pre-miRNA Information
pre-miRNA hsa-mir-4316   
Genomic Coordinates chr17: 77396984 - 77397054
Description Homo sapiens miR-4316 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4316
Sequence 11| GGUGAGGCUAGCUGGUG |27
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs989002279 5 dbSNP
rs957742923 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMC4   
Synonyms CAP-C, CAPC, SMC-4, SMC4L1
Description structural maintenance of chromosomes 4
Transcript NM_001002800   
Other Transcripts NM_005496   
Expression
Putative miRNA Targets on SMC4
3'UTR of SMC4
(miRNA target sites are highlighted)
>SMC4|NM_001002800|3'UTR
   1 ACTTTATGCTGAAGATTCTTCAAGTTGATTCAGTGTATTACTGATTTTTTTCTATTTGTAAAGGATTATGAGTTGTATAA
  81 AATACATACTCCCTAAACTAGATCATGAAACTGGTTTCTGTTTTATGCAGTTGTCATTTGTAAAGTCTAATAAAATATTC
 161 TCTATAATTGCTTCTAGATTACAAAAATATGACAATCTTGTAAGTAGCAGACTATGGAGAAAAATGAGTTACCTGGAGGG
 241 TCAGGTAACTTGCCAAACTAAAAAGTATGTTAGTTGAGGCAAAGTCCTAAGCAAGGTTGTGCTATCAAGGCTCAGCATAC
 321 CTTCGTGGGCCTTTGATTTACCAACACTGGAAATGCCTGCCAACTAATCTTGGATAGATTCTTTAAGGCATTCCACTTAG
 401 CTTGCCAGTTGAGACAATCACCACAGTTATTACCCAAATACTATGAACATATTTTTGTAAACCAGTCATTCTGAATTATA
 481 GTGATGAGAATTTAAATATATGCTTTTCTAGAATTTGATGTTTGACCATTTATGACTTAATTACCAGAGAGCCAGTAAAT
 561 TAGGACAGTGTTTCAACAAGCCTAGGCTATCTCGTAAGTTGAAAAATATCCCACTATAGTTGCTTCATGAGTATGAAGTA
 641 AGATGGCCTCTGATTTACACTGGTTCAATTTACAAATTTTCAACTTTATGATAGGTTTATCCGGGTACTAAATGCATTTC
 721 AACTTGATAGTTTCAACTTATGATAGGTTTACCAGGATGTAGTCCCACTGTTGAGGAGCATCTATTTAGGGGTTAATTAC
 801 TTTAGTAATAAGTGGAAAGTAAGATACCTTGAGTAATGTTTGCCTATAAAATTGTCAGCGTATTTTTACACTATTGGCTC
 881 AAGAATGTTATAATGCTAAGGGACATAAGTTGGCAACCACTTGGTTTTTGGAAGGACTTTCGGTATTGTATTAGAAGTCT
 961 GCCCTAGCTGTTAAATTTCTGGGTATTTATCCTAAGGAATTAATTAAAGAGTTAATTGTTCCTTTCTTCAGTGGGCCATT
1041 GTTTTAGATATTTAAAAAATCCAACAGTTTCTATCATAATGTAACTGTAAAAATGTAAACACATTATTAGCATGGACTTT
1121 TAAATAAAGATTTAAAGAAAGCAAGATCGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gugGUCGAUCGGAGUGg 5'
             :||:| ||:|||: 
Target 5' ctaTAGTT-GCTTCATg 3'
614 - 629 117.00 -9.90
2
miRNA  3' guggUCGAUCGGAGugg 5'
              || |:|||||   
Target 5' agtaAGATGGCCTCtga 3'
637 - 653 113.00 -9.62
3
miRNA  3' guGGUC---GAUCGGAGUGg 5'
            ||||    |||:| ||| 
Target 5' taCCAGGATGTAGTCCCACt 3'
750 - 769 107.00 -13.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31592568 15 COSMIC
COSN31515088 30 COSMIC
COSN31519278 49 COSMIC
COSN31479636 60 COSMIC
COSN30176805 71 COSMIC
COSN30102429 92 COSMIC
COSN30122183 123 COSMIC
COSN31542107 169 COSMIC
COSN27628290 178 COSMIC
COSN15661079 322 COSMIC
COSN21868780 367 COSMIC
COSN6739098 900 COSMIC
COSN24930260 958 COSMIC
COSN20818652 1138 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1196090577 2 dbSNP
rs572416954 3 dbSNP
rs1389659055 4 dbSNP
rs1250641554 6 dbSNP
rs770504164 11 dbSNP
rs1325062912 12 dbSNP
rs774438429 16 dbSNP
rs751957787 17 dbSNP
