miRTarBase - #MIRT561974


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pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol LRRC59   
Synonyms PRO1855, p34
Description leucine rich repeat containing 59
Transcript NM_018509   
Expression
Putative miRNA Targets on LRRC59
3'UTR of LRRC59
(miRNA target sites are highlighted)		 
>LRRC59|NM_018509|3'UTR
   1 GCTTGTCCCCAGCACCTGCTGCCTCCCAGCCTTGGAGTTTGGATTCCTATGGAATTGGGTTCTGCTGGACACAACCTCTT
  81 TTTAGCATCAGACCTACCTGCCATCATCAAATGGCTGCAGATTGGTACATGAGACCTCCTCTTTGTAGGACTTCTTCATT
 161 CCTTAGTCAGGGTTCCCTGAAGGAATGAGGAGAAATGGGAGGTGGCGGGGGGGCGTGGGGGGCAGTTACCTGCATGCCTA
 241 AAGGAGTAGGCTTGGGGGTGGGGAGAGAGAAAACATAGCCTTTTCTAGTTGTTATATAAAGCTGTGTAAAGGCAAGGCTC
 321 GTTTCTACTAAATGGTCAGCTGTCACTACATTTATACTTTTGTATGCCACAAACCCTTTCATTCCTCCCTGGGAATCAGG
 401 GTAGATCAGGAGGAACTGGGGGGGACTAGAACACCACGCTCAGTAAATCCAGTCTAAACTGGGAGGTAGGGGTATTCCTG
 481 TTTTCTTTAGGACCTCAGAGATGTAAGCATTTTAGCAGCCACACAAAATCTCTGGCTATGAAAGGGACTTCATGACCATC
 561 CAGTCCAATATAACACTTGCAGACAGAGAAACTGAGGTCTTCCATGACTTGCCTAGTCTCCCAGCTAGTTTGAGGCAAAA
 641 CTGGATTCCCACTCTGGTATTCTTTCTTCCCTTTACATCATTTTCCCTCCTTTATAATGTCCTGAGAGACCAGAACTCAC
 721 ACCAGAATCGATTATTCCTCAGGTGAAGCATAGACTCTTTCATGGTAGACAGATTTCACGACTCAGAGATAGAAATCTCT
 801 TGCTATCATCAGGTCACGGGCAGCTCCTGTGGAGTCCTGCCCAACTTATGTGGCTTCCATAAAATGGCAACAGTCCAGGC
 881 TCCTTGCCTAATTTTAGAGCATTAACTCCCTAATTGCCAGTAAGCAAGGAGGTGGATCTCTGCAAACCTACACTGTCTAT
 961 GACAGCTCTAGTTGTACTTGGTGTGACTAAATACCTCAAAGGCAACCTGCTTCTGCAGGTTTTGAAGTGTCAGCTTCATA
1041 AGACACTGAGGTTTAGAATTGTTTGATTCTAGACCATAACTGAAGGGCATAAATGGAAACAGGATATGAAGGGAAACAAG
1121 TAGCATCATGGAGCTGAAAAGTGGTGCATCACCCAATGGCTAGCACAAACAAGGATCACACTGTCCATTCTCTTGTCTGC
1201 TAAATTAAGCATTTTCTTGCCTCCTTTGCTTCATCTTTTCACAACAGCTGGATAGAGGGATCAGAAATGACTGTGTCATG
1281 GTGCTCATTCACTGCAAACTCCCAGTTGCAAGCTCCTTGGCTCCCCCGGAGGGAGCAAGAATCTCATAGTTCAGAGACAC
1361 AGAGGGCCTTTTAGCCCTAATGACCTTTTGGATGGGACTGCAACTCATGACTATCCTGATATTGGAAGAAAGGACTTTGT
1441 TAATCTTCTCCCCCATAGCTCTGCTGCGTAGGTCTACATCTTACTCAGAATCACTACACATTCCTTTAGTCTTCCTCCAA
1521 GCTCCAGAGCCATTGGTACAAATGCTTTATTGAAACTAAATACATAATACACACAATGAGATGAAGACAATATAGAAGTC
1601 CGCATAGTCATCATAATCCCGTTCCTTGGCCGGTTGAGGCAGCTCAGTGGCTGAGCCCAGTCAAGCCAACCCGCAGCTTC
1681 ACTCACGACTTCAAGATTTGATGCTAATTCTTTTGGATTTCTACAGTTATTAAATAAGTGTCTGAGTGGACTGTCAAAAA
1761 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaCAUCCGGA-----AA----UC-UAGUGAa 5'
            |||||:||     ||    || |||||| 
Target 5' gcGTAGGTCTACATCTTACTCAGAATCACTa 3'
 1466 - 1496 129.00 -14.60
2 
miRNA  3' uacauccGGAAAUCUAGUGAa 5'
                 |||||| ||||:| 
Target 5' tttcttcCCTTTACATCATTt 3'
 663 - 683 122.00 -11.10
3 
miRNA  3' uacauccggaaaUCUAGUGaa 5'
                      :||||||  
Target 5' tagcacaaacaaGGATCACac 3'
