miRTarBase - #MIRT566348


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pre-miRNA Information
pre-miRNA hsa-mir-4265   
Genomic Coordinates chr2: 109141490 - 109141588
Description Homo sapiens miR-4265 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4265
Sequence 71| CUGUGGGCUCAGCUCUGGG |89
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs547651740 6 dbSNP
rs1455791249 7 dbSNP
rs4676066 12 dbSNP
rs1186905902 15 dbSNP
rs1293703157 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol POLDIP2   
Synonyms PDIP38, POLD4, p38
Description DNA polymerase delta interacting protein 2
Transcript NM_015584   
Expression
Putative miRNA Targets on POLDIP2
3'UTR of POLDIP2
(miRNA target sites are highlighted)		 
>POLDIP2|NM_015584|3'UTR
   1 GCCAGCTGAGGCCCCAAGTGCCCAGGCTTGGTCACCGGGAAGAACAACTCTCATCCCACAATTGCTGCAGAACTCTTCTC
  81 TCCCCATCATGGGCCACAGTGGGTCTCTTAATTTGATTGTGGGGTTCTTTTTGTGGGGAGGGGTGGTATAACTTTTCTTC
 161 AGAAGACCCATGTGGGACACCTCCAAGGCTGGCCTCCTCATAAGCCCTGCCTACACCATGTTCCAGTAAACCTCTCCACC
 241 AAGGAACTGTGTTCAGCTGCCACAGGCCTGGAGGAGTTTCCTGGCCTGTCACGTGAGGTTTGATCAGTAAACCAGTGCAC
 321 GCTTGGCCACCCTTGCCATTTCTGCTCCCAGAGTCTCAGGCTCCCCTTCTGACCCAGTGTGCGCCCTTGACTGCTTTCTT
 401 TGCTGCCCTTCCAGGGAGCTGCCCCCCTGGTAGGGCATGTGCCTGTTTCCCTCTCAGCCTGGAGGCTGGCTGGACATCTC
 481 CTAGGGTCACTGTGCCTCTCAGCTAGTTGGCGGGGGTGCTGGACTGGACTCTTGTTCACTTTACCTTCTGCCAAATGCAG
 561 AGAGGGAGGCCAGTGTCAGGGTCGGAGTGGCCTGGCTCTTAGCACTGACCGACCATTGCCATTTCTGGCCTCGCTAGGCC
 641 CAGGAGAGGAGGGAGGCAAGCCAGTCGGGTTTCCTGGAGCAATGGGTGTGCCAGCCCTCAGCATGACTCTGCCAAGCATC
 721 CAGACCACAAATGCAGGAATTTGGCTGAGGAGCAGCTTTAGGTATGGATTGATGACTAAGTCAAGCTACTTCCTGAGCTT
 801 CTCTCAGATTTCCAAGAGCCAGAGATGAATTGTGCTGCATCTTGCCCCAATTCTTAGGATTTCTTTTCCTCCGCCACTGC
 881 AGTGATTGTTAGAGGTAGTTTTCTTGAATTAATATTAAATCACAGTTCCAGCCCTTGTTATTCTTGTCCTTAGTCCTCCA
 961 GGGGGAGCTGGGGTTGCAGGGCAACAGTACAGTCGCGCTTACGACCTGGCTAGAACACAAGGTCAGATGATAAACAGAAG
1041 CACAGGAACTCAGCCCATGGCCGCAAGCTGGTCAAGGCCTGCTCACTGTAAACATGGCTCTGTACCATTGAGTTTAACAC
1121 AATTTTATTAGAAATTAGTGTTTGCTTCCATCACTTATGCTGAGCAACCAAATATTACAGTTATGTGATAAAGGAAAAAT
1201 TCTTTCCTGCCCAGGACCTGCGCCATCCTTTAGGCCGACCTTGGTCACATACCAAATTCAATAAAACCCAATACTGGCCT
1281 GTGTTGTTAACAGCAGGCTGCCAGGTTTCTCAGAAACTGACAAGAAAATCTGACCTTCATCCATACTTTGTTTACTTACC
1361 CCTGGGCTGCTTGGAGTTGAAAAATGCACACAGCCAAGAGTTGCTTTCTGAATAGGGCTGGAAACTTTCAAAGAAAACCC
1441 CCAAACTTTTAAGTCACAAAGTCTGATTAAAGAAGCTAAGATCATGTCAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gggucUCGACUCGGGUGUc 5'
               |||   |||:||| 
Target 5' tcataAGCCCTGCCTACAc 3'
 198 - 216 130.00 -10.90
2 
miRNA  3' ggGU-CUCGACUCGGGUGUc 5'
            || || || ||||||:: 
Target 5' caCAGGAACTCAGCCCATGg 3'
