pre-miRNA Information
pre-miRNA hsa-mir-4282   
Genomic Coordinates chr6: 72967687 - 72967753
Description Homo sapiens miR-4282 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4282
Sequence 40| UAAAAUUUGCAUCCAGGA |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN32074657 13 COSMIC
COSN6331413 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1195771339 5 dbSNP
rs755058572 6 dbSNP
rs1245753664 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HSPA4   
Synonyms APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
Description heat shock protein family A (Hsp70) member 4
Transcript NM_002154   
Expression
Putative miRNA Targets on HSPA4
3'UTR of HSPA4
(miRNA target sites are highlighted)
>HSPA4|NM_002154|3'UTR
   1 TTCCAACACTTGTTTCTATTAAAACAGACTATTATAAAGCTTTAAGTTGTCAACTTTGTTCTAAATATCAACTAGCGCAA
  81 GTGAATACTGAAGATTTCTTAGTCAGTTTTTAGGGGATTTTCGGGGAGGGGAAATAGGTAATGTATGGAGCATTTTCACT
 161 TCTAAATAGTTAGATACAGAAATTAAGTGCATTGTATCTTTTTCATAATGGTACTATTTAGAAGCCCAGTTAGTCTTACT
 241 GAGCTTATGCTTCACTCCTTTATGTTTAACCATGTGTCTACAAGAATAAGTTTGTTTTGGAAAGTTGAGCTATAGCTACA
 321 GCTCTAGCTATCCAGCAGACTTTTCATTATGACTTACATGGCAGGAGCTCTAATTATGCTTTAAAAATCTGTTGTGGAGA
 401 TTGCTTTAAATGCTCCCTGCCTGGTGTGGGGATGGGGTCCCCCTCTTTGTGAGGGCTGGAGCATGGCACGGCATGGATTA
 481 ACACGGCAGAGGAACAAAGGTGTGCTCTGAGCTTCTTCATATTTCACCTTCACCCTCACCTGTGTTCTCTTCCCTCTCTC
 561 CCAATAAAAGGGCTCCCATTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aggACCUACGUU-UAAAAu 5'
             || ||| |: ||||| 
Target 5' taaTGTATGGAGCATTTTc 3'
139 - 157 111.00 -5.10
2
miRNA  3' agGAC-CUACGUUUAAaau 5'
            |||  :|| |:|||   
Target 5' atCTGTTGTGGAGATTgct 3'
387 - 405 96.00 -6.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31503660 22 COSMIC
COSN28854796 33 COSMIC
COSN20075265 101 COSMIC
COSN30528066 114 COSMIC
COSN2070712 130 COSMIC
COSN28886015 140 COSMIC
COSN32062630 236 COSMIC
COSN25602574 284 COSMIC
COSN20493132 574 COSMIC
COSN21135180 693 COSMIC
COSN29284887 1252 COSMIC
COSN7875180 1488 COSMIC
COSN8381327 1577 COSMIC
COSN24913440 1648 COSMIC
COSN21214933 1653 COSMIC
COSN17908070 1667 COSMIC
COSN27344410 1667 COSMIC
COSN28453761 1670 COSMIC
COSN27567670 1727 COSMIC
COSN21545974 1769 COSMIC
COSN2070713 1972 COSMIC
COSN4843551 1977 COSMIC
COSN1307441 1999 COSMIC
rs571173399 1672 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1223131828 2 dbSNP
rs11289 3 dbSNP
rs1269079420 6 dbSNP
rs1479939281 11 dbSNP
rs181140417 17 dbSNP
rs752003122 19 dbSNP
rs1192741747 29 dbSNP
rs776057437 30 dbSNP
rs1157889853 33 dbSNP
rs762421599 36 dbSNP
rs1398967973 39 dbSNP
rs767749584 40 dbSNP
rs750839090 41 dbSNP
rs1366428323 50 dbSNP
rs1192330420 60 dbSNP
rs571731462 66 dbSNP
rs923029249 72 dbSNP
rs1239917238 73 dbSNP
rs999040730 75 dbSNP
rs73272759 77 dbSNP
rs954450469 78 dbSNP
rs1424240477 82 dbSNP
rs1050581799 85 dbSNP
rs1161942362 89 dbSNP
rs1007348502 91 dbSNP
rs185596478 97 dbSNP
rs1367715201 101 dbSNP
rs911434178 102 dbSNP
rs1359930062 108 dbSNP
rs1288405250 116 dbSNP
rs1017672216 123 dbSNP
rs1359697499 124 dbSNP
rs1432637554 138 dbSNP
rs560851068 139 dbSNP
rs117408810 141 dbSNP
rs1038633904 145 dbSNP
rs552785949 146 dbSNP
rs1416728805 150 dbSNP
rs14355 158 dbSNP
rs1296722572 165 dbSNP
rs747489619 172 dbSNP
rs140572827 178 dbSNP
rs1275862277 184 dbSNP
rs981919189 192 dbSNP
rs771481772 195 dbSNP
rs938766677 197 dbSNP
rs1293435271 201 dbSNP
rs1359729108 206 dbSNP
rs1228980471 213 dbSNP
rs551963404 217 dbSNP
rs1314644944 220 dbSNP
rs1412918532 227 dbSNP
rs1374599769 229 dbSNP
rs776973915 233 dbSNP
rs947422347 236 dbSNP
rs1486801705 241 dbSNP
rs1187091090 243 dbSNP
rs548713405 251 dbSNP
rs1255174247 252 dbSNP
rs568433852 259 dbSNP
rs534186527 262 dbSNP
rs1186400287 264 dbSNP
rs1475191010 271 dbSNP
rs1442500641 272 dbSNP
rs1479749442 273 dbSNP
rs1185218233 282 dbSNP
rs998988097 287 dbSNP
rs1051923161 291 dbSNP
rs758128686 295 dbSNP
rs547673460 296 dbSNP