rs755499340 19 dbSNP
rs767653912 25 dbSNP
rs150864565 28 dbSNP
rs756376849 29 dbSNP
rs377149037 32 dbSNP
rs777924262 33 dbSNP
rs948725313 34 dbSNP
rs745705116 38 dbSNP
rs745762859 39 dbSNP
rs758061505 41 dbSNP
rs780052275 42 dbSNP
rs887334857 44 dbSNP
rs772016913 45 dbSNP
rs746975372 46 dbSNP
rs1393008413 51 dbSNP
rs768707086 52 dbSNP
rs1442238506 62 dbSNP
rs750858667 78 dbSNP
rs756652171 90 dbSNP
rs561188853 96 dbSNP
rs1435146136 100 dbSNP
rs773583005 112 dbSNP
rs1447122040 114 dbSNP
rs1170393323 117 dbSNP
rs527991155 122 dbSNP
rs1363799798 129 dbSNP
rs1395281927 130 dbSNP
rs1183367953 141 dbSNP
rs1473847944 143 dbSNP
rs1004400762 144 dbSNP
rs552867316 149 dbSNP
rs1300735987 150 dbSNP
rs1486177914 159 dbSNP
rs75820811 161 dbSNP
rs1344598061 163 dbSNP
rs1382573435 163 dbSNP
rs993704376 171 dbSNP
rs1027576718 172 dbSNP
rs898825291 173 dbSNP
rs1287703493 176 dbSNP
rs1357083843 190 dbSNP
rs188288803 190 dbSNP
rs1331951503 191 dbSNP
rs1363014584 195 dbSNP
rs139970718 196 dbSNP
rs965681041 201 dbSNP
rs1455236521 202 dbSNP
rs531827409 214 dbSNP
rs1003354987 215 dbSNP
rs1034832790 216 dbSNP
rs1475824747 230 dbSNP
rs1239520955 236 dbSNP
rs956554103 239 dbSNP
rs1262745113 241 dbSNP
rs1312872916 246 dbSNP
rs1235645354 255 dbSNP
rs1254490248 256 dbSNP
rs1344683275 257 dbSNP
rs547034028 261 dbSNP
rs1233751951 263 dbSNP
rs1336871161 265 dbSNP
rs988048845 266 dbSNP
rs1447097109 269 dbSNP
rs1326617965 272 dbSNP
rs1432495069 273 dbSNP
rs915199805 285 dbSNP
rs1165031467 288 dbSNP
rs1462415421 302 dbSNP
rs948943908 305 dbSNP
rs1187367809 312 dbSNP
rs968412861 315 dbSNP
rs980309259 318 dbSNP
rs928679499 320 dbSNP
rs938674372 325 dbSNP
rs975445678 326 dbSNP
rs1463716150 333 dbSNP
rs1376728397 336 dbSNP
rs1247429549 337 dbSNP
rs1214457260 342 dbSNP
rs921318380 345 dbSNP
rs755399373 348 dbSNP
rs554202743 356 dbSNP
rs1051146189 357 dbSNP
rs897194521 364 dbSNP
rs1339788176 371 dbSNP
rs929175940 371 dbSNP
rs1299554311 373 dbSNP
rs1048899744 382 dbSNP
rs1364086464 388 dbSNP
rs1325992099 394 dbSNP
rs3773370 397 dbSNP
rs1434215779 403 dbSNP
rs1326533518 404 dbSNP
rs1368313818 406 dbSNP
rs77573017 418 dbSNP
rs1405323251 422 dbSNP
rs1299453789 434 dbSNP
rs1330810607 436 dbSNP
rs376234157 438 dbSNP
rs573760553 445 dbSNP
rs1170890570 450 dbSNP
rs1447871983 453 dbSNP
rs1038964761 454 dbSNP
rs1194300699 466 dbSNP
rs1479074384 470 dbSNP
rs538072745 473 dbSNP
rs3773371 480 dbSNP
rs1438343664 483 dbSNP
rs1266549344 490 dbSNP
rs1276500366 492 dbSNP
rs35756033 494 dbSNP
rs571798187 500 dbSNP
rs1189007696 503 dbSNP
rs1266224461 507 dbSNP
rs1340982521 519 dbSNP
rs1303758105 521 dbSNP
rs1220621431 525 dbSNP
rs776234714 528 dbSNP
rs1273735960 529 dbSNP
rs904884345 529 dbSNP
rs1436315315 533 dbSNP
rs1355685111 537 dbSNP
rs539131679 545 dbSNP
rs374700568 550 dbSNP
rs373194542 554 dbSNP
rs1174458964 563 dbSNP
rs1011712764 564 dbSNP
rs1423084910 566 dbSNP