 1161 - 1181 121.00 -6.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30449923 9 COSMIC
COSN30103657 58 COSMIC
COSN30128088 60 COSMIC
COSN26983101 71 COSMIC
COSN30180030 78 COSMIC
COSN16810706 236 COSMIC
COSN31568071 269 COSMIC
COSN31988091 818 COSMIC
COSN19227487 882 COSMIC
COSN28654533 1074 COSMIC
COSN20169822 1093 COSMIC
COSN26679506 1164 COSMIC
COSN20725778 1409 COSMIC
COSN17937178 1424 COSMIC
COSN26465955 1454 COSMIC
COSN31530506 1473 COSMIC
COSN31483677 1492 COSMIC
COSN29664038 1524 COSMIC
COSN30164652 1595 COSMIC
COSN1721192 1742 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754469903 2 dbSNP
rs1319233516 7 dbSNP
rs750975889 8 dbSNP
rs202162924 9 dbSNP
rs762113935 12 dbSNP
rs776276398 20 dbSNP
rs1390963636 21 dbSNP
rs1470730216 26 dbSNP
rs1451606761 28 dbSNP
rs1170891165 29 dbSNP
rs1377386976 30 dbSNP
rs754178248 31 dbSNP
rs1453779787 49 dbSNP
rs764232630 50 dbSNP
rs1022003808 61 dbSNP
rs571373096 62 dbSNP
rs1011079030 75 dbSNP
rs1334665175 76 dbSNP
rs892121372 78 dbSNP
rs1406847240 85 dbSNP
rs1368719399 93 dbSNP
rs1296665913 101 dbSNP
rs1168020739 102 dbSNP
rs1052138250 110 dbSNP
rs939233341 115 dbSNP
rs916851282 120 dbSNP
rs1410528158 122 dbSNP
rs1200538708 137 dbSNP
rs1281295504 138 dbSNP
rs187926967 139 dbSNP
rs1208472442 142 dbSNP
rs537463024 144 dbSNP
rs1045018102 145 dbSNP
rs1466414358 176 dbSNP
rs1477551175 186 dbSNP
rs1269162796 187 dbSNP
rs919958128 190 dbSNP
rs1201067043 191 dbSNP
rs972801767 193 dbSNP
rs1481862940 195 dbSNP
rs1250519138 196 dbSNP
rs1174413987 197 dbSNP
rs947892218 198 dbSNP
rs1204573965 200 dbSNP
rs1438953179 203 dbSNP
rs182564736 206 dbSNP
rs961766319 207 dbSNP
rs909709068 208 dbSNP
rs1217861185 209 dbSNP
rs549398671 212 dbSNP
rs116114267 214 dbSNP
rs1466478300 214 dbSNP
rs770529197 215 dbSNP
rs1323187383 216 dbSNP
rs930756638 220 dbSNP
rs919258469 222 dbSNP
rs1158251237 223 dbSNP
rs1471560392 223 dbSNP
rs190245654 229 dbSNP
rs1455115923 246 dbSNP
rs1348853645 248 dbSNP
rs966030097 254 dbSNP
rs912122257 255 dbSNP
rs1387032635 262 dbSNP
rs1442990467 262 dbSNP
rs1348029450 264 dbSNP
rs1408694009 265 dbSNP
rs1289482092 267 dbSNP
rs1319279838 271 dbSNP
rs1243048268 275 dbSNP
rs1265272285 278 dbSNP
rs954550168 279 dbSNP
rs1332035808 287 dbSNP
rs1413714433 294 dbSNP
rs533213855 295 dbSNP
rs1178318837 301 dbSNP
rs1471430468 304 dbSNP
rs996531645 307 dbSNP
rs893471217 308 dbSNP
rs1420854531 313 dbSNP
rs370133634 320 dbSNP
rs564427157 321 dbSNP
rs999251033 322 dbSNP
rs1165015357 326 dbSNP
rs1022917925 332 dbSNP
rs1428490080 344 dbSNP
rs377582963 347 dbSNP
rs544566628 349 dbSNP
rs1010650655 350 dbSNP
rs1376130321 351 dbSNP
rs11548984 352 dbSNP
rs1235102672 357 dbSNP
rs1046528769 360 dbSNP
rs115294777 361 dbSNP