rs1158469111 302 dbSNP
rs570764014 312 dbSNP
rs1455784272 313 dbSNP
rs373318893 317 dbSNP
rs746220783 319 dbSNP
rs1379111611 320 dbSNP
rs1392933115 331 dbSNP
rs1450838457 333 dbSNP
rs1317619799 354 dbSNP
rs1383068277 356 dbSNP
rs1395995168 358 dbSNP
rs890653818 359 dbSNP
rs1007304456 376 dbSNP
rs1017369556 377 dbSNP
rs1011327156 380 dbSNP
rs963353169 381 dbSNP
rs539253680 390 dbSNP
rs1417702967 392 dbSNP
rs1318246015 398 dbSNP
rs1215920102 399 dbSNP
rs190403601 404 dbSNP
rs35329068 415 dbSNP
rs1020178632 416 dbSNP
rs770003052 424 dbSNP
rs967241297 425 dbSNP
rs1255286502 434 dbSNP
rs150455512 437 dbSNP
rs775599447 438 dbSNP
rs1213163551 443 dbSNP
rs1268695879 446 dbSNP
rs1333997078 446 dbSNP
rs1241176739 452 dbSNP
rs1333753662 455 dbSNP
rs950629834 459 dbSNP
rs1386950866 460 dbSNP
rs1323243767 470 dbSNP
rs535150945 470 dbSNP
rs1445451515 471 dbSNP
rs1160788175 474 dbSNP
rs1176889159 478 dbSNP
rs953161260 485 dbSNP
rs1363551169 486 dbSNP
rs183041294 500 dbSNP
rs1177282159 503 dbSNP
rs1455705664 507 dbSNP
rs572573453 512 dbSNP
rs1159943942 513 dbSNP
rs571669253 515 dbSNP
rs540668149 520 dbSNP
rs959226493 522 dbSNP
rs1465397852 527 dbSNP
rs908914371 529 dbSNP
rs372493739 534 dbSNP
rs991504113 535 dbSNP
rs1468765233 538 dbSNP
rs941527122 539 dbSNP
rs1259878686 540 dbSNP
rs1038518348 552 dbSNP
rs918745678 553 dbSNP
rs1300804526 554 dbSNP
rs1339094157 557 dbSNP
rs1407366304 559 dbSNP
rs930232298 561 dbSNP
rs1440990899 562 dbSNP
rs560621313 579 dbSNP
rs1319758809 583 dbSNP
rs1384893713 585 dbSNP
rs1303727790 592 dbSNP
rs577497046 593 dbSNP
rs1277363426 596 dbSNP
rs1375096912 612 dbSNP
rs1046400328 614 dbSNP
rs916015993 617 dbSNP
rs1374826754 618 dbSNP
rs546062182 622 dbSNP
rs1299992995 626 dbSNP
rs907233282 627 dbSNP
rs139230617 629 dbSNP
rs1263502556 641 dbSNP
rs1486523685 647 dbSNP
rs1277987097 648 dbSNP
rs1233065667 662 dbSNP
rs1339692992 667 dbSNP
rs1271376468 674 dbSNP
rs764052508 675 dbSNP
rs1224624433 678 dbSNP
rs1326285399 688 dbSNP
rs1417225316 696 dbSNP
rs978790671 698 dbSNP
rs138343531 706 dbSNP
rs762843022 707 dbSNP
rs1055887232 723 dbSNP
rs1398925142 724 dbSNP
rs1166166096 725 dbSNP
rs924639638 726 dbSNP
rs1481745639 728 dbSNP
rs1369191475 731 dbSNP
rs934895174 733 dbSNP
rs1476171485 740 dbSNP
rs186226562 742 dbSNP
rs1209914277 743 dbSNP
rs1177850764 751 dbSNP
rs548654323 756 dbSNP
rs1011380409 762 dbSNP
rs748266860 773 dbSNP
rs774622577 781 dbSNP
rs1020105053 785 dbSNP
rs1338166855 790 dbSNP
rs1293425098 796 dbSNP
rs943538756 810 dbSNP
rs1293004975 812 dbSNP
rs1179264073 815 dbSNP
rs1327091438 824 dbSNP
rs1337974834 824 dbSNP
rs1409662748 826 dbSNP
rs997483053 836 dbSNP
rs144078357 861 dbSNP
rs146896292 866 dbSNP
rs995030174 870 dbSNP
rs953082893 872 dbSNP
rs986175679 875 dbSNP
rs1025978898 882 dbSNP
rs1234450357 889 dbSNP
rs1442570998 897 dbSNP
rs886131101 897 dbSNP
rs1436903376 912 dbSNP
rs1273216524 914 dbSNP
rs770082540 915 dbSNP
rs547815663 922 dbSNP
rs1273104207 923 dbSNP
rs1333247220 923 dbSNP
rs1034911680 928 dbSNP
rs971785850 928 dbSNP
rs918797969 936 dbSNP
rs761828730 937 dbSNP
rs1441703913 941 dbSNP
rs570634110 946 dbSNP
rs930119419 947 dbSNP
rs959176027 948 dbSNP
rs539684163 951 dbSNP
rs981723714 956 dbSNP
rs1338683430 961 dbSNP
rs990668582 964 dbSNP
rs928842366 965 dbSNP
rs549829719 966 dbSNP
rs1409848759 973 dbSNP
rs1023434933 978 dbSNP
rs1056171558 990 dbSNP
rs1156625051 990 dbSNP
rs548962095 990 dbSNP
rs1195186983 991 dbSNP
rs1309467308 992 dbSNP
rs1251891682 999 dbSNP
rs1217098780 1000 dbSNP
rs1205546701 1001 dbSNP
rs1282529648 1016 dbSNP
rs569786027 1023 dbSNP
rs191832680 1031 dbSNP
rs1348785293 1042 dbSNP
rs1489867503 1053 dbSNP
rs137911219 1060 dbSNP
rs1041783625 1062 dbSNP
rs565487651 1067 dbSNP
rs934662901 1070 dbSNP
rs987700848 1072 dbSNP
rs997725738 1075 dbSNP
rs534299948 1076 dbSNP
rs889001174 1078 dbSNP
rs943484741 1080 dbSNP
