miRTarBase - #MIRT568507


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pre-miRNA Information
pre-miRNA hsa-mir-2117   
Genomic Coordinates chr17: 43444806 - 43444885
Description Homo sapiens miR-2117 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2117
Sequence 51| UGUUCUCUUUGCCAAGGACAG |71
Evidence Experimental
Experiments 454
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1255384593 12 dbSNP
rs1227862494 14 dbSNP
rs1458444919 16 dbSNP
rs1309101018 17 dbSNP
rs1159219853 18 dbSNP
rs1344029538 19 dbSNP
rs747666550 20 dbSNP
rs770495894 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARF1   
Synonyms -
Description ADP ribosylation factor 1
Transcript NM_001024226   
Other Transcripts NM_001024227 , NM_001024228 , NM_001658   
Expression
Putative miRNA Targets on ARF1
3'UTR of ARF1
(miRNA target sites are highlighted)		 
>ARF1|NM_001024226|3'UTR
   1 ACGCGACCCCCCTCCCTCTCACTCCTCTTGCCCTCTGCTTTACTCTCATGTGGCAAACGTGCGGCTCGTGGTGTGAGTGC
  81 CAGAAGCTGCCTCCGTGGTTTGGTCACCGTGTGCATCGCACCGTGCTGTAAATGTGGCAGACGCAGCCTGCGGCCAGGCT
 161 TTTTATTTAATGTAAATAGTTTTTGTTTCCAATGAGGCAGTTTCTGGTACTCCTATGCAATATTACTCAGCTTTTTTTAT
 241 TGTAAAAAGAAAAATCAACTCACTGTTCAGTGCTGAGAGGGGATGTAGGCCCATGGGCACCTGGCCTCCAGGAGTCGCTG
 321 TGTTGGGAGAGCCGGCCACGCCCTTGGCTTTAGAGCTGTGTTGAAATCCATTTTGGTGGTTGGTTTTTAACCCAAACTCA
 401 GTGCATTTTTTAAAATAGTTAAGAATCCAAGTCGAGAACACTTGAACACACAGAAGGGAGACCCCGCCTAGCATAGATTT
 481 GCAGTTACGGCCTGGATGCCAGTCGCCAGCCCAGCTGTTCCCCTCGGGAACATGAGGTGGTGGTGGCGCAGCAGACTGCG
 561 ATCAATTCTGCATGGTCACAGTAGAGATCCCCGCAACTCGCTTGTCCTTGGGTCACCCTGCATTCCATAGCCATGTGCTT
 641 GTCCCTGTGCTCCCACGGTTCCCAGGGGCCAGGCTGGGAGCCCACAGCCACCCCACTATGCCGCAGGCCGCCCTACCCAC
 721 CTTCAGGCAGCCTATGGGACGCAGGGCCCCATCTGTCCCTCGGTCGCCGTGTGGCCAGAGTGGGTCCGTCGTCCCCAACA
 801 CTCGTGCTCGCTCAGACACTTTGGCAGGATGTCTGGGGCCTCACCAGCAGGAGCGCGTGCAAGCCGGGCAGGCGGTCCAC
 881 CTAGACCCACAGCCCCTCGGGAGCACCCCACCTCTGTGTGTGATGTAGCTTTCTCTCCCTCAGCCTGCAAGGGTCCGATT
 961 TGCCATCGAAAAAGACAACCTCTACTTTTTTCTTTTGTATTTTGATAAACACTGAAGCTGGAGCTGTTAAATTTATCTTG
1041 GGGAAACCTCAGAACTGGTCTATTTGGTGTCGTGGAACCTCTTACTGCTTTCAATACACGATTAGTAATCAACTGTTTTG
1121 TATACTTGTTTTCAGTTTTCATTTCGACAAACAAGCACTGTAATTATAGCTATTAGAATAAAATCTCTTAACTATTTCAA
1201 AAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCAGG---AACCG------UUUCUCUUGu 5'
            ||||   ||| |      ||||| ||| 
Target 5' ggGTCCGATTTGCCATCGAAAAAGACAACc 3'
 951 - 980 125.00 -8.30
2 
miRNA  3' gaCAG-GAACCGUUUCUCUUGu 5'
            ||| ||  |: ::||||:| 
Target 5' gaGTCGCTGTGTTGGGAGAGCc 3'
 312 - 333 123.00 -12.60
3 
miRNA  3' gacaggaaccguuuCUCUUGu 5'
                        |||||| 
Target 5' taagaatccaagtcGAGAACa 3'
 420 - 440 120.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28852468 3 COSMIC
COSN30492965 4 COSMIC
COSN26966518 5 COSMIC
COSN30153985 19 COSMIC
COSN30497169 24 COSMIC
COSN30156444 28 COSMIC
COSN31481498 59 COSMIC
COSN31605017 64 COSMIC
COSN30191321 72 COSMIC
COSN30520292 85 COSMIC
