miRTarBase - #MIRT563120


—
pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol THAP5   
Synonyms -
Description THAP domain containing 5
Transcript NM_001130475   
Other Transcripts NM_182529   
Expression
Putative miRNA Targets on THAP5
3'UTR of THAP5
(miRNA target sites are highlighted)		 
>THAP5|NM_001130475|3'UTR
   1 AATAACTAGGTTTTAAAACTATGGCTGTTAAATAAGCTTTTTCCAGCCAAACCAAACTACATGTAAAGTGAACTGTTTCC
  81 TGTATAAAGTTCTCATCTTAATGAACCTATGAGAGTGTTGTAAAGTTATGAACTGTATCCTATTCTTGTAATACTTATTT
 161 AAGAAAAACCAGAGAGTTGGGCTGGAGAGAAAAGCAGTTTTATTACTTGATAATTTTCCAAATTAAAATTTAGCACATAG
 241 AAGGATTCAGTTATAACATGAGAAAACAAAGAAGTGTTCAAAGAGCACAGACTAGAAGTCAGGTTCAGGAATCAGTCCTG
 321 GTTCTACCACTGGCATATGACTTGGGCAAGTTACTTATGATTGTGCCTCAGTCCCTAATTTGTAAAATAAGCACTTACTG
 401 GATTTGTAATTGGTTATTTATAGTCCCTTCCCTTTTTATTAAGATAATTCTATTAGAACACATTTTCTGTAAGATAATAT
 481 ATACGTAATACTAGAAGTTGGCTAGAATTTGATGATATTAACCATGTATTATTTTCAGTATTTATTGAATTCTGTGGTCT
 561 TTGACCTTTTGGCTATAGTTACATATTACAGTTATATTATCTGTAATAGAAAGGAAGATAAACTTTTTTTTTTTTTTTTT
 641 TTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTAACCCAGGCTGGAGTGCAGTGGCCTGATCTTGGCTCACTGCAGCCTC
 721 TGCCTCCCGGGTTCAAGTGATTCTTCTGCCTCAGCTTCCCGAGTAGCTGGGATTATAGGCACACACCACCACATCCAGCT
 801 TATTTTTGTATTTTTAGTAGAAACGGGGTTTCACCATGTTGGCCGGGCTGGCCTCGAACTCCTGACCCCAGGTGATCCAC
 881 CTACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCAAGATAGAACTTTTATAATTTTATT
 961 CCAGTTGAACTAAACTAAGGAACCACCCATTAGCCCAGTTCTTAGGAGAGGTACTTCAAACTTGAAAGAATATGTATTTC
1041 GGTAACTTATATGTGGCTAACCATCAAATACATAGTCATCTAAGCTAAACTTTCTGTATTTATACAGTTAAACTTATAAA
1121 CCAAAAATTTTAATGAGGTTAATTTTAAATATATTTTAGAAATTACAGTTTGTATCTGTTTCTTAGTAGGTGTGGCCTTT
1201 AAAATATGTGCTTATTCATTGTTAAATTCCAGAATAATAGAGTAATACTTAATACTGTACATTCCCACTTACGTATATTT
1281 TATTAAAATTTATAAGCAAGAAATTATACATAAGTGGTCATGATCTTAGGGAGACAAAGAATTTCTCTTAGAAAAGAGAA
1361 GTAATGGTAATGTAAATAAAAATACTGTTTATATTCACATGATTTTAAGAAAACTGTAAAAGCAAAGATTTTGTAGTAAT
1441 GACACAAATGTAACAAATAGATGTTTTCTTAAAATTGGCAGTCAGTATAATTATGTTTCTGCCTATGATGTTGAGGAAGT
1521 TGTATCAGTCTGATTCTTAGTTTTTTCATCTGTTAAGTAGAACGTACTATTACTTACCTTAAAGAGTGGCTTTGAGAATT
1601 TTGTAAGGAACAAACATGTTTTTGGTTCTGGAATATAGGAGGTGCTCAATAAAAGTTGACTCTGACTGGCAAATAATATT
1681 GTTTTGTAAATGCATGATGATTATTTTTGGCCATATTTGACTTAGTTTCATTAGGCTAATATTAATTGGTACTATATGAA
1761 AGTGAGTCAACTAATTATAAAAGATTAGAAATGTCTTAGGTGACGATGGGGGAAAAACTTAAAATTTTTGCATAAATTAT
1841 GGGGAGATGATAGAGTTATTACAGTGTTATTAAGTATTCCTATGTTGCATTTTGCAAATACTTAATTTAATACAGATGAA
1921 AATAATCTTGAGTCACAATAAAGTAATGATATGTTAAGTTTCAACAGTGTACATTGTAGTAATTTTCTGAAAGTTACAGG