rs1162580709 1087 dbSNP
rs1039195057 1091 dbSNP
rs1406183758 1093 dbSNP
rs750178519 1098 dbSNP
rs529516426 1107 dbSNP
rs1487101345 1110 dbSNP
rs1240866311 1122 dbSNP
rs1428616967 1123 dbSNP
rs1271687969 1130 dbSNP
rs971841220 1131 dbSNP
rs1362443434 1134 dbSNP
rs1208959614 1137 dbSNP
rs1347468446 1139 dbSNP
rs1296326151 1142 dbSNP
rs557772176 1143 dbSNP
rs1047963578 1144 dbSNP
rs577578582 1146 dbSNP
rs1399382907 1149 dbSNP
rs1291245014 1154 dbSNP
rs1357576842 1155 dbSNP
rs1375807534 1156 dbSNP
rs1224731707 1174 dbSNP
rs13718 1175 dbSNP
rs1170448929 1188 dbSNP
rs1003180616 1196 dbSNP
rs1429766841 1197 dbSNP
rs1416839457 1199 dbSNP
rs1186420288 1210 dbSNP
rs1034860794 1212 dbSNP
rs1259998499 1218 dbSNP
rs866909497 1223 dbSNP
rs1191730339 1228 dbSNP
rs1244164699 1230 dbSNP
rs951579950 1237 dbSNP
rs1252107014 1240 dbSNP
rs981995479 1246 dbSNP
rs1305817973 1252 dbSNP
rs79554694 1253 dbSNP
rs1272432919 1257 dbSNP
rs1217897865 1258 dbSNP
rs1356041335 1259 dbSNP
rs928917094 1262 dbSNP
rs937619371 1268 dbSNP
rs1475923309 1271 dbSNP
rs991738159 1277 dbSNP
rs1463244185 1288 dbSNP
rs1169377134 1293 dbSNP
rs1352227829 1293 dbSNP
rs895072717 1295 dbSNP
rs1420669107 1307 dbSNP
rs947384096 1308 dbSNP
rs1382934025 1309 dbSNP
rs1423586763 1309 dbSNP
rs1179139256 1314 dbSNP
rs771054708 1321 dbSNP
rs1479800113 1322 dbSNP
rs184070050 1331 dbSNP
rs1214417082 1333 dbSNP
rs754707441 1338 dbSNP
rs903238470 1346 dbSNP
rs542481292 1347 dbSNP
rs1370755916 1348 dbSNP
rs202055921 1348 dbSNP
rs369970490 1353 dbSNP
rs187511171 1354 dbSNP
rs143376396 1360 dbSNP
rs987479749 1366 dbSNP
rs1364701555 1370 dbSNP
rs192747694 1372 dbSNP
rs1161767731 1374 dbSNP
rs1417499599 1375 dbSNP
rs143973960 1376 dbSNP
rs1194570856 1382 dbSNP
rs1469864397 1385 dbSNP
rs1251267956 1387 dbSNP
rs201845125 1394 dbSNP
rs964988021 1394 dbSNP
rs148218880 1401 dbSNP
rs550010978 1403 dbSNP
rs563679407 1416 dbSNP
rs1380854316 1419 dbSNP
rs1047448929 1420 dbSNP
rs760128893 1425 dbSNP
rs898839622 1427 dbSNP
rs569656812 1455 dbSNP
rs1372502659 1462 dbSNP
rs1323348428 1464 dbSNP
rs1350098586 1472 dbSNP
rs1026089324 1474 dbSNP
rs182624158 1476 dbSNP
rs1003282600 1482 dbSNP
rs1174470450 1483 dbSNP
rs1393301715 1484 dbSNP
rs894851987 1484 dbSNP
rs1036292099 1486 dbSNP
rs548796431 1488 dbSNP
rs1241745066 1492 dbSNP
rs1012145169 1495 dbSNP
rs1044050500 1500 dbSNP
rs1183861627 1502 dbSNP
rs903662777 1506 dbSNP
rs11242133 1509 dbSNP
rs565424130 1517 dbSNP
rs1159804538 1522 dbSNP
rs1298351743 1528 dbSNP
rs1326577566 1528 dbSNP
rs1381067328 1529 dbSNP
rs1385502400 1530 dbSNP
rs1360250975 1531 dbSNP
rs747720062 1532 dbSNP
rs1469291522 1535 dbSNP
rs977362451 1538 dbSNP
rs1334436280 1541 dbSNP
rs924619918 1543 dbSNP
rs1031728502 1559 dbSNP
rs757692334 1563 dbSNP
rs1475780232 1572 dbSNP
rs933423026 1574 dbSNP
rs1051851941 1580 dbSNP
rs187283215 1583 dbSNP
rs1236887506 1585 dbSNP
rs775946366 1589 dbSNP
rs1360514816 1600 dbSNP
rs943182945 1611 dbSNP
rs1486412319 1613 dbSNP
rs1276067032 1623 dbSNP
rs1330410405 1624 dbSNP
rs1223491520 1630 dbSNP
rs557586518 1635 dbSNP
rs571718474 1643 dbSNP
rs1340471965 1645 dbSNP
rs1462900959 1645 dbSNP
rs1294227092 1646 dbSNP
rs10479022 1649 dbSNP
rs11242134 1652 dbSNP
rs1333728842 1652 dbSNP
rs1435725985 1653 dbSNP
rs1410782880 1654 dbSNP
rs1422839131 1654 dbSNP
rs1453890304 1654 dbSNP
rs752113680 1654 dbSNP
rs1165655478 1655 dbSNP
rs1183353583 1656 dbSNP
rs1476060065 1664 dbSNP
rs1247884282 1665 dbSNP
rs1412143606 1665 dbSNP
rs1186357788 1666 dbSNP
rs1196221170 1666 dbSNP
rs1235569471 1666 dbSNP
rs1251985694 1666 dbSNP
rs1336522952 1666 dbSNP
rs572973453 1666 dbSNP
rs1162459205 1667 dbSNP
rs1165529450 1667 dbSNP
rs1176467438 1667 dbSNP
rs1216053356 1667 dbSNP
rs1224688420 1667 dbSNP
rs1239753949 1667 dbSNP
rs1289538020 1667 dbSNP
rs1307327843 1667 dbSNP
rs1326856353 1667 dbSNP
rs1337765478 1667 dbSNP
rs1353371929 1667 dbSNP