COSN30498621 109 COSMIC
COSN30104833 112 COSMIC
COSN31526900 118 COSMIC
COSN13521938 119 COSMIC
COSN506967 124 COSMIC
COSN30493395 144 COSMIC
COSN31662939 152 COSMIC
COSN31598012 153 COSMIC
COSN32037196 179 COSMIC
COSN31566768 184 COSMIC
COSN26642135 216 COSMIC
COSN31662566 225 COSMIC
COSN8637607 317 COSMIC
COSN25027482 321 COSMIC
COSN31481693 334 COSMIC
COSN31485405 340 COSMIC
COSN31590564 356 COSMIC
COSN22678181 360 COSMIC
COSN26585453 379 COSMIC
COSN31543127 548 COSMIC
COSN16052637 560 COSMIC
COSN20925316 567 COSMIC
COSN1099211 639 COSMIC
COSN31536095 651 COSMIC
COSN31583909 716 COSMIC
COSN31556664 763 COSMIC
COSN30545050 788 COSMIC
COSN31566322 839 COSMIC
COSN6025862 856 COSMIC
COSN31661808 865 COSMIC
COSN31577073 874 COSMIC
COSN30543744 957 COSMIC
COSN31523634 1089 COSMIC
COSN31588039 1146 COSMIC
COSN15742136 1184 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs546805625 3 dbSNP
rs777310017 4 dbSNP
rs374058258 5 dbSNP
rs368278171 6 dbSNP
rs746250685 7 dbSNP
rs200690064 8 dbSNP
rs1435879137 9 dbSNP
rs372012030 12 dbSNP
rs982949989 13 dbSNP
rs751679760 14 dbSNP
rs761910680 16 dbSNP
rs750370290 18 dbSNP
rs772454881 18 dbSNP
rs201854692 22 dbSNP
rs1283201358 32 dbSNP
rs1362238468 33 dbSNP
rs974205715 36 dbSNP
rs895067230 39 dbSNP
rs776199101 43 dbSNP
rs1271853169 44 dbSNP
rs1281344338 46 dbSNP
rs747063787 47 dbSNP
rs768897179 48 dbSNP
rs915870928 48 dbSNP
rs906260204 49 dbSNP
rs1225679129 54 dbSNP
rs1175698396 59 dbSNP
rs1405397975 60 dbSNP
rs185819366 63 dbSNP
rs948779677 64 dbSNP
rs1336032319 68 dbSNP
rs1044986290 69 dbSNP
rs1166824013 73 dbSNP
rs533722351 76 dbSNP
rs1390985720 91 dbSNP
rs1381942059 95 dbSNP
rs1025298363 96 dbSNP
rs1293895379 98 dbSNP
rs1239592326 105 dbSNP
rs1211355720 106 dbSNP
rs906488895 108 dbSNP
rs1342841974 109 dbSNP
rs1219780657 110 dbSNP
rs1283252811 116 dbSNP
rs1320770206 118 dbSNP
rs1297868331 119 dbSNP
rs1244862487 122 dbSNP
rs748843233 123 dbSNP
rs555307225 124 dbSNP
rs1448611129 125 dbSNP
rs568918854 129 dbSNP
rs747686177 130 dbSNP
rs892301595 134 dbSNP
rs1431701861 137 dbSNP
rs1371310832 141 dbSNP
rs983751851 143 dbSNP
rs1011048178 144 dbSNP
rs1018445979 148 dbSNP
rs964274745 152 dbSNP
rs1416355544 153 dbSNP
rs1157931649 156 dbSNP
rs1485344291 158 dbSNP
rs1203102356 160 dbSNP
rs1231635156 160 dbSNP
rs1265051958 162 dbSNP
rs1022057806 172 dbSNP
rs976922608 173 dbSNP
rs1478047230 175 dbSNP
rs922784186 178 dbSNP
rs899482669 183 dbSNP
rs977943181 189 dbSNP
rs925973998 191 dbSNP
rs935949419 193 dbSNP
rs1372433645 202 dbSNP
rs1431469626 211 dbSNP
rs1286367941 217 dbSNP
rs1178329051 220 dbSNP
rs1411602186 220 dbSNP
rs1351109902 221 dbSNP
rs996547523 225 dbSNP
rs1359900355 228 dbSNP
rs537897365 229 dbSNP
rs555105464 229 dbSNP
rs557821076 230 dbSNP
rs895036120 231 dbSNP
rs947972332 231 dbSNP
rs1161925664 232 dbSNP
rs1046213668 235 dbSNP
rs1251851861 239 dbSNP
rs578074868 241 dbSNP
rs1453305262 250 dbSNP
rs190969663 252 dbSNP
