pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol IFRD2   
Synonyms IFNRP, SKMc15, SM15
Description interferon related developmental regulator 2
Transcript NM_006764   
Expression
Putative miRNA Targets on IFRD2
3'UTR of IFRD2
(miRNA target sites are highlighted)
>IFRD2|NM_006764|3'UTR
   1 AGCAGGACCTGCTGAAGAGGAGACTTTCTATGCCCTTGGTCCGTATTTTTAACAGAAGACAGTGCAACAACTGGTCTCCA
  81 CCAGTATTTGTCACTTTATTTTTTTTAATGACAAAACCAAAAACAGACATGGGGTGGGTAGCTGGGGGCCCGGACACTTG
 161 GGACCCTGACCCCTTTGTCCCTGCACTCAGCCCTGTGGCCCCTTCCTGTCCTGTCTCAGGCCAGGCTAAATATGTGCCTT
 241 CCTCAGGGCTGTGGGGCAGGCACTAGGGGGCCTTTCCCTTCCTTTCCTTTCTCAGGCCTTGCTCCCCCAGGATGACCCAC
 321 TCTTAGGGGGGTGGTGGCATCTGGACAAATGCCACCACAGCAGGTGGGGTGGCAAAGCTACCTGGAATGGATTTGTGTGC
 401 TGATTTTTAAGGATTATTACAGATAATTAAACAGAACGGTCAGCCTTCTGTGGTCTTAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agAUUUAGAGUAUCACGGAAGa 5'
            |||||   || |||||||| 
Target 5' gcTAAAT---AT-GTGCCTTCc 3'
225 - 242 160.00 -15.80
2
miRNA  3' agauuuagaguaucaCGGAAGa 5'
                         |||||| 
Target 5' taaacagaacggtcaGCCTTCt 3'
428 - 449 120.00 -10.30
3
miRNA  3' agauuuAGAGUAUCACGGAAga 5'
                |||||    |||||  
Target 5' ttccttTCTCAG---GCCTTgc 3'
284 - 302 104.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31497408 14 COSMIC
COSN19750846 58 COSMIC
COSN31488171 92 COSMIC
COSN30118814 98 COSMIC
COSN30586162 99 COSMIC
COSN21509451 202 COSMIC
COSN29150335 260 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1206161123 3 dbSNP
rs988109377 4 dbSNP
rs374857927 6 dbSNP
rs1186333587 7 dbSNP
rs1233107144 8 dbSNP
rs1471017762 10 dbSNP
rs782239618 20 dbSNP
rs781963978 22 dbSNP
rs1175290540 23 dbSNP
rs1411024281 27 dbSNP
rs782329301 30 dbSNP
rs782176634 36 dbSNP
rs781815893 39 dbSNP
rs1178570630 40 dbSNP
rs782533487 42 dbSNP
rs185959790 43 dbSNP
rs782613859 46 dbSNP
rs782366952 48 dbSNP
rs1440350419 53 dbSNP
rs1279302671 54 dbSNP
rs1346608471 61 dbSNP
rs1225878505 72 dbSNP
rs181671415 74 dbSNP
rs1320719689 78 dbSNP
rs1199422204 80 dbSNP
rs1273212624 87 dbSNP
rs1439173563 90 dbSNP
rs1202056160 98 dbSNP
rs1480648114 101 dbSNP
rs1201411534 103 dbSNP
rs200386050 107 dbSNP
rs782322172 107 dbSNP
rs1168543646 111 dbSNP
rs1025125129 143 dbSNP
rs1013811585 151 dbSNP
rs962242504 152 dbSNP
rs1408419267 155 dbSNP
rs1307725876 171 dbSNP
rs1366525287 176 dbSNP
rs1407155086 181 dbSNP
rs1281888918 186 dbSNP
rs1345461528 194 dbSNP
rs1014553062 195 dbSNP
rs1270240930 205 dbSNP
rs782511063 207 dbSNP
rs1340947105 213 dbSNP
rs887442363 226 dbSNP
rs587689836 234 dbSNP
rs995925808 237 dbSNP
rs1193658667 242 dbSNP
rs781900138 249 dbSNP
rs901697364 253 dbSNP
rs1490440610 256 dbSNP
rs587632448 262 dbSNP
rs945958905 266 dbSNP
rs1224469848 271 dbSNP
rs3204447 291 dbSNP
rs913117928 303 dbSNP
rs1450929137 305 dbSNP
rs1193891311 308 dbSNP
rs587757661 310 dbSNP
rs1474478084 314 dbSNP
rs1168127381 316 dbSNP
rs1386130729 320 dbSNP
rs1426894446 326 dbSNP
rs936692994 327 dbSNP
rs1390518843 328 dbSNP
rs1383266367 332 dbSNP
rs925296755 334 dbSNP
rs1327608993 343 dbSNP
rs1225584534 366 dbSNP
rs1296352533 369 dbSNP
rs981290329 370 dbSNP
rs782796364 372 dbSNP
rs1247765018 380 dbSNP
rs1289312014 394 dbSNP
rs1205591806 397 dbSNP
rs1263773001 404 dbSNP
rs1445316379 409 dbSNP
rs1188034580 414 dbSNP
rs1243878414 417 dbSNP
rs1446640072 422 dbSNP
rs1161974367 425 dbSNP
rs1368241679 431 dbSNP
rs1454634869 431 dbSNP
rs748027229 437 dbSNP
rs918094156 438 dbSNP
rs1435072699 441 dbSNP
rs1319262459 450 dbSNP
rs992252949 455 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agAUUUAGAGUAUCACGGAAGa 5'
            |||||   || |||||||| 
Target 5' -cUAAAU---AU-GUGCCUUCc 3'
1 - 17
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000417626.2 | 3UTR | CUAAAUAUGUGCCUUCCUCAGGGCUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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