2001 TTCCTCAGAAAAAATTTAAACTAGCTTTATTTCTTTAATAAATTATA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaguuccaggcgacaCUUGUGc 5'
                         |||||| 
Target 5' aagataattctattaGAACACa 3'
 441 - 462 120.00 -6.00
2 
miRNA  3' uaGUUCCAGG-CGACACUUGUGc 5'
            :||| |:|  | ||| |||: 
Target 5' gtTAAGTTTCAACAGTGTACATt 3'
 1953 - 1975 112.00 -7.00
3 
miRNA  3' uaguuccaggCGACACUUGugc 5'
                    |:| |||||   
Target 5' gtgttgtaaaGTTATGAACtgt 3'
 115 - 136 108.00 -6.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30448260 9 COSMIC
COSN30132834 18 COSMIC
COSN30559588 18 COSMIC
COSN28841277 38 COSMIC
COSN30451429 44 COSMIC
COSN31517615 51 COSMIC
COSN31578159 92 COSMIC
COSN31490237 136 COSMIC
COSN30173628 150 COSMIC
COSN30513209 209 COSMIC
COSN20091664 211 COSMIC
COSN30529238 212 COSMIC
COSN24888889 624 COSMIC
COSN24969004 950 COSMIC
COSN18952063 979 COSMIC
COSN20104639 1171 COSMIC
COSN20104638 1455 COSMIC
COSN6343016 1804 COSMIC
COSN20104635 1902 COSMIC
COSN22301570 1927 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1410375641 6 dbSNP
rs1383030431 7 dbSNP
rs774419190 9 dbSNP
rs1470645268 15 dbSNP
rs768664715 16 dbSNP
rs749205160 20 dbSNP
rs780001094 21 dbSNP
rs1418650607 23 dbSNP
rs1463488635 24 dbSNP
rs1254245711 26 dbSNP
rs1214996699 36 dbSNP
rs552067216 38 dbSNP
rs1282982375 43 dbSNP
rs1205304797 44 dbSNP
rs1352414956 46 dbSNP
rs745651772 48 dbSNP
rs532373353 52 dbSNP
rs373107299 54 dbSNP
rs563355182 61 dbSNP
rs774315975 66 dbSNP
rs890053208 71 dbSNP
rs1300247155 77 dbSNP
rs1227390037 79 dbSNP
rs1203438140 82 dbSNP
rs549818055 87 dbSNP
rs1293432407 97 dbSNP
rs1011688033 101 dbSNP
rs1443341302 101 dbSNP
rs1281411222 106 dbSNP
rs1438204197 106 dbSNP
rs1206422449 109 dbSNP
rs891997670 111 dbSNP
rs1482229796 113 dbSNP
rs1181658698 116 dbSNP
rs1258322697 120 dbSNP
rs1473796747 123 dbSNP
rs187797610 125 dbSNP
rs1413769719 128 dbSNP
rs567703186 133 dbSNP
rs1309385197 144 dbSNP
rs1241614923 148 dbSNP
rs1380135600 152 dbSNP
rs560824069 154 dbSNP
rs40943 156 dbSNP
rs1356846705 157 dbSNP
rs1445107450 158 dbSNP
rs1448550878 161 dbSNP
rs1340036412 166 dbSNP
rs948639435 168 dbSNP
rs909102344 169 dbSNP
rs183420038 176 dbSNP
rs565600210 182 dbSNP
rs1316820257 184 dbSNP
rs1258434442 192 dbSNP
rs1444325112 194 dbSNP
rs1185568868 195 dbSNP
rs545255705 210 dbSNP
rs1476058281 211 dbSNP
rs563173093 232 dbSNP
rs1388709074 234 dbSNP
rs919097068 238 dbSNP
rs1173900168 243 dbSNP
rs1159339803 244 dbSNP
rs975797594 258 dbSNP
rs576544513 261 dbSNP
rs1326442944 264 dbSNP
rs538140607 268 dbSNP
rs1017248838 271 dbSNP