rs1190746293 576 dbSNP
rs1470469863 583 dbSNP
rs1179726324 587 dbSNP
rs1253940937 587 dbSNP
rs1456512677 589 dbSNP
rs956521953 593 dbSNP
rs1021776280 594 dbSNP
rs1211710415 594 dbSNP
rs1183989402 595 dbSNP
rs1351605569 595 dbSNP
rs1223916339 599 dbSNP
rs572474188 606 dbSNP
rs970197318 607 dbSNP
rs1290802240 608 dbSNP
rs1459509177 609 dbSNP
rs1009405796 610 dbSNP
rs928858303 614 dbSNP
rs542979274 617 dbSNP
rs1022598091 619 dbSNP
rs1175412170 620 dbSNP
rs116174402 632 dbSNP
rs1414311843 635 dbSNP
rs1156810750 636 dbSNP
rs1409298190 638 dbSNP
rs918694565 640 dbSNP
rs1257891760 644 dbSNP
rs1183439482 647 dbSNP
rs1482066545 648 dbSNP
rs145382103 649 dbSNP
rs1215852848 656 dbSNP
rs1330540753 660 dbSNP
rs921244073 665 dbSNP
rs1227035726 675 dbSNP
rs1048493084 685 dbSNP
rs147239731 688 dbSNP
rs1314047794 694 dbSNP
rs955401816 694 dbSNP
rs1313881486 695 dbSNP
rs1398199882 696 dbSNP
rs986845213 701 dbSNP
rs13403 703 dbSNP
rs1390840284 710 dbSNP
rs1318634323 714 dbSNP
rs1264401958 717 dbSNP
rs1456626506 722 dbSNP
rs1369052722 725 dbSNP
rs1166605738 730 dbSNP
rs1038976050 736 dbSNP
rs1412825101 738 dbSNP
rs1206777492 740 dbSNP
rs532113410 742 dbSNP
rs997209476 743 dbSNP
rs974282507 757 dbSNP
rs1207633449 761 dbSNP
rs1053169407 763 dbSNP
rs1266596173 765 dbSNP
rs1247655410 773 dbSNP
rs1472135589 773 dbSNP
rs113827216 774 dbSNP
rs1415839988 779 dbSNP
rs181064192 785 dbSNP
rs1164027134 792 dbSNP
rs1318617514 793 dbSNP
rs71957551 793 dbSNP
rs1430487694 796 dbSNP
rs970208695 797 dbSNP
rs1456357182 800 dbSNP
rs1349034483 804 dbSNP
rs1001619812 806 dbSNP
rs1450943637 806 dbSNP
rs1187364598 807 dbSNP
rs1310023420 809 dbSNP
rs747243996 819 dbSNP
rs1045072691 820 dbSNP
rs1487798657 825 dbSNP
rs1265209980 828 dbSNP
rs879671027 834 dbSNP
rs1164927626 837 dbSNP
rs904851526 839 dbSNP
rs1344546539 844 dbSNP
rs1409595022 844 dbSNP
rs1303831731 845 dbSNP
rs1295734378 849 dbSNP
rs1381942970 851 dbSNP
rs529665230 860 dbSNP
rs1312642843 861 dbSNP
rs1056187981 863 dbSNP
rs972998096 871 dbSNP
rs892228195 872 dbSNP
rs548136032 874 dbSNP
rs1230052276 875 dbSNP
rs185666437 879 dbSNP
rs1368496897 881 dbSNP
rs1167529063 883 dbSNP
rs766773802 892 dbSNP
rs532011641 893 dbSNP
rs1196201248 902 dbSNP
rs1431939729 905 dbSNP
rs1238942007 906 dbSNP
rs1183320461 911 dbSNP
rs996761894 925 dbSNP
rs943184085 932 dbSNP
rs536398569 933 dbSNP
rs955337993 938 dbSNP
rs372537047 941 dbSNP
rs986773506 942 dbSNP
rs1015604852 943 dbSNP
rs1330432976 943 dbSNP
rs1170634854 944 dbSNP
rs1411619915 944 dbSNP
rs1348324388 948 dbSNP
rs961503024 949 dbSNP
rs1396236172 951 dbSNP
rs1409658080 952 dbSNP
rs1465151454 956 dbSNP
rs535779321 958 dbSNP
rs1177082217 959 dbSNP
rs933262592 965 dbSNP
rs762812036 966 dbSNP
rs1473858671 968 dbSNP
rs764031332 969 dbSNP
rs948936002 984 dbSNP
rs1181628151 986 dbSNP
rs190375752 987 dbSNP
rs1258595753 988 dbSNP
rs1198975669 990 dbSNP
