pre-miRNA Information | |
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pre-miRNA | hsa-mir-3179-1 |
Genomic Coordinates | chr16: 14901508 - 14901591 |
Description | Homo sapiens miR-3179-1 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
pre-miRNA | hsa-mir-3179-2 |
Genomic Coordinates | chr16: 16300159 - 16300242 |
Description | Homo sapiens miR-3179-2 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
pre-miRNA | hsa-mir-3179-3 |
Genomic Coordinates | chr16: 18411894 - 18411977 |
Description | Homo sapiens miR-3179-3 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
pre-miRNA | hsa-mir-3179-4 |
Genomic Coordinates | chr16: 18494493 - 18494576 |
Description | Homo sapiens miR-3179-4 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-3179 | |||||||||||||||
Sequence | 52| AGAAGGGGUGAAAUUUAAACGU |73 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Illumina | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | AKR1B10 | ||||||||||||||||||||
Synonyms | AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI | ||||||||||||||||||||
Description | aldo-keto reductase family 1 member B10 | ||||||||||||||||||||
Transcript | NM_020299 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on AKR1B10 | |||||||||||||||||||||
3'UTR of AKR1B10 (miRNA target sites are highlighted) |
>AKR1B10|NM_020299|3'UTR 1 GGTTGAATCTCCTGGTGAGATTATACAGGAGATTCTCTTTCTTCGCTGAAGTGTGACTACCTCCACTCATGTCCCATTTT 81 AGCCAAGCTTATTTAAGATCACAGTGAACTTAGTCCTGTTATAGACGAGAATCGAGGTGCTGTTTTAGACATTTATTTCT 161 GTATGTTCAACTAGGATCAGAATATCACAGAAAAGCATGGCTTGAATAAGGAAATGACAATTTTTTCCACTTATCTGATC 241 AGAACAAATGTTTATTAAGCATCAGAAACTCTGCCAACACTGAGGATGTAAAGATCAATAAAAAAAATAATAATCATAAC 321 CAACAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545216 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-124 transfection |
Location of target site | ENST00000261636.8 | 3UTR | CUUAUAUUCAUUCUCUGCUGCUUUCUCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||||||||||||||||
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133 hsa-miR-3179 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT102087 | GIGYF1 | GRB10 interacting GYF protein 1 | ![]() |
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2 | 4 | ||||||
MIRT110061 | OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | ![]() |
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2 | 6 | ||||||
MIRT112198 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 2 | ||||||
MIRT117668 | SCAMP4 | secretory carrier membrane protein 4 | ![]() |
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2 | 2 | ||||||
MIRT146657 | MINK1 | misshapen like kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT175505 | ZBTB33 | zinc finger and BTB domain containing 33 | ![]() |
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2 | 4 | ||||||
MIRT180535 | TXNIP | thioredoxin interacting protein | ![]() |
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2 | 2 | ||||||
MIRT190624 | BCL2L2-PABPN1 | BCL2L2-PABPN1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT190650 | PABPN1 | poly(A) binding protein nuclear 1 | ![]() |
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2 | 2 | ||||||
MIRT366902 | NONO | non-POU domain containing octamer binding | ![]() |
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2 | 2 | ||||||
MIRT443554 | ZFP3 | ZFP3 zinc finger protein | ![]() |
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2 | 2 | ||||||
MIRT445953 | MLLT11 | MLLT11, transcription factor 7 cofactor | ![]() |
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2 | 2 | ||||||
MIRT446042 | HMCN1 | hemicentin 1 | ![]() |
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2 | 2 | ||||||
MIRT447968 | MSH6 | mutS homolog 6 | ![]() |
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2 | 2 | ||||||
MIRT448634 | ONECUT1 | one cut homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT449316 | MRO | maestro | ![]() |
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2 | 2 | ||||||
MIRT451380 | C19orf43 | telomerase RNA component interacting RNase | ![]() |
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2 | 2 | ||||||
MIRT451547 | CIAPIN1 | cytokine induced apoptosis inhibitor 1 | ![]() |
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2 | 2 | ||||||
MIRT451807 | CDCA3 | cell division cycle associated 3 | ![]() |
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2 | 4 | ||||||
MIRT451916 | ILK | integrin linked kinase | ![]() |
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2 | 2 | ||||||
MIRT451938 | TMPRSS5 | transmembrane protease, serine 5 | ![]() |
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2 | 2 | ||||||