rs1365189983 1667 dbSNP
rs1395382972 1667 dbSNP
rs1411311283 1667 dbSNP
rs1446120153 1667 dbSNP
rs1450414612 1667 dbSNP
rs1456920668 1667 dbSNP
rs1462989788 1667 dbSNP
rs1470276638 1667 dbSNP
rs199567901 1667 dbSNP
rs70974072 1667 dbSNP
rs755260897 1667 dbSNP
rs908704087 1668 dbSNP
rs1178933466 1669 dbSNP
rs6874036 1670 dbSNP
rs1431396758 1671 dbSNP
rs571173399 1672 dbSNP
rs878856835 1673 dbSNP
rs1396034977 1674 dbSNP
rs536649341 1675 dbSNP
rs1330948894 1676 dbSNP
rs1351225864 1678 dbSNP
rs1404442782 1679 dbSNP
rs1281874502 1680 dbSNP
rs1326292095 1681 dbSNP
rs1234334279 1682 dbSNP
rs1251176512 1683 dbSNP
rs1337030828 1684 dbSNP
rs1197238089 1685 dbSNP
rs1251872190 1686 dbSNP
rs1490032834 1687 dbSNP
rs1212853409 1688 dbSNP
rs1196681529 1689 dbSNP
rs1156436149 1690 dbSNP
rs1184919692 1690 dbSNP
rs1281039975 1690 dbSNP
rs1368486460 1691 dbSNP
rs1395109201 1691 dbSNP
rs1433767478 1692 dbSNP
rs1477286907 1692 dbSNP
rs1262296904 1693 dbSNP
rs1461445767 1693 dbSNP
rs1217199966 1694 dbSNP
rs1449073712 1694 dbSNP
rs1166055048 1695 dbSNP
rs1169470243 1696 dbSNP
rs1284369978 1697 dbSNP
rs1371175476 1701 dbSNP
rs1348901552 1702 dbSNP
rs1398423645 1704 dbSNP
rs55779432 1705 dbSNP
rs1175194344 1706 dbSNP
rs1375680813 1706 dbSNP
rs1412245923 1706 dbSNP
rs1418653211 1706 dbSNP
rs1423912362 1706 dbSNP
rs56373873 1706 dbSNP
rs80083130 1706 dbSNP
rs1187577604 1707 dbSNP
rs1169828959 1708 dbSNP
rs1371424454 1709 dbSNP
rs1193413361 1710 dbSNP
rs1424028393 1711 dbSNP
rs1301373962 1713 dbSNP
rs1282737584 1714 dbSNP
rs1208356472 1716 dbSNP
rs1347938645 1719 dbSNP
rs1311658245 1722 dbSNP
rs1273853772 1723 dbSNP
rs1037623414 1726 dbSNP
rs539526383 1726 dbSNP
rs1133363 1728 dbSNP
rs1355911364 1734 dbSNP
rs531522424 1743 dbSNP
rs1445406793 1744 dbSNP
rs551625746 1746 dbSNP
rs1295280753 1749 dbSNP
rs1325093349 1751 dbSNP
rs1230116082 1752 dbSNP
rs1274855667 1766 dbSNP
rs141272770 1768 dbSNP
rs781671195 1773 dbSNP
rs1422118776 1775 dbSNP
rs899057034 1782 dbSNP
rs1260116026 1784 dbSNP
rs576854498 1784 dbSNP
rs1180304252 1786 dbSNP
rs1018939054 1789 dbSNP
rs1233469983 1790 dbSNP
rs571356042 1795 dbSNP
rs974993413 1796 dbSNP
rs1217984387 1803 dbSNP
rs1335198394 1811 dbSNP
rs906181501 1813 dbSNP
rs1226213981 1822 dbSNP
rs1378012572 1822 dbSNP
rs533946564 1823 dbSNP
rs1003742999 1833 dbSNP
rs920862973 1834 dbSNP
rs1185898366 1836 dbSNP
rs760205578 1842 dbSNP
rs1462466581 1843 dbSNP
rs766340257 1846 dbSNP
rs1423395661 1851 dbSNP
rs952207019 1851 dbSNP
rs983591471 1853 dbSNP
rs1390943203 1854 dbSNP
rs1444306856 1857 dbSNP
rs1161736109 1858 dbSNP
rs1351742337 1867 dbSNP
rs192116762 1870 dbSNP
rs1021851547 1881 dbSNP
rs908082977 1882 dbSNP
rs1380861483 1883 dbSNP
rs1266933203 1890 dbSNP
rs1288761189 1897 dbSNP
rs1320966691 1898 dbSNP
rs968969734 1913 dbSNP
rs939099573 1914 dbSNP
rs556030750 1915 dbSNP
rs1307939299 1921 dbSNP
rs1373973225 1921 dbSNP
rs373586285 1928 dbSNP
rs1384220007 1932 dbSNP
rs1298803232 1933 dbSNP
rs1393522892 1940 dbSNP
rs1292359263 1942 dbSNP
rs1457707533 1944 dbSNP
rs1346207856 1945 dbSNP
rs924643274 1950 dbSNP
rs916234000 1955 dbSNP
rs947731626 1958 dbSNP
rs1194357751 1963 dbSNP
rs1433638798 1964 dbSNP
rs770088476 1965 dbSNP
rs1243378272 1971 dbSNP
rs954722672 1973 dbSNP
rs1043613269 1986 dbSNP
rs910598758 1986 dbSNP
rs1261135863 1991 dbSNP
rs1474823523 1996 dbSNP
rs1321753560 1999 dbSNP
rs903779269 1999 dbSNP
rs1218290505 2004 dbSNP
rs943201723 2010 dbSNP
rs572700286 2012 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000304858.2 | 3UTR | AAAAAAAAUUUUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000304858.2 | 3UTR | AAAAAAAUUUUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000304858.2 | 3UTR | AAAAAAUUUUUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000304858.2 | 3UTR | AAAAAUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000304858.2 | 3UTR | AAAAAUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000304858.2 | 3UTR | AAAAAAAUUUUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000304858.2 | 3UTR | CUUAAAAAAAAAAAAAUUUUUUUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000304858.2 | 3UTR | UUUCUUCUUAAAAAAAAAAAAAUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
