pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol BMP2K   
Synonyms BIKE, HRIHFB2017
Description BMP2 inducible kinase
Transcript NM_017593   
Other Transcripts NM_198892   
Expression
Putative miRNA Targets on BMP2K
3'UTR of BMP2K
(miRNA target sites are highlighted)
>BMP2K|NM_017593|3'UTR
   1 AATAACAGCTCTATTATTATTCAGCAAGGCCAAAGACTTTTGAGAATGTGTATGGAAAATTCTTTTTGTGCATTTGAGGG
  81 CAAAATTCAGGCCATCTTCTTATACATATACTATCAAATTATGTTGTGTGCATTAGAAATCAGTTGCTTGATAGTAGCTA
 161 TTAAACCCAATATTGCTGATAGTATGCTAATATCCTAAAACTTAAATATTGCATATCTATGAATGTTAAATTCAGAATAT
 241 CTCTAAAACATGGAAAATTGATGTTTCAATAAAAAGGGAGACATTTTATTATTTTGCCTTACTAATGATTTTGCAGCTCT
 321 GTTTTTCTGCACACTCAATAGAAAATATTGTGGGTCTGAGATGCCCTTTGAAAATGCCTGAAAGAAAACATGGGCTACTA
 401 CATTATGTTAATGTTTTGTAATGTCCTTTTAATGAGTGGTGACATAAAAGGGCTGCTTTGTTGTCCTGATATGGCAAAAA
 481 TTAAATAAATTCTTTTTCACTTTAAATCAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaCAUCCGGAAAUCUA-GUGAa 5'
            ||:||:| | |||| | || 
Target 5' ttGTGGGTC-TGAGATGCCCTt 3'
348 - 368 102.00 -14.20
2
miRNA  3' uacauccggaaaucuAGUGAa 5'
                         ||||| 
Target 5' taaataaattcttttTCACTt 3'
482 - 502 100.00 -7.50
3
miRNA  3' uaCAUCCGGAA-AUCUAGUGAa 5'
            ||: || ||  | |||| | 
Target 5' ttGTGTGCATTAGAAATCAGTt 3'
124 - 145 95.00 -7.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30509168 31 COSMIC
COSN31504155 81 COSMIC
COSN10035551 127 COSMIC
COSN30542516 275 COSMIC
COSN31608588 385 COSMIC
COSN31561838 438 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1192233990 2 dbSNP
rs371736954 3 dbSNP
rs1479685198 4 dbSNP
rs770143654 9 dbSNP
rs780599093 11 dbSNP
rs749830753 13 dbSNP
rs1330320095 14 dbSNP
rs768753037 17 dbSNP
rs374726656 19 dbSNP
rs1421567283 26 dbSNP
rs562163235 37 dbSNP
rs1347286493 38 dbSNP
rs761978239 40 dbSNP
rs373800828 44 dbSNP
rs111546068 55 dbSNP
rs1489269524 56 dbSNP
rs1246977989 72 dbSNP
rs527748552 77 dbSNP
rs1203343035 79 dbSNP
rs139688273 82 dbSNP
rs1443098984 86 dbSNP
rs1221019083 90 dbSNP
rs1259417312 90 dbSNP
rs1319131140 92 dbSNP
rs1301055048 94 dbSNP
rs1298546128 98 dbSNP
rs1311107127 101 dbSNP
rs986777090 107 dbSNP
rs570781265 109 dbSNP
rs1315731534 114 dbSNP
rs1446307780 116 dbSNP
rs778968716 116 dbSNP
rs1398219372 119 dbSNP
rs1333366102 120 dbSNP
rs1466103423 123 dbSNP
rs994020395 133 dbSNP
rs1051256114 143 dbSNP
rs533413629 154 dbSNP
rs1469292285 168 dbSNP
rs1193435792 169 dbSNP
rs552492296 171 dbSNP
rs1006947490 198 dbSNP
rs1432708019 207 dbSNP
rs1239472305 212 dbSNP
rs1194113962 237 dbSNP
rs1458625606 238 dbSNP
rs1255975787 250 dbSNP
rs1208633154 257 dbSNP
rs14629 261 dbSNP
rs745838051 264 dbSNP
rs760695913 270 dbSNP
rs1279711394 271 dbSNP
rs964921643 271 dbSNP
rs902408172 284 dbSNP
rs1374893878 288 dbSNP
rs1003179073 299 dbSNP
rs763902955 313 dbSNP
rs894925540 314 dbSNP
rs1011989678 315 dbSNP
rs1467514415 319 dbSNP
rs758261022 330 dbSNP
rs1017559270 338 dbSNP
rs1359543557 338 dbSNP
rs962912084 339 dbSNP
rs1381726765 341 dbSNP
rs1022523451 345 dbSNP
rs1395021990 349 dbSNP
rs1178843716 354 dbSNP
rs1443550762 355 dbSNP
rs1253444764 359 dbSNP
rs1462897947 367 dbSNP
rs1291746038 368 dbSNP
rs994709285 369 dbSNP
rs1025921292 375 dbSNP
rs955589742 388 dbSNP
rs569210841 392 dbSNP
rs878868722 395 dbSNP
rs1288474022 401 dbSNP
rs1351929392 401 dbSNP
rs1241147041 411 dbSNP
rs986828012 414 dbSNP
rs911220455 421 dbSNP
rs966824351 437 dbSNP
rs1382275836 442 dbSNP
rs1297150318 445 dbSNP
rs1297378709 452 dbSNP
rs978315572 453 dbSNP
rs1362186924 461 dbSNP
rs990254507 467 dbSNP
rs1277896736 472 dbSNP
rs914608011 473 dbSNP
rs1366206963 483 dbSNP
rs1166232834 491 dbSNP
rs538018527 493 dbSNP
rs1426098842 502 dbSNP
rs960862171 503 dbSNP
rs547623148 507 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000335016.5 | 3UTR | UUAUAACUAAACCUGUUAUACUUGAACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.999 0.01 1.000 0.5 3 Click to see details
BLCA 0.913 0.13 1.000 0.5 3 Click to see details
HNSC 0.221 0.32 0.357 0.22 7 Click to see details
UCEC -0.534 0.32 -0.500 0.33 3 Click to see details
UCEC -0.534 0.32 -0.500 0.33 3 Click to see details
UCEC -0.534 0.32 -0.500 0.33 3 Click to see details
UCEC -0.534 0.32 -0.500 0.33 3 Click to see details
UCEC -0.534 0.32 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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