pre-miRNA Information | |
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pre-miRNA | hsa-mir-758 |
Genomic Coordinates | chr14: 101026020 - 101026107 |
Synonyms | MIRN758, hsa-mir-758, MIR758 |
Description | Homo sapiens miR-758 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-758-5p | |||||||||||||||||||||||||||||||||||||||||||||
Sequence | 15| GAUGGUUGACCAGAGAGCACAC |36 | |||||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||||||||
Experiments | SOLiD | |||||||||||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZNF655 | ||||||||||||||||||||
Synonyms | VIK, VIK-1 | ||||||||||||||||||||
Description | zinc finger protein 655 | ||||||||||||||||||||
Transcript | NM_001009960 | ||||||||||||||||||||
Other Transcripts | NM_001009958 , NM_001083956 , NM_001085366 , NM_001085367 , NM_001085368 , NM_024061 , NM_138494 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZNF655 | |||||||||||||||||||||
3'UTR of ZNF655 (miRNA target sites are highlighted) |
>ZNF655|NM_001009960|3'UTR 1 ATGTAATGAAGATGGGAAGATATTTATCAAATTCAGGCTTCATTCAGCATCTGAGAGTTCACACCAGGGAGAAATCATGT 81 ATGTACTGCATGTGGTAAAGCCTTCAGTCATAGCTCAGCCATTGCTCAGCATCAGATAATTCACACCAGAGAGAAACCCT 161 CTGAATGTGACGAATGAAGAAAAGGTATTAGTGTTAAACTCTTAATCGACTCCTGCAAATCTATACCAGTGAGAAATCTT 241 ACAAATGTATTGAATGTGGCAAATTTTTCATGCTATTAGTATTTTCATACCTTAGTCACATTTGGAGAATTCACATGGGA 321 ATAAAATTCCATTGCTGCAATGAATGTGAAAAAGCCATCAGTCAAAGAAACTACCTTGTTTAGTATCAAATTCACGCCAT 401 GCAAAAAGATTATAAATGTAATAAGCATGTATGTGTGTGAGGAGATTCAGTCATAACCCAACGCTCATTCAACATCAAAG 481 AATTTATACCTAAGAGAACTTATTTGGGTGTAGTAAATGGCAGATCTTTCAATAGGAGTTTAACTAGTCTTTGTCATATC 561 AGAATATCCATAGTAGACAAGAATTTGATGTAACGCAAATGGAAAAACTCGACACCACATTTCAGGCTTTACCCAACATC 641 GAAATAATGGAGAGAAAATTGTTGATTATTTGTTTATGAAATTGTTAATACATAGTCCCAATCTTTTTCATTGCACAAAA 721 ATCTAGGGTTGACTTGGTAAATGCAGTGACATTTTCTCATGGAGTTCCTTTATTTAATATGTATTCTAAGTAGGTACGTT 801 TATTTTTACTTTTTTATTATAATTTTGATATTAAAAAGAACAGAGATGGGGTCTTGCTTTGTTGCCCAGGCTGGTCTTGA 881 ACTCCTGGCCTCAAGCGATCCTCCCACCTGTCCTCCCAAAGTGCTGGGGTTACAGGCGTGTGTCACTGTGCTGGGCCTAT 961 TTTATTTATAGAACTCATTTAAGCTGTTTTTATTTTAATATGCCCTATAAACATTTTTATATTTTTTGAAATTGGTTCTT 1041 AGTGTTCACAACTTCCATAAGATACTGCTAATGCACCAGTATTAAAACACATCGACGTAAGTAGCTCATTTAGCTTTTTC 1121 TGCTGTTCTTGGCCCAAGTTCTTTCCAAAACCAACTCTTAGGCCTGCTCTTTACTAGGGATCTTATGTCGTATTGCTTTA 1201 CAGCCACAACACTTGGATTCCTGTTGATTAACTTCTCCATTCTCTTAAGCACCTTTAGAAGATTTAGAAGTTTCCTAGTT 1281 TTAAGTGTTTCACCAGCAAGTATTCCATACCTACTTGATGTTGCTGGTCTGGTGTCTTATTTCCTAAAGTGAAGCATCTT 1361 TTTTTAAAAAAGAATTTGATTGACAATATATCCAGTCCAATATAAGTATGAAGGATTCTCTCTCCTGAGATTGTAGCAGG 1441 CAGCCAAACATTTTCAAATGATGCCCAAGGTTTTAGCTGTCTTGTGTGCATCCACAGTCTGCGAAGAAGACATGATAAGG 1521 ACATCAGGGAGCCAACAAGACTCCTAATAGCCTCACTACATTCATCCAGTGCCTATTCTGCATGCCTAAGCTTAGAGTTC 1601 TTTTATATACCTCTACGGCCAGCAAAATGCTCAGGTCTGCTCTTGGTAGGGTAAACATAAAGAAGATACACAGGCCGGGC 1681 ATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGATGGATCACGAGGTCAGGCAGTCGAGACCATCC 1761 TGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAGTTAGCCGGGTGTGGTGGCACGCGCCTGTAATCCCAGC 1841 TACTCAGGAGGCTGAGGCAGGAGAACTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCACCACTGCACT 1921 CCAGCCTGGGCGACAGAGCAGGACTCTCTCTCAAAAAAACACAAAAAAACAAAAACAAAAAACCATACACACACACACAC 2001 ACACACAAATCAGCATCATAAGGGAATGTAGCCTTCCAACAGAGATGATGCTGTTCGTATGTTAATCTCAGAGACAGTAT 2081 TTCAAGAGAGTGGCAGGTCTGTTCCTGGTAAAATTTTAACCATTAGGATTGCAGATAAATGTTTGAATTCTGCTCCTCTC 2161 TCATCAATCCAGGACAGTATTTGAAGTGTGAGGGCTTTGTGTATAGTTGTTTATCCATTACCACATTTTTGTATTTTAAT 2241 AGTCTACAGGCTATATAAAAGAACATGGCTTTTTGACTGATAAAAGTGATTACAGATGTTGGCTCAAGTTCAGGGCCACC 2321 ATCATATACCTAACAAGAGTTCATGATTCTTTAGGTAATGTCAAAACATTTTGTATTTTTCCATCTTAAGCTTTATAACA 2401 TTTTGTGAGTAAGACAAATGTTATTTAAAATTCTTGTTGTCAGTCCAGCAATTGAGGCTTTCATAGTTCAGTGTTATAAT 2481 ATTCAGTAGGGACCCTCAACAAATATATAAAAATATGTTGCTCACTCTATAATCCTCCTATGGCTAACCTCTAGGATAGT 2561 TCTGCCACTATATTTTACTTCTTTGCCATCAGCAAGAGTAGGATTTCATCAAGGCAAGGTAGGAATCTAAATGAAATTGA 2641 TATATAAATGAATTGATCTAAATGTAAAAGCAAATGAAAAATGCATGTGTTTTTTCCTGTCAAACATGTATACCCTTATG 2721 TATAGAGACCAGTAGTCACGTATGGTGACTGAAACAGGATTATGTAATCCCTAAAAAGCAGAATATGTAAAAATCACATG 2801 TATGCGTTTGGTTTAGGAATGTGCTTTTGTACTTCCACTTGAATAAAGGTGTGTTTGGTATTCTGAGAAAAAAAAAAAAA 2881 AAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545215 | |