280 hsa-miR-4282 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057628 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT060732 RPS3 ribosomal protein S3 2 2
MIRT063371 ETNK1 ethanolamine kinase 1 2 2
MIRT066257 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT070774 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT070871 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT078056 PCTP phosphatidylcholine transfer protein 2 2
MIRT078408 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT084059 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT093537 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096072 SFXN1 sideroflexin 1 2 2
MIRT098316 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT100493 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT102254 HBP1 HMG-box transcription factor 1 2 4
MIRT105318 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT114143 MZT1 mitotic spindle organizing protein 1 2 4
MIRT114873 DICER1 dicer 1, ribonuclease III 2 2
MIRT134683 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT137640 RCOR1 REST corepressor 1 2 2
MIRT155449 CCNT2 cyclin T2 2 4
MIRT165656 DCTN4 dynactin subunit 4 2 2
MIRT177570 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT188514 E2F7 E2F transcription factor 7 2 10
MIRT193019 TMOD3 tropomodulin 3 2 4
MIRT195823 GADD45A growth arrest and DNA damage inducible alpha 2 2
MIRT195885 DEPDC1 DEP domain containing 1 2 6
MIRT206029 NUP50 nucleoporin 50 2 6
MIRT212148 CLCN3 chloride voltage-gated channel 3 2 2
MIRT213999 DCP2 decapping mRNA 2 2 2
MIRT214650 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT221568 CBX3 chromobox 3 2 2
MIRT224544 ZNF623 zinc finger protein 623 2 2
MIRT227654 SET SET nuclear proto-oncogene 2 2
MIRT229992 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT238968 QKI QKI, KH domain containing RNA binding 2 2
MIRT239825 ACTB actin beta 2 2
MIRT241084 ZXDA zinc finger, X-linked, duplicated A 2 4
MIRT244852 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT264534 TARDBP TAR DNA binding protein 2 2
MIRT271438 SKI SKI proto-oncogene 2 2
MIRT271597 ENAH ENAH, actin regulator 2 2
MIRT294332 ZNF264 zinc finger protein 264 2 2
MIRT296341 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT301715 TEF TEF, PAR bZIP transcription factor 2 2
MIRT308549 ZNF654 zinc finger protein 654 2 2
MIRT313866 DEPDC1B DEP domain containing 1B 2 2
MIRT315529 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT321066 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT343777 NUTF2 nuclear transport factor 2 2 2
MIRT359109 MAP1B microtubule associated protein 1B 2 2
MIRT397393 GOLGA3 golgin A3 2 4
MIRT400822 CPEB2 cytoplasmic polyadenylation element binding protein 2 2 2
MIRT442171 DSEL dermatan sulfate epimerase-like 2 2
MIRT442777 JAG1 jagged 1 2 2
MIRT442862 SCARF1 scavenger receptor class F member 1 2 4
MIRT442919 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT444567 TRA2B transformer 2 beta homolog 2 2
MIRT444718 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT445018 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT445853 LRRC1 leucine rich repeat containing 1 2 2
MIRT446242 HELZ helicase with zinc finger 2 2
MIRT446542 GOLGA8B golgin A8 family member B 2 2
MIRT446643 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT446948 ZMAT3 zinc finger matrin-type 3 2 4
MIRT447061 KCNAB1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 2 2
MIRT447327 ZSCAN21 zinc finger and SCAN domain containing 21 2 2
MIRT447995 CDX1 caudal type homeobox 1 2 2
