miRTarBase - #MIRT562293


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pre-miRNA Information
pre-miRNA hsa-mir-4796   
Genomic Coordinates chr3: 114743445 - 114743525
Description Homo sapiens miR-4796 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4796-5p
Sequence 9| UGUCUAUACUCUGUCACUUUAC |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1466952984 15 dbSNP
rs887451291 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GLO1   
Synonyms GLOD1, GLYI, HEL-S-74
Description glyoxalase I
Transcript NM_006708   
Expression
Putative miRNA Targets on GLO1
3'UTR of GLO1
(miRNA target sites are highlighted)		 
>GLO1|NM_006708|3'UTR
   1 TGCTGTGAGAATTCTCCTTTGAGATTTCAGAAGAAAGGAAACAATGTGATTCAAGATATTTACATACCAGAAGCATCTAG
  81 GACTGATGGATCACTGTCCCGATTCAAATTATTCTTCAGTCCATTTCCCCTTCCTATTTCAGCTGTTCCTTTTCACCTAA
 161 CTGTTCAGTCATTCTGGTTTTCAAGCAGTGCTTTATCTCATGTCCTTGAATATAGTTGTGTAACTTTATTTTTTAGGTAA
 241 TAATTAGAACAGTTCCCTTCAGAGGCTGCATTTGCCTTCTTCTGCCACCTAAATATTACTTCCCTTCAAATCTGCCTTTG
 321 AATCATCATTTTTAAAAAAAAATTAACATGTTTTTGTTGTAGTTATCTTCTGGGGTTTCAATTCCTCAGAAACAACTTTT
 401 TTCACAACGGAAAGGAAAGAACACTAGTGTTCTTTCAGTAAAGTACAAAGTGTTTATTTTACAAAAGAGTAGGTACTCTT
 481 GAGAGCAATTCAAATCATGCTGACAAGGATACTGATAGAAAAAGTGATTTCTTCTTATTATAAAGTACATTTAAAGTTCA
 561 AGGACTAACCTTATTTATTTGGGAAAGGGGAGGAGGAAGGAAATGATATGGTACCCAGACACTGGGCTAGGCTGCAACTT
 641 TATCTCATTTAATACTCCCAGCTGTCATGTGAGAAAGAAAGCAGGCTAGGCATGTGAAATCACTTTCATGGATTATTAAT
 721 GGATTTAAGAGGGCATCAATCAGCTCAACTCAAGATTTCATAATCATTTTTAGTATTTAGATTGTGCCTCAAAGTTGTAG
 801 TACCTCACAATACCTCCACTGGTTTCCTGTTGTAAAAACCTTCAGTGAGTTTGACCATTGTGCTCTTGGCTCTTGGGCTG
 881 GAGTACCGTGGTGAGGGAGTAAACACTAGAAGTCTTTAGTACAAAACTGCTCTAGGGACACCTGGTGATTCCTACACAAG
 961 TGATGTTTATATTTCTCATAAAGAGTCTTCCCTATCCCAAGGTCTTCATGATGCCAGTAGCCATATATGATAAATTATGT
1041 TCAGTGATAACTTAGTTATCAGAAATCAGCTCAGTGGTCTTCCCCGCCATGATTCACATTTGATGAGTTTTTAAAAATCA
1121 AAGTGATTTTGAAAATCTCTAATGGCTCAGAAAATAAAAACATCCAGTTTGTGGATGACTATATTTAGATTTCTCTAGAC
1201 TCTAGTGGAAGACCTTTGGAAAGGCCATGCCAACCGTGCTTGTACTGCTAGAAGCACTTTATGTTTCCTTTTTGGGTGAA
1281 ATGGATTTATGTGAGTGCTTTAAACAAATAGCAATACTTATAGACTGAAATAAAATGAAACTTCAAATAAGACTATGTTT
1361 AATTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caUUUCACUGUCU-CAUAUCUGu 5'
            |||  |  | |  ||||||| 
Target 5' acAAATAGCAATACTTATAGACt 3'
 1304 - 1326 144.00 -5.10
2 
miRNA  3' cauuUCACUGUCUCAUAUCUGu 5'
              :|||| :||||| | || 
Target 5' ccgtGGTGAGGGAGTAAACACt 3'
 886 - 907 110.00 -12.80
3 
miRNA  3' caUUUCACU------GUCUCAUAUCUgu 5'
            |||||||      |  | |||| |  
Target 5' aaAAAGTGATTTCTTCTTATTATAAAgt 3'
 519 - 546 106.00 -5.39
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30109469 37 COSMIC