rs1364222181 271 dbSNP
rs1234817809 272 dbSNP
rs1181476120 273 dbSNP
rs986183616 274 dbSNP
rs1198927920 281 dbSNP
rs1278016055 283 dbSNP
rs1447585099 284 dbSNP
rs1211156701 285 dbSNP
rs1246672406 287 dbSNP
rs1473353800 288 dbSNP
rs1449368957 289 dbSNP
rs560539656 295 dbSNP
rs1191425707 298 dbSNP
rs1021825087 309 dbSNP
rs1476845042 311 dbSNP
rs1171565380 315 dbSNP
rs1385092561 319 dbSNP
rs1458315416 322 dbSNP
rs1446947533 327 dbSNP
rs1387871485 328 dbSNP
rs1287288596 337 dbSNP
rs774455445 340 dbSNP
rs1441542997 345 dbSNP
rs769113973 358 dbSNP
rs1329083972 362 dbSNP
rs1356630726 362 dbSNP
rs1274448212 368 dbSNP
rs1351526699 371 dbSNP
rs148176417 373 dbSNP
rs1228502251 386 dbSNP
rs1464896384 388 dbSNP
rs1031807546 395 dbSNP
rs1002930134 401 dbSNP
rs143753153 407 dbSNP
rs1450193897 418 dbSNP
rs1044507806 424 dbSNP
rs1268220630 426 dbSNP
rs1429691247 452 dbSNP
rs1341058787 459 dbSNP
rs1156401144 468 dbSNP
rs1299956465 469 dbSNP
rs948714734 474 dbSNP
rs1410563038 476 dbSNP
rs1340760128 477 dbSNP
rs887826412 478 dbSNP
rs1048971076 480 dbSNP
rs1388352342 483 dbSNP
rs1401979226 484 dbSNP
rs929217398 485 dbSNP
rs564278725 487 dbSNP
rs1164125559 496 dbSNP
rs1286594752 509 dbSNP
rs573836813 510 dbSNP
rs1234473911 517 dbSNP
rs190875945 517 dbSNP
rs187544353 518 dbSNP
rs565822572 519 dbSNP
rs552415944 524 dbSNP
rs944581320 528 dbSNP
rs985932977 538 dbSNP
rs1250434637 539 dbSNP
rs182915015 561 dbSNP
rs961008322 563 dbSNP
rs374070493 565 dbSNP
rs1264607595 579 dbSNP
rs1457317702 580 dbSNP
rs914911397 583 dbSNP
rs569783812 585 dbSNP
rs1411913918 588 dbSNP
rs866431417 595 dbSNP
rs555225156 598 dbSNP
rs1031775029 601 dbSNP
rs1314900371 610 dbSNP
rs1339292221 610 dbSNP
rs1003433988 614 dbSNP
rs1252263052 615 dbSNP
rs1270363983 621 dbSNP
rs1282985716 622 dbSNP
rs971616206 623 dbSNP
rs1485783051 624 dbSNP
rs1023461089 629 dbSNP
rs1280062976 636 dbSNP
rs1221645495 641 dbSNP
rs1344747090 642 dbSNP
rs1293031778 643 dbSNP
rs1437204999 644 dbSNP
rs1351906086 645 dbSNP
rs1327093097 646 dbSNP
rs1465481983 647 dbSNP
rs1424745075 648 dbSNP
rs1173220640 650 dbSNP
rs1479753841 653 dbSNP
rs1193739060 654 dbSNP
rs1211785820 654 dbSNP
rs1226715159 654 dbSNP
rs1253755929 654 dbSNP
rs1297287256 654 dbSNP
rs1298944115 654 dbSNP
rs1304718731 654 dbSNP
rs1312481511 654 dbSNP
rs1346066643 654 dbSNP
rs1367828077 654 dbSNP
rs1370227317 654 dbSNP
rs1376989007 654 dbSNP
rs1385483745 654 dbSNP
rs1391815484 654 dbSNP
rs1395440267 654 dbSNP
rs1395957719 654 dbSNP
rs1423233807 654 dbSNP
rs1427526646 654 dbSNP
rs1466739101 654 dbSNP