MIRT452189 | KIAA1456 | KIAA1456 | ![]() |
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2 | 2 | ||||||
MIRT452498 | HMGXB3 | HMG-box containing 3 | ![]() |
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2 | 2 | ||||||
MIRT452548 | ZNF467 | zinc finger protein 467 | ![]() |
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2 | 2 | ||||||
MIRT453844 | SDK1 | sidekick cell adhesion molecule 1 | ![]() |
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2 | 2 | ||||||
MIRT454515 | ZFYVE27 | zinc finger FYVE-type containing 27 | ![]() |
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2 | 2 | ||||||
MIRT455363 | KDM5C | lysine demethylase 5C | ![]() |
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2 | 2 | ||||||
MIRT455455 | EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | ![]() |
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2 | 2 | ||||||
MIRT455628 | PABPC1L2B | poly(A) binding protein cytoplasmic 1 like 2B | ![]() |
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2 | 10 | ||||||
MIRT455639 | PABPC1L2A | poly(A) binding protein cytoplasmic 1 like 2A | ![]() |
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2 | 10 | ||||||
MIRT455690 | GLO1 | glyoxalase I | ![]() |
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2 | 2 | ||||||
MIRT456300 | ASH1L | ASH1 like histone lysine methyltransferase | ![]() |
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2 | 2 | ||||||
MIRT456784 | MTHFSD | methenyltetrahydrofolate synthetase domain containing | ![]() |
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2 | 2 | ||||||
MIRT456819 | PIGP | phosphatidylinositol glycan anchor biosynthesis class P | ![]() |
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2 | 2 | ||||||
MIRT457566 | ZNF34 | zinc finger protein 34 | ![]() |
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2 | 2 | ||||||
MIRT457604 | IDS | iduronate 2-sulfatase | ![]() |
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2 | 2 | ||||||
MIRT458236 | NXPH3 | neurexophilin 3 | ![]() |
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2 | 2 | ||||||
MIRT458313 | TNFAIP8L3 | TNF alpha induced protein 8 like 3 | ![]() |
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2 | 2 | ||||||
MIRT458350 | NOC2L | NOC2 like nucleolar associated transcriptional repressor | ![]() |
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2 | 2 | ||||||
MIRT458670 | GPR35 | G protein-coupled receptor 35 | ![]() |
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2 | 2 | ||||||
MIRT459675 | VPS37C | VPS37C, ESCRT-I subunit | ![]() |
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2 | 2 | ||||||
MIRT461126 | RAB36 | RAB36, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT461918 | NECAB3 | N-terminal EF-hand calcium binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT462301 | PPM1H | protein phosphatase, Mg2+/Mn2+ dependent 1H | ![]() |
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2 | 2 | ||||||
MIRT463520 | ZBTB7B | zinc finger and BTB domain containing 7B | ![]() |
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2 | 2 | ||||||
MIRT464378 | URM1 | ubiquitin related modifier 1 | ![]() |
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2 | 2 | ||||||
MIRT464614 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT464711 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 2 | ||||||
MIRT465520 | PRICKLE4 | prickle planar cell polarity protein 4 | ![]() |
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2 | 2 | ||||||
MIRT465974 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT466058 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 2 | ||||||
MIRT466548 | TBL1XR1 | transducin beta like 1 X-linked receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT466647 | TAGLN2 | transgelin 2 | ![]() |
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2 | 2 | ||||||
MIRT467357 | SP2 | Sp2 transcription factor | ![]() |
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2 | 2 | ||||||
MIRT468744 | SDC2 | syndecan 2 | ![]() |
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2 | 2 | ||||||
MIRT470244 | PRRC2A | proline rich coiled-coil 2A | ![]() |
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2 | 2 | ||||||
MIRT471426 | PDIA6 | protein disulfide isomerase family A member 6 | ![]() |
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2 | 2 | ||||||
MIRT471732 | OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | ![]() |
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2 | 2 | ||||||
MIRT472190 | NHP2L1 | small nuclear ribonucleoprotein 13 | ![]() |
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2 | 2 | ||||||
