miRTarBase - #MIRT568312


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pre-miRNA Information
pre-miRNA hsa-mir-921   
Genomic Coordinates chr1: 166154743 - 166154798
Synonyms MIRN921, hsa-mir-921, MIR921
Description Homo sapiens miR-921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-921
Sequence 2| CUAGUGAGGGACAGAACCAGGAUUC |26
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31549221 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1464259216 3 dbSNP
rs768428855 8 dbSNP
rs746970999 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BAG4   
Synonyms BAG-4, SODD
Description BCL2 associated athanogene 4
Transcript NM_004874   
Expression
Putative miRNA Targets on BAG4
3'UTR of BAG4
(miRNA target sites are highlighted)		 
>BAG4|NM_004874|3'UTR
   1 AAGGATTTAGAACAAAGTGGAAGCCTGTTACTAACTTGACCAAAGAACACTTGATTTGGTTAATTACCCTCTTTTTGAAA
  81 TGCCTGTTGATGACAAGAAGCAATACATTCCAGCTTTCCTTTGATTTTATACTTGAAAAACTGGCAAAGGAATGGAAGAA
 161 TATTTTAGTCATGAGTTGTTTTCAGTTTTCAGACGAATGAATGTAATAGGAAACTATGGAGTTACCAATATTGCCAAGTA
 241 GACTCACTCCTTAAAAAATTTATGGATATCTACAAGCTGCTTCTTACCAGCAGGAGGGAAACACACTTCACACAACAGGC
 321 TTATCAGAAACCTACCAGATGAAACTGGATATAATCTGAGACAAACAGGATGTGTTTTTTTAAACATCTGGATATCTTGT
 401 CACATTTTTGTACATTGTGACTGCTTTCAACATATACTTCATGTGTAATTATAGCTTAGACTTTAGCCTTCTTGGACTTC
 481 TGTTTTGTTTTGTTATTTGCAGTTTACAAATATAGTATTATTCTCTACTTCTTGGTACATTTTGTAGTAATATGTTTAAT
 561 ATAATTATTCAAGAGACTATATTGACAGCCAGATAGTATGGCAGTTCTGAAAAAATTTATATCTTTTCACCACTTGAATA
 641 TACTGCAATGTGTAGTGAGTAAATTGTCTCCCTTTTTCTATAGATCATTAGGTTAGAGTTTTTTTCTTCTTTTTTTTTTT
 721 TTTTTTTTTTTACCACTTCTGCTGTTCATGGTAGTAGTGGAAGGTAAATTTGGAAATGGCATTGACATAAAATGAAAATG
 801 TTTACGGACACTTTTCTTTTTTGCTTTTTTATTGTATTTGGATAAAGATCCACTTAAAAGTTATCTGTTTTTTCCTGTTT
 881 TTTTTTTTTTTCCCCAAAGTGTAGTTATGTTTTCACTATTGCTGCTTCTATAGAGGGCATTGTGATAGAGAGTTACAGAT
 961 GAAACATTAAATGCCACAGTGAGTAGAAATAATTACTACAAAAAGTAATAAATATGATTACTTGGTAATATCATTCTCCA
1041 TCTAAAATACTAGTTTCACCTGTGAGCAGATTTCAGCTCAGTTTATAGTTAAAAACAATGAGGGTAAAATGGGATTCATG
1121 CTCAGGGAATGAATCAGCCATAGTTAGAGTGGGAAATTATTATTTTCTTCATTTAAAGGTAGATTTTATGTTTATTTCCC
1201 TAAATTGCATAAGATAAAATTGTCTGTTTAATAAAAAGACATTTATTACCATTATTAACAGTCATTTTAGAGCCAAATTT
1281 AAGAAAAGGATATTGAAAGGGTCTTTATTGGCCTTGTTTGGGTAACTCTATGCTGTTAGATAGAAGAGACTTAGGTAAAT
1361 AACTTTTTATGTCTGAGGTGAGTACACAATATTGGTTCTTGGAAAAATAGCTGTTTCTTCATAAGATACCCAAGTGATAA
1441 TTTTTTTTCCCCTAGACTGTCAGGCCTATGAGTAAATACTAAATCTATTAGCTGTCCCCACTCATAAACCAAACCAAACC
1521 AATACAAACAGATGAGGAGAGGAAATGTAGTAAAAATACTGGCTGGGTCTTATGATTGGGATGAGTGATTTTATAAGATA
1601 ATATGGTGATAATTTTATTCTAGGATTTTATTTTTGGCCTAATATAGGAATGTTTAAAAAAGGCTTTTCTATGAAAATTA
1681 GAAATTTATACTTGAAATTAAAAGTCTAGAAGGGGGAGGACCTTAAAGCTAAGCTACCAGTAAGACAATGAATAATTCAG
1761 AAGAGAACACTATTCTTTTACTGACTGAGTGCCCAAGATGCCAATTTCCATGAAGTCTTGATTTATATATATGTACACAT
1841 GTTATGCACATACATGTTTGTTTTCTAACAGTTATTTTTTAAGCTTTTGAGATAATTTTAGACTTACAGAAGAGTTGTAA
1921 AAGTAGTAGAGTTCTTGTATACTCTGCACCCACCTTGCCCTTATGTTAACATCTTACGTAACAATAGAACATTTGTCAAA
2001 ATTAAGAAATTAACCTTGATATAATACTAACTAAAGTAGAAAGTTTAAAAAGTAGAGATTTTAGTCTTTTCACTAATGTC
