pre-miRNA Information | |
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pre-miRNA | hsa-mir-4280 |
Genomic Coordinates | chr5: 87114879 - 87114954 |
Description | Homo sapiens miR-4280 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||
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Mature miRNA | hsa-miR-4280 | ||||||||||||||||||
Sequence | 11| GAGUGUAGUUCUGAGCAGAGC |31 | ||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||
Experiments | SOLiD | ||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Symbol | H3F3B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms | H3.3B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | H3 histone family member 3B | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Transcript | NM_005324 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Expression | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Putative miRNA Targets on H3F3B | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
3'UTR of H3F3B (miRNA target sites are highlighted) |
>H3F3B|NM_005324|3'UTR 1 GTGAAGGCAGTTTTTATGGCGTTTTGTAGTAAATTCTGTAAAATACTTTGGTTTAATTTGTGACTTTTTTTGTAAGAAAT 81 TGTTTATAATATGTTGCATTTGTACTTAAGTCATTCCATCTTTCACTCAGGATGAATGCGAAAAGTGACTGTTCACAGAC 161 CTCAGTGATGTGAGCACTGTTGCTCAGGAGTGACAAGTTGCTAATATGCAGAAGGGATGGGTGATACTTCTTGCTTCTCA 241 TGATGCATGTTTCTGTATGTTAATGACTTGTTGGGTAGCTATTAAGGTACTAGAGTTGATAAATGTGTACAGGGTCCTTT 321 TGCAATAAAACTGGTTATGACTTGATCCAAGTGTTTAACAATTGGGGCTGTTAAGTCTGACCATACATCACTGTGATAGA 401 ATGTGGGCTTTTTCAAGGGTGAAGATACAAGTCTTAACCACAGTGTAACTTACAGTTTCCTTTAAAAAAAAAAAAAGTAA 481 ACCTGGCAGCTATAGAATACACTATGTGCATTTATAATAGCTATTTTATATATTGTAGTATCAACATTTTTAAATTAAAT 561 GTTTTACATTCACAAGTGGTGGGGAGTCTTGTCATTAAGGTGTGTGTAATTTAGAGTCCAGTTGGTTTTCTTCTGACTGC 641 ACTTGTTCTCATAGTAGTAAAATGCTATGCGCATTTATACCTTGCATAAGTCCTCATTCTACCACATGTTAACCCTCTAG 721 CTGATAATGCAAACACTAACTGGGGGATTTTATTTATAAGGGCTCTAGAAAAAACGAGTTATTCACACCAGCATCATCTT 801 AACTAACATTCTGAACTAGTTAGTGCAGCTTTTCATTGTGTTGTGTGGTTGGTCTCATAACTAGGTTGAGTTTTTCTCCT 881 CTGCTGAGGAAACAGTACCGAAGTTCTTTTTCTTGTGGCATTTGTATTATAAAAACTTGGTGTGGGGGAGGAGCACAAAA 961 CTCCAGCCCACTGAACCTCTGCCAATTAAGATGGTGTTGGGTTAGGTTACATCTGGTTACTGTCCTGGGAAAATCATTTT 1041 TATAGAGATGGCCTTCCAAGTGGTTTTAAAATTTACTGAAGTTTTTAGGTCAATTATGTATGTTGACTAAATTTACAAAT 1121 AAACTTGTTTATCCAACTAAGTGTCCAAAACCTAAATTGAATGTACTAAGTTTTCACATGTCCCATTATCTAGGTCCTTG 1201 TATACTAATGTTTTGAACTTAGATCATTTCAGGTGTTGTTTGGTGGATAAAGGAACCTTTTATTTATAAAGATACTGTAG 1281 AAAGCATGTGAACAGCTCTCTGCTTGATTAAGATGCCATAATAGTGCTGTATTTGCAGTGTGGGCTAAGACAAAGTATAT 1361 TAATAAGCTTTTCAGCCCCCCCACTCCCGTTCCGTAGTGTAGAAGCCCACAGGTGTAGAACTCAGTCTTAAACTTCAGTA 1441 TGAAACCAGTTTCCTTGTGCGATGATGGCCACTAAAGCATAGTACGTGGATGTCAGTGAGACAGCATGAGAGCCAGCAGT 1521 CATCAAAGCGTTCCACGTTTGAAGTTAGCAACTGCTTAAAGTTATGCCCCATTAAAATTGCTTTCTCAAAAGTTTGGGTT 1601 AGTTTCAAATGTGATATTTTGGAGGGAAGGTAAAGTAGGTATCTTTCAGGTCGTGATAATGAGCTCCTATGAAAGGATGC 1681 AATATAATGACCCGCTTTTCTAGAAAGTTCATAATCAGCTCTGGAACAAGCACACTTGATTCCTCACTGTGCTTCAGAAT 1761 GAGATTAAGATCAGATGTTGGAACGTGCTATGCTGTAGCGTGTCTGGAAACAAAGTACACAAACCTGGCTACGGTGATGA 1841 GTTAGCTTCTGCTTACTACCTGTGACAACCCAAGTGGGTGACACTAGTGAACCTTCTCCAGTCTGCAGGCTGGCATAGAA 1921 GGCTCTTAGATTATATTGGGCAGCTTGCAATCTGCCGAAGCAGTGACTTGCATTTCCACACTTGGCTTGAGCACTCAACC 2001 CAGAAGGCGAAGATAGCTTTTGGTTGTAGGCGGCTTCCTGTATGGGATATCCCTCGGTAAGGGTAAAGGAGCAGAGGCAA 2081 AGGAGAAAAGCAGAAGTTGCAGCTGATGCAGGTATCCTATGCCCTTGATGGATGAGACTAAAATAAAATTTTTGAAGTTA 2161 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs |
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SNPs in gene 3'UTRs |
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Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_005324 | 3UTR | UUACAGUUUCCUUUAAAAAAAAAAAAAGUAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUAGCUAUUUUAUAUAUUGUAGUAUCAACAUUUUUAAAUUAAAUGUUUUACAUUCACAAGUGGUGGGGAGUCUUGUCAUUAAGGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903834 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_b |
Location of target site | NM_005324 | 3UTR | ACAGUUUCCUUUAAAAAAAAAAAAAGUAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUAGCUAUUUUAUAUAUUGUAGUAUCAACAUUUUUAAAUUAAAUGUUUUACAUUCACAAGUGGUGGGGAGUCUUGUCAUUAAGGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903835 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_c |
Location of target site | NM_005324 | 3UTR | AGUUUCCUUUAAAAAAAAAAAAAGUAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUAGCUAUUUUAUAUAUUGUAGUAUCAACAUUUUUAAAUUAAAUGUUUUACAUUCACAAGUGGUGGGGAGUCUUGUCAUUAAGGUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM4903836 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_a |