rs1336638024 992 dbSNP
rs1230092863 998 dbSNP
rs559381003 998 dbSNP
rs891490274 998 dbSNP
rs1366647291 999 dbSNP
rs1042791744 1001 dbSNP
rs1245294705 1007 dbSNP
rs928873700 1011 dbSNP
rs1331735668 1017 dbSNP
rs1436609717 1019 dbSNP
rs757403557 1019 dbSNP
rs1294833659 1021 dbSNP
rs1388639601 1024 dbSNP
rs1321985667 1039 dbSNP
rs1459282655 1039 dbSNP
rs905595187 1046 dbSNP
rs1340876452 1052 dbSNP
rs1001670299 1055 dbSNP
rs1219409764 1063 dbSNP
rs938965131 1066 dbSNP
rs556083026 1072 dbSNP
rs1248712333 1075 dbSNP
rs1210740796 1076 dbSNP
rs1463463693 1076 dbSNP
rs1283534148 1079 dbSNP
rs759732190 1082 dbSNP
rs1310155290 1086 dbSNP
rs1282215112 1088 dbSNP
rs1036295349 1091 dbSNP
rs895964494 1097 dbSNP
rs149961791 1098 dbSNP
rs1432325607 1099 dbSNP
rs879865375 1099 dbSNP
rs10923 1100 dbSNP
rs575920997 1103 dbSNP
rs544637274 1108 dbSNP
rs1246213371 1116 dbSNP
rs1161890586 1120 dbSNP
rs1475143716 1120 dbSNP
rs1391061603 1121 dbSNP
rs1444234205 1121 dbSNP
rs1190568259 1124 dbSNP
rs762159843 1128 dbSNP
rs952700246 1134 dbSNP
rs1222123504 1138 dbSNP
rs1028164526 1142 dbSNP
rs984084647 1143 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' guGGUCGAUCGGAGUGg 5'
            | | |  ||||||| 
Target 5' ugCAACCCUGCCUCAC- 3'
6 - 21
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760630. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' guGGUCGAUCGGAGUGg 5'
            | | |  ||||||| 
Target 5' ugCAACCCUGCCUCACg 3'
13 - 29
Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000357388.3 | 3UTR | CUCACUGCAACCCUGCCUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
74 hsa-miR-4316 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080624 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT095088 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT123331 CALU calumenin 2 2
MIRT154964 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT370850 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT442955 SGCD sarcoglycan delta 2 2
MIRT448240 ZNF774 zinc finger protein 774 2 2
MIRT451710 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT452072 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT455665 GLO1 glyoxalase I 2 2
MIRT460354 TXNDC16 thioredoxin domain containing 16 2 2
MIRT461908 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462047 HOXC13 homeobox C13 2 2
MIRT462735 EFNB1 ephrin B1 2 2
MIRT463409 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464952 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT465052 TSR1 TSR1, ribosome maturation factor 2 2
MIRT467549 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT470226 PRRC2A proline rich coiled-coil 2A 2 2
MIRT474081 LMBR1L limb development membrane protein 1 like 2 2
MIRT474481 KLHDC8B kelch domain containing 8B 2 2
MIRT474704 KIF3A kinesin family member 3A 2 2