2081 CTTTTACTGTTCCAAGACCCAGCCTTGCATTTAGCTATCATGCCTACGTCCTGTCTTCCAGTCTGTGACAGTGTATCATA
2161 ACAGGGGATACCTGATGTTGTAATGTATTTCTGGTGTTGTTAACCTTGATCACTATGCTAAGGTGGTGTCTGCTAGGATT
2241 CGCTACTGTAAACTTACTGTGTTTTCCTTGTAATTATTGAATATTTGCTGGAGATACCCGGAGACTATGCAAATGTCCCG
2321 TTTCTGCTTAAACTTTTGCTCATTTTACTATCCATTGGCAGATCTTGCTTGTGGCAGTTACTACTGTGGTGTTCTAATGG
2401 TGATTTTCTATTTCTCTCAATCCTTCTACATTTATTATTGGAATTCTTCTGTAAGGAAGAGTTGTCAGTTCTGGATTTAT
2481 ATTTTTAACTATAATAAGATATTCAGGATAAGTATAGATTTAGAACTTAAAGATGTTAAATCATGTTAAAATTATTCCAA
2561 ATACCAATATCAAAGAAAACTAAGTTGGTAATCTATCTCAGAAAATATATGAACTTAAGAAGGAAAATAGTATTTATGAT
2641 TTGTAGAATTGGTTCAACTTTTGACTTAATACTGACTTTGGACTGAATTCAAAGTTTTCTTGAAATTTCACATCTGGACT
2721 TTTTAAAGTGTCTACATTTATATTACTTTGGGGATCATTTTGTCAAAGTCTTGAATAAAGTTACCCAGTCCTGGCATGAT
2801 AAACACAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuuaggACCAAGACAGGGAGUGAUc 5'
                | ||| ||| ::|||||| 
Target 5' aaagtgTAGTTATGT-TTTCACTAt 3'
 896 - 919 146.00 -9.10
2 
miRNA  3' cuuaggaCCAAGA-CAG-GGAGUGAUc 5'
                 | ||:| ||| ::|||||| 
Target 5' aagtagaGATTTTAGTCTTTTCACTAa 3'
 2050 - 2076 142.00 -9.30
3 
miRNA  3' cuuAGGACCAAGACA---GG---GAGUGAUc 5'
             |:||||| :|||   ||    |||||| 
Target 5' tatTTCTGGTGTTGTTAACCTTGATCACTAt 3'
 2186 - 2216 138.00 -17.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31543046 34 COSMIC
COSN30450109 70 COSMIC
COSN30481899 72 COSMIC
COSN6518606 93 COSMIC
COSN6518607 114 COSMIC
COSN20076533 131 COSMIC
COSN31480731 326 COSMIC
COSN31549145 450 COSMIC
COSN26721371 590 COSMIC
COSN25897532 667 COSMIC
COSN5681257 837 COSMIC
COSN22706391 1681 COSMIC
COSN2275059 1682 COSMIC
COSN16391806 1697 COSMIC
COSN29747716 1786 COSMIC
COSN21854423 2136 COSMIC
COSN21853427 2173 COSMIC
COSN21853428 2365 COSMIC
COSN21852444 2472 COSMIC
COSN9634076 2527 COSMIC
COSN21853769 2572 COSMIC
COSN5111881 2594 COSMIC
COSN9634077 2637 COSMIC
COSN30197778 2718 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs774440063 2 dbSNP
rs1456916837 6 dbSNP
rs187571848 8 dbSNP
rs534585314 16 dbSNP
rs766558104 17 dbSNP
rs553034109 21 dbSNP
rs1465785930 27 dbSNP
rs757324408 28 dbSNP
rs765067904 37 dbSNP
rs572774512 38 dbSNP
rs1316720827 39 dbSNP
rs910867234 46 dbSNP
rs1165525561 47 dbSNP
rs758029217 52 dbSNP
rs1380666074 60 dbSNP
rs1339744911 69 dbSNP
rs752844806 72 dbSNP
rs1314525957 78 dbSNP
rs758890670 88 dbSNP
rs377003478 90 dbSNP
rs111385150 93 dbSNP
rs565399420 95 dbSNP
rs1367223243 104 dbSNP
rs80041165 114 dbSNP
rs1287072535 120 dbSNP
rs1452717370 121 dbSNP
rs941035021 123 dbSNP
rs1354055358 138 dbSNP
rs1037886147 146 dbSNP
rs1422424536 151 dbSNP
rs899419132 160 dbSNP
rs555103516 174 dbSNP
rs758597761 175 dbSNP
rs929597728 179 dbSNP
rs1047870247 182 dbSNP
rs1227555378 183 dbSNP
rs895999960 195 dbSNP
rs193259612 196 dbSNP
rs1247720239 199 dbSNP
rs1044891697 200 dbSNP
rs1398789095 203 dbSNP
rs905823870 225 dbSNP
rs1291361815 229 dbSNP
rs1000204658 251 dbSNP
rs764235854 252 dbSNP
