miRTarBase - #MIRT564970


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pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol WTAP   
Synonyms Mum2
Description WT1 associated protein
Transcript NM_152857   
Other Transcripts NM_004906 , NM_152858   
Expression
Putative miRNA Targets on WTAP
3'UTR of WTAP
(miRNA target sites are highlighted)		 
>WTAP|NM_152857|3'UTR
   1 ACAAATCATACTCCCCAGTCAAGACTTCCCTGACAGTCCCACTACGAGAAAGCTGTGGTGGGACAGCCAAGTACTCGTTT
  81 CCACACCAAGACTCAGACTTTTTGAGCCAAAAAAAAGCCACATTCTTACACTGTCCAGCTTGTAATGGTTAATGTAAAAC
 161 TTACCAGATGAACCTTGTGTTTCAGCTTTTTTCTTTTCCCCTTCCCCTTGCTTCAGAGGCCTGATGGCGTCGGACTATTC
 241 CGAAGAAGTGGCCACCTCCGAAAAATTCCCCTTCTAGAACATGTAGACACTTGAGAAATGTTTCTGTTTGAAGAAAATAG
 321 AGGGAGAAACAGAAGTCTTAAGTCTGTGGCACACTGTGTCTTCAGACAGTTTGAAGGAATGAAAACCTAGAGATTTTAAA
 401 TCATGAATTGAACATGTAAAATTCCAGTAAAATGTAAAAACGGAATATGCATCGCTCTTAACCTTGAGCATAGTGACTTA
 481 GAGACACTGTGTATCAGTTTTGCCAATAAGACTGTGGACTTCATGATTGTTGTTGAACTTCTGGGTCAAAACTCAAATGA
 561 GGTGAATTTTGCCTTTAAAGGGTTTATTTGCTGAGAACCAACTTTCAATAGTCATGAGAGAATCAAATAATAGATGTCCG
 641 TACAAGTAGCGCATATATTTAACCATTTAGTTTGGGGCTCTATATTACTTGCTTGAGCCTTAATCAATGTGGTTTTATTC
 721 AATGGTTTGTTCTTTGAATGGTTGCAAAAACTGTAGATAATCTTACTGAGGACTGTACAAACATGAAGGTGTGGTATCAA
 801 ACTTCAGGTTGAAACTGTTTGAAGCATTATAAACATTCATTTCACAACTAGATTGTATAAGGATATTAGCTGTGATGAGA
 881 CTCACTGCATTATTTTTTTTAGTGAATTTTATGAAATCCCCGTTCCATTCAACAGGCACATGTTTAAAAGAGCTTTGTCG
 961 TTGGTGTTAATGGGGGAATGTGTTCCTTCATTGTATTTGGGCCTTTTGTATTGCACTCTTGATATTAAATTAAATGTGCC
1041 TTGAAATAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaAGACCGAGGUUCAGGUCa 5'
            |||  | |:  |||||| 
Target 5' atTCTTACACT--GTCCAGc 3'
 122 - 139 121.00 -9.70
2 
miRNA  3' gaAGACCGA-GGUUCAGGUCa 5'
            ||   || || |||| || 
Target 5' aaTCATACTCCCCAGTCAAGa 3'
 4 - 24 118.00 -10.70
3 
miRNA  3' gaAGACCG-AGGUUCAGGUCa 5'
            | |||: || || |:||| 
Target 5' ggTGTGGTATCAAACTTCAGg 3'
 788 - 808 114.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM5795350 2 COSMIC
COSN27005175 11 COSMIC
COSN27005174 12 COSMIC
COSN31508174 43 COSMIC
COSN14205742 44 COSMIC
COSN14205746 45 COSMIC
COSN19465407 48 COSMIC
COSN18731431 58 COSMIC
COSN30608384 67 COSMIC
COSN9971771 74 COSMIC
COSN31562302 78 COSMIC
COSN512160 83 COSMIC
COSN31479651 97 COSMIC
COSN20058580 117 COSMIC
COSN7696707 130 COSMIC
COSN31561898 138 COSMIC
COSN30126547 149 COSMIC
COSN6311251 149 COSMIC
COSN30545200 163 COSMIC
COSN30539398 168 COSMIC
COSN26599530 219 COSMIC
COSN26554554 234 COSMIC
COSN28165081 243 COSMIC
COSN31550522 286 COSMIC
COSN19578721 400 COSMIC
COSN31611302 438 COSMIC
COSN31589080 442 COSMIC
COSN31513436 619 COSMIC
COSN2150801 704 COSMIC
COSN31523959 727 COSMIC
COSN31538723 922 COSMIC
COSN26637440 967 COSMIC
COSN26578348 1014 COSMIC
COSN31601128 1023 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1205317005 3 dbSNP
rs1234521215 6 dbSNP
rs776717396 14 dbSNP
rs759984863 24 dbSNP
rs1340971443 32 dbSNP
rs765736170 36 dbSNP
rs1433944448 42 dbSNP
rs374361321 43 dbSNP
rs368579812 45 dbSNP
rs753459755 46 dbSNP
rs755695408 47 dbSNP
rs1356715636 50 dbSNP
rs1293370085 56 dbSNP
rs756971122 58 dbSNP
rs1434871009 77 dbSNP
rs912633927 78 dbSNP
rs1164254535 95 dbSNP
rs867316461 102 dbSNP
rs1429216093 109 dbSNP
rs940152324 109 dbSNP
rs1218051783 110 dbSNP
rs1254420215 117 dbSNP
rs1429405639 122 dbSNP
rs972693243 131 dbSNP
rs117080829 132 dbSNP
rs1487425858 138 dbSNP
rs930540251 165 dbSNP
rs1482424956 183 dbSNP
rs181566690 189 dbSNP
rs1048982308 198 dbSNP
rs904991659 214 dbSNP