MIRT448543 RHEBP1 RHEB pseudogene 1 2 6
MIRT448752 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT448772 GOLGA8A golgin A8 family member A 2 2
MIRT449342 WDR26 WD repeat domain 26 2 2
MIRT450011 SLC16A6 solute carrier family 16 member 6 2 4
MIRT450229 PCNX pecanex homolog 1 2 2
MIRT450340 MRPL17 mitochondrial ribosomal protein L17 2 4
MIRT450381 MSI2 musashi RNA binding protein 2 2 2
MIRT450759 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT450809 NRCAM neuronal cell adhesion molecule 2 2
MIRT450947 ATAD2 ATPase family, AAA domain containing 2 2 2
MIRT459095 CCPG1 cell cycle progression 1 2 2
MIRT462428 TWISTNB TWIST neighbor 2 2
MIRT465200 TROVE2 TROVE domain family member 2 2 4
MIRT467382 SON SON DNA binding protein 2 4
MIRT468546 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT471506 PDE4D phosphodiesterase 4D 2 2
MIRT471981 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT474478 KLHL11 kelch like family member 11 2 8
MIRT475011 KANSL1 KAT8 regulatory NSL complex subunit 1 2 8
MIRT480341 C5orf51 chromosome 5 open reading frame 51 2 2
MIRT482696 TEX9 testis expressed 9 2 6
MIRT483462 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 6
MIRT485623 FAM217B family with sequence similarity 217 member B 2 2
MIRT485714 CASP16 caspase 16, pseudogene 2 8
MIRT486279 SEC23A Sec23 homolog A, coat complex II component 2 2
MIRT491000 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT492594 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT493365 KIF5B kinesin family member 5B 2 2
MIRT494316 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT495208 EDN3 endothelin 3 2 2
MIRT497011 TCF15 transcription factor 15 2 2
MIRT498512 FRK fyn related Src family tyrosine kinase 2 2
MIRT498778 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT501045 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 6
MIRT502939 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504806 VHL von Hippel-Lindau tumor suppressor 2 6
MIRT505656 SHMT1 serine hydroxymethyltransferase 1 2 6
MIRT505964 RAB5C RAB5C, member RAS oncogene family 2 6
MIRT506322 OTUD4 OTU deubiquitinase 4 2 4
MIRT506803 KLHL15 kelch like family member 15 2 6
MIRT506917 KBTBD8 kelch repeat and BTB domain containing 8 2 4
MIRT507400 EMC7 ER membrane protein complex subunit 7 2 8
MIRT507471 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 6
MIRT508058 ATP13A3 ATPase 13A3 2 4
MIRT508135 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT509895 RPS23 ribosomal protein S23 2 4
MIRT510881 RAN RAN, member RAS oncogene family 2 8
MIRT513766 PEX5L peroxisomal biogenesis factor 5 like 2 4
MIRT516898 COPS8 COP9 signalosome subunit 8 2 2
MIRT518703 TIMD4 T-cell immunoglobulin and mucin domain containing 4 2 4
MIRT520429 TTPAL alpha tocopherol transfer protein like 2 6
MIRT521843 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT522116 NUDT3 nudix hydrolase 3 2 4
MIRT525467 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT525583 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT525906 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT526072 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT526232 MTRNR2L5 MT-RNR2-like 5 2 4
MIRT526455 FAM71F2 family with sequence similarity 71 member F2 2 4
MIRT526515 POU5F1B POU class 5 homeobox 1B 2 2
MIRT528032 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT528422 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT528995 ISLR2 immunoglobulin superfamily containing leucine rich repeat 2 2 4
MIRT529311 ATRNL1 attractin like 1 2 2
MIRT529376 SKP1 S-phase kinase associated protein 1 2 4
MIRT530015 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT530089 FMN2 formin 2 2 2
MIRT530942 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 2
MIRT531229 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT533088 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT533299 USP46 ubiquitin specific peptidase 46 2 2
