miRTarBase - #MIRT568759


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pre-miRNA Information
pre-miRNA hsa-mir-548t   
Genomic Coordinates chr4: 173268160 - 173268233
Description Homo sapiens miR-548t stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548t-3p
Sequence 46| AAAAACCACAAUUACUUUUGCACCA |70
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 4 + 173268206 29233923 MiREDiBase
A-to-I 3 4 + 173268207 29233923 MiREDiBase
A-to-I 4 4 + 173268208 29233923 MiREDiBase
A-to-I 10 4 + 173268214 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs73872515 5 dbSNP
rs1426966747 6 dbSNP
rs1158401109 21 dbSNP
rs943938928 24 dbSNP
Putative Targets

Gene Information
Gene Symbol MYBL1   
Synonyms A-MYB, AMYB
Description MYB proto-oncogene like 1
Transcript NM_001080416   
Other Transcripts NM_001144755   
Expression
Putative miRNA Targets on MYBL1
3'UTR of MYBL1
(miRNA target sites are highlighted)		 
>MYBL1|NM_001080416|3'UTR
   1 TTGTTATTAAAATTGATGAAATGCCCCACTCCCTTACTGCAGTCTCTACTAAATTAGGTTGCAGTGAAATTTTTCTCAAT
  81 TAGTTGTTTTTAAAGTTGTAAGATAGCCCTTTTAATACAGCATCTTTTTTCTATTCTATATAGTAGGCAGAAAGCTAGTA
 161 AGTCACTTAAGGGGTAGATAGTTTCATAGTTTATTTTTTAAGAGATGAGATTTTTAAAAATTGTTTTTAAAGAACAAGAT
 241 GGGAAAATAATAGAATGTTCATGGATTTCTAAAAGTAAATTCTCATATATTTTCTTCACAAGATATATGTTGCTACTCTC
 321 TTGATGCTGCAGTTTTGTTATAGATAGGTGTATGAGTATATATGATTTCTGAAATTAGTCTATGTATGGAAAGCACACAT
 401 GATTTTATGAAGTACTTTTGCCCATGTGCTGATTTACTTAGGCTACCATTTACAAAGAAACACATTGAAAAGGAATTTAA
 481 AGGAAGGATAGAAAGTTGCACTACTAATTTTTTGTTTTTTTTTTCAGAAGCAGTAAAATTAACTACAGTGTTAAATGTAT
 561 TTATTTGAGCATAGTACTGAAAACAAAAAGCATTCAAAAAAGAGTTTTTTCTTTATTAGTAAATAGTATTTTCTTAATCT
 641 CAGAGGAGCTGAGAGTTTTGTTGAATGTATTGTACAGTATGTAGGAGCAGGAGAACTTTGTAAATTGGAAAGAAGTCTGT
 721 TTTTATAATTTATTTTTATTTTTAAAGCTTAAATGTAGATATTTATACGTATACAGGGTGCCTAGAAGCCAATGTTGTTT
 801 CCTGTTATTACAGCTAACACAGTAAAGAATAATTTTGACTTTAAGTATGAAACAGTAGTAAGTTATAGCTGCAAAGAATA
 881 CAATATCTATACTGTATGTCACATCTACCTAAATGTTGCACTATGCCCTTTAAATCATGCTGGTTATAAAGTAGTTCTAA
 961 AAATGTACTAAATAATAATTTAATATTTTCTTTTTAAATTATATCGGGGGTGGTCATATACATTAATCTGGTGATTTGTA
1041 TATGTGTTTGAAATTTTTGCATTTTGTTTAAAAAATAATATGGTACCTTGGTCCCTAAAAACAGTCTGCACTTAGAAGTT
1121 TATATTTACTCAGTGTTTCAGAAGTGGAGAACATTATCTTTTATTTATAAAAATATTTTGTCCTTTTTTAAATGTTTTGT
1201 GTTTCTCTACAGGTTACAACAGTTGCTTCAGTTGCCTGTTTTAGGTGTTTGCACTTATTTTATTTCTTCTTGAAAGAATT
1281 TTTATTTGCTTTTGTGGTAGAGATTATATGTAATTTTTTTTCAGTCATATAATGGTGTGCTGTCAACTTAAACACTGACA
1361 GGTAAATAGAATTGTACACTGTAGTTTGAATTATTTATAATTGACACACTCTCTCCCTCTCCACTCCTGAAGTATGCTGC
1441 TATAGAAAATAGCAGAATCGGCTTGCTGCTACGAGAGAAGGAAAGAGCGACCACCACTTGCACTGTGTGAAAAGATAAAA
1521 AACAAATGATGGCAAGTTCTCAAGTTAACTAAATGGAATCAACCATTACCAGGCAAATTCTTGCAAATACCAAAATACTA
1601 CTATGCCTTATAAAACAAAATGAAAGCAGGTTAAGATTTTCTGCTCTGTTTGTATGTTAATAGAAATGGAAATACTAAGT
1681 ATTTTAATGCTTAGCTCTTGAACAGTAGACCTAAAAGGGTTTTAAGCTATTTAAATCTACTTGCTAGTTTTTGCATATTT
1761 TATATATATATATATTTATATATATATATAGTGAGAAGTGAAGAAAATGTATGGTACTAAGATTATGCCTTATTGATAAA
1841 TAGATAAACCAATTTGAATCCTCTTAGCATGTTTAAGTATGTTGATTGCTTTCTAATTAATGAACTTCTCACAGAAATTT
1921 CACTTAGTGAAACCAATGATTGTAGCAAACTCATACTGGATCATTTCAGTTACCTTGAACTAATAGCACATAATGGTTTT
2001 TTGTTGTTGTTGTTTTTAATGTAGCCCTTACCTGGATATACATAGTCTGCAATCACCAAAGTATAATATCTTGTAAGGCT