Location of target site | NM_005324 | 3UTR | ACUUACAGUUUCCUUUAAAAAAAAAAAAAGUAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUAGCUAUUUUAUAUAUUGUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM4903837 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_005324 | 3UTR | ACAGUUUCCUUUAAAAAAAAAAAAAGUAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUAGCUAUUUUAUAUAUUGUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM4903838 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_005324 | 3UTR | CUUUAAAAAAAAAAAAAGUAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUAGCUAUUUUAUAUAUUGUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM545216 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-124 transfection |
Location of target site | ENST00000591890.1 | 3UTR | UAAACCUGGCAGCUAUAGAAUACACUAUGUGCAUUUAUAAUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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67 hsa-miR-4280 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT065612 | DAZAP2 | DAZ associated protein 2 | ![]() |
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2 | 10 | ||||||
MIRT084985 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT088053 | UBXN2A | UBX domain protein 2A | ![]() |
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2 | 4 | ||||||
MIRT097327 | SCAMP1 | secretory carrier membrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT099148 | MYLIP | myosin regulatory light chain interacting protein | ![]() |
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2 | 12 | ||||||
MIRT127042 | FAM208B | family with sequence similarity 208 member B | ![]() |
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2 | 4 | ||||||
MIRT140479 | BNIP2 | BCL2 interacting protein 2 | ![]() |
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2 | 6 | ||||||
MIRT154889 | GNAS | GNAS complex locus | ![]() |
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2 | 4 | ||||||
MIRT187983 | MBD6 | methyl-CpG binding domain protein 6 | ![]() |
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2 | 2 | ||||||
MIRT190440 | EIF5 | eukaryotic translation initiation factor 5 | ![]() |
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2 | 2 | ||||||
MIRT240673 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | ![]() |
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2 | 2 | ||||||
MIRT295049 | EVI5L | ecotropic viral integration site 5 like | ![]() |
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2 | 2 | ||||||
MIRT324749 | ACER2 | alkaline ceramidase 2 | ![]() |
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2 | 2 | ||||||
MIRT366075 | FAM127A | retrotransposon Gag like 8C | ![]() |
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2 | 4 | ||||||
MIRT442625 | LOX | lysyl oxidase | ![]() |
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2 | 2 | ||||||
MIRT445224 | TYRP1 | tyrosinase related protein 1 | ![]() |
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2 | 2 | ||||||
MIRT448967 | CCNT2 | cyclin T2 | ![]() |
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2 | 4 | ||||||
MIRT450137 | PFN4 | profilin family member 4 | ![]() |
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2 | 2 | ||||||
MIRT464350 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT470460 | PPP1R15B | protein phosphatase 1 regulatory subunit 15B | ![]() |
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2 | 2 | ||||||
MIRT473691 | MAPK8 | mitogen-activated protein kinase 8 | ![]() |
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2 | 4 | ||||||
MIRT480188 | CALM2 | calmodulin 2 | ![]() |
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2 | 6 | ||||||
MIRT486355 | PCBD2 | pterin-4 alpha-carbinolamine dehydratase 2 | ![]() |
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2 | 2 | ||||||
MIRT486708 | TROVE2 | TROVE domain family member 2 | ![]() |
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2 | 4 | ||||||
MIRT488337 | SCD | stearoyl-CoA desaturase | ![]() |
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2 | 2 | ||||||
MIRT489322 | PEX26 | peroxisomal biogenesis factor 26 | ![]() |
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2 | 2 | ||||||
MIRT491791 | ZNF24 | zinc finger protein 24 | ![]() |
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2 | 2 | ||||||
MIRT491970 | USP37 | ubiquitin specific peptidase 37 | ![]() |
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2 | 2 | ||||||
MIRT492029 | TWF1 | twinfilin actin binding protein 1 | ![]() |
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2 | 4 | ||||||
MIRT492063 | TMEM245 | transmembrane protein 245 | ![]() |
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2 | 2 | ||||||
MIRT492247 | SLC39A9 | solute carrier family 39 member 9 | ![]() |
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2 | 2 | ||||||
