pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF83   
Synonyms HPF1, ZNF816B
Description zinc finger protein 83
Transcript NM_001105549   
Other Transcripts NM_001105550 , NM_001105551 , NM_001105552 , NM_018300   
Expression
Putative miRNA Targets on ZNF83
3'UTR of ZNF83
(miRNA target sites are highlighted)
>ZNF83|NM_001105549|3'UTR
   1 TGTGGCAGAGTGTTCAGTTAGCATTAAAGCCTTGTAAGACATACAATAATTTATACTGGAGAAAAACTTTGCAAGTATAA
  81 TGAATGTAGCAGAGCCTTTAGTTTTTGTTCAAGGCTTAATAACCGTTAGCTAGACCATAGAGGACAGAAACTTTACTAAT
 161 GTACTGAATGTGGCAAGGTCTTAAGGTAAAATCTGAGACCAGGATTCTTCAAAGAATTCTTGCTGGTGAGAAACCTAACA
 241 AATGTAATGAATGTGGCAAGGTCTTCTGGCACAATTCTCACATTGTACAATATTGCAAAAATTCATGCTTGAGAGAAACA
 321 AAAACACTGAGAGTGGGAAACCATTATGACTTCAAACATTCATCAACATCAGAGAATCCATACTAAAGAGCATTTATAAT
 401 AATTATATGTGATAGAGATTTTCCGCAGGCCAAAGTCTCACTAGGCATCAAAAACTTTTTTGATGAAACCATACAAATGT
 481 AACGTGCATGCTTAAGCTTTTACCCAGGCATCAAAACCGGAACATCACAGGGTTTATACTGGAGAGTAACTACACAAAGA
 561 TAATGTAATAAGCCTTTCAGTGTAATATTCATGATTTTGTCGTGAGAGATCCACTCAATAAAAACCAGGCAAATGTAGTG
 641 AATCTGGAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGAG--GAGGUC-C-UAGGUGUGu 5'
            | ||  | :||| | |||||:|| 
Target 5' ttCATCAACATCAGAGAATCCATACt 3'
359 - 384 138.00 -14.50
2
miRNA  3' acggAGGAGGUCCUAGGUGUGu 5'
              || |  : ||||||| | 
Target 5' tttgTCGTGAGAGATCCACTCa 3'
596 - 617 122.00 -16.20
3
miRNA  3' acggaGGAG-GUCCUAGGUGUGu 5'
               | || ||||:|::|:|| 
Target 5' cggaaCATCACAGGGTTTATACt 3'
518 - 540 117.00 -15.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20079425 30 COSMIC
COSN30530802 37 COSMIC
COSN31486894 41 COSMIC
COSN31570059 43 COSMIC
COSN4891648 46 COSMIC
COSN30534056 54 COSMIC
COSN18716512 125 COSMIC
COSN7448891 162 COSMIC
COSN8975507 320 COSMIC
COSN22620017 553 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765927489 2 dbSNP
rs1397031613 4 dbSNP
rs1169416430 7 dbSNP
rs200247745 10 dbSNP
rs1368049635 11 dbSNP
rs1318928500 17 dbSNP
rs772811659 22 dbSNP
rs927531991 30 dbSNP
rs1045985127 31 dbSNP
rs186220396 35 dbSNP
rs761459864 42 dbSNP
rs768769071 44 dbSNP
rs1188784429 45 dbSNP
rs768473445 46 dbSNP
rs1182170953 48 dbSNP
rs972726171 69 dbSNP
rs1026396662 70 dbSNP
rs994629893 71 dbSNP
rs1424815765 77 dbSNP
rs1468929921 82 dbSNP
rs963465291 83 dbSNP
rs1173820766 86 dbSNP
rs1407586073 88 dbSNP
rs183356999 96 dbSNP
rs1033388827 97 dbSNP
rs1391275612 102 dbSNP
rs1414603755 107 dbSNP
rs963078768 115 dbSNP
rs909975485 123 dbSNP
rs112408119 124 dbSNP
rs552094689 125 dbSNP
rs1223063356 128 dbSNP
rs1191892137 135 dbSNP
rs1281627343 138 dbSNP
rs1325741584 143 dbSNP
rs533924025 145 dbSNP
rs1231423440 160 dbSNP
rs1046707583 161 dbSNP
rs559722737 169 dbSNP
rs1218597037 173 dbSNP
rs1264264561 174 dbSNP
rs1204115061 179 dbSNP
rs372097471 182 dbSNP
rs1010218040 184 dbSNP
rs1196825526 189 dbSNP
rs190358999 200 dbSNP
rs1157532553 204 dbSNP
rs1046648 207 dbSNP
rs965970823 220 dbSNP
rs936654020 244 dbSNP
rs1298733739 259 dbSNP
rs377307964 260 dbSNP
rs1388051471 279 dbSNP
rs1301518929 282 dbSNP
rs1039740906 283 dbSNP
rs1234271976 284 dbSNP
rs1278994546 286 dbSNP
rs10383 289 dbSNP
rs772261150 292 dbSNP
rs1371566906 294 dbSNP
rs1287441316 306 dbSNP
rs1310313845 319 dbSNP
rs1433391600 320 dbSNP
rs1054252742 323 dbSNP
rs1451767157 323 dbSNP
rs1180681119 325 dbSNP
rs575518895 329 dbSNP
rs1470886426 330 dbSNP
rs556973863 332 dbSNP
rs1159166731 336 dbSNP
rs1176825409 337 dbSNP
rs1422479617 348 dbSNP
rs1435000123 348 dbSNP
rs1391229287 364 dbSNP
rs1387500563 369 dbSNP
rs929206228 373 dbSNP
rs1334048231 378 dbSNP
rs1449182091 390 dbSNP
rs1187560337 395 dbSNP
rs1310595107 396 dbSNP
rs906058952 402 dbSNP
rs371761063 404 dbSNP
rs571126369 404 dbSNP
rs1267562693 406 dbSNP
rs950277452 407 dbSNP
rs545314278 408 dbSNP
rs1248049453 413 dbSNP
rs1253687083 417 dbSNP
rs13103 424 dbSNP
rs1046679 425 dbSNP
rs879469146 426 dbSNP
rs909953240 426 dbSNP
rs1165401629 427 dbSNP
rs1368769721 428 dbSNP
rs1033439716 430 dbSNP
rs954284806 437 dbSNP
rs921739339 438 dbSNP
rs980501406 442 dbSNP
rs1234724516 446 dbSNP
rs1382162578 455 dbSNP
rs970911248 461 dbSNP
rs1315450680 462 dbSNP
rs1341433251 466 dbSNP
rs1025563826 470 dbSNP
rs1009858126 471 dbSNP
rs975916879 475 dbSNP
rs965920465 476 dbSNP
rs534340330 479 dbSNP
rs4664 482 dbSNP
rs1261897651 483 dbSNP
rs186042957 484 dbSNP
rs537240795 489 dbSNP
rs1228621452 490 dbSNP
rs376645460 491 dbSNP
rs1352015886 512 dbSNP
rs1427674157 514 dbSNP
rs1010316342 518 dbSNP
rs570274859 519 dbSNP
rs1033161355 523 dbSNP
rs1001260649 526 dbSNP
rs1171653729 528 dbSNP
rs1405361948 531 dbSNP
rs35120053 533 dbSNP
rs1468349151 539 dbSNP
rs905636652 542 dbSNP
rs1045836824 543 dbSNP
rs1381985967 546 dbSNP
rs1293818053 553 dbSNP
rs777402558 555 dbSNP
rs1218801211 558 dbSNP
rs1282305602 560 dbSNP
rs1320792804 564 dbSNP
rs551762850 567 dbSNP
rs1394681466 569 dbSNP
rs558457118 576 dbSNP
rs1014383804 582 dbSNP
rs899815763 583 dbSNP
rs1402056161 587 dbSNP
rs1303945158 590 dbSNP
rs897403976 590 dbSNP
rs755750209 593 dbSNP
rs944123699 599 dbSNP
rs1264974838 601 dbSNP
rs1037284496 602 dbSNP
rs1428936037 606 dbSNP
rs1431480091 606 dbSNP
rs941346297 608 dbSNP
rs890321687 615 dbSNP
rs1287646092 616 dbSNP
rs540159045 618 dbSNP
rs1401063093 634 dbSNP
rs1158595104 636 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggaggagguccUAGGUGUGu 5'
                       |||||||| 
Target 5' ------------aAUCCACACu 3'
1 - 10
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000594682.2 | 3UTR | aauccacacuggagagaaacc
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.542 0.17 -0.800 0.05 5 Click to see details
HNSC -0.338 0.23 -0.429 0.17 7 Click to see details
THCA -0.344 0.33 -0.800 0.1 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
LUSC -0.093 0.45 0.400 0.3 4 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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