2081 ATATTTTTTAAAGCATATTTTTTCTTGAGCATTAAATTATCCTAAATGGTAATATATTGTGGATAAGTCTGGGCTTATTG
2161 GACATAATACATATTTGGGTTGGTACTGGTTGAATCCTTCAGTTAACTGCTTTGTTGCTTTTTGCAAGATTTTTTATCTT
2241 AAACATGTCAGGCATCTTAAGTCACCTTTATACTGTTTTGTTCCTCTGAGTTTCTTTCAGTATGTTATACAAATGCCAGA
2321 CATAACATGTAGCAGCCATACTTGCATGGAAACTGACTACACATACATAATACTGCATTTTATTGTAAGGTTTTCACATT
2401 AATACAGCAATTACCCTGACTAAATTGAGTTTTGTGATATATGGAAAACTTCATTGTAAGAGAATCTTGCATACAATGTT
2481 GACATATTAACATCCAAAATAAAGCATCTGTGTACAAGCTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' accacGUUUUCAU-UAACACCAAAAa 5'
               :|| || | ||  ||||||| 
Target 5' tgaacTAATAGCACATAATGGTTTTt 3'
 1976 - 2001 156.00 -6.00
2 
miRNA  3' accACGU---UUUCA------UUAA-CACCAAAAa 5'
             ||||   ||| |      |||| || ||||| 
Target 5' ggtTGCAGTGAAATTTTTCTCAATTAGTTGTTTTt 3'
 57 - 91 132.00 -6.50
3 
miRNA  3' accACGUUUUCAUUAACACCAAAAa 5'
             || :|||| || | || |||| 
Target 5' aatTG-GAAAG-AAGTCTGTTTTTa 3'
 703 - 725 132.00 -6.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31503172 28 COSMIC
COSN21244815 34 COSMIC
COSN20076318 48 COSMIC
COSN8519240 49 COSMIC
COSN30168681 56 COSMIC
COSN2285628 65 COSMIC
COSN30112207 74 COSMIC
COSN31493996 95 COSMIC
COSN31558114 179 COSMIC
COSN23300113 275 COSMIC
COSN28688958 295 COSMIC
COSN8096776 386 COSMIC
COSN29012657 514 COSMIC
COSN7675873 515 COSMIC
COSN21119684 621 COSMIC
COSN27359291 759 COSMIC
COSN31521273 768 COSMIC
COSN26646901 770 COSMIC
COSN8096775 1013 COSMIC
COSN31485517 1170 COSMIC
COSN31579454 1275 COSMIC
COSN8578110 1303 COSMIC
COSN31594758 1313 COSMIC
COSN31536491 1453 COSMIC
COSN31520727 1472 COSMIC
COSN31531868 1473 COSMIC
COSN9666333 1481 COSMIC
COSN17181742 1541 COSMIC
COSN31512770 1572 COSMIC
COSN17181741 1606 COSMIC
COSN28767030 1631 COSMIC
COSN31515518 1737 COSMIC
COSN23235258 1777 COSMIC
COSN17181743 1863 COSMIC
COSN31516239 1938 COSMIC
COSN17725487 2003 COSMIC
COSN17181740 2070 COSMIC
COSN31546684 2163 COSMIC
COSN23385505 2248 COSMIC
COSN26551524 2345 COSMIC
COSN16756581 2370 COSMIC
COSN31548717 2466 COSMIC
COSN26649709 2483 COSMIC
COSN8519239 2516 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751896536 1 dbSNP
rs766672793 3 dbSNP
rs892826375 4 dbSNP
rs367785536 25 dbSNP
rs1406732040 26 dbSNP
rs1413907886 27 dbSNP
rs374716760 28 dbSNP
rs1444599973 29 dbSNP
rs1346013100 30 dbSNP
rs1268624505 32 dbSNP
rs765360615 44 dbSNP
rs1321887381 46 dbSNP
rs1034216279 53 dbSNP
rs1012408421 57 dbSNP
rs1281773240 58 dbSNP
rs1352067876 63 dbSNP
rs1240060293 65 dbSNP
rs1001420053 68 dbSNP
rs1477862711 79 dbSNP
rs1362066593 101 dbSNP
rs1207674444 102 dbSNP
rs1261949600 115 dbSNP
rs1266280890 117 dbSNP
rs1055487722 120 dbSNP
rs1183430836 124 dbSNP
rs907012259 127 dbSNP
rs941087182 132 dbSNP
rs1164156553 133 dbSNP
rs574703266 136 dbSNP
rs749427324 138 dbSNP
rs1456232758 140 dbSNP
rs1390357855 143 dbSNP
rs1392200291 158 dbSNP
rs1256998624 166 dbSNP
rs1046675578 170 dbSNP
rs1210006626 172 dbSNP
rs533060729 186 dbSNP
rs570322566 194 dbSNP
rs1219266414 203 dbSNP
rs1339578371 206 dbSNP
rs1197213731 210 dbSNP
rs929925213 215 dbSNP
rs1456968183 218 dbSNP
rs1184094765 229 dbSNP
rs1340012509 234 dbSNP
rs1244961769 239 dbSNP
rs922539199 241 dbSNP
rs1186502619 250 dbSNP
rs977017971 253 dbSNP
rs550564485 257 dbSNP