rs1307732515 219 dbSNP
rs184315896 221 dbSNP
rs1217869465 230 dbSNP
rs1370301636 231 dbSNP
rs1056339045 233 dbSNP
rs1175481318 237 dbSNP
rs1368780245 252 dbSNP
rs896216496 268 dbSNP
rs1009342669 296 dbSNP
rs566921107 300 dbSNP
rs1377287272 340 dbSNP
rs1175040786 345 dbSNP
rs1020609109 354 dbSNP
rs1431215308 355 dbSNP
rs1804050 403 dbSNP
rs1200056118 411 dbSNP
rs903533052 416 dbSNP
rs1001082583 425 dbSNP
rs750128467 426 dbSNP
rs776591945 431 dbSNP
rs1480733447 432 dbSNP
rs545400549 442 dbSNP
rs954356666 443 dbSNP
rs565316075 444 dbSNP
rs552947042 447 dbSNP
rs987364214 451 dbSNP
rs1284399511 454 dbSNP
rs758217147 455 dbSNP
rs1349187151 456 dbSNP
rs1290218487 489 dbSNP
rs1392065487 490 dbSNP
rs1401704761 492 dbSNP
rs961743291 497 dbSNP
rs972812649 498 dbSNP
rs527705015 507 dbSNP
rs1433766443 508 dbSNP
rs573024719 514 dbSNP
rs1313834797 515 dbSNP
rs1472187613 528 dbSNP
rs1455729270 538 dbSNP
rs1409709132 542 dbSNP
rs1183292111 546 dbSNP
rs1377715779 552 dbSNP
rs919899661 554 dbSNP
rs140380891 559 dbSNP
rs1279423317 581 dbSNP
rs558742727 594 dbSNP
rs1374703653 601 dbSNP
rs1264076549 606 dbSNP
rs931322968 607 dbSNP
rs575547098 609 dbSNP
rs1263039166 611 dbSNP
rs544712219 613 dbSNP
rs1339941909 635 dbSNP
rs926530765 636 dbSNP
rs1454730546 640 dbSNP
rs1383808844 641 dbSNP
rs937977387 648 dbSNP
rs1347404899 651 dbSNP
rs1211917096 652 dbSNP
rs1056687608 663 dbSNP
rs1280779710 665 dbSNP
rs896338566 669 dbSNP
rs1486563078 677 dbSNP
rs1394818806 679 dbSNP
rs1446009062 682 dbSNP
rs1202201311 683 dbSNP
rs1232192814 687 dbSNP
rs746963545 689 dbSNP
rs1463806247 692 dbSNP
rs1206226349 694 dbSNP
rs759814614 702 dbSNP
rs1042166980 703 dbSNP
rs1248305538 707 dbSNP
rs879236001 708 dbSNP
rs1297117330 709 dbSNP
rs1470484121 710 dbSNP
rs1178407808 713 dbSNP
rs374140651 713 dbSNP
rs1324459645 719 dbSNP
rs1392766294 721 dbSNP
rs1430980989 723 dbSNP
rs903480610 725 dbSNP
rs1389926025 732 dbSNP
rs1173939710 733 dbSNP
rs1396517579 735 dbSNP
rs1426026828 736 dbSNP
rs1167536175 739 dbSNP
rs1310332693 758 dbSNP
rs11962969 760 dbSNP
rs1194353242 765 dbSNP
rs768413542 765 dbSNP
rs1265911032 774 dbSNP
rs1225434910 777 dbSNP
rs778036758 781 dbSNP
rs144344337 785 dbSNP
rs1226438554 790 dbSNP
rs540233207 799 dbSNP
rs1341748178 800 dbSNP
rs1445054965 801 dbSNP
rs1291831756 808 dbSNP
rs1330398265 816 dbSNP
rs1008501851 821 dbSNP
rs1406739382 831 dbSNP
rs1370433119 835 dbSNP
rs1235284804 836 dbSNP
rs1305827723 837 dbSNP
rs1020180501 848 dbSNP
rs1398225189 850 dbSNP
rs1340309186 853 dbSNP
rs1212538352 880 dbSNP
rs1376328248 882 dbSNP
rs1272085943 887 dbSNP
rs560560068 890 dbSNP
rs200108787 891 dbSNP
rs1203112686 893 dbSNP
rs1251093029 893 dbSNP
rs35160875 893 dbSNP
rs373306588 904 dbSNP
rs961582501 907 dbSNP
rs1200141026 918 dbSNP
rs972760133 920 dbSNP
rs759634960 922 dbSNP
rs546098413 923 dbSNP
rs1346075788 928 dbSNP
rs1287117199 933 dbSNP
rs1467590882 942 dbSNP
rs1042081 951 dbSNP
rs1193715000 960 dbSNP
rs562735446 961 dbSNP
rs1404342220 971 dbSNP
rs1179055135 990 dbSNP
rs1470553113 998 dbSNP
rs1254450490 1003 dbSNP
rs879349764 1005 dbSNP
rs1175509160 1017 dbSNP
rs531832621 1045 dbSNP
rs1233565952 1047 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagaccgagguuCAG-GUca 5'
                       ||| ||  
Target 5' aaugcauacuuuuGUCACAau 3'
 		7 - 27
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000358372.4 | 3UTR | AAAAUUAAUGCAUACUUUUGUCACAAUUUGCCUUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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