 1041 - 1060 129.00 -17.50
3 
miRNA  3' ggGUCUCGACU-----CGGGUGUc 5'
            ::|||:|||     || |||| 
Target 5' ctTGGAGTTGAAAAATGCACACAg 3'
 1370 - 1393 125.00 -18.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1194911 20 COSMIC
COSN31567346 39 COSMIC
COSN30130779 61 COSMIC
COSN30118910 70 COSMIC
COSN30164082 80 COSMIC
COSN30691322 152 COSMIC
COSN31520603 157 COSMIC
COSN31480617 160 COSMIC
COSN8833995 674 COSMIC
COSN6101118 738 COSMIC
COSN27299185 800 COSMIC
COSN9657544 907 COSMIC
COSN31961304 1193 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1489017711 7 dbSNP
rs782197706 12 dbSNP
rs201484357 20 dbSNP
rs1010021060 24 dbSNP
rs1264908595 28 dbSNP
rs1440964619 30 dbSNP
rs782353200 35 dbSNP
rs200545657 36 dbSNP
rs3093715 37 dbSNP
rs782524049 45 dbSNP
rs781794154 48 dbSNP
rs1350194805 49 dbSNP
rs1457270979 59 dbSNP
rs1293157743 61 dbSNP
rs373318419 68 dbSNP
rs903870811 69 dbSNP
rs1392607965 78 dbSNP
rs1449067086 88 dbSNP
rs1376253650 89 dbSNP
rs1238533538 90 dbSNP
rs1315501068 91 dbSNP
rs1050827441 92 dbSNP
rs1244564411 94 dbSNP
rs1263292029 129 dbSNP
rs1458780728 144 dbSNP
rs1198919408 148 dbSNP
rs996300256 150 dbSNP
rs782196778 156 dbSNP
rs545702948 158 dbSNP
rs1456080967 160 dbSNP
rs147515660 168 dbSNP
rs1183514915 171 dbSNP
rs868950105 174 dbSNP
rs1414533498 180 dbSNP
rs1422997940 186 dbSNP
rs782080433 200 dbSNP
rs1162494710 205 dbSNP
rs1425541263 214 dbSNP
rs1040599131 223 dbSNP
rs1332310258 225 dbSNP
rs143265731 226 dbSNP
rs781922822 229 dbSNP
rs1305077395 232 dbSNP
rs1380588788 235 dbSNP
rs1395981380 236 dbSNP
rs1291776283 238 dbSNP
rs1320452436 241 dbSNP
rs782756361 242 dbSNP
rs908005672 242 dbSNP
rs1257099068 248 dbSNP
rs782418736 254 dbSNP
rs1211672399 263 dbSNP
rs1237965266 273 dbSNP
rs1180080639 274 dbSNP
rs1264985440 277 dbSNP
rs1478057130 279 dbSNP
rs930862804 280 dbSNP
rs1423230377 281 dbSNP
rs1408252934 284 dbSNP
rs1178265423 288 dbSNP
rs1359847679 290 dbSNP
rs535628049 292 dbSNP
rs1311607239 293 dbSNP
rs1342760129 295 dbSNP
rs1401064120 317 dbSNP
rs980155785 320 dbSNP
rs1359496480 325 dbSNP
rs1065361 327 dbSNP
rs139356949 352 dbSNP
rs1278670238 355 dbSNP
rs1311113960 361 dbSNP
rs949868583 365 dbSNP
rs3093714 382 dbSNP
rs1488475384 383 dbSNP
rs3093713 391 dbSNP
rs1260793009 397 dbSNP
rs1474526382 401 dbSNP
rs782487052 404 dbSNP
rs955875506 407 dbSNP
rs1193143555 412 dbSNP
rs1425890900 420 dbSNP
rs1032783530 423 dbSNP
rs978660624 426 dbSNP
rs570463058 427 dbSNP
rs1420671580 428 dbSNP
rs1053195 430 dbSNP
rs1438087829 432 dbSNP
rs1275129179 436 dbSNP
rs1366281985 442 dbSNP
rs1029035256 451 dbSNP
rs1231486713 453 dbSNP
rs550196006 465 dbSNP
rs1215845253 470 dbSNP