rs1398046586 258 dbSNP
rs1220206385 262 dbSNP
rs1173125266 264 dbSNP
rs867911759 265 dbSNP
rs989575268 275 dbSNP
rs1047218477 282 dbSNP
rs1382039034 283 dbSNP
rs931285683 284 dbSNP
rs1303161192 285 dbSNP
rs1220062396 287 dbSNP
rs1031009425 288 dbSNP
rs1465382701 291 dbSNP
rs978084283 293 dbSNP
rs1403727246 297 dbSNP
rs1172752420 305 dbSNP
rs1264471002 306 dbSNP
rs919955119 317 dbSNP
rs1482194468 318 dbSNP
rs1199836967 319 dbSNP
rs1465682095 320 dbSNP
rs1318936265 324 dbSNP
rs1422378991 327 dbSNP
rs1430138521 328 dbSNP
rs1196079272 337 dbSNP
rs975635575 358 dbSNP
rs1177170747 359 dbSNP
rs1425240865 364 dbSNP
rs942966038 369 dbSNP
rs1464940201 374 dbSNP
rs971420452 378 dbSNP
rs1386088569 382 dbSNP
rs866007187 388 dbSNP
rs912694793 396 dbSNP
rs1339378233 397 dbSNP
rs1181599214 404 dbSNP
rs1302717631 411 dbSNP
rs1309961362 418 dbSNP
rs987364193 422 dbSNP
rs1260536699 423 dbSNP
rs1261286204 431 dbSNP
rs1012890155 448 dbSNP
rs1214255752 472 dbSNP
rs967608758 487 dbSNP
rs1488048336 491 dbSNP
rs895331533 504 dbSNP
rs1427327563 516 dbSNP
rs1431551384 523 dbSNP
rs1019972632 524 dbSNP
rs1175969459 525 dbSNP
rs1422071771 525 dbSNP
rs199738311 525 dbSNP
rs1005263491 526 dbSNP
rs1360319605 546 dbSNP
rs531895194 554 dbSNP
rs563222820 555 dbSNP
rs888196288 563 dbSNP
rs1364840034 567 dbSNP
rs1385801760 569 dbSNP
rs1199899125 574 dbSNP
rs1317339255 575 dbSNP
rs1256290389 577 dbSNP
rs1247109605 578 dbSNP
rs1341251391 579 dbSNP
rs1312279010 584 dbSNP
rs1237875884 598 dbSNP
rs1284982782 602 dbSNP
rs1222543284 604 dbSNP
rs1359947827 604 dbSNP
rs1046752169 605 dbSNP
rs770698072 605 dbSNP
rs957006420 608 dbSNP
rs549162852 624 dbSNP
rs1190625117 625 dbSNP
rs1033993952 627 dbSNP
rs1442041043 641 dbSNP
rs1466115919 643 dbSNP
rs76043847 649 dbSNP
rs1165605580 652 dbSNP
rs1166470045 653 dbSNP
rs1425734948 653 dbSNP
rs1347819613 672 dbSNP
rs1435327125 675 dbSNP
rs1459022222 677 dbSNP
rs1368617544 680 dbSNP
rs1378515429 681 dbSNP
rs1444449866 684 dbSNP
rs1163705772 686 dbSNP
rs1308496921 691 dbSNP
rs1383250048 693 dbSNP
rs942582056 695 dbSNP
rs911064610 696 dbSNP
rs1320071651 708 dbSNP
rs971728171 711 dbSNP
rs1221145221 712 dbSNP
rs1258735304 727 dbSNP
rs1459186559 730 dbSNP
rs1177285363 733 dbSNP
rs1238177295 747 dbSNP
rs1024260415 750 dbSNP
rs989272604 757 dbSNP
rs1183906028 759 dbSNP
rs1005122341 760 dbSNP
rs781766494 768 dbSNP
rs867777872 769 dbSNP
rs970772834 776 dbSNP
rs1179787413 778 dbSNP
rs1463665523 789 dbSNP
rs995606110 792 dbSNP
rs1249070200 796 dbSNP
rs991095472 798 dbSNP
rs372960521 800 dbSNP
rs1357155339 801 dbSNP
rs959578333 807 dbSNP
rs1265074073 811 dbSNP
rs898478804 812 dbSNP
rs1039732359 827 dbSNP
rs1356973055 831 dbSNP
rs1311250381 841 dbSNP
rs942747985 844 dbSNP
rs1376009624 845 dbSNP
rs181983434 847 dbSNP
rs369301495 861 dbSNP
rs1390910434 869 dbSNP
rs1025327480 876 dbSNP
rs76077785 882 dbSNP
rs189376264 889 dbSNP
rs1236039054 891 dbSNP
rs1422415852 892 dbSNP
rs989834425 895 dbSNP
rs1193926942 896 dbSNP
rs900848276 902 dbSNP
rs1476642436 909 dbSNP
rs1266305877 910 dbSNP
rs1169256426 913 dbSNP
rs1402332860 920 dbSNP
rs957121260 932 dbSNP
rs1416046346 942 dbSNP
rs1332166260 945 dbSNP
rs926927133 955 dbSNP
rs1431296133 964 dbSNP
rs1381801985 965 dbSNP