MIRT492254 | SLC35F5 | solute carrier family 35 member F5 | ![]() |
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2 | 2 | ||||||
MIRT492592 | PPIL4 | peptidylprolyl isomerase like 4 | ![]() |
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2 | 2 | ||||||
MIRT493436 | KAT7 | lysine acetyltransferase 7 | ![]() |
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2 | 2 | ||||||
MIRT493470 | IPMK | inositol polyphosphate multikinase | ![]() |
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2 | 2 | ||||||
MIRT493639 | HECTD1 | HECT domain E3 ubiquitin protein ligase 1 | ![]() |
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2 | 2 | ||||||
MIRT493919 | FAM127B | retrotransposon Gag like 8A | ![]() |
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2 | 4 | ||||||
MIRT494639 | ARNTL | aryl hydrocarbon receptor nuclear translocator like | ![]() |
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2 | 2 | ||||||
MIRT500032 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 8 | ||||||
MIRT504589 | ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | ![]() |
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2 | 4 | ||||||
MIRT505535 | SP4 | Sp4 transcription factor | ![]() |
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2 | 6 | ||||||
MIRT507539 | DNAJB6 | DnaJ heat shock protein family (Hsp40) member B6 | ![]() |
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2 | 6 | ||||||
MIRT508846 | TMCO1 | transmembrane and coiled-coil domains 1 | ![]() |
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2 | 4 | ||||||
MIRT510488 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | ![]() |
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2 | 2 | ||||||
MIRT511402 | IFNAR2 | interferon alpha and beta receptor subunit 2 | ![]() |
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2 | 6 | ||||||
MIRT523252 | HIST1H2AH | histone cluster 1 H2A family member h | ![]() |
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2 | 2 | ||||||
MIRT525939 | C11orf74 | chromosome 11 open reading frame 74 | ![]() |
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2 | 2 | ||||||
MIRT531453 | HSD17B12 | hydroxysteroid 17-beta dehydrogenase 12 | ![]() |
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2 | 2 | ||||||
MIRT533317 | UNKL | unkempt family like zinc finger | ![]() |
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2 | 2 | ||||||
MIRT541034 | STRBP | spermatid perinuclear RNA binding protein | ![]() |
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2 | 8 | ||||||
MIRT546734 | RNF217 | ring finger protein 217 | ![]() |
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2 | 2 | ||||||
MIRT555125 | PTPRJ | protein tyrosine phosphatase, receptor type J | ![]() |
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2 | 2 | ||||||
MIRT556105 | MOAP1 | modulator of apoptosis 1 | ![]() |
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2 | 2 | ||||||
MIRT560205 | AK4 | adenylate kinase 4 | ![]() |
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2 | 2 | ||||||
MIRT561087 | LLPH | LLP homolog, long-term synaptic facilitation | ![]() |
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2 | 2 | ||||||
MIRT566967 | LBR | lamin B receptor | ![]() |
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2 | 2 | ||||||
MIRT567344 | H3F3B | H3 histone family member 3B | ![]() |
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2 | 2 | ||||||
MIRT567863 | DCAF12 | DDB1 and CUL4 associated factor 12 | ![]() |
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2 | 2 | ||||||
MIRT574449 | SCML2 | Scm polycomb group protein like 2 | ![]() |
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2 | 2 | ||||||
MIRT575700 | Map1b | microtubule-associated protein 1B | ![]() |
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2 | 2 | ||||||
MIRT651432 | YIPF6 | Yip1 domain family member 6 | ![]() |
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2 | 2 | ||||||
MIRT659728 | CCDC93 | coiled-coil domain containing 93 | ![]() |
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2 | 2 | ||||||
MIRT686937 | SFT2D3 | SFT2 domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT699385 | SLC30A6 | solute carrier family 30 member 6 | ![]() |
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2 | 2 | ||||||
MIRT710287 | CSNK1G3 | casein kinase 1 gamma 3 | ![]() |
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2 | 2 | ||||||
MIRT715123 | PANK3 | pantothenate kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT721847 | VLDLR | very low density lipoprotein receptor | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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