rs1282695585 655 dbSNP
rs1425009636 655 dbSNP
rs1232239167 656 dbSNP
rs1357536111 657 dbSNP
rs1465568299 660 dbSNP
rs1013007649 662 dbSNP
rs887746313 670 dbSNP
rs1191270141 676 dbSNP
rs1489172516 682 dbSNP
rs191693560 687 dbSNP
rs529802993 689 dbSNP
rs561011979 691 dbSNP
rs1259779240 693 dbSNP
rs1201479373 696 dbSNP
rs770493884 715 dbSNP
rs897728078 717 dbSNP
rs1311228745 722 dbSNP
rs1322742960 723 dbSNP
rs1301893788 728 dbSNP
rs112709864 729 dbSNP
rs1369797239 731 dbSNP
rs746366243 743 dbSNP
rs1193169407 753 dbSNP
rs944529707 754 dbSNP
rs1446356880 755 dbSNP
rs1160089349 757 dbSNP
rs1401237483 760 dbSNP
rs777280042 761 dbSNP
rs910425966 766 dbSNP
rs1050559000 770 dbSNP
rs946495118 771 dbSNP
rs757871080 781 dbSNP
rs1177406066 782 dbSNP
rs1434448026 783 dbSNP
rs914880114 787 dbSNP
rs527487545 799 dbSNP
rs10259656 820 dbSNP
rs1289690584 824 dbSNP
rs1326370729 825 dbSNP
rs1227737811 828 dbSNP
rs1290441010 830 dbSNP
rs1323413477 831 dbSNP
rs547394410 840 dbSNP
rs752355172 844 dbSNP
rs527316857 845 dbSNP
rs564741960 846 dbSNP
rs778469082 856 dbSNP
rs1471628505 862 dbSNP
rs545636765 868 dbSNP
rs1415206470 870 dbSNP
rs981749639 871 dbSNP
rs1256570780 877 dbSNP
rs971935692 883 dbSNP
rs1023144148 886 dbSNP
rs1309421728 893 dbSNP
rs1315010801 913 dbSNP
rs1283995856 916 dbSNP
rs1284247883 923 dbSNP
rs117154461 925 dbSNP
rs1226524373 926 dbSNP
rs768690034 927 dbSNP
rs1311734867 928 dbSNP
rs1206177005 935 dbSNP
rs1450989159 936 dbSNP
rs1378872836 940 dbSNP
rs1276979426 945 dbSNP
rs1027765238 948 dbSNP
rs993484882 953 dbSNP
rs1238110363 963 dbSNP
rs1474066157 964 dbSNP
rs1468050119 967 dbSNP
rs1466290470 975 dbSNP
rs1180550215 977 dbSNP
rs897863322 983 dbSNP
rs1040691974 987 dbSNP
rs1170846623 988 dbSNP
rs1368363637 1005 dbSNP
rs888912893 1023 dbSNP
rs1334312426 1024 dbSNP
rs1157536356 1030 dbSNP
rs946444172 1040 dbSNP
rs1283485707 1041 dbSNP
rs914972022 1050 dbSNP
rs753690364 1051 dbSNP
rs1295123043 1059 dbSNP
rs1181350514 1086 dbSNP
rs1423074325 1089 dbSNP
rs1195384588 1090 dbSNP
rs1052163426 1091 dbSNP
rs1183327444 1104 dbSNP
rs1444161194 1104 dbSNP
rs1208664707 1106 dbSNP
rs1484859290 1110 dbSNP
rs1262298194 1117 dbSNP
rs1190984063 1144 dbSNP
rs1216066516 1147 dbSNP
rs1474887157 1148 dbSNP
rs1172734177 1149 dbSNP
rs1426704750 1151 dbSNP
rs563087871 1155 dbSNP
rs1412218729 1178 dbSNP
rs2067173 1180 dbSNP
rs66679907 1180 dbSNP
rs759552681 1180 dbSNP
rs927670616 1192 dbSNP
rs1437173078 1207 dbSNP
rs1318310179 1208 dbSNP
rs982069217 1211 dbSNP
rs1227004589 1212 dbSNP
rs1275608861 1218 dbSNP