rs1341383141 362 dbSNP
rs562141195 362 dbSNP
rs373546654 381 dbSNP
rs1295623538 382 dbSNP
rs1461251190 384 dbSNP
rs777976263 390 dbSNP
rs542554507 391 dbSNP
rs574022831 404 dbSNP
rs1253185883 407 dbSNP
rs1481572090 412 dbSNP
rs931558220 418 dbSNP
rs553967060 419 dbSNP
rs1224412613 420 dbSNP
rs1185221891 421 dbSNP
rs1375552164 422 dbSNP
rs1012586206 424 dbSNP
rs940095472 425 dbSNP
rs888278705 435 dbSNP
rs868719870 437 dbSNP
rs930730808 438 dbSNP
rs954520488 438 dbSNP
rs919313159 441 dbSNP
rs1455404161 443 dbSNP
rs1454869935 453 dbSNP
rs1036422589 456 dbSNP
rs1364687142 460 dbSNP
rs1229496899 464 dbSNP
rs1298016618 468 dbSNP
rs1310450857 475 dbSNP
rs1232665921 478 dbSNP
rs533977611 485 dbSNP
rs1255290971 488 dbSNP
rs944670494 497 dbSNP
rs1461753923 498 dbSNP
rs911897593 502 dbSNP
rs1159287508 506 dbSNP
rs1401947635 517 dbSNP
rs1464153531 520 dbSNP
rs149657552 533 dbSNP
rs748594153 539 dbSNP
rs953795528 545 dbSNP
rs1421209171 549 dbSNP
rs915392652 554 dbSNP
rs1174768027 568 dbSNP
rs1180764713 568 dbSNP
rs116922736 576 dbSNP
rs537976825 578 dbSNP
rs541503522 580 dbSNP
rs1388439155 585 dbSNP
rs1436285332 597 dbSNP
rs956873911 599 dbSNP
rs755023879 612 dbSNP
rs753906292 614 dbSNP
rs1386261753 616 dbSNP
rs1302122421 623 dbSNP
rs1324183807 625 dbSNP
rs1225340298 626 dbSNP
rs1463772700 627 dbSNP
rs1266183425 628 dbSNP
rs1328139200 632 dbSNP
rs999618490 633 dbSNP
rs780457038 634 dbSNP
rs7210866 636 dbSNP
rs1318955586 649 dbSNP
rs1287867111 655 dbSNP
rs1269058551 662 dbSNP
rs1013326063 669 dbSNP
rs895276951 674 dbSNP
rs970348318 679 dbSNP
rs1317030592 682 dbSNP
rs1023340968 691 dbSNP
rs1432635465 693 dbSNP
rs1161797555 695 dbSNP
rs1360937472 696 dbSNP
rs1289214878 701 dbSNP
rs1436115478 703 dbSNP
rs1055708037 704 dbSNP
rs747550283 710 dbSNP
rs931552188 713 dbSNP
rs1286333562 715 dbSNP
rs1347722041 717 dbSNP
rs1349817319 720 dbSNP
rs1012164494 729 dbSNP
rs1224105448 730 dbSNP
rs756360581 734 dbSNP
rs1162427852 743 dbSNP
rs888386907 744 dbSNP
rs1424687687 754 dbSNP
rs1386444647 757 dbSNP
rs1220446511 760 dbSNP
rs1048319152 761 dbSNP
rs1448190895 764 dbSNP
rs994382200 771 dbSNP
rs778183060 779 dbSNP
rs1251700745 780 dbSNP
rs1470822585 785 dbSNP
rs1037309624 786 dbSNP
rs1187442301 786 dbSNP
rs1405157979 786 dbSNP
rs1487002029 790 dbSNP
rs549012319 797 dbSNP
rs1036371513 805 dbSNP
rs1221887847 811 dbSNP
rs944824332 817 dbSNP
rs201511926 818 dbSNP
rs1050879625 821 dbSNP
rs912602395 822 dbSNP
rs1307547684 826 dbSNP
rs28522122 827 dbSNP
rs546745409 837 dbSNP
rs751452660 841 dbSNP
rs1281057944 842 dbSNP
rs879242691 843 dbSNP
rs1376623493 849 dbSNP
rs1365080320 852 dbSNP
rs1227563548 859 dbSNP
rs376657475 866 dbSNP
rs1315252002 868 dbSNP
rs1361219699 886 dbSNP