MIRT533318 UNKL unkempt family like zinc finger 2 2
MIRT533721 TMEM30A transmembrane protein 30A 2 2
MIRT534096 AZF1 azoospermia factor 1 2 2
MIRT534188 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534493 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT536077 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT536242 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT537524 FAM104A family with sequence similarity 104 member A 2 2
MIRT538088 DGKH diacylglycerol kinase eta 2 2
MIRT538475 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT538853 BTG1 BTG anti-proliferation factor 1 2 4
MIRT539075 GDNF glial cell derived neurotrophic factor 2 2
MIRT539480 ACVR2B activin A receptor type 2B 2 4
MIRT540210 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT541940 TSPAN2 tetraspanin 2 2 2
MIRT543812 COCH cochlin 2 2
MIRT545120 PDZRN4 PDZ domain containing ring finger 4 2 2
MIRT545571 GIMAP4 GTPase, IMAP family member 4 2 2
MIRT545989 XKR4 XK related 4 2 2
MIRT547213 PANK3 pantothenate kinase 3 2 4
MIRT547740 KIAA1468 KIAA1468 2 2
MIRT548022 GRB2 growth factor receptor bound protein 2 2 4
MIRT548032 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548102 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT548217 FKBP1A FK506 binding protein 1A 2 2
MIRT548588 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT548953 CDC27 cell division cycle 27 2 2
MIRT549072 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT550368 INCENP inner centromere protein 2 6
MIRT550546 MYZAP myocardial zonula adherens protein 2 2
MIRT551491 TMEM192 transmembrane protein 192 2 4
MIRT553078 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT554104 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555127 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT555477 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT555978 NPTN neuroplastin 2 2
MIRT557011 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT557706 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT558333 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558488 DBN1 drebrin 1 2 2
MIRT559942 ZNF567 zinc finger protein 567 2 2
MIRT561127 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT561791 PAWR pro-apoptotic WT1 regulator 2 2
MIRT562438 EEF2 eukaryotic translation elongation factor 2 2 2
MIRT563102 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT563212 ZNF813 zinc finger protein 813 2 2
MIRT563426 KIF3A kinesin family member 3A 2 2
MIRT563473 SPIN4 spindlin family member 4 2 2
MIRT564015 HSPA4 heat shock protein family A (Hsp70) member 4 2 4
MIRT564117 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT564223 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT564503 CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1 2 2
MIRT564515 DUSP3 dual specificity phosphatase 3 2 2
MIRT564811 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT565265 TPD52 tumor protein D52 2 2
MIRT566012 RHOB ras homolog family member B 2 2
MIRT566216 PTMA prothymosin, alpha 2 2
MIRT566638 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT566821 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT566948 LEPROT leptin receptor overlapping transcript 2 2
MIRT567290 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT567895 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT568731 MTRNR2L3 MT-RNR2-like 3 2 2
MIRT571263 ZNF239 zinc finger protein 239 2 2
MIRT572593 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2 2
MIRT573827 TGOLN2 trans-golgi network protein 2 2 2
MIRT576391 Fhl2 four and a half LIM domains 2 2 2
MIRT609901 SMS spermine synthase 2 2
MIRT613710 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT614406 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT615042 DCX doublecortin 2 2