MIRT472450 | NAV2 | neuron navigator 2 | ![]() |
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2 | 6 | ||||||
MIRT474563 | KLHDC3 | kelch domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT474936 | KCTD15 | potassium channel tetramerization domain containing 15 | ![]() |
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2 | 2 | ||||||
MIRT475165 | IP6K1 | inositol hexakisphosphate kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT475399 | ICMT | isoprenylcysteine carboxyl methyltransferase | ![]() |
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2 | 4 | ||||||
MIRT475426 | ICK | intestinal cell kinase | ![]() |
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2 | 2 | ||||||
MIRT477090 | FAM168A | family with sequence similarity 168 member A | ![]() |
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2 | 2 | ||||||
MIRT478458 | DAB2 | DAB2, clathrin adaptor protein | ![]() |
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2 | 2 | ||||||
MIRT478953 | COX15 | COX15, cytochrome c oxidase assembly homolog | ![]() |
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2 | 2 | ||||||
MIRT480096 | CALR | calreticulin | ![]() |
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2 | 2 | ||||||
MIRT481924 | ANKRD33B | ankyrin repeat domain 33B | ![]() |
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2 | 2 | ||||||
MIRT483217 | APOA1 | apolipoprotein A1 | ![]() |
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2 | 6 | ||||||
MIRT483882 | TGIF1 | TGFB induced factor homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT483923 | SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | ![]() |
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2 | 2 | ||||||
MIRT483942 | LENG8 | leukocyte receptor cluster member 8 | ![]() |
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2 | 4 | ||||||
MIRT484209 | SUMO1 | small ubiquitin-like modifier 1 | ![]() |
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2 | 2 | ||||||
MIRT484512 | SYT7 | synaptotagmin 7 | ![]() |
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2 | 2 | ||||||
MIRT484709 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT485356 | MYO1C | myosin IC | ![]() |
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2 | 4 | ||||||
MIRT485615 | FOSL1 | FOS like 1, AP-1 transcription factor subunit | ![]() |
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2 | 4 | ||||||
MIRT486584 | ZNF619 | zinc finger protein 619 | ![]() |
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2 | 2 | ||||||
MIRT487013 | C2orf82 | chromosome 2 open reading frame 82 | ![]() |
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2 | 2 | ||||||
MIRT487621 | C20orf96 | chromosome 20 open reading frame 96 | ![]() |
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2 | 2 | ||||||
MIRT487801 | GPR20 | G protein-coupled receptor 20 | ![]() |
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2 | 4 | ||||||
MIRT488134 | GPR107 | G protein-coupled receptor 107 | ![]() |
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2 | 2 | ||||||
MIRT488773 | FXYD1 | FXYD domain containing ion transport regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT488854 | UBTF | upstream binding transcription factor, RNA polymerase I | ![]() |
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2 | 2 | ||||||
MIRT489783 | GRINA | glutamate ionotropic receptor NMDA type subunit associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT490102 | FN3K | fructosamine 3 kinase | ![]() |
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2 | 2 | ||||||
MIRT490389 | LHFPL3 | LHFPL tetraspan subfamily member 3 | ![]() |
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2 | 2 | ||||||
MIRT490434 | MYL9 | myosin light chain 9 | ![]() |
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2 | 2 | ||||||
MIRT490451 | GLUD1 | glutamate dehydrogenase 1 | ![]() |
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2 | 2 | ||||||
MIRT490880 | OSBP | oxysterol binding protein | ![]() |
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2 | 2 | ||||||
MIRT491037 | ALPK3 | alpha kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT491250 | HCN2 | hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 | ![]() |
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2 | 2 | ||||||
MIRT491748 | SEMA3F | semaphorin 3F | ![]() |
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2 | 2 | ||||||
MIRT492235 | SLC48A1 | solute carrier family 48 member 1 | ![]() |
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2 | 2 | ||||||
MIRT492490 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | ![]() |