rs1344431853 258 dbSNP
rs1033044511 261 dbSNP
rs751610425 265 dbSNP
rs1295120942 266 dbSNP
rs543869203 267 dbSNP
rs1244353612 273 dbSNP
rs1364523428 278 dbSNP
rs1168859489 288 dbSNP
rs1471989518 297 dbSNP
rs1431044133 298 dbSNP
rs1010187305 310 dbSNP
rs1029470127 312 dbSNP
rs1043782 314 dbSNP
rs532501974 315 dbSNP
rs1426280988 322 dbSNP
rs1202089834 325 dbSNP
rs1409060641 335 dbSNP
rs985189379 338 dbSNP
rs910972600 341 dbSNP
rs1206149017 346 dbSNP
rs1481658271 349 dbSNP
rs1359735542 350 dbSNP
rs1249750613 353 dbSNP
rs1226575076 357 dbSNP
rs1312744704 361 dbSNP
rs1303361366 365 dbSNP
rs1221409039 370 dbSNP
rs962471207 370 dbSNP
rs1308189857 374 dbSNP
rs1411348741 375 dbSNP
rs1393671159 381 dbSNP
rs973709672 389 dbSNP
rs1461890124 390 dbSNP
rs780857982 405 dbSNP
rs1378672561 409 dbSNP
rs3313 410 dbSNP
rs1426228100 411 dbSNP
rs918273493 412 dbSNP
rs541002014 413 dbSNP
rs1479625387 418 dbSNP
rs929545276 433 dbSNP
rs1183147835 446 dbSNP
rs1048459576 461 dbSNP
rs1401197784 462 dbSNP
rs745639660 472 dbSNP
rs1320149313 478 dbSNP
rs950265102 481 dbSNP
rs1044450826 485 dbSNP
rs1322555237 494 dbSNP
rs1288810743 502 dbSNP
rs144321800 508 dbSNP
rs1333660163 513 dbSNP
rs1315540593 514 dbSNP
rs1000321098 516 dbSNP
rs1054446688 519 dbSNP
rs529981937 521 dbSNP
rs1403729944 524 dbSNP
rs1339269124 528 dbSNP
rs1468757737 529 dbSNP
rs1405782717 544 dbSNP
rs1307145865 545 dbSNP
rs1455705088 556 dbSNP
rs1349980619 579 dbSNP
rs1205822246 584 dbSNP
rs1424401027 589 dbSNP
rs1245114329 590 dbSNP
rs891816580 592 dbSNP
rs371085485 604 dbSNP
rs1460850053 605 dbSNP
rs531386655 610 dbSNP
rs1286872148 618 dbSNP
rs1010132175 620 dbSNP
rs1203423729 622 dbSNP
rs759685558 644 dbSNP
rs1348295510 650 dbSNP
rs1259715429 657 dbSNP
rs1446052261 660 dbSNP
rs1176450596 676 dbSNP
rs1384351647 681 dbSNP
rs1312342525 686 dbSNP
rs1451058954 693 dbSNP
rs1362886885 704 dbSNP
rs1382643614 704 dbSNP
rs1042663656 707 dbSNP
rs1007130581 710 dbSNP
rs1195246928 710 dbSNP
rs1248512607 710 dbSNP
rs1260854071 710 dbSNP
rs1352357583 710 dbSNP
rs1402743519 710 dbSNP
rs1445064803 710 dbSNP
rs758224495 710 dbSNP
rs76098501 710 dbSNP
rs955202724 710 dbSNP
rs1159809214 711 dbSNP
rs1399962357 712 dbSNP
rs79588397 712 dbSNP
rs1413902214 713 dbSNP
rs1271215618 717 dbSNP
rs1433581166 725 dbSNP
rs1325034699 731 dbSNP
rs1318130123 732 dbSNP
rs1367634918 732 dbSNP
rs1327574465 733 dbSNP
rs1365203020 734 dbSNP
rs1408085606 737 dbSNP
rs1444331764 740 dbSNP
rs1390940741 741 dbSNP
rs1307295057 745 dbSNP
rs764186642 761 dbSNP
rs529901123 766 dbSNP
rs1199257908 775 dbSNP
rs1018148783 776 dbSNP
rs1266256232 782 dbSNP
rs144659234 787 dbSNP
rs184097066 787 dbSNP
rs1343490618 789 dbSNP
rs112471179 796 dbSNP
rs1264121383 798 dbSNP
rs1221350887 805 dbSNP
rs1462897451 806 dbSNP
rs563471945 807 dbSNP
rs1224449443 809 dbSNP
rs1347793756 817 dbSNP
rs951067953 817 dbSNP
rs1249300566 819 dbSNP
rs1404631314 825 dbSNP
rs4579494 836 dbSNP
rs1355168972 838 dbSNP
rs1438103547 853 dbSNP
rs983680830 864 dbSNP