COSN31523520 66 COSMIC
COSN30124737 86 COSMIC
COSN30705930 115 COSMIC
COSN7790188 334 COSMIC
COSN7872184 343 COSMIC
COSN21440530 741 COSMIC
COSN14876005 842 COSMIC
COSN17198017 1155 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1238721754 5 dbSNP
rs372960211 9 dbSNP
rs748249302 16 dbSNP
rs1398872032 17 dbSNP
rs779122254 21 dbSNP
rs1446222418 29 dbSNP
rs755608541 31 dbSNP
rs754339809 38 dbSNP
rs1355045513 42 dbSNP
rs761808625 49 dbSNP
rs1053170132 52 dbSNP
rs908001034 53 dbSNP
rs41273110 62 dbSNP
rs930421249 64 dbSNP
rs916330118 65 dbSNP
rs1363736179 67 dbSNP
rs1454890826 73 dbSNP
rs1313950780 76 dbSNP
rs923734769 77 dbSNP
rs772914774 88 dbSNP
rs1339464007 96 dbSNP
rs1367432363 98 dbSNP
rs982352377 99 dbSNP
rs949271637 100 dbSNP
rs2293868 101 dbSNP
rs550808645 110 dbSNP
rs1266131562 111 dbSNP
rs1462633702 114 dbSNP
rs1182181685 122 dbSNP
rs577076975 123 dbSNP
rs1423393909 124 dbSNP
rs556946001 152 dbSNP
rs554635238 159 dbSNP
rs1034918236 162 dbSNP
rs990765097 163 dbSNP
rs16890915 164 dbSNP
rs11544287 168 dbSNP
rs369417583 176 dbSNP
rs1387066266 193 dbSNP
rs1471256409 200 dbSNP
rs1026612975 205 dbSNP
rs1215646472 214 dbSNP
rs761324247 217 dbSNP
rs11544285 223 dbSNP
rs201683245 229 dbSNP
rs1393875083 232 dbSNP
rs961105841 237 dbSNP
rs775925376 238 dbSNP
rs1019397103 239 dbSNP
rs1227218068 242 dbSNP
rs1008792357 245 dbSNP
rs1285936700 266 dbSNP
rs1325538740 272 dbSNP
rs954264426 276 dbSNP
rs1255134269 277 dbSNP
rs1482144010 278 dbSNP
rs893236728 281 dbSNP
rs1028962477 283 dbSNP
rs1254213433 286 dbSNP
rs745836149 290 dbSNP
rs1029068039 294 dbSNP
rs1011853100 302 dbSNP
rs1409890127 304 dbSNP
rs770231594 312 dbSNP
rs1292792744 314 dbSNP
rs1177445234 315 dbSNP
rs746424331 321 dbSNP
rs1464829877 322 dbSNP
rs776834649 329 dbSNP
rs567882403 333 dbSNP
rs75200860 334 dbSNP
rs1430496857 341 dbSNP
rs1005102574 343 dbSNP
rs1305565245 343 dbSNP
rs115662320 346 dbSNP
rs1049733592 350 dbSNP
rs930809111 358 dbSNP
rs916329139 372 dbSNP
rs566571027 388 dbSNP
rs1412460547 397 dbSNP
rs949213833 405 dbSNP
rs747233390 408 dbSNP
rs778149215 409 dbSNP
rs546578131 410 dbSNP
rs533317351 411 dbSNP
rs752561926 413 dbSNP
rs1489499454 418 dbSNP
rs1425053137 419 dbSNP
rs939024319 419 dbSNP
rs919879751 420 dbSNP
rs142823052 423 dbSNP
rs977722194 424 dbSNP
rs1391169369 428 dbSNP
rs1185534119 437 dbSNP
rs1166314998 438 dbSNP
rs1351323393 439 dbSNP
rs961051327 446 dbSNP
rs966639544 447 dbSNP
rs1292489583 460 dbSNP
rs1365351259 488 dbSNP
rs1383888845 494 dbSNP
rs915145911 494 dbSNP
rs544860359 498 dbSNP
rs986577740 502 dbSNP
rs954328781 507 dbSNP
rs953872981 508 dbSNP
rs1451037144 509 dbSNP