rs145265135 890 dbSNP
rs1273374015 892 dbSNP
rs1405043984 897 dbSNP
rs974996418 906 dbSNP
rs1207174391 907 dbSNP
rs1236239924 907 dbSNP
rs139468680 912 dbSNP
rs529846479 912 dbSNP
rs1184610899 916 dbSNP
rs564570664 928 dbSNP
rs989768637 929 dbSNP
rs185928403 931 dbSNP
rs1447929496 934 dbSNP
rs1168032980 935 dbSNP
rs1397373075 936 dbSNP
rs924114228 941 dbSNP
rs981850617 950 dbSNP
rs925176374 956 dbSNP
rs1330732694 959 dbSNP
rs763767480 959 dbSNP
rs970505396 964 dbSNP
rs1446989047 965 dbSNP
rs1023283205 975 dbSNP
rs1460952525 976 dbSNP
rs1384539422 981 dbSNP
rs1225801299 989 dbSNP
rs1296437057 994 dbSNP
rs1339401746 995 dbSNP
rs1215852215 997 dbSNP
rs1277059200 1006 dbSNP
rs749820389 1008 dbSNP
rs531080720 1015 dbSNP
rs1245424640 1017 dbSNP
rs1463700199 1018 dbSNP
rs150945444 1029 dbSNP
rs1004580935 1030 dbSNP
rs994105772 1035 dbSNP
rs542252379 1038 dbSNP
rs1476405095 1040 dbSNP
rs1013252940 1041 dbSNP
rs896982900 1048 dbSNP
rs752775746 1059 dbSNP
rs1407955965 1065 dbSNP
rs1427461607 1065 dbSNP
rs573934615 1069 dbSNP
rs3744526 1074 dbSNP
rs1326677534 1084 dbSNP
rs1490572249 1088 dbSNP
rs540392219 1089 dbSNP
rs1008916477 1120 dbSNP
rs1271227795 1123 dbSNP
rs553058740 1125 dbSNP
rs755195144 1129 dbSNP
rs1344915577 1133 dbSNP
rs996059780 1141 dbSNP
rs1251769099 1142 dbSNP
rs1327434055 1152 dbSNP
rs1229380713 1153 dbSNP
rs898691818 1159 dbSNP
rs1282383204 1160 dbSNP
rs1037681335 1163 dbSNP
rs12902 1168 dbSNP
rs759075812 1177 dbSNP
rs893811615 1179 dbSNP
rs932694474 1182 dbSNP
rs1305693487 1184 dbSNP
rs776068611 1187 dbSNP
rs573440313 1189 dbSNP
rs935605939 1191 dbSNP
rs1396447054 1193 dbSNP
rs1157828036 1197 dbSNP
rs557962967 1206 dbSNP
rs1054571272 1220 dbSNP
rs936491702 1223 dbSNP
rs116683952 1224 dbSNP
rs978372000 1230 dbSNP
rs770618995 1231 dbSNP
rs575339593 1241 dbSNP
rs1405033563 1244 dbSNP
rs1285702991 1256 dbSNP
rs1404439824 1269 dbSNP
rs1176158053 1277 dbSNP
rs949103878 1281 dbSNP
rs916291297 1284 dbSNP
rs8066794 1286 dbSNP
rs1431690165 1297 dbSNP
rs1261750752 1303 dbSNP
rs1353099393 1306 dbSNP
rs952446099 1309 dbSNP
rs1179777684 1311 dbSNP
rs1026682634 1312 dbSNP
rs1490523824 1314 dbSNP
rs1418539112 1316 dbSNP
rs760289756 1318 dbSNP
rs773689195 1321 dbSNP
rs1471590577 1327 dbSNP
rs1197542455 1328 dbSNP
rs535086710 1329 dbSNP
rs991803982 1330 dbSNP
rs1019392330 1335 dbSNP
rs1364603870 1336 dbSNP
rs182993927 1345 dbSNP
rs963201284 1352 dbSNP
rs1391382742 1358 dbSNP
rs1308357879 1361 dbSNP
rs1015765609 1362 dbSNP
rs1286024616 1381 dbSNP
rs1314575104 1388 dbSNP
rs1237703008 1390 dbSNP
rs1360504226 1402 dbSNP
rs1004435288 1412 dbSNP
rs1224770797 1413 dbSNP
rs889646557 1414 dbSNP
rs139604088 1423 dbSNP
rs17741 1424 dbSNP
rs9341 1425 dbSNP
rs35110086 1426 dbSNP
