miRTarBase - #MIRT563259


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pre-miRNA Information
pre-miRNA hsa-mir-215   
Genomic Coordinates chr1: 220117853 - 220117962
Synonyms MIRN215, miRNA215, mir-215, MIR215
Description Homo sapiens miR-215 stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-215-3p
Sequence 64| UCUGUCAUUUCUUUAGGCCAAUA |86
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs768393822 2 dbSNP
rs1345487830 5 dbSNP
rs757646667 7 dbSNP
rs754286532 11 dbSNP
rs749489380 17 dbSNP
rs1333471638 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC29A1   
Synonyms ENT1
Description solute carrier family 29 member 1 (Augustine blood group)
Transcript NM_001078175   
Other Transcripts NM_001078177   
Expression
Putative miRNA Targets on SLC29A1
3'UTR of SLC29A1
(miRNA target sites are highlighted)		 
>SLC29A1|NM_001078175|3'UTR
   1 CAAAGGATGGACAGAAGGACTGCCTGCCTCCCTCCCTGTCTGCCTCCTGCCCCTTCCTTCTGCCAGGGGTGATCCTGAGT
  81 GGTCTGGCGGTTTTTTCTTCTAACTGACTTCTGCTTTCCACGGCGTGTGCTGGGCCCGGATCTCCAGGCCCTGGGGAGGG
 161 AGCCTCTGGACGGACAGTGGGGACATTGTGGGTTTGGGGCTCAGAGTCGAGGGACGGGGTGTAGCCTCGGCATTTGCTTG
 241 AGTTTCTCCACTCTTGGCTCTGACTGATCCCTGCTTGTGCAGGCCAGTGGAGGCTCTTGGGCTTGGAGAACACGTGTGTC
 321 TCTGTGTATGTGTCTGTGTGTCTGCGTCCGTGTCTGTCAGACTGTCTGCCTGTCCTGGGGTGGCTAGGAGCTGGGTCTGA
 401 CCGTTGTATGGTTTGACCTGATATACTCCATTCTCCCCTGCGCCTCCTCCTCTGTGTTCTCTCCATGTCCCCCTCCCAAC
 481 TCCCCATGCCCAGTTCTTACCCATCATGCACCCTGTACAGTTGCCACGTTACTGCCTTTTTTAAAAATATATTTGACAGA
 561 AACCAGGTGCCTTCAGAGGCTCTCTGATTTAAATAAACCTTTCTTGTTTTTTTCTCCATGGCTAAAAAAAAAAAAAAAAA
 641 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaaccggaUUUCUUUA-CUGUCu 5'
                   |||| :|| ||||| 
Target 5' --------cAAAG-GATGGACAGa 3'
 1 - 15 121.00 -11.80
2 
miRNA  3' auaaccggauuucuuuACUGUCu 5'
                          |||||| 
Target 5' tttttaaaaatatattTGACAGa 3'
 538 - 560 120.00 -7.70
3 
miRNA  3' auaaCCGGAUUUC--UUUACUGUCu 5'
              |||: |:||  :|: |||:| 
Target 5' ttggGGCTCAGAGTCGAGGGACGGg 3'
 194 - 218 101.00 -15.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26995159 10 COSMIC
COSN31554361 10 COSMIC
COSN30179152 36 COSMIC
COSN30540732 57 COSMIC
COSN30491717 64 COSMIC
COSN7883678 90 COSMIC
COSN31481170 112 COSMIC
COSN1333542 139 COSMIC
COSN15661808 247 COSMIC
COSN31591725 280 COSMIC
COSN7883679 443 COSMIC
COSN5630511 464 COSMIC
COSN31541407 532 COSMIC
COSN24945292 563 COSMIC
COSN19023843 568 COSMIC
COSN30176185 575 COSMIC
COSN31533513 614 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755595105 7 dbSNP
rs779358682 8 dbSNP
rs753237989 9 dbSNP
rs1218589894 18 dbSNP
rs750692095 20 dbSNP
rs756185570 23 dbSNP
rs1214141199 24 dbSNP
rs1340384856 24 dbSNP
rs1021651946 27 dbSNP
rs1261363373 29 dbSNP
rs1488079409 32 dbSNP
rs1194566528 33 dbSNP
rs758770756 34 dbSNP
rs1366388988 36 dbSNP
rs1366772742 37 dbSNP
rs1477050319 39 dbSNP
rs8187637 47 dbSNP
rs201301264 48 dbSNP
rs1370606709 50 dbSNP
rs771297314 51 dbSNP
rs369843834 52 dbSNP
rs745985327 53 dbSNP
rs1396526514 54 dbSNP
rs1209561391 57 dbSNP
rs1434146421 65 dbSNP
rs960203143 69 dbSNP
rs1189958610 70 dbSNP
rs1010497330 83 dbSNP
rs1252620158 85 dbSNP
rs528317649 87 dbSNP
rs1022005087 89 dbSNP
rs993042991 90 dbSNP
rs1233642684 91 dbSNP
rs980923239 91 dbSNP
rs927848582 99 dbSNP
rs1225390663 100 dbSNP
rs1257366796 111 dbSNP
rs546769025 122 dbSNP
rs1180332719 123 dbSNP
rs769046429 125 dbSNP
rs930632954 126 dbSNP
rs949020089 134 dbSNP
rs571306317 138 dbSNP
rs984177713 139 dbSNP
rs1173104289 146 dbSNP
rs909566926 154 dbSNP
rs1393427567 156 dbSNP
rs1181499885 167 dbSNP
rs532283884 172 dbSNP
rs1259761178 173 dbSNP
rs1483086991 179 dbSNP
rs910546260 179 dbSNP
rs1303190182 180 dbSNP
rs1217696800 197 dbSNP
rs1395559159 203 dbSNP
rs1287678047 209 dbSNP
rs1329708322 209 dbSNP
rs866512035 210 dbSNP
rs900982685 216 dbSNP
rs902025879 217 dbSNP
rs1327035706 222 dbSNP
rs933810890 227 dbSNP
rs999397746 228 dbSNP
rs550425829 229 dbSNP
rs889683446 230 dbSNP
