miRTarBase - #MIRT564913


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pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol YTHDF1   
Synonyms C20orf21
Description YTH N6-methyladenosine RNA binding protein 1
Transcript NM_017798   
Expression
Putative miRNA Targets on YTHDF1
3'UTR of YTHDF1
(miRNA target sites are highlighted)		 
>YTHDF1|NM_017798|3'UTR
   1 GGGCGAACCAGTTTCTTACATGTTCTAACGTTTGACTTTGAAAACAGTTTAAAACACGTGTGCTTGGTCAGCTCCAGTGT
  81 GTCGTCCCGTGCGGGGGTTGAGTGTTGCATCTTTGCCTTTCTTGTCGTTGATTTTTGCCCAGATGGATCTGCATTTATTT
 161 GTACTTTTTCTATGTATTATAATCCTGTAGAAGTCACTAATAAAGGAGTATTTTTTTTGTCAGCTTATCAATCAGACTGA
 241 TCTAATGTGAAATGTAAGTATCCTTAAAAACAAAGCATCTATTTTGGCAGAAATTGTGTTCTTAAATTCAGTCATTTGAT
 321 ATTCTGTGAGACTTCATATTTCTCATCCCTTTATTGCTTTTTAGCAAACATAAGAAACCATGAGTCATTTTGTCATTTAG
 401 AGTATTCTGATAAAATCTCTTGAAAATACTGAAATCAAAAGGTTAATGATTTTTTGTTCATTCTGATTTGTCATTTTATT
 481 ATCTGTTATCGGTCTAAAGTGCTAATTTACCCATTTGATTTTTCTGCTAGACAGATAACTTTTAATTTTTCAAATTTGGC
 561 AGACACTTTTTTTTTTTTTTTGAAAATCTTTCCTTCCAGATCTGTTGCCCACTGAACAGCCACCCGTCCCTCACTGTCCT
 641 GGTGTCCGATTGGGCTGGATGGTGTTGGGGCATGATGTGTGGAGGAACTGGAAGGTGCTTTAGGTCTGGTTCAGGGTCGG
 721 GCATTCTTTGTTGTTTGCACATCTTTTTAAATTTTACACCTTTTCTTAAGAATTCTAATGCCGTCTTAAGTTTTTATACC
 801 AATAATGCTGAGCTTTAAGTGTAGGATCTGGTAGTACAGACAGTGTGATGGATGATGCTGCTGGTTGTAAATTTCATCGT
 881 GTGTGTCTAATTTTTTTTCCTGTTGAATGGGTAAAAACAAAACAAAACTTTTTTTAGAAGATGAATTTGCTGTCATGTTT
 961 TGTGGAATGAGGGACCGTTGAGCTCACTACCACCTGGAGTTTGAGTTGAAGCATGAAAATGGTGCCCATGCCTGACGCTC
1041 CAGCGCCTGGATCTGCACGTGCCCTTGTAGAGGATCCTTACCGTCCTAGAGAGCAGACGCTTTCTGAAAACTACTTGCTC
1121 CAAAAGACCCTCTGAGTTAACGTTTCAGCTGTATCATTAGACTTGTATTTAGAGCGTGTCACTTCCTCTGAACTGTTACT
1201 GCCTGAATGGAGTCCTGGACGACATTGGGTTTTTCCTCTAGGAGAATACAAGCCTTAATAAACAATACTATTTAGCAAAA
1281 AAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acggUCGGAGCGGGUCg 5'
              | ::|:|||||| 
Target 5' gttgATTTTTGCCCAGa 3'
 127 - 143 133.00 -14.20
2 
miRNA  3' acGGU-CGGA--GCG-GGUCg 5'
            ||| ||||  ||| |||| 
Target 5' gcCCATGCCTGACGCTCCAGc 3'
 1024 - 1044 125.00 -21.10
3 
miRNA  3' acGGUC--GG-AGCGGGUcg 5'
            ||||  |: |:|||||  
Target 5' ttCCAGATCTGTTGCCCAct 3'
 594 - 613 117.00 -15.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31604289 3 COSMIC
COSN13873247 4 COSMIC
COSN30111836 5 COSMIC
COSN30187932 50 COSMIC
COSN30494043 57 COSMIC
COSN13873244 58 COSMIC
COSN30447230 59 COSMIC
COSN30108368 84 COSMIC
COSN13873243 89 COSMIC
COSN26143386 92 COSMIC
COSN31493132 100 COSMIC
COSN30513061 140 COSMIC
COSN31581935 161 COSMIC
COSN31572805 162 COSMIC
COSN30534142 176 COSMIC