rs901810032 475 dbSNP
rs1281802461 476 dbSNP
rs1453126756 484 dbSNP
rs1224033215 487 dbSNP
rs1019043422 496 dbSNP
rs561670604 506 dbSNP
rs1247580403 511 dbSNP
rs3093724 512 dbSNP
rs1191885696 514 dbSNP
rs1440808921 515 dbSNP
rs1158583785 519 dbSNP
rs1383240158 525 dbSNP
rs117812302 531 dbSNP
rs1323769412 533 dbSNP
rs1348991011 534 dbSNP
rs1438285904 535 dbSNP
rs1332743502 552 dbSNP
rs1377000125 561 dbSNP
rs1239264616 562 dbSNP
rs1277763187 570 dbSNP
rs1358196629 572 dbSNP
rs1049248196 574 dbSNP
rs930936210 580 dbSNP
rs1468167428 583 dbSNP
rs1212094930 584 dbSNP
rs1240035499 595 dbSNP
rs1458285457 606 dbSNP
rs906104331 610 dbSNP
rs1362606535 611 dbSNP
rs1044100397 618 dbSNP
rs75193644 632 dbSNP
rs916872663 633 dbSNP
rs1459483636 644 dbSNP
rs201283045 651 dbSNP
rs1400374771 657 dbSNP
rs183009209 666 dbSNP
rs925817337 667 dbSNP
rs1342247007 673 dbSNP
rs1448701012 674 dbSNP
rs1283344406 682 dbSNP
rs1332423271 697 dbSNP
rs1231626595 704 dbSNP
rs782803460 707 dbSNP
rs954021349 724 dbSNP
rs1195346064 732 dbSNP
rs1444593261 734 dbSNP
rs532431070 736 dbSNP
rs78853973 740 dbSNP
rs3093723 743 dbSNP
rs797038956 743 dbSNP
rs1257184733 756 dbSNP
rs1474464608 764 dbSNP
rs1195391644 768 dbSNP
rs1028667776 771 dbSNP
rs976659159 779 dbSNP
rs1165605682 782 dbSNP
rs966461012 783 dbSNP
rs782505764 790 dbSNP
rs1414907512 799 dbSNP
rs1333449420 800 dbSNP
rs1353321285 801 dbSNP
rs564952836 803 dbSNP
rs1401654829 806 dbSNP
rs540207132 814 dbSNP
rs1018929240 820 dbSNP
rs1341305834 821 dbSNP
rs117164290 827 dbSNP
rs1249621191 828 dbSNP
rs1347232134 839 dbSNP
rs1201515847 853 dbSNP
rs1280323575 858 dbSNP
rs1196359567 868 dbSNP
rs1264378742 871 dbSNP
rs547374450 872 dbSNP
rs560223771 876 dbSNP
rs1378807709 877 dbSNP
rs782752310 907 dbSNP
rs1172896312 912 dbSNP
rs1373625093 914 dbSNP
rs886506810 922 dbSNP
rs1298514840 924 dbSNP
rs192011699 926 dbSNP
rs1293768821 929 dbSNP
rs1332875342 932 dbSNP
rs995404512 935 dbSNP
rs1234140177 936 dbSNP
rs574594599 943 dbSNP
rs1346268742 944 dbSNP
rs1045043828 947 dbSNP
rs782092477 948 dbSNP
rs1287137935 961 dbSNP
rs1485757134 972 dbSNP
rs1202978476 975 dbSNP
rs1269068639 978 dbSNP
rs1451666139 980 dbSNP
rs1192401563 985 dbSNP
rs1392733249 986 dbSNP
rs1441427585 990 dbSNP
rs781813756 991 dbSNP
rs3093712 992 dbSNP
rs59057792 992 dbSNP
rs895497879 994 dbSNP
rs556280094 995 dbSNP
rs1287328540 996 dbSNP
rs1393220227 997 dbSNP
rs1441931866 999 dbSNP
rs1325225797 1002 dbSNP
rs386796345 1009 dbSNP
rs1477636834 1011 dbSNP
rs140055200 1012 dbSNP
rs3093711 1012 dbSNP
rs71372372 1017 dbSNP
rs1242884563 1018 dbSNP
rs1052706407 1036 dbSNP
rs1316663535 1037 dbSNP
rs1237417000 1040 dbSNP
rs3093710 1049 dbSNP