rs1347364838 1226 dbSNP
rs950345218 1232 dbSNP
rs1262588370 1235 dbSNP
rs542860493 1241 dbSNP
rs1465796723 1246 dbSNP
rs1242840170 1252 dbSNP
rs1246581106 1252 dbSNP
rs1321295002 1257 dbSNP
rs573777338 1259 dbSNP
rs376129336 1272 dbSNP
rs952220262 1273 dbSNP
rs1458753792 1276 dbSNP
rs1156806172 1283 dbSNP
rs1383995733 1285 dbSNP
rs1387182671 1287 dbSNP
rs1027733722 1288 dbSNP
rs1333116533 1293 dbSNP
rs1298112824 1301 dbSNP
rs1282748505 1303 dbSNP
rs972181733 1307 dbSNP
rs1230807691 1310 dbSNP
rs1266729332 1313 dbSNP
rs962000150 1317 dbSNP
rs1210855194 1322 dbSNP
rs186481054 1325 dbSNP
rs1449527648 1336 dbSNP
rs1457111239 1339 dbSNP
rs1018953372 1342 dbSNP
rs1166653788 1353 dbSNP
rs1009201416 1364 dbSNP
rs889056318 1364 dbSNP
rs777066689 1387 dbSNP
rs1010679289 1390 dbSNP
rs775914011 1401 dbSNP
rs1164844118 1406 dbSNP
rs1388241021 1418 dbSNP
rs1194269452 1439 dbSNP
rs1488681325 1445 dbSNP
rs1351208246 1447 dbSNP
rs56135117 1449 dbSNP
rs376828990 1450 dbSNP
rs375473656 1458 dbSNP
rs1208079114 1460 dbSNP
rs893673273 1487 dbSNP
rs1246092694 1502 dbSNP
rs1267611811 1509 dbSNP
rs1052130398 1522 dbSNP
rs1247519508 1527 dbSNP
rs1316426637 1529 dbSNP
rs935091221 1532 dbSNP
rs1179472337 1535 dbSNP
rs1278169021 1540 dbSNP
rs1219820582 1542 dbSNP
rs906165948 1546 dbSNP
rs772657596 1554 dbSNP
rs1046083883 1558 dbSNP
rs947736611 1563 dbSNP
rs577944403 1564 dbSNP
rs1168967702 1566 dbSNP
rs1371448033 1569 dbSNP
rs1431857361 1575 dbSNP
rs1296535590 1578 dbSNP
rs557868738 1580 dbSNP
rs991775212 1581 dbSNP
rs1315381315 1582 dbSNP
rs40942 1585 dbSNP
rs767583194 1590 dbSNP
rs1298788024 1594 dbSNP
rs1343926969 1602 dbSNP
rs1385663854 1611 dbSNP
rs1202519684 1616 dbSNP
rs1250274594 1619 dbSNP
rs1483270098 1631 dbSNP
rs972108102 1637 dbSNP
rs1391083057 1640 dbSNP
rs1254055261 1643 dbSNP
rs757732912 1664 dbSNP
rs1460318104 1667 dbSNP
rs1391722467 1670 dbSNP
rs971973559 1679 dbSNP
rs138585007 1680 dbSNP
rs556387594 1696 dbSNP
rs1372599099 1699 dbSNP
rs1024645668 1701 dbSNP
rs1304624632 1702 dbSNP
rs1404619567 1707 dbSNP
rs1452527092 1709 dbSNP
rs40941 1710 dbSNP
rs1367717024 1713 dbSNP
rs567353214 1738 dbSNP
rs1432657960 1739 dbSNP
rs40940 1741 dbSNP
rs1234833624 1743 dbSNP
rs1260703415 1746 dbSNP
rs1322810531 1746 dbSNP
rs1209205062 1767 dbSNP
rs1006326735 1769 dbSNP
rs1249693401 1778 dbSNP
rs1028901186 1783 dbSNP
rs1211831211 1783 dbSNP
rs527403212 1791 dbSNP
rs181239834 1795 dbSNP
rs893599606 1798 dbSNP
rs1030806983 1802 dbSNP
rs1320625626 1804 dbSNP
rs551130827 1805 dbSNP
rs999210657 1809 dbSNP
rs1391322443 1813 dbSNP
