |||||||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|||||
MIRT207399 | MAT2A | methionine adenosyltransferase 2A | ![]() |
![]() |
2 | 6 | ||||||
MIRT284537 | PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT291946 | TPM4 | tropomyosin 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT293609 | PVR | poliovirus receptor | ![]() |
![]() |
2 | 2 | ||||||
MIRT357688 | PAIP2 | poly(A) binding protein interacting protein 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT451607 | MEIS3P1 | Meis homeobox 3 pseudogene 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT452110 | IFITM1 | interferon induced transmembrane protein 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT457804 | KLHL25 | kelch like family member 25 | ![]() |
![]() |
2 | 2 | ||||||
MIRT462730 | EFNB1 | ephrin B1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT463219 | ZNF131 | zinc finger protein 131 | ![]() |
![]() |
2 | 2 | ||||||
MIRT464141 | VPS28 | VPS28, ESCRT-I subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT467582 | SLC7A5 | solute carrier family 7 member 5 | ![]() |
![]() |
2 | 6 | ||||||
MIRT470824 | PLXND1 | plexin D1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT474230 | LCLAT1 | lysocardiolipin acyltransferase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT478989 | COLGALT1 | collagen beta(1-O)galactosyltransferase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT479462 | CDK6 | cyclin dependent kinase 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT483558 | SYT2 | synaptotagmin 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT484483 | SLC9A1 | solute carrier family 9 member A1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT485224 | PRICKLE1 | prickle planar cell polarity protein 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT490356 | DPYSL5 | dihydropyrimidinase like 5 | ![]() |
![]() |
2 | 4 | ||||||
MIRT493177 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT509802 | CHAF1B | chromatin assembly factor 1 subunit B | ![]() |
![]() |
2 | 4 | ||||||
MIRT511815 | HDGF | heparin binding growth factor | ![]() |
![]() |
2 | 2 | ||||||
MIRT512254 | ARPP19 | cAMP regulated phosphoprotein 19 | ![]() |
![]() |
2 | 6 | ||||||
MIRT513025 | GPT2 | glutamic--pyruvic transaminase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT519640 | ZNF772 | zinc finger protein 772 | ![]() |
![]() |
2 | 4 | ||||||
MIRT531178 | SIGLEC12 | sialic acid binding Ig like lectin 12 (gene/pseudogene) | ![]() |
![]() |
2 | 2 | ||||||
MIRT537870 | EDA2R | ectodysplasin A2 receptor | ![]() |
![]() |
2 | 2 | ||||||
MIRT551914 | IGLON5 | IgLON family member 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT558359 | DMTF1 | cyclin D binding myb like transcription factor 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT559771 | URGCP-MRPS24 | URGCP-MRPS24 readthrough | ![]() |
![]() |
2 | 4 | ||||||
MIRT559813 | ZNF83 | zinc finger protein 83 | ![]() |
![]() |
2 | 2 | ||||||
MIRT561999 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
![]() |
2 | 2 | ||||||
MIRT565754 | SERTAD2 | SERTA domain containing 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT569423 | DCAF8 | DDB1 and CUL4 associated factor 8 | ![]() |
![]() |
2 | 2 | ||||||
MIRT569845 | RGS5 | regulator of G protein signaling 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT606928 | CDK15 | cyclin dependent kinase 15 | ![]() |
![]() |
2 | 2 | ||||||
MIRT607616 | TMEM130 | transmembrane protein 130 | ![]() |
![]() |
2 | 4 | ||||||
MIRT607629 | TRIOBP | TRIO and F-actin binding protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT607885 | SATB1 | SATB homeobox 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT607942 | SSX2 | SSX family member 2 | ![]() |
![]() |
2 | 4 | ||||||
MIRT608017 | CARNS1 | carnosine synthase 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT608036 | UBLCP1 | ubiquitin like domain containing CTD phosphatase 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT608063 | SSX2B | SSX family member 2B | ![]() |
![]() |
2 | 4 | ||||||
MIRT608558 | SBK1 | SH3 domain binding kinase 1 | ![]() |
![]() |
2 | 6 | ||||||
MIRT608915 | NCDN | neurochondrin | ![]() |
![]() |
2 | 6 | ||||||
MIRT615876 | HIF1AN | hypoxia inducible factor 1 alpha subunit inhibitor | ![]() |
![]() |
2 | 4 | ||||||
MIRT618023 | ELFN1 | extracellular leucine rich repeat and fibronectin type III domain containing 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT620505 | SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide | ![]() |
![]() |
2 | 2 | ||||||
MIRT628101 | IL1RAPL1 | interleukin 1 receptor accessory protein like 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT628700 | ZNF548 | zinc finger protein 548 | ![]() |
![]() |
2 | 2 | ||||||
MIRT630658 | POU2F1 | POU class 2 homeobox 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT643508 | ZNF28 | zinc finger protein 28 | ![]() |
![]() |
2 | 2 | ||||||
MIRT646379 | SLC22A6 | solute carrier family 22 member 6 | ![]() |
![]() |
2 | 2 | ||||||
MIRT660041 | C15orf61 | chromosome 15 open reading frame 61 | ![]() |
![]() |
2 | 2 | ||||||
MIRT687700 | KRR1 | KRR1, small subunit processome component homolog | ![]() |
![]() |
2 | 2 | ||||||
MIRT688858 | CAMKK2 | calcium/calmodulin dependent protein kinase kinase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT690443 | REPIN1 | replication initiator 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT690456 | ZNF33A | zinc finger protein 33A | ![]() |
![]() |
2 | 2 | ||||||
MIRT693796 | RHOG | ras homolog family member G | ![]() |
![]() |
2 | 2 | ||||||
MIRT694274 | ZNF529 | zinc finger protein 529 | ![]() |
![]() |
2 | 4 | ||||||
MIRT697697 | WAC | WW domain containing adaptor with coiled-coil | ![]() |
![]() |
2 | 2 | ||||||
MIRT700242 | RCC2 | regulator of chromosome condensation 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT701836 | MRPL37 | mitochondrial ribosomal protein L37 | ![]() |
![]() |
2 | 2 | ||||||
MIRT704255 | DHCR24 | 24-dehydrocholesterol reductase | ![]() |
![]() |
2 | 2 | ||||||
MIRT707203 | SDK2 | sidekick cell adhesion molecule 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT710365 | CREB5 | cAMP responsive element binding protein 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT711943 | WDFY1 | WD repeat and FYVE domain containing 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT715496 | MAZ | MYC associated zinc finger protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT719250 | MS4A1 | membrane spanning 4-domains A1 | ![]() |
![]() |
2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|