COSN31578446 199 COSMIC
COSN31582286 210 COSMIC
COSN22868287 211 COSMIC
COSN8002678 298 COSMIC
COSN20584850 386 COSMIC
COSN27336153 566 COSMIC
COSN27579417 567 COSMIC
COSN21369874 839 COSMIC
COSN29019169 1004 COSMIC
COSN29257511 1059 COSMIC
COSN30165679 1104 COSMIC
COSN30175111 1134 COSMIC
COSN31483335 1188 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756032281 2 dbSNP
rs752500107 3 dbSNP
rs780821500 4 dbSNP
rs373068552 5 dbSNP
rs754866257 10 dbSNP
rs1270410024 18 dbSNP
rs751241936 20 dbSNP
rs766197150 25 dbSNP
rs749914499 29 dbSNP
rs765723935 30 dbSNP
rs200812888 32 dbSNP
rs1368220438 35 dbSNP
rs1292812855 36 dbSNP
rs762257104 41 dbSNP
rs202048114 44 dbSNP
rs777245392 45 dbSNP
rs761095073 46 dbSNP
rs373457427 58 dbSNP
rs1194063712 72 dbSNP
rs1342349249 74 dbSNP
rs574094617 83 dbSNP
rs1282479152 84 dbSNP
rs555429707 88 dbSNP
rs903953111 89 dbSNP
rs183864484 92 dbSNP
rs534136172 93 dbSNP
rs1202895738 95 dbSNP
rs1287509031 96 dbSNP
rs771230069 101 dbSNP
rs1042421707 103 dbSNP
rs928038533 106 dbSNP
rs935346735 106 dbSNP
rs945221841 107 dbSNP
rs1199892807 116 dbSNP
rs1317481941 118 dbSNP
rs1259153344 124 dbSNP
rs917781005 126 dbSNP
rs1216666541 127 dbSNP
rs1451870055 129 dbSNP
rs1160431217 132 dbSNP
rs1361246012 141 dbSNP
rs992387594 172 dbSNP
rs1420241979 173 dbSNP
rs948215909 180 dbSNP
rs747266198 182 dbSNP
rs1449311191 201 dbSNP
rs926525427 203 dbSNP
rs973738167 208 dbSNP
rs1301679353 219 dbSNP
rs963582644 219 dbSNP
rs973985616 219 dbSNP
rs1382903401 221 dbSNP
rs573056522 221 dbSNP
rs962338581 222 dbSNP
rs1338067994 225 dbSNP
rs1463761783 227 dbSNP
rs1015365457 229 dbSNP
rs1222431565 231 dbSNP
rs1290170559 237 dbSNP
rs1489736777 238 dbSNP
rs558054152 242 dbSNP
rs982434227 246 dbSNP
rs1417628497 247 dbSNP
rs951052294 249 dbSNP
rs140334224 253 dbSNP
rs1381020453 261 dbSNP
rs955283764 268 dbSNP
rs1444027673 279 dbSNP
rs73611769 306 dbSNP
rs1044505 325 dbSNP
rs997981521 329 dbSNP
rs1170959816 337 dbSNP
rs1459358230 346 dbSNP
rs1293951709 347 dbSNP
rs998087180 354 dbSNP
rs1389326624 367 dbSNP
rs73317686 369 dbSNP
rs1377035394 370 dbSNP
rs1244659247 377 dbSNP
rs1312255030 378 dbSNP
rs1162607547 380 dbSNP
rs1017776153 383 dbSNP
rs1000832221 384 dbSNP
rs1010713471 386 dbSNP
rs1176826221 397 dbSNP
rs111999571 400 dbSNP
rs1479831919 400 dbSNP
rs903837038 401 dbSNP
rs1042762457 407 dbSNP
rs945509198 415 dbSNP
rs896553592 425 dbSNP
rs1416033592 426 dbSNP
rs6010871 441 dbSNP
rs1425553914 451 dbSNP
rs1289538137 456 dbSNP
rs1056337431 472 dbSNP
rs1460242389 474 dbSNP
rs777970236 479 dbSNP
rs760151391 484 dbSNP