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Method / RBP | PAR-CLIP / AGO4 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000394163.2 | 3UTR | AAAAAACCAUACACACACACACACAC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT085323 | MORC3 | MORC family CW-type zinc finger 3 | ![]() |
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2 | 2 | ||||||
MIRT089441 | STAMBP | STAM binding protein | ![]() |
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2 | 2 | ||||||
MIRT089456 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT111856 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT184933 | ZNF268 | zinc finger protein 268 | ![]() |
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2 | 2 | ||||||
MIRT215288 | CREBRF | CREB3 regulatory factor | ![]() |
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2 | 2 | ||||||
MIRT237300 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
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2 | 2 | ||||||
MIRT238446 | MYO10 | myosin X | ![]() |
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2 | 4 | ||||||
MIRT273827 | RPL41 | ribosomal protein L41 | ![]() |
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2 | 2 | ||||||
MIRT282703 | HOOK1 | hook microtubule tethering protein 1 | ![]() |
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2 | 2 | ||||||
MIRT347970 | ZNF850 | zinc finger protein 850 | ![]() |
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2 | 2 | ||||||
MIRT371076 | KLF3 | Kruppel like factor 3 | ![]() |
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2 | 2 | ||||||
MIRT464339 | USP6NL | USP6 N-terminal like | ![]() |
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2 | 2 | ||||||
MIRT470034 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT477506 | ELL2 | elongation factor for RNA polymerase II 2 | ![]() |
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2 | 2 | ||||||
MIRT482886 | CACNA2D3 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | ![]() |
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2 | 2 | ||||||
MIRT492606 | POLR3E | RNA polymerase III subunit E | ![]() |
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2 | 2 | ||||||
MIRT502294 | GNG12 | G protein subunit gamma 12 | ![]() |
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2 | 6 | ||||||
MIRT507600 | DCTN4 | dynactin subunit 4 | ![]() |
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2 | 4 | ||||||
MIRT510728 | SON | SON DNA binding protein | ![]() |
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2 | 6 | ||||||
MIRT514065 | KCNJ6 | potassium voltage-gated channel subfamily J member 6 | ![]() |
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2 | 8 | ||||||
MIRT519718 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 4 | ||||||
MIRT520890 | STRN | striatin | ![]() |
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2 | 2 | ||||||
MIRT521760 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 6 | ||||||
MIRT526874 | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | ![]() |
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2 | 2 | ||||||
MIRT530232 | WSB2 | WD repeat and SOCS box containing 2 | ![]() |
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2 | 2 | ||||||
MIRT532003 | ACTR2 | ARP2 actin related protein 2 homolog | ![]() |