rs1389956599 232 dbSNP
rs1159048087 238 dbSNP
rs1349577762 254 dbSNP
rs1370268543 256 dbSNP
rs1010835510 258 dbSNP
rs1256920817 261 dbSNP
rs1021610992 265 dbSNP
rs568929212 271 dbSNP
rs1188009428 275 dbSNP
rs904526527 278 dbSNP
rs1267314973 288 dbSNP
rs1206705672 291 dbSNP
rs1336938542 297 dbSNP
rs998906302 300 dbSNP
rs1031751074 313 dbSNP
rs960188769 315 dbSNP
rs543538594 317 dbSNP
rs1338266867 319 dbSNP
rs557132527 323 dbSNP
rs1435424087 327 dbSNP
rs528640310 329 dbSNP
rs1251274410 335 dbSNP
rs536221050 346 dbSNP
rs970688365 347 dbSNP
rs1177010699 350 dbSNP
rs1372744953 351 dbSNP
rs1460227968 355 dbSNP
rs960578377 359 dbSNP
rs1172565063 363 dbSNP
rs984410265 364 dbSNP
rs909514759 378 dbSNP
rs554798146 387 dbSNP
rs939699769 388 dbSNP
rs1267978941 403 dbSNP
rs1208687139 404 dbSNP
rs781038578 407 dbSNP
rs972407048 408 dbSNP
rs1228674101 411 dbSNP
rs1341088899 420 dbSNP
rs1297247723 424 dbSNP
rs984691424 425 dbSNP
rs1333290505 437 dbSNP
rs145776583 438 dbSNP
rs78098903 442 dbSNP
rs14623 443 dbSNP
rs976204345 445 dbSNP
rs576891489 446 dbSNP
rs1430632309 447 dbSNP
rs112703920 448 dbSNP
rs1166411051 451 dbSNP
rs1294344879 457 dbSNP
rs1478904795 460 dbSNP
rs3734703 470 dbSNP
rs1198043814 473 dbSNP
rs1225612689 476 dbSNP
rs1253325802 478 dbSNP
rs1205267992 481 dbSNP
rs1046309 497 dbSNP
rs1482484172 504 dbSNP
rs1272076922 509 dbSNP
rs1226579963 513 dbSNP
rs946585960 521 dbSNP
rs1043671838 526 dbSNP
rs544943554 529 dbSNP
rs1260467320 536 dbSNP
rs72548775 543 dbSNP
rs1213665497 556 dbSNP
rs1410522231 558 dbSNP
rs1370144276 566 dbSNP
rs1306427604 578 dbSNP
rs1416419294 586 dbSNP
rs1402636311 587 dbSNP
rs1171842261 590 dbSNP
rs947669985 595 dbSNP
rs1414093011 600 dbSNP
rs1182217909 604 dbSNP
rs745899359 607 dbSNP
rs1249042998 609 dbSNP
rs1211766025 615 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000393844.1 | 3UTR | CCACGUUACUGCCUUUUUUAAAAAUAUAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
96 hsa-miR-215-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT058509 TEAD1 TEA domain transcription factor 1 2 2
MIRT445625 TMEM50A transmembrane protein 50A 2 2
MIRT449286 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT456702 LDB1 LIM domain binding 1 2 2
MIRT467723 SLC38A1 solute carrier family 38 member 1 2 2
MIRT474253 LATS2 large tumor suppressor kinase 2 2 2
MIRT481811 AP4E1 adaptor related protein complex 4 epsilon 1 subunit 2 2
MIRT491969 USP37 ubiquitin specific peptidase 37 2 2
MIRT513203 RFT1 RFT1 homolog 2 2
MIRT532737 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT535706 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT536138 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT536463 KLF12 Kruppel like factor 12 2 4
MIRT552615 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT554011 SPIRE1 spire type actin nucleation factor 1 2 2
MIRT563259 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT571054 POLQ DNA polymerase theta 2 4
MIRT573556 TMEM120B transmembrane protein 120B 2 2
MIRT573772 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT575328 Fbxo6 F-box protein 6 2 2
MIRT575497 Sept3 septin 3 2 5
MIRT607051 IDS iduronate 2-sulfatase 2 2
MIRT607070 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607497 HEBP2 heme binding protein 2 2 2
MIRT607799 RHBDL2 rhomboid like 2 2 2
MIRT610832 COL9A1 collagen type IX alpha 1 chain 2 2
MIRT616853 DSG2 desmoglein 2 2 2
MIRT617154 C18orf42 A-kinase anchor inhibitor 1 2 2
MIRT620823 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT625698 OPTN optineurin 2 2
MIRT628082 KAT7 lysine acetyltransferase 7 2 2
MIRT633540 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634343 SGOL1 shugoshin 1 2 2
MIRT634605 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT636759 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637044 SEPT3 septin 3 2 7
MIRT637213 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT639634 ZSCAN23 zinc finger and SCAN domain containing 23 2 2