rs1487244374 265 dbSNP
rs184012798 267 dbSNP
rs1248090851 268 dbSNP
rs559423180 269 dbSNP
rs1385247393 275 dbSNP
rs983000891 282 dbSNP
rs1015693216 283 dbSNP
rs1230109476 294 dbSNP
rs993926187 295 dbSNP
rs1047210897 305 dbSNP
rs1385117841 309 dbSNP
rs962925269 310 dbSNP
rs1294323451 311 dbSNP
rs549568902 312 dbSNP
rs567491415 314 dbSNP
rs1430291117 317 dbSNP
rs1386862857 318 dbSNP
rs561622315 322 dbSNP
rs1803042 328 dbSNP
rs748699232 329 dbSNP
rs530513739 332 dbSNP
rs1220391642 334 dbSNP
rs1005145583 335 dbSNP
rs1017913018 340 dbSNP
rs544263833 341 dbSNP
rs1426683649 344 dbSNP
rs1191347500 350 dbSNP
rs1464184609 361 dbSNP
rs1245909685 363 dbSNP
rs1301379949 366 dbSNP
rs1210336433 371 dbSNP
rs189047528 372 dbSNP
rs964243921 374 dbSNP
rs553449887 377 dbSNP
rs1287775656 381 dbSNP
rs1231047385 384 dbSNP
rs772689927 388 dbSNP
rs1302073765 399 dbSNP
rs1214157967 400 dbSNP
rs1363264010 403 dbSNP
rs1029822091 404 dbSNP
rs967989735 414 dbSNP
rs977620615 422 dbSNP
rs1488464124 427 dbSNP
rs1401897216 444 dbSNP
rs1221504121 446 dbSNP
rs528958456 448 dbSNP
rs1266604378 449 dbSNP
rs1468036328 449 dbSNP
rs1489430955 457 dbSNP
rs1176181313 460 dbSNP
rs928628401 464 dbSNP
rs925993387 466 dbSNP
rs1190183994 467 dbSNP
rs939210649 469 dbSNP
rs1052368939 472 dbSNP
rs1425955899 472 dbSNP
rs372563172 475 dbSNP
rs533072312 476 dbSNP
rs763523737 478 dbSNP
rs1382425042 480 dbSNP
rs1204490526 487 dbSNP
rs1340218511 487 dbSNP
rs1300080214 488 dbSNP
rs1043846822 489 dbSNP
rs947941251 490 dbSNP
rs1398253083 496 dbSNP
rs1163348994 505 dbSNP
rs879430273 506 dbSNP
rs35381840 520 dbSNP
rs11541554 523 dbSNP
rs929762344 526 dbSNP
rs1050682598 527 dbSNP
rs1443958827 528 dbSNP
rs1185117794 534 dbSNP
rs1049309 535 dbSNP
rs1256777449 536 dbSNP
rs1353977584 536 dbSNP
rs1482081603 537 dbSNP
rs1276871756 542 dbSNP
rs1039358906 545 dbSNP
rs566673918 545 dbSNP
rs766862626 548 dbSNP
rs190655227 549 dbSNP
rs963186169 550 dbSNP
rs548867962 553 dbSNP
rs1288255085 554 dbSNP
rs995729445 555 dbSNP
rs376889700 560 dbSNP
rs568854378 561 dbSNP
rs1389532752 567 dbSNP
rs1480322587 573 dbSNP
rs999458048 578 dbSNP
rs1176890038 579 dbSNP
rs770784114 580 dbSNP
rs760809809 581 dbSNP
rs1158247792 589 dbSNP
rs766760036 589 dbSNP
rs928595746 591 dbSNP
rs940852074 593 dbSNP
rs1182959640 594 dbSNP
rs1451147922 600 dbSNP
rs1412076604 601 dbSNP
rs6920 607 dbSNP
rs557759351 610 dbSNP
rs1267893344 612 dbSNP
rs571623240 617 dbSNP
rs1227050344 619 dbSNP
rs1354497120 623 dbSNP
rs913841944 627 dbSNP
rs1289573130 628 dbSNP
rs534318618 631 dbSNP
rs1442299811 635 dbSNP
rs1330065216 636 dbSNP
rs1321112598 637 dbSNP
rs554035684 639 dbSNP
rs1388158418 642 dbSNP
rs1391133537 649 dbSNP
rs991540415 652 dbSNP
rs1455490056 656 dbSNP
rs574182209 657 dbSNP
rs182737956 658 dbSNP
rs1377066275 664 dbSNP
rs1043598845 669 dbSNP
rs78445387 675 dbSNP
rs1376011634 680 dbSNP
rs1201183448 681 dbSNP
rs757278530 686 dbSNP
rs1452436429 692 dbSNP