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2 | 2 | ||||||
MIRT533371 | UBE2D4 | ubiquitin conjugating enzyme E2 D4 (putative) | ![]() |
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2 | 4 | ||||||
MIRT547106 | PIGW | phosphatidylinositol glycan anchor biosynthesis class W | ![]() |
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2 | 2 | ||||||
MIRT548189 | FOXA1 | forkhead box A1 | ![]() |
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2 | 2 | ||||||
MIRT552935 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT560085 | ZNF195 | zinc finger protein 195 | ![]() |
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2 | 2 | ||||||
MIRT561726 | PPP2CA | protein phosphatase 2 catalytic subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT562713 | ZNF415 | zinc finger protein 415 | ![]() |
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2 | 2 | ||||||
MIRT562761 | ZNF846 | zinc finger protein 846 | ![]() |
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2 | 2 | ||||||
MIRT564159 | ZNF117 | zinc finger protein 117 | ![]() |
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2 | 2 | ||||||
MIRT565673 | SETD5 | SET domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT565718 | SESN3 | sestrin 3 | ![]() |
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2 | 2 | ||||||
MIRT566026 | RFX1 | regulatory factor X1 | ![]() |
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2 | 2 | ||||||
MIRT569048 | ZNF655 | zinc finger protein 655 | ![]() |
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2 | 2 | ||||||
MIRT570367 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 2 | ||||||
MIRT570410 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT570443 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 2 | ||||||
MIRT571738 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT575042 | Tpgs2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 4 | ||||||
MIRT614330 | ZDHHC22 | zinc finger DHHC-type containing 22 | ![]() |
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2 | 2 | ||||||
MIRT617629 | RAB3IP | RAB3A interacting protein | ![]() |
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2 | 2 | ||||||
MIRT621667 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT639906 | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | ![]() |
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2 | 2 | ||||||
MIRT651436 | XRCC5 | X-ray repair cross complementing 5 | ![]() |
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2 | 2 | ||||||
MIRT683853 | ZNF208 | zinc finger protein 208 | ![]() |
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2 | 2 | ||||||
MIRT684841 | TPGS2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 5 | ||||||
MIRT689347 | ZNF83 | zinc finger protein 83 | ![]() |
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2 | 2 | ||||||
MIRT692492 | SPIN4 | spindlin family member 4 | ![]() |
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2 | 2 | ||||||
MIRT695711 | OLA1 | Obg like ATPase 1 | ![]() |
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2 | 2 | ||||||
MIRT698219 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT711560 | FAM20B | FAM20B, glycosaminoglycan xylosylkinase | ![]() |
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2 | 2 | ||||||
MIRT712867 | TMEM67 | transmembrane protein 67 | ![]() |
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2 | 2 | ||||||
MIRT722956 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT723622 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT724176 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 2 | ||||||
MIRT755363 | LMBR1 | limb development membrane protein 1 | 3 | 1 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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