MIRT617514 C5orf45 MRN complex interacting protein 2 2
MIRT619476 PRDM10 PR/SET domain 10 2 2
MIRT620349 TLN1 talin 1 2 2
MIRT620910 PLA2G7 phospholipase A2 group VII 2 2
MIRT622131 SP4 Sp4 transcription factor 2 2
MIRT622955 OTUD7B OTU deubiquitinase 7B 2 2
MIRT623351 MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2 2
MIRT623619 INTU inturned planar cell polarity protein 2 2
MIRT624409 CCDC171 coiled-coil domain containing 171 2 2
MIRT625171 CCS copper chaperone for superoxide dismutase 2 2
MIRT625685 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT625875 ALDH18A1 aldehyde dehydrogenase 18 family member A1 2 2
MIRT626002 FAM107A family with sequence similarity 107 member A 2 2
MIRT626872 HRH4 histamine receptor H4 2 4
MIRT628220 FKBP9 FK506 binding protein 9 2 2
MIRT628265 DIO2 iodothyronine deiodinase 2 2 2
MIRT628402 C8orf37 chromosome 8 open reading frame 37 2 2
MIRT630564 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT631577 RASSF9 Ras association domain family member 9 2 2
MIRT635730 CCDC58 coiled-coil domain containing 58 2 2
MIRT636224 SLC8A1 solute carrier family 8 member A1 2 2
MIRT636613 CLIC5 chloride intracellular channel 5 2 2
MIRT638899 CDK9 cyclin dependent kinase 9 2 2
MIRT640167 ATXN7L1 ataxin 7 like 1 2 2
MIRT642070 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT643034 CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2 2
MIRT644572 SPOP speckle type BTB/POZ protein 2 2
MIRT644954 IFNB1 interferon beta 1 2 2
MIRT645948 TTF2 transcription termination factor 2 2 2
MIRT646440 XRCC2 X-ray repair cross complementing 2 2 2
MIRT647896 EPN2 epsin 2 2 2
MIRT648276 ZNF582 zinc finger protein 582 2 2
MIRT649381 NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2 2
MIRT650254 CD68 CD68 molecule 2 2
MIRT650333 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT651707 VMP1 vacuole membrane protein 1 2 2
MIRT651774 VASP vasodilator stimulated phosphoprotein 2 2
MIRT653144 SRPK2 SRSF protein kinase 2 2 2
MIRT654112 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654161 RORB RAR related orphan receptor B 2 2
MIRT655716 MLF2 myeloid leukemia factor 2 2 2
MIRT657476 HDAC4 histone deacetylase 4 2 2
MIRT658095 FOXO1 forkhead box O1 2 2
MIRT658860 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT658988 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 2
MIRT660767 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT661622 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661694 TFDP2 transcription factor Dp-2 2 2
MIRT662208 PLA2G4E phospholipase A2 group IVE 2 2
MIRT662443 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664422 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT687505 NECAB1 N-terminal EF-hand calcium binding protein 1 2 2
MIRT689910 SOD2 superoxide dismutase 2 2 2
MIRT690781 PLA2G2C phospholipase A2 group IIC 2 2
MIRT698488 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT699685 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT700926 PDS5A PDS5 cohesin associated factor A 2 2
MIRT702258 LMNB1 lamin B1 2 2
MIRT703166 GPR137C G protein-coupled receptor 137C 2 2
MIRT703242 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT704737 CENPQ centromere protein Q 2 2
MIRT707310 GLRX2 glutaredoxin 2 2 2
MIRT710021 KCNQ5 potassium voltage-gated channel subfamily Q member 5 2 2
MIRT712212 SCOC short coiled-coil protein 2 2
MIRT714742 SETBP1 SET binding protein 1 2 2
MIRT718268 ZNF749 zinc finger protein 749 2 2
MIRT720553 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT722248 RBM41 RNA binding motif protein 41 2 2
MIRT723767 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT723977 KIAA0146 scaffolding protein involved in DNA repair 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4282 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)

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