miRTarBase - #MIRT561069


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pre-miRNA Information
pre-miRNA hsa-mir-7161   
Genomic Coordinates chr6: 158609707 - 158609790
Description Homo sapiens miR-7161 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-7161-5p
Sequence 1| UAAAGACUGUAGAGGCAACUGGU |23
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1198027002 1 dbSNP
rs530077902 10 dbSNP
rs1446817450 13 dbSNP
rs774892048 14 dbSNP
rs1438482648 16 dbSNP
rs1167166990 19 dbSNP
rs760372681 19 dbSNP
Putative Targets

Gene Information
Gene Symbol EIF4A3   
Synonyms DDX48, Fal1, MUK34, NMP265, NUK34, RCPS, eIF4AIII
Description eukaryotic translation initiation factor 4A3
Transcript NM_014740   
Expression
Putative miRNA Targets on EIF4A3
3'UTR of EIF4A3
(miRNA target sites are highlighted)		 
>EIF4A3|NM_014740|3'UTR
   1 AGCAGCAGATCAGTGGGATGAGGGAGACTGTTCACCTGCTGTGTACTCCTGTTTGGAAGTATTTAGATCCAGATTCTACT
  81 TAATGGGGTTTATATGGACTTTCTTCTCATAAATGGCCTGCCGTCTCCCTTCCTTTGAAGAGGATATGGGGATTCTGCTC
 161 TCTTTTCTTATTTACATGTAAATAATACATTGTTCTAAGTCTTTTTCATTAAAAATTTAAAACTTTTCCCATAAACTCTA
 241 TACTTCTAAGGTGCCACCACCTTCTCTAGTAACTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugGUCAACGGAGAUGUCAGAAAu 5'
            || ||| :|||| ||||||| 
Target 5' taCA-TTG-TTCTA-AGTCTTTt 3'
 186 - 205 162.00 -11.60
2 
miRNA  3' uggUCAACGG-------AGAUGUCA--GAAau 5'
             || ||||       ||| :|||  |||  
Target 5' ctaAGGTGCCACCACCTTCTCTAGTAACTTa- 3'
 246 - 276 100.00 -9.61
3 
miRNA  3' uggucaacggagaugucAGAAAu 5'
                           ||||| 
Target 5' atatggggattctgctcTCTTTt 3'
 144 - 166 100.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24400135 30 COSMIC
COSN28187662 43 COSMIC
COSN30112353 116 COSMIC
COSN21237698 240 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1303550179 8 dbSNP
rs1052725986 11 dbSNP
rs1426419445 13 dbSNP
rs772600459 16 dbSNP
rs1371271106 21 dbSNP
rs1194435805 22 dbSNP
rs1162639530 24 dbSNP
rs1452637380 27 dbSNP
rs777367238 29 dbSNP
rs755541775 30 dbSNP
rs1184168641 32 dbSNP
rs747806046 41 dbSNP
rs1251481640 43 dbSNP
rs1223725433 44 dbSNP
rs780769222 46 dbSNP
rs897105334 47 dbSNP
rs1290193399 51 dbSNP
rs1188697524 63 dbSNP
rs1038284720 69 dbSNP
rs542979591 72 dbSNP
rs1474254875 87 dbSNP
rs1167047140 88 dbSNP
rs935483822 92 dbSNP
rs1462909867 94 dbSNP
rs1323826721 103 dbSNP
rs766604487 105 dbSNP
rs1440219830 108 dbSNP
rs1298511909 109 dbSNP
rs887742470 122 dbSNP
rs188408639 123 dbSNP
rs866935469 127 dbSNP
rs866374349 128 dbSNP
rs111881225 132 dbSNP
rs953422695 139 dbSNP
rs1357536139 148 dbSNP
rs866492869 160 dbSNP
rs1271801089 163 dbSNP
rs1468477648 164 dbSNP
rs1263236693 170 dbSNP
rs937378220 170 dbSNP
rs750762246 171 dbSNP
rs1192057988 186 dbSNP
rs966108334 195 dbSNP
rs767779903 202 dbSNP
rs1162572736 205 dbSNP
rs1361393850 207 dbSNP
rs1417077496 213 dbSNP
rs946233660 222 dbSNP
rs545253149 238 dbSNP
rs1019933152 240 dbSNP
rs1335355169 243 dbSNP
rs1004164118 254 dbSNP
rs1409683977 256 dbSNP
rs866706208 257 dbSNP
rs1394620521 266 dbSNP
rs1170663796 279 dbSNP
rs780603477 279 dbSNP
rs577908595 285 dbSNP
rs75483110 287 dbSNP
rs990378760 289 dbSNP
rs1416978264 294 dbSNP
rs1384728370 300 dbSNP
rs1291884764 302 dbSNP
rs1181802182 303 dbSNP
rs1229553165 305 dbSNP
rs957279842 305 dbSNP
rs1446428822 307 dbSNP
rs117481396 317 dbSNP
rs1347944013 317 dbSNP
rs1256380586 322 dbSNP
rs1486485181 322 dbSNP
rs995342890 324 dbSNP
rs1203560890 327 dbSNP
rs1256562662 327 dbSNP
rs1472841391 328 dbSNP
rs28479732 328 dbSNP
rs1435819351 330 dbSNP
rs1365560549 332 dbSNP
rs182859157 339 dbSNP
rs77811869 340 dbSNP