rs980168782 966 dbSNP
rs1439472495 969 dbSNP
rs1277600852 970 dbSNP
rs971127199 978 dbSNP
rs1362504114 985 dbSNP
rs1201716055 988 dbSNP
rs1221404859 990 dbSNP
rs1452253690 994 dbSNP
rs1277201510 995 dbSNP
rs1024625628 998 dbSNP
rs747507175 1005 dbSNP
rs1041073332 1011 dbSNP
rs1265796050 1014 dbSNP
rs1487079579 1018 dbSNP
rs1006809733 1019 dbSNP
rs950504089 1032 dbSNP
rs1489367563 1038 dbSNP
rs1287050710 1040 dbSNP
rs889704109 1059 dbSNP
rs1420248646 1079 dbSNP
rs143363878 1081 dbSNP
rs1358426192 1104 dbSNP
rs1398330808 1115 dbSNP
rs995554084 1140 dbSNP
rs1297874523 1153 dbSNP
rs898571706 1153 dbSNP
rs936475915 1163 dbSNP
rs923746275 1167 dbSNP
rs1241542499 1189 dbSNP
rs1042490416 1198 dbSNP
rs1039827576 1199 dbSNP
rs917928267 1205 dbSNP
rs991227066 1207 dbSNP
rs780348890 1209 dbSNP
rs758475071 1211 dbSNP
rs1235375321 1225 dbSNP
rs1245633568 1229 dbSNP
rs1440195865 1233 dbSNP
rs1160408785 1235 dbSNP
rs746911031 1245 dbSNP
rs959651450 1247 dbSNP
rs1418939814 1252 dbSNP
rs1158197805 1255 dbSNP
rs1391648812 1258 dbSNP
rs1331158082 1266 dbSNP
rs1051755018 1269 dbSNP
rs575448177 1272 dbSNP
rs1402590131 1274 dbSNP
rs1370366478 1280 dbSNP
rs913362942 1300 dbSNP
rs575936174 1301 dbSNP
rs1298442877 1303 dbSNP
rs936208210 1304 dbSNP
rs927043531 1306 dbSNP
rs1375146280 1307 dbSNP
rs555873703 1311 dbSNP
rs1266420596 1314 dbSNP
rs950900676 1322 dbSNP
rs1207735392 1323 dbSNP
rs1457863822 1326 dbSNP
rs1026868198 1327 dbSNP
rs539471212 1330 dbSNP
rs1439019513 1342 dbSNP
rs1478674004 1346 dbSNP
rs1187911397 1348 dbSNP
rs965460434 1353 dbSNP
rs1019315156 1369 dbSNP
rs1161724716 1387 dbSNP
rs1006552110 1388 dbSNP
rs777442165 1397 dbSNP
rs1377583764 1401 dbSNP
rs757033622 1412 dbSNP
rs889735487 1421 dbSNP
rs1478846468 1423 dbSNP
rs1053684609 1424 dbSNP
rs916936744 1442 dbSNP
rs149207980 1443 dbSNP
rs1000755844 1454 dbSNP
rs758143885 1459 dbSNP
rs983752105 1460 dbSNP
rs1042576149 1471 dbSNP
rs950618139 1472 dbSNP
rs917989310 1475 dbSNP
rs573025203 1488 dbSNP
rs553224156 1489 dbSNP
rs1257979319 1499 dbSNP
rs866854247 1505 dbSNP
rs539504557 1538 dbSNP
rs1440524047 1551 dbSNP
rs570559933 1552 dbSNP
rs1185682561 1562 dbSNP
rs1398693195 1563 dbSNP
rs973228185 1565 dbSNP
rs372035031 1573 dbSNP
rs145410594 1600 dbSNP
rs1421622378 1605 dbSNP
rs747890218 1606 dbSNP
rs1018769483 1607 dbSNP
rs1461878791 1616 dbSNP
rs753562338 1617 dbSNP
rs73261704 1631 dbSNP
rs1404764833 1646 dbSNP
rs1221088963 1650 dbSNP
rs1394724170 1654 dbSNP
rs909191129 1657 dbSNP
rs114829583 1661 dbSNP
rs761378845 1674 dbSNP
rs1010415758 1675 dbSNP
rs1306461156 1676 dbSNP
rs1233839080 1677 dbSNP
rs1257754599 1694 dbSNP
rs1482144160 1703 dbSNP
rs1429643210 1710 dbSNP
rs950932822 1716 dbSNP
rs919434620 1717 dbSNP
rs1196151466 1741 dbSNP
rs1415438503 1743 dbSNP
rs892033736 1748 dbSNP
rs1428037353 1758 dbSNP
rs549224354 1760 dbSNP
rs976653450 1764 dbSNP
rs1464986857 1765 dbSNP
rs1173360560 1768 dbSNP
rs1054658559 1774 dbSNP
rs529565203 1775 dbSNP
rs1296001692 1776 dbSNP
rs796410626 1776 dbSNP
rs965191626 1776 dbSNP
rs796065569 1778 dbSNP
rs1360653176 1784 dbSNP
rs906064017 1788 dbSNP
rs1019768844 1789 dbSNP
rs985148381 1790 dbSNP
rs1000788530 1791 dbSNP
rs1466456277 1791 dbSNP
rs953706011 1791 dbSNP
rs902427122 1811 dbSNP