MIRT474897 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475203 IL2RB interleukin 2 receptor subunit beta 2 2
MIRT477664 EFHD2 EF-hand domain family member D2 2 2
MIRT477775 E2F3 E2F transcription factor 3 2 2
MIRT477940 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478224 DDX52 DExD-box helicase 52 2 2
MIRT479904 CCDC117 coiled-coil domain containing 117 2 2
MIRT480639 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT482435 ADM adrenomedullin 2 10
MIRT483908 GNB1L G protein subunit beta 1 like 2 2
MIRT484161 FAM71B family with sequence similarity 71 member B 2 2
MIRT484405 SNX19 sorting nexin 19 2 2
MIRT485426 LASP1 LIM and SH3 protein 1 2 2
MIRT489788 KRT80 keratin 80 2 4
MIRT490813 ASB1 ankyrin repeat and SOCS box containing 1 2 4
MIRT491176 LAMA5 laminin subunit alpha 5 2 2
MIRT491573 HSDL1 hydroxysteroid dehydrogenase like 1 2 2
MIRT492633 PLXNA1 plexin A1 2 2
MIRT492984 NAV1 neuron navigator 1 2 2
MIRT496441 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501829 NCOA3 nuclear receptor coactivator 3 2 2
MIRT502165 KIAA0195 transmembrane protein 94 2 2
MIRT508652 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT509554 ACTG1 actin gamma 1 2 4
MIRT520033 YOD1 YOD1 deubiquitinase 2 6
MIRT523969 DVL3 dishevelled segment polarity protein 3 2 2
MIRT526150 KIAA1456 KIAA1456 2 2
MIRT530330 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT539985 SLC24A4 solute carrier family 24 member 4 2 4
MIRT540851 NUP155 nucleoporin 155 2 2
MIRT542326 LIMD1 LIM domains containing 1 2 2
MIRT558908 CBX5 chromobox 5 2 2
MIRT563663 SMC4 structural maintenance of chromosomes 4 2 2
MIRT565433 SURF4 surfeit 4 2 2
MIRT567773 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT615573 NCS1 neuronal calcium sensor 1 2 2
MIRT627336 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT632965 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT634307 SNTN sentan, cilia apical structure protein 2 2
MIRT641569 RAX retina and anterior neural fold homeobox 2 2
MIRT660509 ARL5A ADP ribosylation factor like GTPase 5A 2 2
MIRT662703 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT663214 ZNF277 zinc finger protein 277 2 2
MIRT665318 YIPF4 Yip1 domain family member 4 2 2
MIRT695264 CD209 CD209 molecule 2 2
MIRT696231 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT698867 SRPR SRP receptor alpha subunit 2 2
MIRT702700 IPO9 importin 9 2 2
MIRT704236 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704935 CCDC120 coiled-coil domain containing 120 2 2
MIRT724285 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT735579 VEGFA vascular endothelial growth factor A 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4316 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-4316 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4316 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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