pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol CENPQ   
Synonyms C6orf139, CENP-Q
Description centromere protein Q
Transcript NM_018132   
Expression
Putative miRNA Targets on CENPQ
3'UTR of CENPQ
(miRNA target sites are highlighted)
>CENPQ|NM_018132|3'UTR
   1 AGAGTGTTTTTTTTTTAGATTGTTCCATATTAATTTAATGTTCGTGAATTTGTAAAACTGTTAACCTATGATTATATGTA
  81 CAGAGGCTAAGGCTTCTGCAGGATTTATTATCTCCTGATATGCACTTTAAAATTAGTCTTTGTAGTTCTATCATTAGCAT
 161 CTAATGTAGTTCTGAAGACTGTTTTTAGCAGTTGCCAAATCTAGGAAACTAACATTTATATTGCTGTATCTATAAGTATT
 241 TGCCTAAAACCATAAAATAGGAATTGCCTTAAGGATCTAATAGTTTATAATGCCTGAATGGAACTCATTTATTGGTTAAC
 321 AGCTCATATCAGGAGCTGTGATAAGTAAGTGTTTACATACACTGTCTAGTGCATAAAAACCTTAGTGTTTGCTATCATTC
 401 ATTCTGTAGCCAATGGCTTACAGTTTCTGTCTGGTCATCTGGAACTTGAAAAATCCTCAAATGCCTTCACTCTTTTACCT
 481 AACTCCCTAGTCTTTTTGGGAAGTAGTTAAGATATGCCTGCTATCTTTAACTTTGGAGGTAGTATCAAAATTTTACTTCT
 561 TTGGTTGTTTAGTGAATTAATGTTGAATATTTTCTACTGTCATCAAAACATATTCCCAAAAAGTATTAAAAAGGAACCTT
 641 AGCACATTTATTTTATTAAAACAAGAAAACCCAAAATATATAAACCTTTTCTTATTATGATAATAAGCTTATATATGTGA
 721 ATAAGTTATAACCTAGTGTATAAAAAATTATTTCTAACAAACTACAGTATACTGTCTTGGGTTTTTTTTTTTTTTTTTAG
 801 TCTGTAAAATAAAATGACTGCAATTACTTTTTAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agaUUUA-GAGUAUCACGGAAGa 5'
             |||| |||| | ||||||| 
Target 5' gaaAAATCCTCA-AATGCCTTCa 3'
448 - 469 166.00 -13.00
2
miRNA  3' agAUUUAGAGUAUCACGGAAga 5'
            |||| :  : | ||||||  
Target 5' caTAAAATAGGAATTGCCTTaa 3'
251 - 272 132.00 -6.90
3
miRNA  3' agAUU-UAGAGUAUCACGGAaga 5'
            ||| | :|:||| |||||   
Target 5' tcTAATAGTTTATAATGCCTgaa 3'
276 - 298 128.00 -11.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20121477 17 COSMIC
COSN28836884 17 COSMIC
COSN30525823 26 COSMIC
COSN30472026 27 COSMIC
COSN28638294 87 COSMIC
COSN30545018 104 COSMIC
COSN31584035 146 COSMIC
COSN29628702 347 COSMIC
COSN21965081 489 COSMIC
COSN28815214 490 COSMIC
COSN31529231 592 COSMIC
COSN31608014 649 COSMIC
COSN20481287 662 COSMIC
COSN20480250 663 COSMIC
COSN18723422 780 COSMIC
COSN19186169 783 COSMIC
COSN20445867 785 COSMIC
COSN20091396 787 COSMIC
COSN20102925 799 COSMIC
rs1471539 165 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs568913239 2 dbSNP
rs1173532002 3 dbSNP
rs144722464 7 dbSNP
rs749100991 7 dbSNP
rs749945343 7 dbSNP
rs756060282 7 dbSNP
rs780812513 7 dbSNP
rs1449710950 8 dbSNP
rs1001661654 17 dbSNP
rs1438195867 18 dbSNP
rs1305211469 19 dbSNP
rs757236888 20 dbSNP
rs1220188875 23 dbSNP
rs778793747 26 dbSNP
rs745976688 28 dbSNP
rs1181557822 35 dbSNP
rs368444649 39 dbSNP
rs1384532907 43 dbSNP
rs766685297 44 dbSNP
rs372696964 45 dbSNP
rs1203804952 46 dbSNP
rs768918489 47 dbSNP
rs962262257 63 dbSNP
rs995067451 75 dbSNP
rs554533571 76 dbSNP
rs1028265308 81 dbSNP
rs953562739 84 dbSNP
rs985655912 99 dbSNP
rs566787635 103 dbSNP
rs533830395 106 dbSNP
rs1241827743 112 dbSNP
rs893363175 121 dbSNP
rs910935955 136 dbSNP
rs1359027369 143 dbSNP
rs549568758 158 dbSNP
rs1230214521 160 dbSNP
rs1380417173 162 dbSNP
rs1471539 165 dbSNP
rs976361250 169 dbSNP
rs1372885230 178 dbSNP
rs377241945 180 dbSNP
rs1429781902 182 dbSNP
rs1172418648 201 dbSNP
rs1162320018 202 dbSNP
rs576936215 212 dbSNP
rs1425174594 213 dbSNP