rs1044502783 1812 dbSNP
rs1467238448 1814 dbSNP
rs11786211 1817 dbSNP
rs1259257144 1825 dbSNP
rs949830914 1832 dbSNP
rs1424471325 1841 dbSNP
rs200492226 1843 dbSNP
rs916875435 1856 dbSNP
rs983149206 1859 dbSNP
rs1193612966 1860 dbSNP
rs754605263 1861 dbSNP
rs1381273086 1868 dbSNP
rs928981820 1871 dbSNP
rs560279354 1874 dbSNP
rs546826947 1875 dbSNP
rs1239460953 1877 dbSNP
rs1189277414 1879 dbSNP
rs920510250 1880 dbSNP
rs973354099 1887 dbSNP
rs1344177020 1896 dbSNP
rs1458103438 1903 dbSNP
rs1442799584 1910 dbSNP
rs143975532 1913 dbSNP
rs1055639551 1914 dbSNP
rs1309938674 1922 dbSNP
rs760661689 1929 dbSNP
rs1378832527 1932 dbSNP
rs1237765450 1933 dbSNP
rs1283298530 1934 dbSNP
rs1316513970 1947 dbSNP
rs1222616084 1953 dbSNP
rs1267278190 1955 dbSNP
rs112630407 1956 dbSNP
rs1258201201 1957 dbSNP
rs1213606886 1963 dbSNP
rs1239377169 1973 dbSNP
rs1213506113 1975 dbSNP
rs775398307 1981 dbSNP
rs1177092811 1989 dbSNP
rs1407761045 1990 dbSNP
rs887785132 1994 dbSNP
rs985926082 1997 dbSNP
rs532447665 2003 dbSNP
rs1331942633 2015 dbSNP
rs929597890 2015 dbSNP
rs184183692 2024 dbSNP
rs575556738 2025 dbSNP
rs1444510610 2026 dbSNP
rs1278684835 2027 dbSNP
rs1379683492 2033 dbSNP
rs1382581007 2033 dbSNP
rs1229073462 2038 dbSNP
rs1315180767 2042 dbSNP
rs1332747447 2045 dbSNP
rs1232686345 2050 dbSNP
rs1258796128 2052 dbSNP
rs1459453900 2056 dbSNP
rs1203066411 2061 dbSNP
rs372208236 2073 dbSNP
rs1232645994 2075 dbSNP
rs1483808785 2081 dbSNP
rs1010173786 2084 dbSNP
rs1335314067 2104 dbSNP
rs553911660 2107 dbSNP
rs944851440 2126 dbSNP
rs140244577 2129 dbSNP
rs1328146627 2130 dbSNP
rs1169777222 2132 dbSNP
rs1359517743 2137 dbSNP
rs1000410876 2145 dbSNP
rs905985072 2158 dbSNP
rs1044585710 2163 dbSNP
rs949808338 2164 dbSNP
rs1416151802 2171 dbSNP
rs533926485 2173 dbSNP
rs1472999809 2177 dbSNP
rs895550611 2189 dbSNP
rs1242340450 2200 dbSNP
rs1047553086 2201 dbSNP
rs928950531 2209 dbSNP
rs953737999 2212 dbSNP
rs920267421 2213 dbSNP
rs1032051401 2215 dbSNP
rs979085990 2217 dbSNP
rs1313136283 2222 dbSNP
rs973279169 2228 dbSNP
rs1458999625 2236 dbSNP
rs1238752978 2237 dbSNP
rs562063406 2244 dbSNP
rs910349595 2252 dbSNP
rs1021275411 2253 dbSNP
rs1396850231 2255 dbSNP
rs1167242202 2269 dbSNP
rs1203130951 2271 dbSNP
rs542113868 2274 dbSNP
rs987309201 2280 dbSNP
rs568158254 2288 dbSNP
rs1305273152 2290 dbSNP
rs192716760 2291 dbSNP
rs1228600474 2295 dbSNP
rs1359133945 2297 dbSNP
rs1313308545 2298 dbSNP
rs1242807603 2302 dbSNP
rs1414378307 2303 dbSNP
rs1299077731 2333 dbSNP
rs1428791189 2367 dbSNP
rs1033437525 2372 dbSNP
rs954726176 2377 dbSNP
rs573187876 2384 dbSNP
rs1221466753 2397 dbSNP
rs922707093 2398 dbSNP
rs1347662107 2399 dbSNP
rs1378211755 2400 dbSNP
rs1287783797 2405 dbSNP
rs887858817 2414 dbSNP
rs1444933504 2441 dbSNP
rs1049083338 2447 dbSNP
rs1246812801 2453 dbSNP
rs929284753 2459 dbSNP
rs1191725273 2462 dbSNP
rs1440091855 2466 dbSNP
rs988889292 2470 dbSNP
rs767050799 2474 dbSNP
rs1032976062 2476 dbSNP
rs944943028 2490 dbSNP
rs1387341808 2492 dbSNP
rs368516029 2499 dbSNP
rs1399180045 2503 dbSNP
rs1317681771 2504 dbSNP
rs1331801153 2504 dbSNP
rs189404028 2505 dbSNP
rs1301968768 2522 dbSNP