rs1046908687 488 dbSNP
rs926535275 489 dbSNP
rs144631884 490 dbSNP
rs113297329 491 dbSNP
rs1443920607 492 dbSNP
rs191710564 497 dbSNP
rs1375779469 499 dbSNP
rs1298400991 504 dbSNP
rs527503834 509 dbSNP
rs1443855720 511 dbSNP
rs916652776 515 dbSNP
rs1220886742 517 dbSNP
rs1037847520 520 dbSNP
rs1163764086 523 dbSNP
rs1425271030 524 dbSNP
rs1323165385 526 dbSNP
rs908233695 533 dbSNP
rs772327406 535 dbSNP
rs1386986618 542 dbSNP
rs1239289214 544 dbSNP
rs1483585634 544 dbSNP
rs1156988568 546 dbSNP
rs1182408705 556 dbSNP
rs371710863 559 dbSNP
rs1439157800 561 dbSNP
rs1408722564 563 dbSNP
rs1179182523 565 dbSNP
rs1487599230 566 dbSNP
rs1246522251 567 dbSNP
rs1424070434 567 dbSNP
rs1468974760 577 dbSNP
rs1173452089 581 dbSNP
rs200005756 582 dbSNP
rs535731736 582 dbSNP
rs76136987 582 dbSNP
rs762776719 582 dbSNP
rs908109565 582 dbSNP
rs942206503 582 dbSNP
rs1222734226 583 dbSNP
rs143913977 583 dbSNP
rs1279304931 586 dbSNP
rs981346153 588 dbSNP
rs1284499315 591 dbSNP
rs6122392 593 dbSNP
rs1280941064 599 dbSNP
rs1312963583 600 dbSNP
rs1215218917 601 dbSNP
rs1259029078 621 dbSNP
rs1239974342 623 dbSNP
rs983744899 624 dbSNP
rs551537877 625 dbSNP
rs1263652534 626 dbSNP
rs200141223 626 dbSNP
rs1225151054 628 dbSNP
rs1189133103 634 dbSNP
rs1426874536 643 dbSNP
rs115217679 644 dbSNP
rs772860528 647 dbSNP
rs866545778 648 dbSNP
rs1422066794 658 dbSNP
rs976283105 666 dbSNP
rs150941477 669 dbSNP
rs1405312661 683 dbSNP
rs922259446 693 dbSNP
rs6010870 694 dbSNP
rs6010869 703 dbSNP
rs1352005401 713 dbSNP
rs964818391 714 dbSNP
rs73310829 718 dbSNP
rs1001096543 719 dbSNP
rs1218729614 721 dbSNP
rs1286594109 723 dbSNP
rs1490158509 740 dbSNP
rs573935675 756 dbSNP
rs957887904 759 dbSNP
rs561852148 760 dbSNP
rs1030872734 770 dbSNP
rs1020987945 772 dbSNP
rs999430161 775 dbSNP
rs906449157 777 dbSNP
rs6011659 782 dbSNP
rs1431701398 783 dbSNP
rs1385211380 787 dbSNP
rs1012678337 789 dbSNP
rs1326022934 790 dbSNP
rs1350761953 791 dbSNP
rs1424698013 818 dbSNP
rs1441764839 819 dbSNP
rs1200686124 828 dbSNP
rs1329498799 844 dbSNP
rs1379245368 859 dbSNP
rs779538954 860 dbSNP
rs188746917 861 dbSNP
rs1314444803 862 dbSNP
rs1358718482 867 dbSNP
rs895220439 878 dbSNP
rs1037814787 879 dbSNP
rs1486458046 887 dbSNP
rs1203405285 889 dbSNP
rs1322040139 889 dbSNP
rs1328584567 891 dbSNP
rs896572321 899 dbSNP
rs1056918555 905 dbSNP
rs1458798875 908 dbSNP
rs368095360 909 dbSNP
rs1002050929 911 dbSNP
rs774738289 923 dbSNP
rs1178775255 928 dbSNP
rs1294070468 929 dbSNP
rs908077118 929 dbSNP
rs942175457 929 dbSNP
rs1047933785 930 dbSNP
rs933549744 931 dbSNP
rs1409706616 933 dbSNP