rs1183349219 865 dbSNP
rs761168065 867 dbSNP
rs1173105074 868 dbSNP
rs1312138624 878 dbSNP
rs1427021476 878 dbSNP
rs1481258377 878 dbSNP
rs530635719 879 dbSNP
rs950364530 880 dbSNP
rs1044955156 881 dbSNP
rs1436742674 881 dbSNP
rs927474297 887 dbSNP
rs78509021 892 dbSNP
rs1431392032 893 dbSNP
rs1281832977 896 dbSNP
rs142140385 901 dbSNP
rs768224588 903 dbSNP
rs1223105950 905 dbSNP
rs1374279362 906 dbSNP
rs1281515321 909 dbSNP
rs1440041163 910 dbSNP
rs936042747 918 dbSNP
rs570542482 930 dbSNP
rs1463801207 931 dbSNP
rs1337304695 953 dbSNP
rs34203247 993 dbSNP
rs1470947915 999 dbSNP
rs1054563599 1001 dbSNP
rs1175492298 1004 dbSNP
rs113784638 1012 dbSNP
rs1409637353 1021 dbSNP
rs1396028594 1026 dbSNP
rs1175130902 1035 dbSNP
rs187833453 1036 dbSNP
rs546609713 1042 dbSNP
rs1469120567 1063 dbSNP
rs1392256679 1071 dbSNP
rs533402086 1089 dbSNP
rs1329470885 1103 dbSNP
rs747528787 1114 dbSNP
rs1261854693 1117 dbSNP
rs946048392 1124 dbSNP
rs142541037 1133 dbSNP
rs1286527044 1141 dbSNP
rs891036430 1141 dbSNP
rs1350026343 1144 dbSNP
rs1315880636 1146 dbSNP
rs764963918 1150 dbSNP
rs1018047056 1151 dbSNP
rs1336020230 1153 dbSNP
rs1431117446 1159 dbSNP
rs1251171024 1176 dbSNP
rs536899920 1177 dbSNP
rs1339621125 1183 dbSNP
rs1156484762 1187 dbSNP
rs554983876 1208 dbSNP
rs1197232584 1214 dbSNP
rs1264850008 1223 dbSNP
rs1385283637 1242 dbSNP
rs1490031489 1244 dbSNP
rs1442269579 1252 dbSNP
rs192460147 1254 dbSNP
rs1181798211 1263 dbSNP
rs995191639 1264 dbSNP
rs1025348836 1269 dbSNP
rs1213877475 1270 dbSNP
rs537229765 1274 dbSNP
rs951016003 1279 dbSNP
rs1270882556 1284 dbSNP
rs1292816023 1291 dbSNP
rs1248200991 1295 dbSNP
rs559132942 1301 dbSNP
rs1314208704 1302 dbSNP
rs576920781 1309 dbSNP
rs1024682291 1314 dbSNP
rs1363792393 1332 dbSNP
rs1373474991 1337 dbSNP
rs1286944366 1340 dbSNP
rs184086295 1351 dbSNP
rs1169822693 1356 dbSNP
rs559277839 1367 dbSNP
rs1424023336 1373 dbSNP
rs980394130 1377 dbSNP
rs1384143663 1384 dbSNP
rs574517243 1395 dbSNP
rs1347934131 1414 dbSNP
rs143366565 1422 dbSNP
rs1488178564 1428 dbSNP
rs563421546 1430 dbSNP
rs1327341122 1437 dbSNP
rs1230108411 1449 dbSNP
rs1489878517 1449 dbSNP
rs990200848 1452 dbSNP
rs1309145125 1456 dbSNP
rs530862761 1458 dbSNP
rs1293378381 1470 dbSNP
rs1213718260 1474 dbSNP
rs568661348 1475 dbSNP
rs551837982 1480 dbSNP
rs1284804772 1484 dbSNP
rs1358299589 1488 dbSNP
rs1402783815 1493 dbSNP
rs60530611 1498 dbSNP
rs746578011 1504 dbSNP
rs1487251426 1505 dbSNP
rs1356734528 1506 dbSNP
rs1463095215 1506 dbSNP
rs1168968695 1532 dbSNP
rs946194363 1534 dbSNP
rs1430514115 1538 dbSNP
rs1201839632 1541 dbSNP
rs1479603383 1545 dbSNP
rs1266981083 1550 dbSNP
rs188766347 1553 dbSNP
rs891154476 1556 dbSNP
rs1249483954 1560 dbSNP
rs528152851 1566 dbSNP
rs372784467 1587 dbSNP
rs754459743 1600 dbSNP
rs898293326 1607 dbSNP
rs1221270217 1614 dbSNP
rs1383561679 1621 dbSNP
rs995306138 1626 dbSNP
rs1424335868 1630 dbSNP
rs1392563126 1638 dbSNP
rs1370545072 1639 dbSNP
rs1296951630 1641 dbSNP
rs1025465927 1643 dbSNP