rs1323781219 527 dbSNP
rs1028493772 531 dbSNP
rs758496839 556 dbSNP
rs377664484 564 dbSNP
rs772595921 583 dbSNP
rs1214398782 587 dbSNP
rs1246231852 602 dbSNP
rs1487752678 606 dbSNP
rs1029508075 609 dbSNP
rs9470916 610 dbSNP
rs562246078 611 dbSNP
rs1018989300 615 dbSNP
rs541994930 634 dbSNP
rs1405621601 664 dbSNP
rs1163418405 678 dbSNP
rs1004883304 679 dbSNP
rs886714543 681 dbSNP
rs1321127189 684 dbSNP
rs1364455997 689 dbSNP
rs1432607370 690 dbSNP
rs1031953518 703 dbSNP
rs995432628 705 dbSNP
rs1229105448 710 dbSNP
rs547833846 712 dbSNP
rs778954901 715 dbSNP
rs895277587 716 dbSNP
rs762891015 720 dbSNP
rs1210739816 733 dbSNP
rs1269282260 742 dbSNP
rs1370926400 743 dbSNP
rs998844178 757 dbSNP
rs572966196 760 dbSNP
rs927717777 770 dbSNP
rs1042061793 791 dbSNP
rs553064775 798 dbSNP
rs1472886061 799 dbSNP
rs945033667 802 dbSNP
rs915159066 804 dbSNP
rs371858314 810 dbSNP
rs1397441657 813 dbSNP
rs1169110038 821 dbSNP
rs568110423 822 dbSNP
rs1455603348 832 dbSNP
rs1421204816 833 dbSNP
rs1046208485 843 dbSNP
rs1359538870 844 dbSNP
rs921070294 849 dbSNP
rs11544277 856 dbSNP
rs1353842503 857 dbSNP
rs1453514678 863 dbSNP
rs966155729 865 dbSNP
rs1019022119 872 dbSNP
rs894941334 883 dbSNP
rs1329038617 885 dbSNP
rs188973590 887 dbSNP
rs950723608 888 dbSNP
rs1209941478 891 dbSNP
rs1028324406 896 dbSNP
rs1421470049 905 dbSNP
rs753862662 906 dbSNP
rs919822842 918 dbSNP
rs1456366409 922 dbSNP
rs995066743 932 dbSNP
rs1471535179 938 dbSNP
rs1236475806 942 dbSNP
rs1036936508 949 dbSNP
rs11544286 950 dbSNP
rs1203906028 953 dbSNP
rs939651136 956 dbSNP
rs912245903 964 dbSNP
rs1425864485 975 dbSNP
rs1308361336 978 dbSNP
rs895380307 980 dbSNP
rs986916463 997 dbSNP
rs1332000251 998 dbSNP
rs1373819117 1001 dbSNP
rs1411937385 1015 dbSNP
rs1033849876 1016 dbSNP
rs1349968637 1021 dbSNP
rs1237047742 1025 dbSNP
rs537338882 1028 dbSNP
rs1346376711 1032 dbSNP
rs1218986450 1033 dbSNP
rs772019736 1038 dbSNP
rs1483792933 1039 dbSNP
rs111411963 1063 dbSNP
rs185037650 1067 dbSNP
rs921046715 1072 dbSNP
rs750688747 1075 dbSNP
rs1028924838 1081 dbSNP
rs1042094735 1082 dbSNP
rs1200418162 1082 dbSNP
rs755941564 1084 dbSNP
rs765409451 1085 dbSNP
rs1477668215 1086 dbSNP
rs957555128 1086 dbSNP
rs1031899765 1097 dbSNP
rs1431803044 1116 dbSNP
rs554337343 1123 dbSNP
rs932618050 1144 dbSNP
rs921176220 1154 dbSNP
rs548690487 1164 dbSNP
rs1325669969 1168 dbSNP
rs977688758 1183 dbSNP
rs762046072 1184 dbSNP
rs1436394346 1189 dbSNP
rs1297172040 1198 dbSNP
rs1442290005 1202 dbSNP
rs943839883 1215 dbSNP
rs143734257 1235 dbSNP
rs192487325 1236 dbSNP
rs1024319406 1245 dbSNP
rs1290011061 1263 dbSNP
rs1433887702 1270 dbSNP
rs547025736 1273 dbSNP
rs7604 1275 dbSNP