rs35011021 1054 dbSNP
rs576974820 1054 dbSNP
rs925696899 1057 dbSNP
rs1250546351 1058 dbSNP
rs1458750705 1061 dbSNP
rs879964640 1062 dbSNP
rs558605818 1063 dbSNP
rs1417067422 1064 dbSNP
rs932480903 1067 dbSNP
rs1166576632 1071 dbSNP
rs1368834456 1076 dbSNP
rs921083309 1081 dbSNP
rs1462125433 1086 dbSNP
rs1164504871 1089 dbSNP
rs1392345029 1096 dbSNP
rs1449137101 1100 dbSNP
rs1299235057 1105 dbSNP
rs533797536 1112 dbSNP
rs1373173198 1118 dbSNP
rs1390176524 1120 dbSNP
rs148004236 1122 dbSNP
rs1322724642 1135 dbSNP
rs1232280614 1144 dbSNP
rs1270928971 1145 dbSNP
rs1319380902 1153 dbSNP
rs977089587 1158 dbSNP
rs1250280636 1160 dbSNP
rs143481279 1161 dbSNP
rs1479578639 1163 dbSNP
rs1183557488 1164 dbSNP
rs1256531706 1171 dbSNP
rs1474784579 1175 dbSNP
rs150639318 1180 dbSNP
rs965277291 1184 dbSNP
rs1467397549 1185 dbSNP
rs911922306 1193 dbSNP
rs1354046177 1202 dbSNP
rs536948161 1205 dbSNP
rs1305164212 1209 dbSNP
rs1356469418 1210 dbSNP
rs1414624557 1212 dbSNP
rs950809070 1215 dbSNP
rs1291043247 1219 dbSNP
rs1028159083 1222 dbSNP
rs994890972 1236 dbSNP
rs1214801301 1237 dbSNP
rs970648062 1239 dbSNP
rs569362068 1247 dbSNP
rs3093709 1250 dbSNP
rs3093708 1252 dbSNP
rs1212121139 1254 dbSNP
rs571436398 1271 dbSNP
rs1485217508 1274 dbSNP
rs1208530155 1281 dbSNP
rs782016481 1283 dbSNP
rs3093707 1285 dbSNP
rs375960000 1288 dbSNP
rs1478904554 1289 dbSNP
rs1052753548 1294 dbSNP
rs1418870344 1309 dbSNP
rs60150286 1309 dbSNP
rs187185696 1312 dbSNP
rs1376657106 1313 dbSNP
rs998485185 1321 dbSNP
rs782395730 1331 dbSNP
rs1311370460 1332 dbSNP
rs528508896 1334 dbSNP
rs561334970 1339 dbSNP
rs904159817 1341 dbSNP
rs1362878322 1343 dbSNP
rs1043217872 1350 dbSNP
rs932392326 1354 dbSNP
rs1269278171 1355 dbSNP
rs1359211100 1357 dbSNP
rs1220515679 1359 dbSNP
rs541764554 1362 dbSNP
rs182494703 1370 dbSNP
rs879953557 1373 dbSNP
rs529957030 1376 dbSNP
rs1447416921 1377 dbSNP
rs1241815794 1385 dbSNP
rs1484926669 1394 dbSNP
rs1192934393 1399 dbSNP
rs561737573 1401 dbSNP
rs1454188203 1405 dbSNP
rs1172338441 1410 dbSNP
rs1382532225 1417 dbSNP
rs908449882 1431 dbSNP
rs982659988 1440 dbSNP
rs950696880 1457 dbSNP
rs1343127564 1463 dbSNP
rs562555076 1482 dbSNP
rs1438183557 1484 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggGUCUCGACUCGGGUGUc 5'
            ||   || | |||||| 
Target 5' aaCAACUCUCAUCCCACAa 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000540200.1 | 3UTR | AACAACUCUCAUCCCACAAUUGCUGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
47 hsa-miR-4265 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061451 NEK7 NIMA related kinase 7 2 2
MIRT121365 RNF4 ring finger protein 4 2 2