rs781715553 214 dbSNP
rs998006976 222 dbSNP
rs1360778275 225 dbSNP
rs753334995 226 dbSNP
rs1402011563 227 dbSNP
rs1053696956 233 dbSNP
rs1183030660 234 dbSNP
rs1490219889 237 dbSNP
rs953472461 245 dbSNP
rs1224137039 246 dbSNP
rs915097175 250 dbSNP
rs1322481297 251 dbSNP
rs1284023775 252 dbSNP
rs1430601440 253 dbSNP
rs1316042194 261 dbSNP
rs947872690 266 dbSNP
rs1045564343 268 dbSNP
rs906586984 274 dbSNP
rs1289570263 277 dbSNP
rs756813288 278 dbSNP
rs1471538 281 dbSNP
rs1291284949 284 dbSNP
rs1459127266 286 dbSNP
rs897814725 291 dbSNP
rs556255367 294 dbSNP
rs1158135898 297 dbSNP
rs1455411967 301 dbSNP
rs1027904966 316 dbSNP
rs889287879 326 dbSNP
rs1159889772 329 dbSNP
rs1233690956 333 dbSNP
rs917563980 334 dbSNP
rs949118717 337 dbSNP
rs778844666 345 dbSNP
rs1488941601 352 dbSNP
rs980846365 366 dbSNP
rs926324823 372 dbSNP
rs1331720126 373 dbSNP
rs1269148561 395 dbSNP
rs936417159 401 dbSNP
rs1054604391 406 dbSNP
rs893332081 411 dbSNP
rs1284084055 430 dbSNP
rs1287970078 465 dbSNP
rs1432423376 466 dbSNP
rs1390640890 468 dbSNP
rs183888285 470 dbSNP
rs1201700376 471 dbSNP
rs11554555 473 dbSNP
rs1375840535 484 dbSNP
rs148692494 485 dbSNP
rs1433875779 513 dbSNP
rs1418832806 517 dbSNP
rs1017994157 522 dbSNP
rs1454173395 524 dbSNP
rs1192465999 529 dbSNP
rs1380367258 530 dbSNP
rs1249105167 535 dbSNP
rs997494428 556 dbSNP
rs965075326 559 dbSNP
rs889177771 561 dbSNP
rs766353022 563 dbSNP
rs532059725 565 dbSNP
rs1312284208 569 dbSNP
rs1016040486 571 dbSNP
rs758166325 575 dbSNP
rs1165523072 594 dbSNP
rs551649425 601 dbSNP
rs1366906157 610 dbSNP
rs956366863 621 dbSNP
rs1451609006 624 dbSNP
rs961935500 637 dbSNP
rs1304537329 643 dbSNP
rs1466434122 644 dbSNP
rs1354016237 646 dbSNP
rs541896969 647 dbSNP
rs1405773097 651 dbSNP
rs1166791239 670 dbSNP
rs1327613492 681 dbSNP
rs779723572 687 dbSNP
rs1414495870 688 dbSNP
rs915127676 692 dbSNP
rs1422464341 696 dbSNP
rs947893554 699 dbSNP
rs980606921 700 dbSNP
rs1201539603 701 dbSNP
rs971057961 705 dbSNP
rs1480591966 715 dbSNP
rs1273362508 717 dbSNP
rs980403507 729 dbSNP
rs559869048 736 dbSNP
rs528813777 739 dbSNP
rs540535000 741 dbSNP
rs1244724873 748 dbSNP
rs189396607 755 dbSNP
rs936387438 756 dbSNP
rs989257802 760 dbSNP
rs1237222551 765 dbSNP
rs1395666442 766 dbSNP
rs1306309868 773 dbSNP
rs1431669591 774 dbSNP
rs199576942 779 dbSNP
rs796542803 780 dbSNP
rs11335563 782 dbSNP
rs1163198121 782 dbSNP
rs1188667175 782 dbSNP
rs1366230412 782 dbSNP
rs568958575 782 dbSNP
rs1357257030 784 dbSNP
rs78512419 784 dbSNP
rs3209645 785 dbSNP
rs200487614 786 dbSNP
rs1346416887 787 dbSNP
rs1199806655 788 dbSNP
rs1238308240 789 dbSNP
rs1208875701 792 dbSNP
rs914722569 793 dbSNP
rs1178995471 798 dbSNP
rs1335137640 799 dbSNP
rs756408768 799 dbSNP
rs1362888243 800 dbSNP
rs1311795811 801 dbSNP
rs1042287142 802 dbSNP
rs1048984177 803 dbSNP
rs1415389584 805 dbSNP
rs1460912869 807 dbSNP
rs1331934607 814 dbSNP
rs1398783927 820 dbSNP
rs902066598 823 dbSNP
rs1328194856 827 dbSNP
rs1341297469 828 dbSNP
rs1410155059 829 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000335783.3 | 3UTR | CCUUCACUCUUUUACCUAACUCCCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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