rs879640219 1426 dbSNP
rs899862603 1430 dbSNP
rs1185169472 1433 dbSNP
rs1384189502 1434 dbSNP
rs1054942456 1435 dbSNP
rs1164922892 1438 dbSNP
rs369378272 1442 dbSNP
rs1387726268 1445 dbSNP
rs1470480912 1450 dbSNP
rs769248654 1450 dbSNP
rs1299206402 1452 dbSNP
rs377207080 1453 dbSNP
rs935553441 1456 dbSNP
rs1383788678 1467 dbSNP
rs1156978549 1468 dbSNP
rs1295692623 1477 dbSNP
rs902797744 1484 dbSNP
rs1228282173 1485 dbSNP
rs551196623 1494 dbSNP
rs751858584 1495 dbSNP
rs147401502 1497 dbSNP
rs1201531592 1500 dbSNP
rs945269916 1503 dbSNP
rs535416681 1513 dbSNP
rs1242361776 1514 dbSNP
rs1461614839 1516 dbSNP
rs1184981818 1518 dbSNP
rs1245851861 1525 dbSNP
rs917813317 1530 dbSNP
rs1184041426 1541 dbSNP
rs1170598682 1544 dbSNP
rs1375259622 1545 dbSNP
rs949491421 1546 dbSNP
rs916760490 1550 dbSNP
rs1407222575 1552 dbSNP
rs1055273905 1553 dbSNP
rs931116511 1560 dbSNP
rs926348584 1563 dbSNP
rs1382825857 1564 dbSNP
rs919567029 1565 dbSNP
rs1309171806 1572 dbSNP
rs1043277 1573 dbSNP
rs972401852 1574 dbSNP
rs3744527 1576 dbSNP
rs1323944573 1581 dbSNP
rs114758981 1583 dbSNP
rs1258563457 1590 dbSNP
rs1262021455 1593 dbSNP
rs986683509 1595 dbSNP
rs1241959929 1600 dbSNP
rs982968831 1601 dbSNP
rs1314916945 1602 dbSNP
rs187115073 1605 dbSNP
rs1430653388 1609 dbSNP
rs1028191419 1610 dbSNP
rs1157468925 1614 dbSNP
rs1385365157 1615 dbSNP
rs1454554562 1616 dbSNP
rs182547525 1619 dbSNP
rs955549367 1620 dbSNP
rs958174247 1621 dbSNP
rs1282502411 1626 dbSNP
rs997137265 1631 dbSNP
rs540509156 1632 dbSNP
rs1315954273 1636 dbSNP
rs1032333034 1643 dbSNP
rs1422774400 1646 dbSNP
rs1384536400 1653 dbSNP
rs1262130986 1657 dbSNP
rs1164064396 1672 dbSNP
rs999499773 1673 dbSNP
rs1033020209 1674 dbSNP
rs1000657417 1684 dbSNP
rs1192168709 1686 dbSNP
rs78410714 1687 dbSNP
rs1407640218 1696 dbSNP
rs1046648307 1698 dbSNP
rs1161501782 1713 dbSNP
rs564120352 1725 dbSNP
rs1348379223 1727 dbSNP
rs1424069932 1728 dbSNP
rs1303874376 1730 dbSNP
rs142822246 1734 dbSNP
rs1406762668 1738 dbSNP
rs1277720833 1739 dbSNP
rs945197788 1745 dbSNP
rs568114581 1746 dbSNP
rs756448745 1750 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000225972.7 | 3UTR | AAUCACUACACAUUCCUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.864 0.17 -0.500 0.33 3 Click to see details
HNSC -0.347 0.22 -0.714 0.04 7 Click to see details
BRCA 0.265 0.41 0.500 0.33 3 Click to see details
UCEC -0.142 0.45 -0.500 0.33 3 Click to see details
UCEC -0.142 0.45 -0.500 0.33 3 Click to see details
UCEC -0.142 0.45 -0.500 0.33 3 Click to see details
UCEC -0.142 0.45 -0.500 0.33 3 Click to see details
UCEC -0.142 0.45 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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