rs773911365 2523 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000522677.3 | 3UTR | UAAUAGCACAUAAUGGUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000522677.3 | 3UTR | UAAUAGCACAUAAUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
168 hsa-miR-548t-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059365 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT072839 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 6
MIRT076945 PCGF2 polycomb group ring finger 2 2 6
MIRT083941 TFAP2C transcription factor AP-2 gamma 2 2
MIRT085401 ETS2 ETS proto-oncogene 2, transcription factor 2 2
MIRT109790 KLHL15 kelch like family member 15 2 2
MIRT114046 AKAP11 A-kinase anchoring protein 11 2 10
MIRT130165 TXNIP thioredoxin interacting protein 2 6
MIRT150013 MIDN midnolin 2 2
MIRT181258 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT205594 NCL nucleolin 2 2
MIRT222253 ACTB actin beta 2 4
MIRT245653 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT250947 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT252497 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT271990 ARF1 ADP ribosylation factor 1 2 4
MIRT280804 RNF11 ring finger protein 11 2 2
MIRT293803 FEM1A fem-1 homolog A 2 2
MIRT318231 RREB1 ras responsive element binding protein 1 2 2
MIRT341455 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT347413 CEBPG CCAAT/enhancer binding protein gamma 2 4
MIRT351860 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT357983 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT377094 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT407303 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT441564 LMOD3 leiomodin 3 2 2
MIRT442364 ZC3H12C zinc finger CCCH-type containing 12C 2 2
MIRT443228 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT443404 HMX3 H6 family homeobox 3 2 2
MIRT446055 NR5A2 nuclear receptor subfamily 5 group A member 2 2 2
MIRT448277 ZNF652 zinc finger protein 652 2 2
MIRT450822 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT453016 CCDC115 coiled-coil domain containing 115 2 17
MIRT454463 PPP2R2B protein phosphatase 2 regulatory subunit Bbeta 2 2
MIRT456360 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 2 2
MIRT460007 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT463154 ZNF385A zinc finger protein 385A 2 6
MIRT463766 YPEL2 yippee like 2 2 2
MIRT468310 SFT2D2 SFT2 domain containing 2 2 2
MIRT470668 POLR2D RNA polymerase II subunit D 2 4
MIRT478517 CTTN cortactin 2 2
MIRT480507 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT484718 INHBA inhibin beta A subunit 2 12
MIRT485494 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT487302 SLC38A9 solute carrier family 38 member 9 2 2
MIRT487771 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491876 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494304 CEP120 centrosomal protein 120 2 2
MIRT495396 TRIM24 tripartite motif containing 24 2 2
MIRT495646 CDK1 cyclin dependent kinase 1 2 2
MIRT496665 TMEM237 transmembrane protein 237 2 2
MIRT496837 ZNF460 zinc finger protein 460 2 2
MIRT498638 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT503928 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT506063 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT506582 MIER3 MIER family member 3 2 4
