pre-miRNA Information | |
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pre-miRNA | hsa-mir-4481 |
Genomic Coordinates | chr10: 12653138 - 12653197 |
Description | Homo sapiens miR-4481 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-4481 | ||||||||||||
Sequence | 1| GGAGUGGGCUGGUGGUU |17 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | Illumina | ||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | BCL2L12 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | BCL2 like 12 | ||||||||||||||||||||
Transcript | NM_001040668 | ||||||||||||||||||||
Other Transcripts | NM_138639 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on BCL2L12 | |||||||||||||||||||||
3'UTR of BCL2L12 (miRNA target sites are highlighted) |
>BCL2L12|NM_001040668|3'UTR 1 GCTCTTTCTCAGAAGCTGCTACAAGATGACACCTCATGTCCCTGCCCTCTTCGTGTGCTTTTCCAAGTCTTCCTATTCCA 81 CTCAGGGCTGTGGGGTGGTGGTTGCCCTACCTGTTTTTGCCAAAAATAAATTGTTTAAAACTTTTCTTATTAAAAACGTT 161 ACAAAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | ||||||||||
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miRNA:Target | ---- | |||||||||
Validation Method |
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Conditions | HEK293 | |||||||||
Location of target site | 3'UTR | |||||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | |||||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545217 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-7 transfection |
Location of target site | ENST00000246784.3 | 3UTR | CCCUCUUCGUGUGCUUUUCCAAGUCUUCCUAUUCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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84 hsa-miR-4481 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT100715 | TJAP1 | tight junction associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT183589 | ZC3H11A | zinc finger CCCH-type containing 11A | ![]() |
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2 | 2 | ||||||
MIRT338033 | DAZAP2 | DAZ associated protein 2 | ![]() |
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2 | 4 | ||||||
MIRT395796 | SPCS3 | signal peptidase complex subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT443947 | LRIT3 | leucine rich repeat, Ig-like and transmembrane domains 3 | ![]() |
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2 | 2 | ||||||
MIRT450580 | HIST1H2BG | histone cluster 1 H2B family member g | ![]() |
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2 | 6 | ||||||
MIRT451617 | MEIS3P1 | Meis homeobox 3 pseudogene 1 | ![]() |
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2 | 2 | ||||||
MIRT452331 | EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | ![]() |
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2 | 2 | ||||||
MIRT453279 | EFTUD2 | elongation factor Tu GTP binding domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT455212 | GNL1 | G protein nucleolar 1 (putative) | ![]() |
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2 | 2 | ||||||
MIRT455470 | LYPLA2 | lysophospholipase II | ![]() |
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2 | 2 | ||||||
MIRT456503 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | ![]() |
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2 | 2 | ||||||
MIRT456687 | LDB1 | LIM domain binding 1 | ![]() |
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2 | 2 | ||||||
MIRT456915 | DDA1 | DET1 and DDB1 associated 1 | ![]() |
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2 | 2 | ||||||
MIRT457603 | IDS | iduronate 2-sulfatase | ![]() |
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2 | 2 | ||||||
MIRT457848 | RNASEH2B | ribonuclease H2 subunit B | ![]() |
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2 | 4 | ||||||
MIRT458455 | RPRM | reprimo, TP53 dependent G2 arrest mediator homolog | ![]() |
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2 | 2 | ||||||
MIRT460179 | UNK | unkempt family zinc finger | ![]() |
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2 | 6 | ||||||
MIRT461465 | SLC19A3 | solute carrier family 19 member 3 | ![]() |
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2 | 2 | ||||||
MIRT464739 | UBE2Q1 | ubiquitin conjugating enzyme E2 Q1 | ![]() |
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2 | 2 | ||||||
MIRT465279 | TRIM28 | tripartite motif containing 28 | ![]() |
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2 | 2 | ||||||
MIRT468450 | SETD1B | SET domain containing 1B | ![]() |
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2 | 2 | ||||||
MIRT468620 | SUMO1 | small ubiquitin-like modifier 1 | ![]() |
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2 | 6 | ||||||
MIRT469152 | RNF121 | ring finger protein 121 | ![]() |
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2 | 2 | ||||||
MIRT470073 | PTGES2 | prostaglandin E synthase 2 | ![]() |
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2 | 2 | ||||||
MIRT470172 | PSMD11 | proteasome 26S subunit, non-ATPase 11 | ![]() |
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2 | 4 | ||||||
MIRT473156 | MLLT1 | MLLT1, super elongation complex subunit | ![]() |
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2 | 2 | ||||||
MIRT474308 | LAMC1 | laminin subunit gamma 1 | ![]() |
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2 | 2 | ||||||
MIRT474782 | KIAA0895L | KIAA0895 like | ![]() |
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2 | 2 | ||||||
MIRT476484 | GATAD2A | GATA zinc finger domain containing 2A | ![]() |
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2 | 2 | ||||||
MIRT477613 | EFNA3 | ephrin A3 | ![]() |
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2 | 2 | ||||||
MIRT479525 | CDCA4 | cell division cycle associated 4 | ![]() |
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2 | 2 | ||||||
MIRT479973 | CARD10 | caspase recruitment domain family member 10 | ![]() |
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2 | 2 | ||||||
MIRT480410 | C19orf47 | chromosome 19 open reading frame 47 | ![]() |
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2 | 2 | ||||||
MIRT480426 | C17orf85 | nuclear cap binding subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT483573 | SYT2 | synaptotagmin 2 | ![]() |