rs997327620 1817 dbSNP
rs906265226 1819 dbSNP
rs1273574005 1823 dbSNP
rs140910277 1829 dbSNP
rs947739092 1834 dbSNP
rs1331156021 1835 dbSNP
rs1038927294 1836 dbSNP
rs40939 1843 dbSNP
rs1444163982 1845 dbSNP
rs1214886640 1851 dbSNP
rs1265794387 1854 dbSNP
rs778498600 1856 dbSNP
rs1331797041 1861 dbSNP
rs1056018514 1864 dbSNP
rs914689901 1865 dbSNP
rs1054431552 1870 dbSNP
rs1480124978 1879 dbSNP
rs930890928 1882 dbSNP
rs1200008757 1883 dbSNP
rs934677841 1888 dbSNP
rs1158912407 1894 dbSNP
rs796098532 1905 dbSNP
rs1459148633 1908 dbSNP
rs1300845523 1910 dbSNP
rs2067172 1912 dbSNP
rs397832979 1912 dbSNP
rs911967445 1916 dbSNP
rs987992258 1921 dbSNP
rs770295949 1928 dbSNP
rs1378308552 1930 dbSNP
rs1223083252 1938 dbSNP
rs1313163398 1947 dbSNP
rs1323246302 1951 dbSNP
rs982108352 1952 dbSNP
rs1201024511 1957 dbSNP
rs1490240025 1961 dbSNP
rs1438085305 1971 dbSNP
rs1234661359 1973 dbSNP
rs921928534 1974 dbSNP
rs542799056 1980 dbSNP
rs1179731674 1982 dbSNP
rs1425977138 1983 dbSNP
rs1459360830 1993 dbSNP
rs916076378 1995 dbSNP
rs1277183965 2007 dbSNP
rs991639582 2015 dbSNP
rs1364641708 2020 dbSNP
rs1429980652 2024 dbSNP
rs1346278332 2035 dbSNP
rs1257266850 2036 dbSNP
rs2190404 2055 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaguuccaggcgacaCUUGUGc 5'
                         |||||| 
Target 5' ---auaauucuauuaGAACACa 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000415914.3 | 3UTR | AUAAUUCUAUUAGAACACAUUUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.794 6.0e-4 -0.797 5.5e-4 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.535 4.3e-3 0.428 2.1e-2 23 Click to see details
GSE32688 Pancreatic cancer -0.37 1.9e-2 -0.253 8.1e-2 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.345 4.6e-2 0.447 1.3e-2 25 Click to see details
GSE21687 Ependynoma primary tumors -0.197 5.9e-2 0.019 4.4e-1 64 Click to see details
GSE19350 CNS germ cell tumors -0.474 6.0e-2 -0.308 1.7e-1 12 Click to see details
GSE28544 Breast cancer -0.309 7.1e-2 -0.338 5.3e-2 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.228 1.4e-1 0.176 2.1e-1 24 Click to see details
GSE38226 Liver fibrosis -0.21 1.8e-1 0.100 3.3e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.08 3.7e-1 -0.711 2.2e-4 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.08 3.7e-1 -0.711 2.2e-4 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.08 3.7e-1 -0.711 2.2e-4 20 Click to see details
-0.08 3.7e-1 -0.711 2.2e-4 20 Click to see details
-0.08 3.7e-1 -0.711 2.2e-4 20 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission