pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol EIF2S3   
Synonyms EIF2, EIF2G, EIF2gamma, MRXSBRK, eIF-2gA
Description eukaryotic translation initiation factor 2 subunit gamma
Transcript NM_001415   
Expression
Putative miRNA Targets on EIF2S3
3'UTR of EIF2S3
(miRNA target sites are highlighted)
>EIF2S3|NM_001415|3'UTR
   1 AGAATACCAGTTAAATAATACATTCGGATGGATTTGGAAGTTGGAATTCCTCTTAACAACCAAGGGGTTTATTTTCAAAG
  81 CAATATTGGGGAATTGATTTCACAGTTCGTTACCTTAGTAGGTAACGGTAAGGTTATTCTCTTTTTTTTTTTTTTTTTTT
 161 TTGGTTATGAAAACTTAGGGACTAAAATTAATATAAAAATTGGCATAATGTTGGATTGAATCTACATTTTGGCAGAAGTT
 241 AAACATTCCCACATAATGTCAAAATTATACATCATGCAGTTCTGTTTTTTTGTTTGTTTTATTTTGTTTTGTTTTTGAGT
 321 CTGGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTGCAACCTCTGCCCCCCGGGTTCAAGCGATTCTCCTGCCTC
 401 AGCCTCCCGAGTAGCTGAGATTACAGGTGCGCGCCACCACACTTGGCTAATTTTTGTATTATTAGTAGAGACGGGGTTTC
 481 AGCATGTTGGCTAGGCCGGTCTCTCCTGACCTCAGGGTGATCAGCCCACCTCGGCCTCACAAAGTGCTGGGATTACAGGC
 561 GTGAGCCACCTTGCCCAGCCCACATCATACAGTTTGAAATGAAACTTTGCCACAACCAGCCTTTGCTGTAGCACACACAT
 641 ATATCACTGAACCTGTTTGAAATAAAGTTTTTTTTCTTTTTCATGATTCGTCTTTGAGTACCTCCAGGCTGAAAGACTGT
 721 TGTACCAGTAAAAACTTAAAGGCACAAATTCTCCTTGAAGACCTTCTCCCTTTTATGTGGCCCCATATTTTATGTTGCTT
 801 TATCTTTGAAATTTTGCATGAAAAGGAAATGAATGGATTCGAATGAAATTGTCCTTTAGAGCATGATTACTTGTTCCCAT
 881 GGACAAATATTTTTCTCCCCTTGCTCTTCCTGGCCTGAAACACGGGAAACCAGAGTCAAAAGTTATCTCCCTCTCCCTGT
 961 GATGCCTTGAGATTTTTTTCTGCGTTGTTTAATGCCTGAAATCCAAGTCTTCCTCCATGGGAAAATACTGTTATACCAAA
1041 TAATTCTAGATGAGTAACAAAGATCTTTTTAGGCCTTCATTTTATGTTTTTTCTTAACTGTTATATTATGATTGTGACAT
1121 AGATTATACTACTACTAATTTTTGGATGTTTCAAAAGGTCAAGAAGTAAAAGATGTTAGAAAGCAATGAGTGAGTCCTTT
1201 TGATTTTTAACTTATTCCCCATGTCCCTATACTTCGTGTGCTTTTCCTTTTTTTTTTTGAGACGGAGGCTCACTCCGTCA
1281 CCTAGGCTAGAGTACAGTGGCACGATCTTGGCTCGCTGCAACCTCTGCCTCCCTGATTCAAGTGATTCTCGTGCTTCAGC
1361 CTCCCATGTAGCTGATATTACAGGCACTTGCCACCATACCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACC
1441 ATGTTGCCCAGGCTGGTCTTGAACTCCTAACCTCAGGTGATCCGCCCGCCTCTGCCTTCCAAAGTGCTGGGATTACAGGC
1521 GTGAGCCACTCTGCCCGGCTTATTTTTCTTTATGTTTTTGCTTCGTAAGAGGTTCTGTTGAGCAGTGATTTGCAACTCTT
1601 GCTGACGTTGCTGGGGAAGCTTTAAAAAAAAAAAAGATGCCCCACAGAGATTCTGATTTTAATTGTTCTGATTTAATTGG
1681 CTTGGAGTAGAATTCAGGCATTGATATCTTTAAAAACTCCCCAGTGTTGAGAAACAAATTTAGAGAGTTGAGAAGTAGGT
1761 ATATTAAATTACAGAATCTTACTGAGTTTTGGTAGACTGATAATACAATTTGCTTTGCTTTTCTTAAATTTGCATTGAGA
1841 TGGGATTTGAAGCATATTGTGCTCTTGTGAATGTTGAAGTTGCATTGTAGAAGTTTAGAAGCTCTGGCTATGGGTTGCCT
1921 AAATTGATGTTTTGAGGAAGCATATTAATGTTATAAACTTCGCTGACTTTGAAGGTTGTGTTGTAGCATGAGGAACACAA
2001 ATAAAACAATTCTAAATCAAACTAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgGUUCCCUUACCGUCCCUUua 5'
            ||| | |||  ::|||||  
Target 5' ttCAAAGCAATATTGGGGAAtt 3'
74 - 95 128.00 -10.20
2
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' cctggcctgaaacacGGGAAAc 3'
909 - 930 120.00 -9.20
3
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' caagtcttcctccatGGGAAAa 3'
1004 - 1025 120.00 -9.10
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773796835 7 dbSNP
rs749718018 14 dbSNP
rs1246106249 23 dbSNP
rs1466144042 24 dbSNP
rs1284964911 25 dbSNP
rs369749610 26 dbSNP
rs1242265121 27 dbSNP
rs771163509 37 dbSNP
rs776241535 43 dbSNP
rs1368600750 53 dbSNP
rs761773962 59 dbSNP
rs1332120579 61 dbSNP
rs111630683 84 dbSNP
rs1469285068 85 dbSNP
rs1389178273 86 dbSNP
rs1012096463 87 dbSNP
rs111372663 109 dbSNP
rs1236761845 127 dbSNP
rs1419609574 128 dbSNP
rs191563492 134 dbSNP
rs1182097205 137 dbSNP
rs199708557 138 dbSNP
rs372625244 139 dbSNP
rs762440475 139 dbSNP
rs1209395867 140 dbSNP
rs1230580744 140 dbSNP
rs1271987474 140 dbSNP
rs1290879026 140 dbSNP
rs1293619037 140 dbSNP
rs1323808715 140 dbSNP
rs1351341333 140 dbSNP
rs1354416948 140 dbSNP
rs1365797552 140 dbSNP
rs1401264495 140 dbSNP
rs1432657141 140 dbSNP
rs747088489 140 dbSNP
rs376888206 141 dbSNP
rs1167335026 142 dbSNP
rs1225992450 142 dbSNP
rs1275201860 142 dbSNP
rs1309420361 142 dbSNP
rs1329029211 142 dbSNP
rs1369329118 142 dbSNP
rs1369543346 142 dbSNP
rs1388015465 142 dbSNP
rs1416643297 142 dbSNP
rs1429845927 142 dbSNP
rs1435366723 142 dbSNP
rs5949273 142 dbSNP
rs879230822 142 dbSNP
rs1426372221 144 dbSNP
rs1190945241 145 dbSNP
rs1166426545 161 dbSNP
rs1234835856 163 dbSNP
rs1477220455 163 dbSNP
rs754534322 163 dbSNP
rs1394516373 164 dbSNP
rs1386262070 165 dbSNP
rs5949274 166 dbSNP
rs900330663 168 dbSNP
rs1329141651 169 dbSNP
rs1375273518 170 dbSNP
rs764546995 171 dbSNP
rs1391750919 175 dbSNP
rs1313855138 176 dbSNP
rs1279198665 180 dbSNP
rs1218454786 199 dbSNP
rs1342546504 203 dbSNP
rs747020844 206 dbSNP
rs1340066979 216 dbSNP
rs1349400994 233 dbSNP
rs1305619807 248 dbSNP
rs1450862926 254 dbSNP
rs755285963 269 dbSNP
rs1360280324 283 dbSNP
rs1175914194 286 dbSNP
rs1413132709 287 dbSNP
rs754187586 289 dbSNP
rs1231579216 293 dbSNP
rs1295222170 297 dbSNP
rs905941576 297 dbSNP
rs146275076 301 dbSNP
rs779548178 312 dbSNP
rs1409905249 313 dbSNP
rs1198572182 325 dbSNP
rs1003391589 332 dbSNP
rs1238001289 335 dbSNP
rs1250064959 354 dbSNP
rs1209257363 355 dbSNP
rs746010027 365 dbSNP
rs1196739600 371 dbSNP
rs1255092947 375 dbSNP
rs183853883 377 dbSNP
rs112482955 378 dbSNP
rs1379186500 384 dbSNP
rs796118641 387 dbSNP
rs111579157 388 dbSNP
rs1477176898 409 dbSNP
rs1457011812 410 dbSNP
rs1410068194 420 dbSNP
rs3207873 424 dbSNP
rs781513490 431 dbSNP
rs748355601 432 dbSNP
rs1356206711 433 dbSNP
rs1462346340 434 dbSNP
rs1016472778 457 dbSNP
rs1249706276 457 dbSNP
rs769666674 473 dbSNP
rs747279131 474 dbSNP
rs1265863628 477 dbSNP
rs1223225739 482 dbSNP
rs375249551 486 dbSNP
rs1311367463 498 dbSNP
rs1227153109 499 dbSNP
rs1413197882 518 dbSNP
rs1368016672 529 dbSNP
rs1295278157 531 dbSNP
rs974879790 533 dbSNP
rs1434849534 534 dbSNP
rs922129214 540 dbSNP
rs1295578573 549 dbSNP
rs1458592680 553 dbSNP
rs1349423621 561 dbSNP
rs768724793 566 dbSNP
rs772875198 570 dbSNP
rs954473303 576 dbSNP
rs1391970843 584 dbSNP
rs749304872 585 dbSNP
rs1228674533 591 dbSNP
rs923608421 593 dbSNP
rs3207877 613 dbSNP
rs1259389405 614 dbSNP
rs934996622 626 dbSNP
rs1255804151 627 dbSNP
rs1264389796 635 dbSNP
rs1053671498 636 dbSNP
rs1484857345 642 dbSNP
rs1343610520 644 dbSNP
rs1275986323 653 dbSNP
rs570029856 660 dbSNP
rs1363538680 668 dbSNP
rs1303832306 671 dbSNP
rs114095209 677 dbSNP
rs1367210277 691 dbSNP
rs947988877 698 dbSNP
rs1291952281 705 dbSNP
rs1257766181 710 dbSNP
rs1487716246 711 dbSNP
rs1044901008 716 dbSNP
rs1184227680 726 dbSNP
rs1169217032 739 dbSNP
rs1421632011 754 dbSNP
rs1429066938 763 dbSNP
rs1177927385 765 dbSNP
rs1433508297 766 dbSNP
rs34373297 771 dbSNP
rs17217346 781 dbSNP
rs1196757951 793 dbSNP
rs906386831 804 dbSNP
rs773914313 808 dbSNP
rs1436286197 812 dbSNP
rs73626807 826 dbSNP
rs1337983273 837 dbSNP
rs1376285359 842 dbSNP
rs1234445068 843 dbSNP
rs1311915055 861 dbSNP
rs1281617929 862 dbSNP
rs1411892847 864 dbSNP
rs1351241922 876 dbSNP
rs1307470397 879 dbSNP
rs1399519715 890 dbSNP
rs773100426 891 dbSNP
rs1287168103 898 dbSNP
rs369824654 901 dbSNP
rs1364123042 910 dbSNP
rs1409174902 924 dbSNP
rs111365706 925 dbSNP
rs1002930205 934 dbSNP
rs373279652 936 dbSNP
rs1466367632 942 dbSNP
rs1346240824 943 dbSNP
rs1376855977 950 dbSNP
rs1057466974 951 dbSNP
rs1473356631 952 dbSNP
rs886403120 955 dbSNP
rs5990022 958 dbSNP
rs1280651947 961 dbSNP
rs1258888671 973 dbSNP
rs1342519226 984 dbSNP
rs1201458520 985 dbSNP
rs1483166346 985 dbSNP
rs1261645682 995 dbSNP
rs1230513328 1004 dbSNP
rs1004847506 1008 dbSNP
rs1287917658 1015 dbSNP
rs1352506294 1035 dbSNP
rs1342276151 1041 dbSNP
rs1314852841 1043 dbSNP
rs1396526484 1066 dbSNP
rs759230168 1066 dbSNP
rs1401294331 1075 dbSNP
rs767019726 1099 dbSNP
rs554809635 1101 dbSNP
rs1388950085 1104 dbSNP
rs775164804 1105 dbSNP
rs1213156622 1106 dbSNP
rs1468158474 1112 dbSNP
rs1369688654 1115 dbSNP
rs1188921069 1119 dbSNP
rs1016259343 1120 dbSNP
rs1243373088 1122 dbSNP
rs1241722441 1124 dbSNP
rs899406195 1127 dbSNP
rs1211002940 1131 dbSNP
rs1465588019 1134 dbSNP
rs1485867854 1138 dbSNP
rs1203614025 1146 dbSNP
rs754310279 1161 dbSNP
rs760316459 1169 dbSNP
rs996413792 1174 dbSNP
rs1251042981 1187 dbSNP
rs1029089110 1203 dbSNP
rs757690866 1207 dbSNP
rs1395971817 1212 dbSNP
rs73626808 1219 dbSNP
rs1365567969 1221 dbSNP
rs765692976 1230 dbSNP
rs1317279861 1232 dbSNP
rs1398579534 1233 dbSNP
rs750946562 1235 dbSNP
rs1392316981 1236 dbSNP
rs1163297275 1239 dbSNP
rs1190994172 1248 dbSNP
rs748940396 1248 dbSNP
rs955065747 1248 dbSNP
rs1347053215 1249 dbSNP
rs1191368812 1253 dbSNP
rs1431556918 1260 dbSNP
rs1290813907 1265 dbSNP
rs1209343348 1266 dbSNP
rs548443882 1272 dbSNP
rs1289507418 1274 dbSNP
rs547123775 1277 dbSNP
rs755245748 1278 dbSNP
rs1269356001 1289 dbSNP
rs1428258331 1291 dbSNP
rs750699468 1295 dbSNP
rs1332488934 1304 dbSNP
rs1323749509 1315 dbSNP
rs758953483 1316 dbSNP
rs5949219 1319 dbSNP
rs1143263 1324 dbSNP
rs1389994331 1330 dbSNP
rs989141936 1339 dbSNP
rs1479182441 1340 dbSNP
rs751714842 1354 dbSNP
rs914932158 1365 dbSNP
rs1489898757 1367 dbSNP
rs947937933 1368 dbSNP
rs1207268769 1376 dbSNP
rs980694694 1382 dbSNP
rs1317045842 1384 dbSNP
rs748006785 1386 dbSNP
rs1271237824 1387 dbSNP
rs927794624 1392 dbSNP
rs1469746644 1398 dbSNP
rs1194130070 1402 dbSNP
rs769550938 1403 dbSNP
rs939183367 1409 dbSNP
rs1222511082 1411 dbSNP
rs772939344 1422 dbSNP
rs368898207 1423 dbSNP
rs1354490660 1434 dbSNP
rs1327372623 1438 dbSNP
rs770703518 1439 dbSNP
rs1175763122 1442 dbSNP
rs940802458 1448 dbSNP
rs1410435050 1457 dbSNP
rs1037654609 1464 dbSNP
rs1164278160 1468 dbSNP
rs1414332623 1468 dbSNP
rs1183020463 1472 dbSNP
rs1392320983 1476 dbSNP
rs1463506923 1484 dbSNP
rs1223435424 1485 dbSNP
rs899185377 1488 dbSNP
rs1327082062 1489 dbSNP
rs773924394 1505 dbSNP
rs996362954 1510 dbSNP
rs1029663579 1518 dbSNP
rs890597491 1521 dbSNP
rs1440450048 1522 dbSNP
rs1202687405 1529 dbSNP
rs758955981 1543 dbSNP
rs184593345 1544 dbSNP
rs1321015647 1545 dbSNP
rs1373567071 1551 dbSNP
rs1228486289 1565 dbSNP
rs539509978 1566 dbSNP
rs775251721 1568 dbSNP
rs1031207075 1572 dbSNP
rs956639049 1572 dbSNP
rs1360157107 1576 dbSNP
rs1336241454 1592 dbSNP
rs762318972 1601 dbSNP
rs1468528733 1603 dbSNP
rs1226042067 1606 dbSNP
rs1214260302 1607 dbSNP
rs1257331424 1608 dbSNP
rs373127191 1617 dbSNP
rs1175463356 1624 dbSNP
rs1266765067 1624 dbSNP
rs1405875681 1624 dbSNP
rs989256175 1625 dbSNP
rs1202821171 1635 dbSNP
rs1459768879 1636 dbSNP
rs1269633658 1652 dbSNP
rs1208962648 1666 dbSNP
rs1315871108 1673 dbSNP
rs1281496105 1691 dbSNP
rs755153516 1698 dbSNP
rs1234865939 1705 dbSNP
rs1450926876 1712 dbSNP
rs1470649304 1715 dbSNP
rs1321544854 1726 dbSNP
rs1453297974 1732 dbSNP
rs969060745 1746 dbSNP
rs1167043643 1748 dbSNP
rs1415780465 1751 dbSNP
rs1385806067 1762 dbSNP
rs1182844554 1776 dbSNP
rs980643723 1777 dbSNP
rs1476192130 1781 dbSNP
rs927878640 1783 dbSNP
rs1485321144 1808 dbSNP
rs1239960571 1809 dbSNP
rs939316474 1814 dbSNP
rs140754709 1815 dbSNP
rs1396399033 1818 dbSNP
rs1408611550 1823 dbSNP
rs1244416398 1833 dbSNP
rs1331263873 1860 dbSNP
rs908400426 1865 dbSNP
rs1381972121 1868 dbSNP
rs1360162580 1873 dbSNP
rs34323788 1884 dbSNP
rs1355429284 1885 dbSNP
rs1437291429 1901 dbSNP
rs1365035593 1906 dbSNP
rs940751588 1911 dbSNP
rs190407199 1920 dbSNP
rs763524866 1921 dbSNP
rs1170915806 1941 dbSNP
rs931993635 1955 dbSNP
rs1233360434 1962 dbSNP
rs1192501864 1963 dbSNP
rs781385103 1968 dbSNP
rs1490389384 1987 dbSNP
rs1129148 1998 dbSNP
rs1267538844 2003 dbSNP
rs1337346361 2003 dbSNP
rs1216210176 2013 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001415 | 3UTR | CUGCGUUGUUUAAUGCCUGAAAUCCAAGUCUUCCUCCAUGGGAAAAUACUGUUAUACCAAAUAAUUCUAGAUGAGUAACAAAGAUCUUUUUAGGCCUUCAUUUUAUGUUUUUUCUUAACUGUUAUAUUAUGAUUGUGACAUAGAUUAUACUACUACUAAUUUUUGGAUGUUUCAAAAGGUCAAGAAGUAAAAGAUGUUAGAAAGCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001415 | 3UTR | UGCGUUGUUUAAUGCCUGAAAUCCAAGUCUUCCUCCAUGGGAAAAUACUGUUAUACCAAAUAAUUCUAGAUGAGUAACAAAGAUCUUUUUAGGCCUUCAUUUUAUGUUUUUUCUUAACUGUUAUAUUAUGAUUGUGACAUAGAUUAUACUACUACUAAUUUUUGGAUGUUUCAAAAGGUCAAGAAGUAAAAGAUGUUAGAAAGCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001415 | 3UTR | CUCUCCCUGUGAUGCCUUGAGAUUUUUUUCUGCGUUGUUUAAUGCCUGAAAUCCAAGUCUUCCUCCAUGGGAAAAUACUGUUAUACCAAAUAAUUCUAGAUGAGUAACAAAGAUCUUUUUAGGCCUUCAUUUUAUGUUUUUUCUUAACUGUUAUAUUAUGAUUGUGACAUAGAUUAUACUACUACUAAUUUUUGGAUGUUUCAAAAGGUCAAGAAGUAAAAGAUGUUAGAAAGCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001415 | 3UTR | CCCUGUGAUGCCUUGAGAUUUUUUUCUGCGUUGUUUAAUGCCUGAAAUCCAAGUCUUCCUCCAUGGGAAAAUACUGUUAUACCAAAUAAUUCUAGAUGAGUAACAAAGAUCUUUUUAGGCCUUCAUUUUAUGUUUUUUCUUAACUGUUAUAUUAUGAUUGUGACAUAGAUUAUACUACUACUAAUUUUUGGAUGUUUCAAAAGGUCAAGAAGUAAAAGAUGUUAGAAAGCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001415 | 3UTR | GUUGUUUAAUGCCUGAAAUCCAAGUCUUCCUCCAUGGGAAAAUACUGUUAUACCAAAUAAUUCUAGAUGAGUAACAAAGAUCUUUUUAGGCCUUCAUUUUAUGUUUUUUCUUAACUGUUAUAUUAUGAUUGUGACAUAGAUUAUACUACUACUAAUUUUUGGAUGUUUCAAAAGGUCAAGAAGUAAAAGAUGUUAGAAAGCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001415 | 3UTR | UUUCUGCGUUGUUUAAUGCCUGAAAUCCAAGUCUUCCUCCAUGGGAAAAUACUGUUAUACCAAAUAAUUCUAGAUGAGUAACAAAGAUCUUUUUAGGCCUUCAUUUUAUGUUUUUUCUUAACUGUUAUAUUAUGAUUGUGACAUAGAUUAUACUACUACUAAUUUUUGGAUGUUUCAAAAGGUCAAGAAGUAAAAGAUGUUAGAAAGCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000253039.4 | 3UTR | AAAAUACUGUUAUACCAAAUAAUUCUAGAUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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