rs1168939817 936 dbSNP
rs1260848701 936 dbSNP
rs923537743 936 dbSNP
rs976417235 936 dbSNP
rs755443032 938 dbSNP
rs1336242420 944 dbSNP
rs905003663 949 dbSNP
rs1038193942 955 dbSNP
rs541890854 957 dbSNP
rs754170365 960 dbSNP
rs1046767245 967 dbSNP
rs572852211 968 dbSNP
rs112508567 976 dbSNP
rs557623820 977 dbSNP
rs142508321 983 dbSNP
rs963743291 988 dbSNP
rs567242964 999 dbSNP
rs1347173724 1003 dbSNP
rs185145199 1009 dbSNP
rs1399358408 1010 dbSNP
rs1385539902 1021 dbSNP
rs1190258390 1024 dbSNP
rs1238594374 1031 dbSNP
rs533907607 1032 dbSNP
rs1464606369 1036 dbSNP
rs1426232045 1038 dbSNP
rs1353908449 1040 dbSNP
rs999315359 1045 dbSNP
rs970645799 1053 dbSNP
rs979561375 1055 dbSNP
rs540267409 1058 dbSNP
rs1341051830 1059 dbSNP
rs1399317880 1062 dbSNP
rs751248826 1066 dbSNP
rs1342078620 1068 dbSNP
rs1012233269 1082 dbSNP
rs1021584375 1083 dbSNP
rs764133347 1088 dbSNP
rs1009579356 1094 dbSNP
rs762520382 1098 dbSNP
rs1016352611 1099 dbSNP
rs1006278225 1100 dbSNP
rs886526301 1110 dbSNP
rs1265814578 1113 dbSNP
rs1478326196 1118 dbSNP
rs1047902601 1119 dbSNP
rs1376174244 1131 dbSNP
rs1479116948 1132 dbSNP
rs1173301540 1142 dbSNP
rs1384260995 1151 dbSNP
rs933499820 1156 dbSNP
rs1187828353 1163 dbSNP
rs1362251380 1168 dbSNP
rs546446386 1175 dbSNP
rs148804419 1176 dbSNP
rs1203926498 1177 dbSNP
rs1325194202 1185 dbSNP
rs1234962228 1186 dbSNP
rs1039715784 1199 dbSNP
rs866915213 1203 dbSNP
rs748583158 1207 dbSNP
rs1002312721 1209 dbSNP
rs1352264468 1219 dbSNP
rs1217763809 1220 dbSNP
rs905267644 1221 dbSNP
rs1488886315 1225 dbSNP
rs752156187 1235 dbSNP
rs1209672081 1242 dbSNP
rs1327013062 1244 dbSNP
rs1005388734 1249 dbSNP
rs1394159085 1254 dbSNP
rs989111502 1264 dbSNP
rs887035422 1270 dbSNP
rs527626839 1274 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_017798 | 3UTR | GCUUGGUCAGCUCCAGUGUGUCGUCCCGUGCGGGGGUUGAGUGUUGCAUCUUUGCCUUUCUUGUCGUUGAUUUUUGCCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_017798 | 3UTR | GUUGCAUCUUUGCCUUUCUUGUCGUUGAUUUUUGCCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_017798 | 3UTR | UCUUGUCGUUGAUUUUUGCCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_017798 | 3UTR | UGCCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_017798 | 3UTR | AUCUUUGCCUUUCUUGUCGUUGAUUUUUGCCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_017798 | 3UTR | CCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000370339.3 | 3UTR | UUGUCGUUGAUUUUUGCCCAGAUGGAUCUGCAUUUAUUUGUACUUUUUCUAUGUAUUAUAAUCCUGUAGAAGUCACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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