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2 | 2 | ||||||
MIRT492505 | RANBP10 | RAN binding protein 10 | ![]() |
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2 | 4 | ||||||
MIRT492773 | PDGFB | platelet derived growth factor subunit B | ![]() |
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2 | 2 | ||||||
MIRT492922 | NFAT5 | nuclear factor of activated T-cells 5 | ![]() |
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2 | 2 | ||||||
MIRT493459 | ITFG3 | family with sequence similarity 234 member A | ![]() |
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2 | 2 | ||||||
MIRT493654 | HDLBP | high density lipoprotein binding protein | ![]() |
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2 | 2 | ||||||
MIRT494011 | DUSP9 | dual specificity phosphatase 9 | ![]() |
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2 | 2 | ||||||
MIRT499412 | PLCG2 | phospholipase C gamma 2 | ![]() |
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2 | 4 | ||||||
MIRT499552 | C15orf43 | telomere repeat binding bouquet formation protein 2 | ![]() |
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2 | 2 | ||||||
MIRT501836 | NCOA2 | nuclear receptor coactivator 2 | ![]() |
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2 | 2 | ||||||
MIRT501950 | MAT2A | methionine adenosyltransferase 2A | ![]() |
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2 | 10 | ||||||
MIRT504066 | KCTD12 | potassium channel tetramerization domain containing 12 | ![]() |
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2 | 4 | ||||||
MIRT504509 | PPP1R9B | protein phosphatase 1 regulatory subunit 9B | ![]() |
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2 | 2 | ||||||
MIRT508466 | HOXB6 | homeobox B6 | ![]() |
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2 | 4 | ||||||
MIRT512373 | CPM | carboxypeptidase M | ![]() |
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2 | 2 | ||||||
MIRT513578 | EVX1 | even-skipped homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT517763 | ZNF366 | zinc finger protein 366 | ![]() |
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2 | 4 | ||||||
MIRT519773 | ZNF354B | zinc finger protein 354B | ![]() |
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2 | 8 | ||||||
MIRT523568 | GGCX | gamma-glutamyl carboxylase | ![]() |
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2 | 4 | ||||||
MIRT532802 | CLDN11 | claudin 11 | ![]() |
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2 | 2 | ||||||
MIRT544299 | TSPYL1 | TSPY like 1 | ![]() |
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2 | 2 | ||||||
MIRT544862 | MYH2 | myosin heavy chain 2 | ![]() |
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2 | 4 | ||||||
MIRT556731 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 4 | ||||||
MIRT564347 | AKR1B10 | aldo-keto reductase family 1 member B10 | ![]() |
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2 | 2 | ||||||
MIRT568924 | SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | ![]() |
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2 | 2 | ||||||
MIRT569012 | CXorf36 | chromosome X open reading frame 36 | ![]() |
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2 | 2 | ||||||
MIRT569256 | FAM129B | family with sequence similarity 129 member B | ![]() |
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2 | 2 | ||||||
MIRT569591 | PRELP | proline and arginine rich end leucine rich repeat protein | ![]() |
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2 | 2 | ||||||
MIRT569779 | SAMD14 | sterile alpha motif domain containing 14 | ![]() |
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2 | 2 | ||||||
MIRT570034 | FAM228A | family with sequence similarity 228 member A | ![]() |
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2 | 2 | ||||||
MIRT573803 | FRMPD4 | FERM and PDZ domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT574190 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 2 | ||||||
MIRT576153 | Hmox1 | heme oxygenase 1 | ![]() |
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2 | 2 | ||||||
MIRT611311 | CA8 | carbonic anhydrase 8 | ![]() |
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2 | 4 | ||||||
MIRT673429 | APAF1 | apoptotic peptidase activating factor 1 | ![]() |
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2 | 2 | ||||||
MIRT674976 | SH3BP2 | SH3 domain binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT692712 | MEAF6 | MYST/Esa1 associated factor 6 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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