MIRT184855 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT458214 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT468493 SESN2 sestrin 2 2 2
MIRT470574 POTEM POTE ankyrin domain family member M 2 2
MIRT470604 POTEG POTE ankyrin domain family member G 2 2
MIRT470897 PLIN3 perilipin 3 2 2
MIRT484480 SLC9A1 solute carrier family 9 member A1 2 2
MIRT486669 WDR81 WD repeat domain 81 2 2
MIRT490907 STRN4 striatin 4 2 2
MIRT493426 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT504168 FAM127B retrotransposon Gag like 8A 2 2
MIRT510345 ZNF703 zinc finger protein 703 2 6
MIRT514287 FXYD5 FXYD domain containing ion transport regulator 5 2 2
MIRT520125 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT522065 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT530484 FADS6 fatty acid desaturase 6 2 2
MIRT536055 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT546050 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT549084 C5orf51 chromosome 5 open reading frame 51 2 4
MIRT551250 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT559432 ARSJ arylsulfatase family member J 2 2
MIRT565560 SMAD5 SMAD family member 5 2 2
MIRT566348 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT572109 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 2 2
MIRT572646 ID4 inhibitor of DNA binding 4, HLH protein 2 2
MIRT608936 SATB1 SATB homeobox 1 2 2
MIRT610608 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT612582 SYNGAP1 synaptic Ras GTPase activating protein 1 2 4
MIRT628951 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT631030 ZNF878 zinc finger protein 878 2 2
MIRT633020 DNAL1 dynein axonemal light chain 1 2 2
MIRT633252 ZNF581 zinc finger protein 581 2 2
MIRT637165 TMEM50A transmembrane protein 50A 2 2
MIRT637264 KLHL12 kelch like family member 12 2 2
MIRT641366 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT653808 SIN3A SIN3 transcription regulator family member A 2 2
MIRT663202 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT694269 ZNF529 zinc finger protein 529 2 4
MIRT708318 NT5C 5', 3'-nucleotidase, cytosolic 2 2
MIRT710038 POLL DNA polymerase lambda 2 2
MIRT717092 PXDC1 PX domain containing 1 2 2
MIRT721739 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT721877 TMPRSS6 transmembrane protease, serine 6 2 2
MIRT723340 SCRT1 scratch family transcriptional repressor 1 2 2
MIRT725561 CPT1A carnitine palmitoyltransferase 1A 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4265 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4265 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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