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2 | 2 | ||||||
MIRT483664 | QSOX2 | quiescin sulfhydryl oxidase 2 | ![]() |
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2 | 4 | ||||||
MIRT484532 | POLD3 | DNA polymerase delta 3, accessory subunit | ![]() |
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2 | 2 | ||||||
MIRT484616 | SIX3 | SIX homeobox 3 | ![]() |
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2 | 6 | ||||||
MIRT485897 | ZFP36 | ZFP36 ring finger protein | ![]() |
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2 | 2 | ||||||
MIRT486505 | MYH11 | myosin heavy chain 11 | ![]() |
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2 | 2 | ||||||
MIRT487505 | GRK5 | G protein-coupled receptor kinase 5 | ![]() |
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2 | 2 | ||||||
MIRT488852 | UBTF | upstream binding transcription factor, RNA polymerase I | ![]() |
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2 | 2 | ||||||
MIRT489464 | MSC | musculin | ![]() |
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2 | 2 | ||||||
MIRT491170 | LRP3 | LDL receptor related protein 3 | ![]() |
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2 | 2 | ||||||
MIRT496627 | TMEM67 | transmembrane protein 67 | ![]() |
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2 | 2 | ||||||
MIRT497616 | ANG | angiogenin | ![]() |
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2 | 2 | ||||||
MIRT497766 | KIAA0895 | KIAA0895 | ![]() |
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2 | 2 | ||||||
MIRT499680 | MRE11A | MRE11 homolog, double strand break repair nuclease | ![]() |
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2 | 6 | ||||||
MIRT499774 | SLC29A2 | solute carrier family 29 member 2 | ![]() |
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2 | 2 | ||||||
MIRT501745 | NSD1 | nuclear receptor binding SET domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT504995 | ZNF652 | zinc finger protein 652 | ![]() |
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2 | 2 | ||||||
MIRT511664 | HIST1H3C | histone cluster 1 H3 family member c | ![]() |
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2 | 2 | ||||||
MIRT511690 | HIST1H2BO | histone cluster 1 H2B family member o | ![]() |
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2 | 4 | ||||||
MIRT511703 | HIST1H2BL | histone cluster 1 H2B family member l | ![]() |
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2 | 4 | ||||||
MIRT511734 | HIST1H2BE | histone cluster 1 H2B family member e | ![]() |
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2 | 8 | ||||||
MIRT512858 | TBC1D13 | TBC1 domain family member 13 | ![]() |
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2 | 2 | ||||||
MIRT513444 | EMP1 | epithelial membrane protein 1 | ![]() |
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2 | 6 | ||||||
MIRT515681 | TFPI | tissue factor pathway inhibitor | ![]() |
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2 | 2 | ||||||
MIRT523529 | GLUL | glutamate-ammonia ligase | ![]() |
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2 | 2 | ||||||
MIRT525546 | PHB2 | prohibitin 2 | ![]() |
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2 | 4 | ||||||
MIRT526209 | SNX24 | sorting nexin 24 | ![]() |
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2 | 2 | ||||||
MIRT531554 | SRD5A1 | steroid 5 alpha-reductase 1 | ![]() |
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2 | 2 | ||||||
MIRT533764 | TMEM135 | transmembrane protein 135 | ![]() |
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2 | 2 | ||||||
MIRT545582 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' | ![]() |
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2 | 2 | ||||||
MIRT552434 | ZNF460 | zinc finger protein 460 | ![]() |
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2 | 2 | ||||||
MIRT561159 | BCL2L12 | BCL2 like 12 | ![]() |
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2 | 2 | ||||||
MIRT562345 | EXOSC2 | exosome component 2 | ![]() |
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2 | 2 | ||||||
MIRT570659 | KDM6B | lysine demethylase 6B | ![]() |
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2 | 2 | ||||||
MIRT571076 | TCHHL1 | trichohyalin like 1 | ![]() |
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2 | 2 | ||||||
MIRT571330 | TPCN2 | two pore segment channel 2 | ![]() |
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2 | 2 | ||||||
MIRT571603 | TOB2 | transducer of ERBB2, 2 | ![]() |
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2 | 2 | ||||||
MIRT573013 | RPP25 | ribonuclease P and MRP subunit p25 | ![]() |
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2 | 2 | ||||||
MIRT609041 | EP300 | E1A binding protein p300 | ![]() |
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2 | 2 | ||||||
MIRT613398 | DNAH17 | dynein axonemal heavy chain 17 | ![]() |
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2 | 2 | ||||||
MIRT635589 | TTC9C | tetratricopeptide repeat domain 9C | ![]() |
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2 | 2 | ||||||
MIRT661118 | FPR1 | formyl peptide receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT690103 | PNMA2 | paraneoplastic Ma antigen 2 | ![]() |
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2 | 2 | ||||||
MIRT694972 | PLAC8 | placenta specific 8 | ![]() |
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2 | 2 | ||||||
MIRT695515 | ALPI | alkaline phosphatase, intestinal | ![]() |
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2 | 2 | ||||||
MIRT695578 | ASB16 | ankyrin repeat and SOCS box containing 16 | ![]() |
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2 | 2 | ||||||
MIRT699570 | SIT1 | signaling threshold regulating transmembrane adaptor 1 | ![]() |
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2 | 2 | ||||||
MIRT701991 | MIER3 | MIER family member 3 | ![]() |
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2 | 2 | ||||||
MIRT725464 | GRAP2 | GRB2-related adaptor protein 2 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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