pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-16-2 |
Genomic Coordinates | chr3: 160404745 - 160404825 |
Description | Homo sapiens miR-16-2 stem-loop |
Comment | This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references . |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-16-2-3p | ||||||||||||||||||
Sequence | 53| CCAAUAUUACUGUGCUGCUUUA |74 | ||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||
Experiments | Cloned | DRVs in miRNA |
|
||||||||||||||||
SNPs in miRNA |
|
||||||||||||||||||
Putative Targets |
miRNA Expression profile | |
---|---|
Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
|
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Symbol | RNF44 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | ring finger protein 44 | ||||||||||||||||||||
Transcript | NM_014901 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on RNF44 | |||||||||||||||||||||
3'UTR of RNF44 (miRNA target sites are highlighted) |
>RNF44|NM_014901|3'UTR 1 GGCCACGCAGCCGCCTGCCCGGGAGAACCCTGCCTGAAGCTCTGGAAACTTGTGGGTGGGGCCCAGGGAGGATGGGGAGG 81 GAGTGGCCCAGGCCTGCCCCTTCGCTCCTGCCTGCATTTCCAGAGCTGGTGCCAGGGTCAGCCCAGCGAGGAGTCCCTGC 161 AATAAGCCCCTGCATTTGCCAAGCTCCAAAGACTCCCTCCCTAGTCTGCCTGCCTGCCCGCCCGCCACGGAGCTGCCTGA 241 GTGTCCCTGATCGGGTCTCCCTCCTGTGCACCCTCAGGTCCCTCCTTTTCCTGCTGGCACTGAGTGCCAGGGGTCCGCTC 321 CCTCAGTGGGGCCGGTGGAGATCCTTGGCCCCAGGATGGGCAGACAGAGCACCATCCTGGGTCAGAAGGTCTCATGCTCT 401 GAAATGGCGTGCCCTCTGCCCAGGTGGCACTGCCAGGTGCGTAGACAGACGGTGTCACGAGCCATTTCCTGAGCCCCAGG 481 GCTGAATCCCCCCTCCTTGACCCCGAACAGTGAACTCAGGCAGCTGGCTCTGTGTTGGCTGCTGTGAGGGCTGAGTCTGG 561 TTCCCTAGGGGACCCTCATCCCAGGAACAACATTCCAGCCCCACCCTCAGGCTGGAGGGCGTCCCAGCCTAATCCCGAGC 641 TGGGGCACACGTATCCTGAGGGGCTTGGGCCATACGGGGAGAGGGAGCCCTGTGTTCCCGGTGGTTGTCCCTCCCAGGGA 721 TGCAGCCAGACCCGTGCCCAATCTCCTCTCCCTCTGTTGTTTTGCATGAACGTGAGGAGCAGCAGTTTTTGTTCATTCAT 801 TTGGCCCAAAATCACGTGTAGGATTTGGGGATGTGGATATTTAAGACAATTTCTTTTTTCTTTTGGTTTAATAGGGGCGG 881 GTATAGGGACCAACTGGGACCGAGTGCCCAGGGGGCCGAGCACGGTCATGCTGGCCGGCCTGCATGCATGCGTGTGCCGG 961 GCTGGGCTGGGCGGCCGGCGGTCGTGGGGCAGGGTTGGGGGTCTGTGCTCAGCTGATAACTGCCATGCACTGTACTGCAC 1041 ACGTCCCTAGAGCCTACCGGGACCCGACGCTTTTCAGGGCATTTCTCCCTCCAGCCAGGGCCCAACTCCCACCTGCCTGG 1121 GCGAATCTCCTCCAAGGAAGTCCCAGGAGGATGGGGACCAGGAAGGCTGTGGACCCCCATCTCCAGGGGGCCTTCCCAGC 1201 CTGATCCCTGTCCTCCAAGTTCTGGAGGAGGCCGCTGTAGGGTCTGGCTGAGCTTCCCACCCACTTTCCCTGGTCCCAAT 1281 CCTTTCTTGTCCTATACCCAGCTGGGGTTGCTGCCCTGAACGAACTGCGTGTGGGGCCGGCACATCCTAGCAGGCAGCCC 1361 CTGGCGCCTGCTGCCTCAGGGATGCTCCAACCACCCTCGTTCTCCTCGCAGTGGCCCTGGCTCCCACCTCCCGCCCCAGC 1441 CTGCCGTGGGGCCCGTCAGCCTGGTCCCACCCCCATGGAGAACCCAAAGTCTTACTGTATATAACTCCAGGTGACGTTTC 1521 TATATTTATAGCAGTGTTGAAAACCCACGTGTTTTACACAGAACCACCCTCTCCAACCCCTCCCTTCCCGACCCCAACAA 1601 AACGTTTTCAAACCCCTTACAGTTCCTGGGGCAGGCGGAAACAGGCTCACAGATTGTGTGTCGGCTGCAGCAGTGATTCC 1681 AACAAGCAGCTATTGGGGGGGAAACACAGCATTTAAAAAGATCATCATTAAAAAACAAGATTTATACAACAATTACTTAG 1761 GATGTTTGTGATCTGCCGACCTTGCTATAGATGCCATGTTACCAATGATTTCCTGTGGTGGGGGCTTGCCATTGTTTACT 1841 CTCTTATTTACCAACTTCTGGCCTAGGCATGACAGTGGGCACCTTCCCCCAGCCCTGGCTGGGCCCAGCGCCTGTGTTCT 1921 GTGTTAGAAAGGTTTTATATATATATAAAATTACATATATATGTAGAAATATATGTAATTTTGGGGGCCCTGTTCCTTGC 2001 ACATTTTACAGTTACCTCATTTTTCCCATGTATGTATTTGAGAAAATGCTAATATATAGAGAAAAAAATGGTTCTTAAAG 2081 CTTAAATGTGTGGTTTTTTCCATTCCATGGGATTCACATTGGTTTGTAGCATTTAACATAACTAGTATGTTGTATTATAT 2161 ATATGTGTATACTGATTGAAATTTTTAACAGATTTGTACTTTTTTTAAAATGAAAGTTGCTAGTTCTGCTTGACCAAGTA 2241 GTGCAATCATTATTTTTTTTAATATTGTTGCTGATTTCAGAGGGATATTCACTAATAAATGTATGATGTATACCAACGAC 2321 CGCCCACGC Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
---|---|
miRNA:Target | ---- |
Validation Method |
|
Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
|
CLIP-seq Support 1 for dataset GSM545216 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-124 transfection |
Location of target site | ENST00000274811.4 | 3UTR | CAAUCAUUAUUUUUUUUAAUAUU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
![]() |
![]() |
|||||||
Strong evidence | Less strong evidence | |||||||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|||||
MIRT004488 | RARB | retinoic acid receptor beta | ![]() |
![]() |
![]() |
3 | 1 | |||||
MIRT038707 | NUCKS1 | nuclear casein kinase and cyclin dependent kinase substrate 1 | ![]() |
1 | 1 | |||||||
MIRT057208 | PPIF | peptidylprolyl isomerase F | ![]() |
![]() |
2 | 4 | ||||||
MIRT058726 | RSBN1 | round spermatid basic protein 1 | ![]() |
![]() |
2 | 8 | ||||||
MIRT074502 | NFATC2IP | nuclear factor of activated T-cells 2 interacting protein | ![]() |
![]() |
2 | 4 | ||||||
MIRT081544 | ZNF431 | zinc finger protein 431 | ![]() |
![]() |
2 | 4 | ||||||
MIRT096893 | ERBB2IP | erbb2 interacting protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT105124 | MYC | MYC proto-oncogene, bHLH transcription factor | ![]() |
![]() |
2 | 2 | ||||||
MIRT107898 | PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT109432 | KLHL15 | kelch like family member 15 | ![]() |
![]() |
2 | 6 | ||||||
MIRT166742 | PAPD7 | poly(A) RNA polymerase D7, non-canonical | ![]() |
![]() |
2 | 6 | ||||||
MIRT171257 | YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | ![]() |
![]() |
2 | 2 | ||||||
MIRT192760 | B2M | beta-2-microglobulin | ![]() |
![]() |
2 | 2 | ||||||
MIRT194905 | RBBP6 | RB binding protein 6, ubiquitin ligase | ![]() |
![]() |
2 | 8 | ||||||
MIRT215599 | SUB1 | SUB1 homolog, transcriptional regulator | ![]() |
![]() |
2 | 2 | ||||||
MIRT223632 | ATP6V1C1 | ATPase H+ transporting V1 subunit C1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT241605 | AMOTL1 | angiomotin like 1 | ![]() |
![]() |
2 | 4 | ||||||
MIRT291174 | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT444286 | ABCG2 | ATP binding cassette subfamily G member 2 (Junior blood group) | ![]() |
![]() |
2 | 2 | ||||||
MIRT463285 | ZFX | zinc finger protein, X-linked | ![]() |
![]() |
2 | 4 | ||||||
MIRT471759 | NUS1 | NUS1 dehydrodolichyl diphosphate synthase subunit | ![]() |
![]() |
2 | 8 | ||||||
MIRT479611 | CDC25A | cell division cycle 25A | ![]() |
![]() |
2 | 2 | ||||||
MIRT481497 | ARL6IP1 | ADP ribosylation factor like GTPase 6 interacting protein 1 | ![]() |
![]() |
2 | 8 | ||||||
MIRT483117 | SH3BP5 | SH3 domain binding protein 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT502279 | GRPEL2 | GrpE like 2, mitochondrial | ![]() |
![]() |
2 | 8 | ||||||
MIRT507838 | CCNT1 | cyclin T1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT508179 | MTRNR2L6 | MT-RNR2-like 6 | ![]() |
![]() |
2 | 4 | ||||||
MIRT510576 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 | ![]() |
![]() |
2 | 6 | ||||||
MIRT517853 | RPS4X | ribosomal protein S4, X-linked | ![]() |
![]() |
2 | 4 | ||||||
MIRT521690 | PRKAA1 | protein kinase AMP-activated catalytic subunit alpha 1 | ![]() |
![]() |
2 | 8 | ||||||
MIRT525070 | FRK | fyn related Src family tyrosine kinase | ![]() |
![]() |
2 | 2 | ||||||
MIRT527082 | UBE2E3 | ubiquitin conjugating enzyme E2 E3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT529552 | EI24 | EI24, autophagy associated transmembrane protein | ![]() |
![]() |
2 | 2 | ||||||
MIRT530426 | SULT1B1 | sulfotransferase family 1B member 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT533909 | TBC1D15 | TBC1 domain family member 15 | ![]() |