MIRT506606 MAT2A methionine adenosyltransferase 2A 2 4
MIRT506844 KIF23 kinesin family member 23 2 6
MIRT508536 RPP14 ribonuclease P/MRP subunit p14 2 4
MIRT509669 ZNF354B zinc finger protein 354B 2 10
MIRT511170 MBNL3 muscleblind like splicing regulator 3 2 6
MIRT512147 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT512831 ID4 inhibitor of DNA binding 4, HLH protein 2 6
MIRT514558 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515856 AJAP1 adherens junctions associated protein 1 2 4
MIRT521848 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT525364 SYNM synemin 2 2
MIRT527120 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT527271 FBLN2 fibulin 2 2 2
MIRT527439 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT527658 CD300E CD300e molecule 2 2
MIRT528334 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529033 EXOC8 exocyst complex component 8 2 2
MIRT529321 PDE5A phosphodiesterase 5A 2 2
MIRT529677 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529846 SMTN smoothelin 2 2
MIRT530385 ZNF431 zinc finger protein 431 2 2
MIRT530913 GPR85 G protein-coupled receptor 85 2 2
MIRT531794 KDR kinase insert domain receptor 2 2
MIRT532246 KLF2 Kruppel like factor 2 2 4
MIRT532658 CBX7 chromobox 7 2 2
MIRT533630 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT534811 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT534975 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536588 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT536779 HNRNPD heterogeneous nuclear ribonucleoprotein D 2 2
MIRT538764 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539294 ANGEL2 angel homolog 2 2 2
MIRT539621 SHISA9 shisa family member 9 2 2
MIRT539651 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540347 OPHN1 oligophrenin 1 2 2
MIRT540413 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541396 CDC27 cell division cycle 27 2 2
MIRT542916 HSBP1 heat shock factor binding protein 1 2 2
MIRT544710 EIF5A eukaryotic translation initiation factor 5A 2 4
MIRT544998 MFF mitochondrial fission factor 2 4
MIRT553289 TSPAN3 tetraspanin 3 2 2
MIRT553455 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT553782 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT554656 ROBO1 roundabout guidance receptor 1 2 2
MIRT555104 PURB purine rich element binding protein B 2 2
MIRT557235 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT560861 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561545 SON SON DNA binding protein 2 2
MIRT561554 SLMO2 PRELI domain containing 3B 2 2
MIRT563764 ZNF678 zinc finger protein 678 2 2
MIRT565653 SIX4 SIX homeobox 4 2 2
MIRT568080 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568759 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569078 CADM2 cell adhesion molecule 2 2 2
MIRT569509 THYN1 thymocyte nuclear protein 1 2 2
MIRT571268 CDKN2AIP CDKN2A interacting protein 2 2
MIRT571809 PHF19 PHD finger protein 19 2 2
MIRT572554 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT573782 SLC24A4 solute carrier family 24 member 4 2 4
MIRT576441 Ccdc115 coiled-coil domain containing 115 2 10
MIRT576712 Slc30a3 solute carrier family 30 (zinc transporter), member 3 2 3