MIRT640818 GPR107 G protein-coupled receptor 107 2 2
MIRT641033 PITPNB phosphatidylinositol transfer protein beta 2 2
MIRT641545 MOCOS molybdenum cofactor sulfurase 2 2
MIRT642091 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT645528 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT647017 ADCY2 adenylate cyclase 2 2 2
MIRT648044 FADS6 fatty acid desaturase 6 2 2
MIRT648514 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648869 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT656722 LMLN leishmanolysin like peptidase 2 2
MIRT658260 FAXC failed axon connections homolog 2 2
MIRT659063 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT659364 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT660318 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT663345 ZNF74 zinc finger protein 74 2 2
MIRT663526 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663975 ZNF786 zinc finger protein 786 2 2
MIRT664354 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664473 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664975 TDRD1 tudor domain containing 1 2 2
MIRT665488 VPS53 VPS53, GARP complex subunit 2 2
MIRT667758 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT669552 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT670183 CCDC142 coiled-coil domain containing 142 2 2
MIRT671342 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671873 ZNF429 zinc finger protein 429 2 2
MIRT672018 PXMP4 peroxisomal membrane protein 4 2 2
MIRT672068 KIAA0930 KIAA0930 2 2
MIRT672551 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT672849 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT672988 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT673088 AK1 adenylate kinase 1 2 2
MIRT673578 KDELC2 KDEL motif containing 2 2 2
MIRT674582 SLC35B4 solute carrier family 35 member B4 2 2
MIRT674999 STRN3 striatin 3 2 2
MIRT675596 ZNF106 zinc finger protein 106 2 2
MIRT675778 YIPF4 Yip1 domain family member 4 2 2
MIRT676029 C9orf69 transmembrane protein 250 2 2
MIRT679015 MTMR10 myotubularin related protein 10 2 2
MIRT679169 PSMB2 proteasome subunit beta 2 2 2
MIRT687413 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT688038 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT691644 SLC43A3 solute carrier family 43 member 3 2 2
MIRT695630 SLC26A2 solute carrier family 26 member 2 2 2
MIRT697562 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT699153 SMC1A structural maintenance of chromosomes 1A 2 2
MIRT699683 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT702177 LYRM4 LYR motif containing 4 2 2
MIRT706217 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT711243 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT712343 NLN neurolysin 2 2
MIRT716574 HOPX HOP homeobox 2 2
MIRT717443 TENM1 teneurin transmembrane protein 1 2 2
MIRT717759 KCNRG potassium channel regulator 2 2
MIRT717945 TUBD1 tubulin delta 1 2 2
MIRT718343 PURA purine rich element binding protein A 2 2
MIRT718773 ABHD15 abhydrolase domain containing 15 2 2
MIRT737073 FOXM1 forkhead box M1 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-215 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-215 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-215 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-215 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-215 Furan NULL 8029 Quantitative real-time PCR liver 22079235 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-215 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-215 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-215 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-215-3p Fluorouracil 3385 NSC19893 approved sensitive Low Colon Cancer cell line (HCT-116)
hsa-miR-215-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-215-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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