rs1311618112 341 dbSNP
rs1376275500 341 dbSNP
rs1392425704 341 dbSNP
rs1416868260 341 dbSNP
rs1205482746 342 dbSNP
rs1358258497 343 dbSNP
rs1309754988 346 dbSNP
rs1334549664 347 dbSNP
rs1447591006 347 dbSNP
rs1237693890 351 dbSNP
rs1256139177 352 dbSNP
rs955150037 357 dbSNP
rs1247528632 360 dbSNP
rs1279297307 361 dbSNP
rs1483273613 364 dbSNP
rs1178780312 367 dbSNP
rs1381978450 373 dbSNP
rs1418502871 374 dbSNP
rs1181101645 378 dbSNP
rs1013651691 381 dbSNP
rs1285239847 382 dbSNP
rs1172031542 392 dbSNP
rs896181621 394 dbSNP
rs114578253 397 dbSNP
rs1394949072 398 dbSNP
rs191123889 398 dbSNP
rs139762904 399 dbSNP
rs1303416310 404 dbSNP
rs1310205092 405 dbSNP
rs925539025 406 dbSNP
rs1043838287 420 dbSNP
rs1231566534 421 dbSNP
rs1017264766 430 dbSNP
rs1005442754 435 dbSNP
rs1206355396 437 dbSNP
rs1249462734 440 dbSNP
rs932183201 447 dbSNP
rs887785725 448 dbSNP
rs1055831563 454 dbSNP
rs922005549 461 dbSNP
rs976219104 463 dbSNP
rs1365171189 465 dbSNP
rs1429395230 466 dbSNP
rs1172918186 469 dbSNP
rs1161820628 470 dbSNP
rs966429518 478 dbSNP
rs569444652 481 dbSNP
rs572182786 482 dbSNP
rs551059973 485 dbSNP
rs564634378 487 dbSNP
rs907842340 489 dbSNP
rs1055130824 495 dbSNP
rs553398440 495 dbSNP
rs1468511599 500 dbSNP
rs983878045 502 dbSNP
rs1293125316 503 dbSNP
rs1306728961 504 dbSNP
rs1233726210 506 dbSNP
rs936296316 511 dbSNP
rs1467132245 512 dbSNP
rs911457539 514 dbSNP
rs1253774756 522 dbSNP
rs951239140 523 dbSNP
rs985132205 540 dbSNP
rs1417756445 542 dbSNP
rs1026912630 543 dbSNP
rs1224092529 550 dbSNP
rs995331600 554 dbSNP
rs1420649788 556 dbSNP
rs969249628 557 dbSNP
rs1291259062 563 dbSNP
rs146379937 568 dbSNP
rs1345301244 569 dbSNP
rs1013307369 573 dbSNP
rs972468025 574 dbSNP
rs1360881293 578 dbSNP
rs928130855 582 dbSNP
rs1294960766 584 dbSNP
rs1332513303 586 dbSNP
rs896242526 587 dbSNP
rs1290657374 588 dbSNP
rs1232609820 598 dbSNP
rs4889828 600 dbSNP
rs140110973 601 dbSNP
rs1218103769 608 dbSNP
rs904103931 614 dbSNP
rs528804777 616 dbSNP
rs932130731 617 dbSNP
rs186325795 622 dbSNP
rs776026464 627 dbSNP
rs368922851 628 dbSNP
rs1414086492 637 dbSNP
rs1159638346 642 dbSNP
rs1344224434 651 dbSNP
rs1001569921 652 dbSNP
rs1314409676 652 dbSNP
rs774697502 652 dbSNP
rs900701021 657 dbSNP
rs770575345 659 dbSNP
rs1266355646 662 dbSNP
rs746643992 664 dbSNP
rs1488584934 667 dbSNP
rs1282322079 671 dbSNP
rs1353188122 673 dbSNP
rs944787823 675 dbSNP
rs1211876975 678 dbSNP
rs907955204 679 dbSNP
rs1241064539 682 dbSNP
rs1213015324 690 dbSNP
rs764692515 692 dbSNP
rs1315727518 698 dbSNP
rs1187327987 708 dbSNP
rs1233962661 712 dbSNP
rs144511079 719 dbSNP
rs930665664 722 dbSNP
rs1406611960 723 dbSNP
rs1454417578 724 dbSNP
rs1175152204 725 dbSNP
rs1366499993 726 dbSNP
rs919838347 727 dbSNP
rs1433834180 734 dbSNP
rs1329376142 739 dbSNP
rs777563300 751 dbSNP
rs890071697 752 dbSNP
rs530906381 754 dbSNP
rs748018447 760 dbSNP
rs1023443549 762 dbSNP
rs992402288 769 dbSNP
rs1288438459 790 dbSNP
rs1157963881 793 dbSNP
rs972905729 797 dbSNP
rs960451629 799 dbSNP
rs939813302 801 dbSNP
rs909604202 803 dbSNP
rs1439993829 804 dbSNP
rs1031200920 806 dbSNP
rs373831278 807 dbSNP
rs1390768697 819 dbSNP
rs1454317511 820 dbSNP
rs769153765 821 dbSNP
rs984009782 823 dbSNP
rs999142671 829 dbSNP
rs903550488 833 dbSNP
rs1033603293 835 dbSNP
rs1469127758 838 dbSNP
rs1426986846 841 dbSNP
rs1022492375 843 dbSNP
rs982002740 845 dbSNP
rs971401163 847 dbSNP
rs558452388 850 dbSNP
rs118121948 860 dbSNP
rs1328074067 864 dbSNP
rs1418345277 874 dbSNP
rs1010635507 875 dbSNP
rs891920565 877 dbSNP
rs1341940695 901 dbSNP
rs1033504372 908 dbSNP
rs1257945022 910 dbSNP
rs1000379031 914 dbSNP
rs1215008290 926 dbSNP
rs1250618211 931 dbSNP
rs889915166 934 dbSNP
rs900771626 934 dbSNP
rs934213474 935 dbSNP
rs1474284342 938 dbSNP
rs149270835 940 dbSNP
rs1418463293 943 dbSNP
rs1462960411 948 dbSNP
rs1250466369 951 dbSNP
rs1036722449 955 dbSNP
rs939678426 958 dbSNP
rs944878785 961 dbSNP
rs1461246486 962 dbSNP
rs1319206727 964 dbSNP
rs886517964 965 dbSNP
rs1047882242 966 dbSNP
rs930613242 967 dbSNP
rs909665504 968 dbSNP
rs8069324 970 dbSNP
rs113791996 971 dbSNP
rs937829723 972 dbSNP
rs1444977842 973 dbSNP
rs1491363726 973 dbSNP
rs926415042 973 dbSNP
rs970657552 973 dbSNP
rs980117227 973 dbSNP
rs913807015 974 dbSNP
rs1476123059 976 dbSNP
rs947957164 979 dbSNP
rs956202717 984 dbSNP
rs916492416 991 dbSNP
rs1367390749 994 dbSNP
rs183318482 1005 dbSNP
rs573866078 1006 dbSNP
rs1030687380 1010 dbSNP
rs1297904345 1014 dbSNP
rs1356540761 1016 dbSNP
rs1417113177 1020 dbSNP
rs977837019 1027 dbSNP
rs967786515 1033 dbSNP
rs1304441390 1034 dbSNP
rs1239117366 1042 dbSNP
rs780032134 1042 dbSNP
rs1261983954 1044 dbSNP
rs1028474095 1047 dbSNP
rs1215481824 1053 dbSNP
rs555618021 1054 dbSNP
rs995802551 1057 dbSNP
rs900720739 1059 dbSNP
rs569011960 1061 dbSNP
rs1019648608 1074 dbSNP
rs1486516297 1077 dbSNP
rs1353573340 1080 dbSNP
rs756295745 1089 dbSNP
rs1009065944 1092 dbSNP
rs1419660903 1093 dbSNP
rs1182545987 1095 dbSNP
rs1450912549 1098 dbSNP
rs536673295 1101 dbSNP
rs879795794 1105 dbSNP
rs1436960161 1106 dbSNP
rs998288879 1106 dbSNP
rs1182431131 1107 dbSNP
rs1402043474 1111 dbSNP
rs1374043167 1112 dbSNP
rs568770401 1112 dbSNP
rs886629974 1115 dbSNP
rs1254613105 1116 dbSNP
rs1037681256 1119 dbSNP
rs1231790317 1119 dbSNP
rs1255207863 1120 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000269349.3 | 3UTR | UUUUUCAUUAAAAAUUUAAAACUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-7161-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT131193 INCENP inner centromere protein 2 4
MIRT318016 CENPQ centromere protein Q 2 2
MIRT405275 ZNF678 zinc finger protein 678 2 2
MIRT442570 CCDC59 coiled-coil domain containing 59 2 2
MIRT442611 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT444013 GOLGA8H golgin A8 family member H 2 2
MIRT444024 GOLGA8M golgin A8 family member M 2 2
MIRT444339 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT444611 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT446342 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT446558 GOLGA8J golgin A8 family member J 2 2
MIRT447671 PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2 2
MIRT447975 MSH6 mutS homolog 6 2 2
MIRT448895 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT448936 CHD7 chromodomain helicase DNA binding protein 7 2 2
MIRT449414 TRIM5 tripartite motif containing 5 2 2
MIRT450291 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT454877 PCNA proliferating cell nuclear antigen 2 4
MIRT456615 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT462108 TMEM214 transmembrane protein 214 2 2
MIRT471923 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT474437 KLHL21 kelch like family member 21 2 2
MIRT476600 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT480573 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT483890 IL20RB interleukin 20 receptor subunit beta 2 6
MIRT493363 KIF5B kinesin family member 5B 2 2
MIRT494934 TMEM167A transmembrane protein 167A 2 2
MIRT495915 CLDN1 claudin 1 2 2
MIRT501574 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT502193 IGF1R insulin like growth factor 1 receptor 2 4
MIRT502928 CDC42SE1 CDC42 small effector 1 2 4
MIRT506393 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 4
MIRT506570 MNX1 motor neuron and pancreas homeobox 1 2 4
MIRT509478 GNL3L G protein nucleolar 3 like 2 6
MIRT518537 FLCN folliculin 2 6
MIRT519577 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT524088 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 4
MIRT524146 LDHD lactate dehydrogenase D 2 4
MIRT524659 C1orf50 chromosome 1 open reading frame 50 2 10
MIRT526324 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526566 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526612 ZNF780A zinc finger protein 780A 2 4
MIRT526889 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT527115 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT528023 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT529589 TMEM220 transmembrane protein 220 2 2
MIRT532797 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT537099 GPC6 glypican 6 2 2
MIRT539070 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 2
MIRT545495 DAPK2 death associated protein kinase 2 2 2
MIRT545814 ZNF608 zinc finger protein 608 2 4
MIRT553533 TMEM185B transmembrane protein 185B 2 4
MIRT557285 HIST2H2BE histone cluster 2 H2B family member e 2 2
MIRT559552 ARGLU1 arginine and glutamate rich 1 2 4
MIRT561069 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT561710 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT561995 LRRC58 leucine rich repeat containing 58 2 2
MIRT565896 NHS NHS actin remodeling regulator 2 2
MIRT567333 HMGB1 high mobility group box 1 2 2
MIRT568042 CLDN12 claudin 12 2 2
MIRT568315 BAG4 BCL2 associated athanogene 4 2 2
MIRT570677 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT571047 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT571359 SFT2D2 SFT2 domain containing 2 2 2
MIRT571935 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT572786 ZNF277 zinc finger protein 277 2 2
MIRT573936 CNTNAP2 contactin associated protein like 2 2 2
MIRT576962 Anxa4 annexin A4 2 3
MIRT608297 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT613342 AFF1 AF4/FMR2 family member 1 2 2
MIRT613529 ANAPC7 anaphase promoting complex subunit 7 2 2
MIRT614705 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT616658 ORAI1 ORAI calcium release-activated calcium modulator 1 2 2
MIRT624731 ANXA4 annexin A4 2 3
MIRT626525 TSC1 TSC complex subunit 1 2 2
MIRT627647 SCN1A sodium voltage-gated channel alpha subunit 1 2 2
MIRT637423 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT641059 TCP11L1 t-complex 11 like 1 2 4
MIRT645591 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT646455 ZNF705A zinc finger protein 705A 2 2
MIRT656454 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT676551 TMPPE transmembrane protein with metallophosphoesterase domain 2 4
MIRT682720 KIAA1456 KIAA1456 2 2
MIRT698307 TMEM2 transmembrane protein 2 2 2
MIRT701906 MMGT1 membrane magnesium transporter 1 2 2
MIRT702228 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT708642 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT709326 HMBOX1 homeobox containing 1 2 2
MIRT711400 RANBP2 RAN binding protein 2 2 2
MIRT712130 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT714226 ARMC10 armadillo repeat containing 10 2 2
MIRT716914 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT723060 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT723846 MN1 MN1 proto-oncogene, transcriptional regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-7161-5p Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (HEYA8)

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