rs1191687502 1295 dbSNP
rs894559467 1300 dbSNP
rs1249889345 1311 dbSNP
rs149374228 1318 dbSNP
rs551020297 1321 dbSNP
rs1389760219 1323 dbSNP
rs1437821799 1327 dbSNP
rs1165006656 1334 dbSNP
rs1391559486 1337 dbSNP
rs1404896656 1343 dbSNP
rs1324466156 1347 dbSNP
rs1368017854 1350 dbSNP
rs1436244904 1351 dbSNP
rs1297348701 1354 dbSNP
rs1407143606 1355 dbSNP
rs149705108 1357 dbSNP
rs1480962104 1370 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000373365.4 | 3UTR | CUUUAAACAAAUAGCAAUACUUAUAGACUGAAAUAAAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000373365.4 | 3UTR | AUUUAUGUGAGUGCUUUAAACAAAUAGCAAUACUUAUAGACUGAAAUAAAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000373365.4 | 3UTR | AUUUAUGUGAGUGCUUUAAACAAAUAGCAAUACUUAUAGACUGAAAUAAAAUGAAACUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4796-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT446014 VNN1 vanin 1 2 2
MIRT493828 FRS2 fibroblast growth factor receptor substrate 2 2 6
MIRT506324 ONECUT2 one cut homeobox 2 2 2
MIRT515488 PRKCD protein kinase C delta 2 4
MIRT515543 KRT222 keratin 222 2 4
MIRT518502 DEPTOR DEP domain containing MTOR interacting protein 2 6
MIRT519278 DDX55 DEAD-box helicase 55 2 2
MIRT528638 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT532130 NOL11 nucleolar protein 11 2 2
MIRT558240 EDA2R ectodysplasin A2 receptor 2 2
MIRT562293 GLO1 glyoxalase I 2 2
MIRT575346 Cacul1 CDK2 associated, cullin domain 1 2 2
MIRT610250 SLC35B4 solute carrier family 35 member B4 2 2
MIRT616752 SVOP SV2 related protein 2 2
MIRT627810 PTCHD1 patched domain containing 1 2 4
MIRT643062 CCDC149 coiled-coil domain containing 149 2 2
MIRT652031 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT658708 EMB embigin 2 2
MIRT687624 LRRC40 leucine rich repeat containing 40 2 2
MIRT692723 INPP5B inositol polyphosphate-5-phosphatase B 2 2
MIRT697508 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT702301 LAMP3 lysosomal associated membrane protein 3 2 2
MIRT718288 MINA ribosomal oxygenase 2 2 2
MIRT755767 BRCC3 BRCA1/BRCA2-containing complex subunit 3 5 1
MIRT755769 BARD1 BRCA1 associated RING domain 1 5 1
MIRT755770 ATM ATM serine/threonine kinase 5 1
MIRT755771 PARP14 poly(ADP-ribose) polymerase family member 14 5 1
MIRT755775 PARP2 poly(ADP-ribose) polymerase 2 5 1
MIRT755777 PARP11 poly(ADP-ribose) polymerase family member 11 5 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4796-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4796-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4796-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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