rs1247740665 694 dbSNP
rs1207186283 695 dbSNP
rs1466582665 696 dbSNP
rs921102371 697 dbSNP
rs1282108998 700 dbSNP
rs1381042768 703 dbSNP
rs187026506 704 dbSNP
rs1050817072 707 dbSNP
rs576840789 711 dbSNP
rs1003858777 714 dbSNP
rs1234902799 715 dbSNP
rs759971760 717 dbSNP
rs1371253660 719 dbSNP
rs1296465931 722 dbSNP
rs1037689305 735 dbSNP
rs1318821175 739 dbSNP
rs1295121122 741 dbSNP
rs1348356580 743 dbSNP
rs898783205 744 dbSNP
rs1063427 747 dbSNP
rs1478423763 747 dbSNP
rs1305702736 752 dbSNP
rs1023094964 753 dbSNP
rs76865338 754 dbSNP
rs564128136 759 dbSNP
rs767439441 760 dbSNP
rs1451660050 761 dbSNP
rs1249045110 762 dbSNP
rs1046899408 763 dbSNP
rs532852550 766 dbSNP
rs540332311 767 dbSNP
rs560041250 769 dbSNP
rs541637429 770 dbSNP
rs956005689 776 dbSNP
rs1182807295 779 dbSNP
rs1367004052 780 dbSNP
rs745567330 782 dbSNP
rs374538849 787 dbSNP
rs1270582173 788 dbSNP
rs191562404 789 dbSNP
rs988849065 791 dbSNP
rs913798981 792 dbSNP
rs3210485 797 dbSNP
rs1336168874 799 dbSNP
rs967955681 804 dbSNP
rs548800807 805 dbSNP
rs1050769389 808 dbSNP
rs921079892 810 dbSNP
rs779498954 811 dbSNP
rs1468880351 813 dbSNP
rs1802279 816 dbSNP
rs1181619814 822 dbSNP
rs184526515 823 dbSNP
rs912353393 827 dbSNP
rs1188917590 844 dbSNP
rs770829536 845 dbSNP
rs939682831 850 dbSNP
rs1036667174 854 dbSNP
rs1013005705 855 dbSNP
rs774901829 856 dbSNP
rs1803142 857 dbSNP
rs760208582 858 dbSNP
rs1354068586 860 dbSNP
rs981874669 866 dbSNP
rs1045054963 867 dbSNP
rs531523370 869 dbSNP
rs775361920 870 dbSNP
rs1003065399 874 dbSNP
rs951389696 875 dbSNP
rs1269393719 877 dbSNP
rs1803139 881 dbSNP
rs1416425221 899 dbSNP
rs1220391036 900 dbSNP
rs1278814707 905 dbSNP
rs1472566928 908 dbSNP
rs748971089 911 dbSNP
rs1318635156 912 dbSNP
rs1179358596 914 dbSNP
rs187703170 915 dbSNP
rs941237485 920 dbSNP
rs1276680479 923 dbSNP
rs1449590397 925 dbSNP
rs1444354712 932 dbSNP
rs118063156 934 dbSNP
rs1328369548 935 dbSNP
rs14892 935 dbSNP
rs1286427885 936 dbSNP
rs767722916 938 dbSNP
rs1241885104 941 dbSNP
rs1803143 941 dbSNP
rs1803141 951 dbSNP
rs1293099097 952 dbSNP
rs933736016 953 dbSNP
rs1021584669 956 dbSNP
rs1327021061 957 dbSNP
rs1457089178 958 dbSNP
rs567693214 960 dbSNP
rs1425001043 962 dbSNP
rs779388721 968 dbSNP
rs13338 969 dbSNP
rs1170303443 972 dbSNP
rs1487314594 978 dbSNP
rs777082212 981 dbSNP
rs979361364 983 dbSNP
rs1414671277 985 dbSNP
rs934906415 985 dbSNP
rs1464330598 986 dbSNP
rs1054671656 992 dbSNP
rs1317285986 993 dbSNP
rs748455009 996 dbSNP
rs1358360794 1000 dbSNP
rs144083555 1005 dbSNP
rs1028222153 1006 dbSNP
rs1210526348 1007 dbSNP
rs772748962 1012 dbSNP
rs1300712274 1016 dbSNP
rs74140959 1021 dbSNP
rs762166638 1022 dbSNP
rs1803140 1025 dbSNP
rs575222805 1030 dbSNP
rs1344806962 1036 dbSNP
rs1304496677 1045 dbSNP
rs986632635 1047 dbSNP
rs1434818670 1048 dbSNP
rs912403915 1049 dbSNP
rs1013122804 1052 dbSNP
rs550219266 1053 dbSNP
rs972912581 1063 dbSNP
rs919574631 1066 dbSNP
rs907301461 1069 dbSNP