MIRT608377 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608484 NKTR natural killer cell triggering receptor 2 6
MIRT610186 FAM49A family with sequence similarity 49 member A 2 2
MIRT611631 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT613534 TRA2B transformer 2 beta homolog 2 2
MIRT616221 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT622370 SALL1 spalt like transcription factor 1 2 2
MIRT624371 CDK12 cyclin dependent kinase 12 2 2
MIRT624995 ZNF665 zinc finger protein 665 2 4
MIRT626875 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627737 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT628490 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT633647 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 4
MIRT634028 SLC30A3 solute carrier family 30 member 3 2 3
MIRT635923 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638287 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT641959 RNF115 ring finger protein 115 2 2
MIRT643573 CTNNA3 catenin alpha 3 2 2
MIRT645180 NOL9 nucleolar protein 9 2 4
MIRT647497 ZNF639 zinc finger protein 639 2 2
MIRT647682 PCK1 phosphoenolpyruvate carboxykinase 1 2 2
MIRT648422 MYOZ3 myozenin 3 2 2
MIRT650113 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT651076 ZNF518B zinc finger protein 518B 2 4
MIRT651415 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT651456 XKR4 XK related 4 2 2
MIRT653619 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653637 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654896 POU2F1 POU class 2 homeobox 1 2 2
MIRT656483 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT658016 GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit 2 2
MIRT658041 FZD10 frizzled class receptor 10 2 2
MIRT660093 BTBD3 BTB domain containing 3 2 2
MIRT663923 MAGEF1 MAGE family member F1 2 2
MIRT665882 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT669051 CEP128 centrosomal protein 128 2 2
MIRT669711 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT686812 SNX2 sorting nexin 2 2 4
MIRT689883 SOD2 superoxide dismutase 2 2 2
MIRT693274 GLRX2 glutaredoxin 2 2 4
MIRT697056 BCAR1 BCAR1, Cas family scaffolding protein 2 2
MIRT703297 GID4 GID complex subunit 4 homolog 2 2
MIRT704087 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT707719 CDC6 cell division cycle 6 2 2
MIRT708136 GK5 glycerol kinase 5 (putative) 2 2
MIRT709212 KLHL30 kelch like family member 30 2 2
MIRT710062 RWDD2A RWD domain containing 2A 2 2
MIRT712770 POU6F2 POU class 6 homeobox 2 2 2
MIRT715073 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715387 TADA3 transcriptional adaptor 3 2 2
MIRT717712 NCKAP1 NCK associated protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548t Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-548t Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-548t Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-548t Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-548t Vincristine 5978 approved sensitive cell line (W1)
hsa-miR-548t-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-548t-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-548t-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)

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