rs886855592 1646 dbSNP
rs1013360167 1651 dbSNP
rs1025032955 1654 dbSNP
rs1451749439 1670 dbSNP
rs1377225105 1673 dbSNP
rs1182810049 1677 dbSNP
rs1288753259 1682 dbSNP
rs1386317536 1689 dbSNP
rs1384215941 1690 dbSNP
rs796434181 1697 dbSNP
rs568032855 1701 dbSNP
rs113567191 1717 dbSNP
rs1034610817 1718 dbSNP
rs1244923926 1720 dbSNP
rs1201482895 1729 dbSNP
rs372560655 1735 dbSNP
rs1344044976 1738 dbSNP
rs1350805435 1746 dbSNP
rs1240826972 1747 dbSNP
rs533762425 1747 dbSNP
rs1261171079 1749 dbSNP
rs1307957079 1768 dbSNP
rs56077534 1774 dbSNP
rs764323615 1776 dbSNP
rs758363232 1778 dbSNP
rs1384120261 1780 dbSNP
rs550583052 1780 dbSNP
rs570230357 1787 dbSNP
rs990315625 1790 dbSNP
rs748689591 1791 dbSNP
rs913428299 1798 dbSNP
rs1242341678 1802 dbSNP
rs1444209795 1805 dbSNP
rs1159356798 1816 dbSNP
rs1184388717 1824 dbSNP
rs1362105839 1830 dbSNP
rs1158080480 1837 dbSNP
rs770290941 1839 dbSNP
rs1244830829 1855 dbSNP
rs986914194 1860 dbSNP
rs866025843 1861 dbSNP
rs942717320 1870 dbSNP
rs1039560695 1871 dbSNP
rs919834206 1872 dbSNP
rs1284895234 1893 dbSNP
rs1246002401 1902 dbSNP
rs1360980348 1908 dbSNP
rs761691088 1912 dbSNP
rs1364863557 1915 dbSNP
rs192014496 1922 dbSNP
rs1455864661 1927 dbSNP
rs767444366 1937 dbSNP
rs1319442466 1947 dbSNP
rs558715364 1948 dbSNP
rs1335108245 1950 dbSNP
rs1046862405 1952 dbSNP
rs36118987 1953 dbSNP
rs184563970 1964 dbSNP
rs1405875130 1965 dbSNP
rs1383000335 1978 dbSNP
rs1453871207 1985 dbSNP
rs1338252753 1986 dbSNP
rs1425301754 1990 dbSNP
rs1387232543 2003 dbSNP
rs1161582056 2017 dbSNP
rs190199472 2021 dbSNP
rs1373398609 2031 dbSNP
rs1432542302 2043 dbSNP
rs1370731980 2044 dbSNP
rs886976079 2053 dbSNP
rs1261934649 2055 dbSNP
rs1013730122 2058 dbSNP
rs1490694553 2073 dbSNP
rs1289024825 2076 dbSNP
rs76228049 2077 dbSNP
rs553068093 2081 dbSNP
rs1046149814 2087 dbSNP
rs1356217873 2089 dbSNP
rs1271305271 2090 dbSNP
rs750308446 2094 dbSNP
rs1229996751 2097 dbSNP
rs1231038874 2100 dbSNP
rs904823786 2104 dbSNP
rs1405841222 2113 dbSNP
rs35866749 2118 dbSNP
rs541838086 2123 dbSNP
rs1404870074 2124 dbSNP
rs779822144 2126 dbSNP
rs1169583823 2128 dbSNP
rs1474301491 2129 dbSNP
rs1422731329 2134 dbSNP
rs1199675074 2145 dbSNP
rs1481237960 2146 dbSNP
rs1266373267 2150 dbSNP
rs749600246 2151 dbSNP
rs1245129209 2154 dbSNP
rs1479812443 2158 dbSNP
rs555309483 2159 dbSNP
rs748106356 2163 dbSNP
rs1408860932 2168 dbSNP
rs1421377622 2169 dbSNP
rs1257874610 2170 dbSNP
rs753547985 2172 dbSNP
rs1174846784 2181 dbSNP
rs1224321408 2183 dbSNP
rs1429244868 2188 dbSNP
rs1011866197 2195 dbSNP
rs545014970 2195 dbSNP
rs1336500285 2198 dbSNP
rs1330797327 2199 dbSNP
rs1464047115 2206 dbSNP
rs1179048596 2208 dbSNP
rs567333339 2222 dbSNP
rs1399241255 2223 dbSNP
rs1441114762 2229 dbSNP
rs1176841239 2230 dbSNP
rs1020840389 2231 dbSNP
rs967592272 2233 dbSNP
rs987253116 2234 dbSNP
rs912657290 2240 dbSNP
rs964131437 2242 dbSNP
rs1184573158 2243 dbSNP
rs975383270 2246 dbSNP
rs1238132441 2257 dbSNP
rs1204653966 2258 dbSNP
rs754566892 2265 dbSNP