rs931001114 1070 dbSNP
rs1430995930 1071 dbSNP
rs1044632409 1072 dbSNP
rs1193939697 1073 dbSNP
rs1002931958 1082 dbSNP
rs1220002971 1084 dbSNP
rs1188155109 1093 dbSNP
rs1026743246 1095 dbSNP
rs1487485060 1096 dbSNP
rs906152682 1098 dbSNP
rs950708696 1099 dbSNP
rs747474293 1100 dbSNP
rs112104801 1101 dbSNP
rs373235197 1103 dbSNP
rs1451550863 1105 dbSNP
rs1803041 1106 dbSNP
rs1022158289 1109 dbSNP
rs1247945739 1120 dbSNP
rs904507535 1124 dbSNP
rs1157613408 1129 dbSNP
rs1378128189 1134 dbSNP
rs975240317 1136 dbSNP
rs1388034120 1137 dbSNP
rs1428737389 1137 dbSNP
rs996621285 1146 dbSNP
rs1180102932 1147 dbSNP
rs560178180 1147 dbSNP
rs933746690 1149 dbSNP
rs1364793800 1154 dbSNP
rs149161835 1168 dbSNP
rs1204643513 1179 dbSNP
rs1340274989 1184 dbSNP
rs986531636 1186 dbSNP
rs1321558315 1188 dbSNP
rs924272189 1188 dbSNP
rs953931155 1189 dbSNP
rs1311138016 1192 dbSNP
rs1398307238 1195 dbSNP
rs1325489184 1196 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacaggaaccguuuCUCUUGu 5'
                        |||||| 
Target 5' ----aauccaagucGAGAACa 3'
 		1 - 17
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001658 | 3UTR | CCUUGGCUUUAGAGCUGUGUUGAAAUCCAUUUUGGUGGUUGGUUUUUAACCCAAACUCAGUGCAUUUUUUAAAAUAGUUAAGAAUCCAAGUCGAGAACACUUGAACACACAGAAGGGAGACCCCGCCUAGCAUAGAUUUGCAGUUACGGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001658 | 3UTR | GAGCUGUGUUGAAAUCCAUUUUGGUGGUUGGUUUUUAACCCAAACUCAGUGCAUUUUUUAAAAUAGUUAAGAAUCCAAGUCGAGAACACUUGAACACACAGAAGGGAGACCCCGCCUAGCAUAGAUUUGCAGUUACGGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001658 | 3UTR | CCUUGGCUUUAGAGCUGUGUUGAAAUCCAUUUUGGUGGUUGGUUUUUAACCCAAACUCAGUGCAUUUUUUAAAAUAGUUAAGAAUCCAAGUCGAGAACACUUGAACACACAGAAGGGAGACCCCGCCUAGCAUAGAUUUGCAGUUACGGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001658 | 3UTR | CCUUGGCUUUAGAGCUGUGUUGAAAUCCAUUUUGGUGGUUGGUUUUUAACCCAAACUCAGUGCAUUUUUUAAAAUAGUUAAGAAUCCAAGUCGAGAACACUUGAACACACAGAAGGGAGACCCCGCCUAGCAUAGAUUUGCAGUUACGGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001658 | 3UTR | UGUUGAAAUCCAUUUUGGUGGUUGGUUUUUAACCCAAACUCAGUGCAUUUUUUAAAAUAGUUAAGAAUCCAAGUCGAGAACACUUGAACACACAGAAGGGAGACCCCGCCUAGCAUAGAUUUGCAGUUACGGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001658 | 3UTR | CCUUGGCUUUAGAGCUGUGUUGAAAUCCAUUUUGGUGGUUGGUUUUUAACCCAAACUCAGUGCAUUUUUUAAAAUAGUUAAGAAUCCAAGUCGAGAACACUUGAACACACAGAAGGGAGACCCCGCCUAGCAUAGAUUUGCAGUUACGGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000540651.1 | 3UTR | AAUCCAAGUCGAGAACACUUGAACACACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
50 hsa-miR-2117 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080059 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT253245 ZNF264 zinc finger protein 264 2 4
MIRT279706 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT359344 TMEM167A transmembrane protein 167A 2 2
MIRT465598 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT479860 CCDC6 coiled-coil domain containing 6 2 2