![]() |
2 | 2 | ||||||
MIRT536627 | IPO7 | importin 7 | ![]() |
![]() |
2 | 2 | ||||||
MIRT537647 | ERGIC2 | ERGIC and golgi 2 | ![]() |
![]() |
2 | 4 | ||||||
MIRT538512 | CLCN3 | chloride voltage-gated channel 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT539219 | ANP32E | acidic nuclear phosphoprotein 32 family member E | ![]() |
![]() |
2 | 6 | ||||||
MIRT539348 | AGO2 | argonaute 2, RISC catalytic component | ![]() |
![]() |
2 | 4 | ||||||
MIRT539954 | CCT4 | chaperonin containing TCP1 subunit 4 | ![]() |
![]() |
2 | 2 | ||||||
MIRT541208 | HOXA10 | homeobox A10 | ![]() |
![]() |
2 | 2 | ||||||
MIRT543216 | TMEM117 | transmembrane protein 117 | ![]() |
![]() |
2 | 2 | ||||||
MIRT543399 | DROSHA | drosha ribonuclease III | ![]() |
![]() |
2 | 2 | ||||||
MIRT546648 | RPS6KA5 | ribosomal protein S6 kinase A5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT546852 | RAB1A | RAB1A, member RAS oncogene family | ![]() |
![]() |
2 | 2 | ||||||
MIRT549917 | MRPS30 | mitochondrial ribosomal protein S30 | ![]() |
![]() |
2 | 2 | ||||||
MIRT552998 | USP46 | ubiquitin specific peptidase 46 | ![]() |
![]() |
2 | 2 | ||||||
MIRT555254 | PREPL | prolyl endopeptidase-like | ![]() |
![]() |
2 | 2 | ||||||
MIRT555956 | NRIP1 | nuclear receptor interacting protein 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT557095 | HOXA9 | homeobox A9 | ![]() |
![]() |
2 | 2 | ||||||
MIRT561396 | TUBB2A | tubulin beta 2A class IIa | ![]() |
![]() |
2 | 2 | ||||||
MIRT561654 | RNF219 | ring finger protein 219 | ![]() |
![]() |
2 | 2 | ||||||
MIRT563101 | PABPC4L | poly(A) binding protein cytoplasmic 4 like | ![]() |
![]() |
2 | 2 | ||||||
MIRT565979 | RNF44 | ring finger protein 44 | ![]() |
![]() |
2 | 2 | ||||||
MIRT572396 | CCDC14 | coiled-coil domain containing 14 | ![]() |
![]() |
2 | 2 | ||||||
MIRT574400 | TM9SF3 | transmembrane 9 superfamily member 3 | ![]() |
![]() |
2 | 2 | ||||||
MIRT607623 | VSNL1 | visinin like 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT610645 | CTGF | connective tissue growth factor | ![]() |
![]() |
2 | 2 | ||||||
MIRT623379 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
![]() |
2 | 2 | ||||||
MIRT624687 | AR | androgen receptor | ![]() |
![]() |
2 | 2 | ||||||
MIRT632089 | ALDH1A2 | aldehyde dehydrogenase 1 family member A2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT644216 | CBS | cystathionine-beta-synthase | ![]() |
![]() |
2 | 2 | ||||||
MIRT647841 | BID | BH3 interacting domain death agonist | ![]() |
![]() |
2 | 2 | ||||||
MIRT651649 | WASF2 | WAS protein family member 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT689064 | AGMAT | agmatinase | ![]() |
![]() |
2 | 2 | ||||||
MIRT698150 | TNPO1 | transportin 1 | ![]() |
![]() |
2 | 2 | ||||||
MIRT700516 | PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | ![]() |
![]() |
2 | 2 | ||||||
MIRT704081 | DYRK2 | dual specificity tyrosine phosphorylation regulated kinase 2 | ![]() |
![]() |
2 | 2 | ||||||
MIRT705970 | ACBD5 | acyl-CoA binding domain containing 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT715694 | COMMD3-BMI1 | COMMD3-BMI1 readthrough | ![]() |
![]() |
2 | 2 | ||||||
MIRT717184 | BMI1 | BMI1 proto-oncogene, polycomb ring finger | ![]() |
![]() |
2 | 2 | ||||||
MIRT724607 | AP3B1 | adaptor related protein complex 3 beta 1 subunit | ![]() |
![]() |
2 | 2 | ||||||
MIRT724854 | IGFBP5 | insulin like growth factor binding protein 5 | ![]() |
![]() |
2 | 2 | ||||||
MIRT725401 | LRIG2 | leucine rich repeats and immunoglobulin like domains 2 | ![]() |
![]() |
2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|