rs1276768470 2274 dbSNP
rs1218919277 2278 dbSNP
rs931217796 2285 dbSNP
rs868172345 2289 dbSNP
rs182385280 2293 dbSNP
rs778399424 2298 dbSNP
rs1305951673 2300 dbSNP
rs1337322361 2301 dbSNP
rs1372294326 2305 dbSNP
rs575440050 2307 dbSNP
rs1233692462 2320 dbSNP
rs1174894662 2343 dbSNP
rs949255413 2344 dbSNP
rs1409492325 2352 dbSNP
rs747654742 2353 dbSNP
rs1046693102 2356 dbSNP
rs1438563094 2372 dbSNP
rs187376240 2375 dbSNP
rs771361882 2393 dbSNP
rs1197372436 2398 dbSNP
rs1268730771 2401 dbSNP
rs1184823136 2403 dbSNP
rs904937443 2405 dbSNP
rs1236137335 2417 dbSNP
rs781746412 2421 dbSNP
rs771126812 2423 dbSNP
rs1237981302 2438 dbSNP
rs1286642342 2438 dbSNP
rs1353080019 2462 dbSNP
rs893486438 2478 dbSNP
rs1417875093 2481 dbSNP
rs1376667588 2482 dbSNP
rs1409771410 2491 dbSNP
rs1170658618 2493 dbSNP
rs564225430 2497 dbSNP
rs1355922858 2515 dbSNP
rs1295976598 2520 dbSNP
rs1011815215 2534 dbSNP
rs1365721692 2535 dbSNP
rs1164751254 2557 dbSNP
rs1426118538 2559 dbSNP
rs1020539679 2560 dbSNP
rs967918302 2568 dbSNP
rs1475955961 2582 dbSNP
rs1008389203 2593 dbSNP
rs1346060754 2594 dbSNP
rs1214804374 2606 dbSNP
rs1020242980 2609 dbSNP
rs964079385 2611 dbSNP
rs1292652127 2614 dbSNP
rs1224588664 2628 dbSNP
rs975497911 2629 dbSNP
rs919898045 2630 dbSNP
rs1406735802 2639 dbSNP
rs1363895754 2650 dbSNP
rs1268177598 2658 dbSNP
rs138231001 2659 dbSNP
rs1399066743 2666 dbSNP
rs189383231 2669 dbSNP
rs1455956279 2670 dbSNP
rs561749941 2670 dbSNP
rs1348595385 2671 dbSNP
rs1344599401 2676 dbSNP
rs1164701743 2677 dbSNP
rs1410871763 2683 dbSNP
rs1220334731 2704 dbSNP
rs180939735 2713 dbSNP
rs1191748194 2725 dbSNP
rs550301901 2729 dbSNP
rs1477639688 2736 dbSNP
rs1490647783 2737 dbSNP
rs1202161675 2745 dbSNP
rs1240896703 2757 dbSNP
rs981947604 2758 dbSNP
rs1264719092 2784 dbSNP
rs1205207371 2786 dbSNP
rs1309017056 2791 dbSNP
rs142725480 2793 dbSNP
rs1421183952 2797 dbSNP
rs1345699821 2798 dbSNP
rs937713411 2805 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuaggaccaAGACAGGGAGUGAUc 5'
                    |||   ::|||||| 
Target 5' ----------UCU---UUUCACUAa 3'
 		1 - 12
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001204878 | 3UTR | AAAUUAACCUUGAUAUAAUACUAACUAAAGUAGAAAGUUUAAAAAGUAGAGAUUUUAGUCUUUUCACUAAUGUCCUUUUACUGUUCCAAGACCCAGCCUUGCAUUUAGCUAUCAUGCCUACGUCCUGUCUUCCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001204878 | 3UTR | ACCUUGAUAUAAUACUAACUAAAGUAGAAAGUUUAAAAAGUAGAGAUUUUAGUCUUUUCACUAAUGUCCUUUUACUGUUCCAAGACCCAGCCUUGCAUUUAGCUAUCAUGCCUACGUCCUGUCUUCCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001204878 | 3UTR | GAAAUUAACCUUGAUAUAAUACUAACUAAAGUAGAAAGUUUAAAAAGUAGAGAUUUUAGUCUUUUCACUAAUGUCCUUUUACUGUUCCAAGACCCAGCCUUGCAUUUAGCUAUCAUGCCUACGUCCUGUCUUCCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001204878 | 3UTR | AAAUUAACCUUGAUAUAAUACUAACUAAAGUAGAAAGUUUAAAAAGUAGAGAUUUUAGUCUUUUCACUAAUGUCCUUUUACUGUUCCAAGACCCAGCCUUGCAUUUAGCUAUCAUGCCUACGUCCUGUCUUCCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001204878 | 3UTR | ACCUUGAUAUAAUACUAACUAAAGUAGAAAGUUUAAAAAGUAGAGAUUUUAGUCUUUUCACUAAUGUCCUUUUACUGUUCCAAGACCCAGCCUUGCAUUUAGCUAUCAUGCCUACGUCCUGUCUUCCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001204878 | 3UTR | GAUAUAAUACUAACUAAAGUAGAAAGUUUAAAAAGUAGAGAUUUUAGUCUUUUCACUAAUGUCCUUUUACUGUUCCAAGACCCAGCCUUGCAUUUAGCUAUCAUGCCUACGUCCUGUCUUCCAGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000287322.4 | 3UTR | UCUUUUCACUAAUGUCCUUUUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.46 5.7e-2 0.319 1.4e-1 13 Click to see details
GSE28544 Breast cancer -0.175 2.1e-1 -0.113 3.0e-1 24 Click to see details
GSE19783 ER+ ER+ breast cancer -0.159 2.5e-1 -0.080 3.7e-1 20 Click to see details
GSE17498 Multiple myeloma -0.094 2.8e-1 -0.224 8.2e-2 40 Click to see details
GSE19783 ER- ER- breast cancer 0.059 3.0e-1 0.128 1.3e-1 79 Click to see details
GSE26953 Aortic valvular endothelial cells -0.108 3.1e-1 -0.070 3.7e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.086 3.2e-1 -0.079 3.3e-1 32 Click to see details
GSE19536 Breast cancer 0.042 3.4e-1 0.070 2.4e-1 100 Click to see details
GSE38226 Liver fibrosis -0.09 3.5e-1 0.055 4.1e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.063 4.0e-1 -0.150 2.6e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.052 4.0e-1 -0.160 2.2e-1 25 Click to see details
GSE21687 Ependynoma primary tumors -0.015 4.5e-1 -0.051 3.4e-1 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.014 4.7e-1 -0.013 4.8e-1 23 Click to see details
GSE19350 CNS germ cell tumors 0.007 4.9e-1 0.070 4.1e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.007 4.9e-1 0.070 4.1e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.007 4.9e-1 0.070 4.1e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054764 ANGPTL1 angiopoietin like 1 3 1
MIRT066171 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT069409 ZFYVE21 zinc finger FYVE-type containing 21 2 8
MIRT102284 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 4
MIRT107595 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 6
MIRT178618 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT182407 TIPRL TOR signaling pathway regulator 2 4
MIRT186552 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT273662 HOXC8 homeobox C8 2 2
MIRT283191 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT284890 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT347670 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT400222 SLC35F6 solute carrier family 35 member F6 2 2
MIRT403517 ASPH aspartate beta-hydroxylase 2 2
MIRT442251 DCTN5 dynactin subunit 5 2 2
MIRT443023 SDR39U1 short chain dehydrogenase/reductase family 39U member 1 2 2
MIRT443097 RNF20 ring finger protein 20 2 2
MIRT444560 TRA2B transformer 2 beta homolog 2 2
MIRT445696 PRKG1 protein kinase, cGMP-dependent, type I 2 2
MIRT454084 TMEM209 transmembrane protein 209 2 2
MIRT455463 LYPLA2 lysophospholipase II 2 2
MIRT456653 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT458147 LYRM4 LYR motif containing 4 2 6