MIRT512413 KIAA0391 KIAA0391 2 2
MIRT525342 TUBGCP4 tubulin gamma complex associated protein 4 2 2
MIRT528092 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT529254 TRIM4 tripartite motif containing 4 2 4
MIRT550782 VAV3 vav guanine nucleotide exchange factor 3 2 2
MIRT554467 SAMD12 sterile alpha motif domain containing 12 2 2
MIRT560164 ZNF286A zinc finger protein 286A 2 2
MIRT562613 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT568507 ARF1 ADP ribosylation factor 1 2 2
MIRT571536 ZNF286B zinc finger protein 286B 2 2
MIRT609660 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT612022 PAK6 p21 (RAC1) activated kinase 6 2 8
MIRT615677 NAV2 neuron navigator 2 2 2
MIRT616035 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT617771 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT628757 MX2 MX dynamin like GTPase 2 2 4
MIRT635089 AKIRIN1 akirin 1 2 2
MIRT638261 SIX1 SIX homeobox 1 2 2
MIRT638492 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT639400 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT641791 USP32 ubiquitin specific peptidase 32 2 2
MIRT642309 FPR1 formyl peptide receptor 1 2 2
MIRT645902 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT649701 ZNF175 zinc finger protein 175 2 2
MIRT656848 KLF13 Kruppel like factor 13 2 2
MIRT659911 CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 2 2
MIRT667275 NAV1 neuron navigator 1 2 2
MIRT674145 ZNF793 zinc finger protein 793 2 2
MIRT692839 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT698520 TFRC transferrin receptor 2 2
MIRT698731 STX6 syntaxin 6 2 4
MIRT700931 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT706080 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT710008 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT711059 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711285 PSME3 proteasome activator subunit 3 2 2
MIRT716172 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT716761 TRABD2A TraB domain containing 2A 2 2
MIRT718683 FZD2 frizzled class receptor 2 2 2
MIRT719675 SPDYE1 speedy/RINGO cell cycle regulator family member E1 2 2
MIRT721610 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT722188 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT725156 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT725239 PDE1B phosphodiesterase 1B 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-2117 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miR-2117 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-2117 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2117 Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-2117 Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-2117 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-2117 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-2117 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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