MIRT467073 SRRD SRR1 domain containing 2 4
MIRT467245 SPPL2A signal peptide peptidase like 2A 2 2
MIRT468246 SFXN4 sideroflexin 4 2 2
MIRT471589 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT476639 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT482433 ADM adrenomedullin 2 10
MIRT486848 PERP PERP, TP53 apoptosis effector 2 6
MIRT489656 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT493441 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT493841 FOXN3 forkhead box N3 2 4
MIRT501378 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT509679 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510280 MED28 mediator complex subunit 28 2 2
MIRT512221 ATXN3 ataxin 3 2 6
MIRT514030 BNIP2 BCL2 interacting protein 2 2 2
MIRT521375 RDX radixin 2 4
MIRT521444 RAD51 RAD51 recombinase 2 2
MIRT526055 CBR1 carbonyl reductase 1 2 2
MIRT528658 FUNDC2 FUN14 domain containing 2 2 2
MIRT529975 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT544098 IPMK inositol polyphosphate multikinase 2 2
MIRT545579 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT547424 MED4 mediator complex subunit 4 2 2
MIRT548955 CD2AP CD2 associated protein 2 2
MIRT549537 NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 2 4
MIRT552550 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554640 ROBO1 roundabout guidance receptor 1 2 2
MIRT564904 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT565578 SLC6A8 solute carrier family 6 member 8 2 2
MIRT568312 BAG4 BCL2 associated athanogene 4 2 2
MIRT617891 PTCHD3 patched domain containing 3 2 2
MIRT621892 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT642850 RNF135 ring finger protein 135 2 2
MIRT665395 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT697879 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT698492 THOC2 THO complex 2 2 2
MIRT701227 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT701872 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT707045 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT715216 NPVF neuropeptide VF precursor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-921 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miR-921 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-921 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-921 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-921 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-921 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-miR-921 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-921 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-921 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-921 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-921 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-921 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-921 Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-921 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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