pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol FSCN1   
Synonyms FAN1, HSN, SNL, p55
Description fascin actin-bundling protein 1
Transcript NM_003088   
Expression
Putative miRNA Targets on FSCN1
3'UTR of FSCN1
(miRNA target sites are highlighted)
>FSCN1|NM_003088|3'UTR
   1 GGCCGGCCCGTCCTTCCCCGCCCCTGCCCACATGGCGGCTCCTGCCAACCCTCCCTGCTAACCCCTTCTCCGCCAGGTGG
  81 GCTCCAGGGCGGGAGGCAAGCCCCCTTGCCTTTCAAACTGGAAACCCCAGAGAAAACGGTGCCCCCACCTGTCGCCCCTA
 161 TGGACTCCCCACTCTCCCCTCCGCCCGGGTTCCCTACTCCCCTCGGGTCAGCGGCTGCGGCCTGGCCCTGGGAGGGATTT
 241 CAGATGCCCCTGCCCTCTTGTCTGCCACGGGGCGAGTCTGGCACCTCTTTCTTCTGACCTCAGACGGCTCTGAGCCTTAT
 321 TTCTCTGGAAGCGGCTAAGGGACGGTTGGGGGCTGGGAGCCCTGGGCGTGTAGTGTAACTGGAATCTTTTGCCTCTCCCA
 401 GCCACCTCCTCCCAGCCCCCCAGGAGAGCTGGGCACATGTCCCAAGCCTGTCAGTGGCCCTCCCTGGTGCACTGTCCCCG
 481 AAACCCCTGCTTGGGAAGGGAAGCTGTCGGGTGGGCTAGGACTGACCCTTGTGGTGTTTTTTTGGGTGGTGGCTGGAAAC
 561 AGCCCCTCTCCCACGTGGCAGAGGCTCAGCCTGGCTCCCTTCCCTGGAGCGGCAGGGCGTGACGGCCACAGGGTCTGCCC
 641 GCTGCACGTTCTGCCAAGGTGGTGGTGGCGGGCGGGTAGGGGTGTGGGGGCCGTCTTCCTCCTGTCTCTTTCCTTTCACC
 721 CTAGCCTGACTGGAAGCAGAAAATGACCAAATCAGTATTTTTTTTAATGAAATATTATTGCTGGAGGCGTCCCAGGCAAG
 801 CCTGGCTGTAGTAGCGAGTGATCTGGCGGGGGGCGTCTCAGCACCCTCCCCAGGGGGTGCATCTCAGCCCCCTCTTTCCG
 881 TCCTTCCCGTCCAGCCCCAGCCCTGGGCCTGGGCTGCCGACACCTGGGCCAGAGCCCCTGCTGTGATTGGTGCTCCCTGG
 961 GCCTCCCGGGTGGATGAAGCCAGGCGTCGCCCCCTCCGGGAGCCCTGGGGTGAGCCGCCGGGGCCCCCCTGCTGCCAGCC
1041 TCCCCCGTCCCCAACATGCATCTCACTCTGGGTGTCTTGGTCTTTTATTTTTTGTAAGTGTCATTTGTATAACTCTAAAC
1121 GCCCATGATAGTAGCTTCAAACTGGAAATAGCGAAATAAAATAACTCAGTCTGCAGCCCCAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgUCGGUCG---AGAUGGGGGCGGu 5'
            :|||:||   ||  :||||||| 
Target 5' --GGCCGGCCCGTCCTTCCCCGCCc 3'
1 - 23 160.00 -26.60
2
miRNA  3' cguCGGUCGAGAUGGGGGCGGu 5'
             |||||| || ||||||:| 
Target 5' gctGCCAGC-CT-CCCCCGTCc 3'
1031 - 1050 153.00 -31.10
3
miRNA  3' cgucGGUCGAGA-UGGGGGCGGu 5'
              ||| ||||  ||:||||| 
Target 5' ctccCCA-CTCTCCCCTCCGCCc 3'
165 - 186 145.00 -23.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30533096 11 COSMIC
COSN30513428 16 COSMIC
COSN513079 37 COSMIC
COSN21845936 38 COSMIC
COSN30661722 75 COSMIC
COSN25868135 91 COSMIC
COSN9994678 99 COSMIC
COSN9994682 364 COSMIC
COSN5102303 511 COSMIC
COSN24354220 859 COSMIC
COSN1351489 982 COSMIC
COSN25528255 999 COSMIC
COSN1351490 1029 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776850441 2 dbSNP
rs759751694 4 dbSNP
rs1390514991 5 dbSNP
rs537660305 6 dbSNP
rs374456091 7 dbSNP
rs1336106001 8 dbSNP
rs116867877 10 dbSNP
rs1282503626 11 dbSNP
rs116036920 12 dbSNP
rs542353285 14 dbSNP
rs1029693597 15 dbSNP
rs751908793 17 dbSNP
rs1256429793 18 dbSNP
rs985388192 20 dbSNP
rs373433239 21 dbSNP
rs1275424422 22 dbSNP
rs746388244 23 dbSNP
rs1198855661 24 dbSNP
rs755554618 33 dbSNP
rs1481742199 37 dbSNP
rs376574679 38 dbSNP
rs748891986 39 dbSNP
rs1460787498 41 dbSNP
rs1248829127 42 dbSNP
rs1165753688 43 dbSNP
rs1262957883 45 dbSNP
rs1372045458 45 dbSNP
rs1429799366 49 dbSNP
rs1302031161 51 dbSNP
rs546182272 55 dbSNP
rs1314470188 58 dbSNP
rs973663175 64 dbSNP
rs564777200 73 dbSNP
rs1439807520 75 dbSNP
rs1381791413 90 dbSNP
rs775096381 91 dbSNP
rs1303483388 92 dbSNP
rs375923451 94 dbSNP
rs1363571237 102 dbSNP
rs1162434498 105 dbSNP
rs1419145337 109 dbSNP
rs1409758590 110 dbSNP
rs531993808 129 dbSNP
rs774812920 131 dbSNP
rs1425311230 133 dbSNP
rs1415658393 134 dbSNP
rs1044073961 138 dbSNP
rs1225098813 139 dbSNP
rs868791394 140 dbSNP
rs544123174 143 dbSNP
rs1217525946 145 dbSNP
rs936286568 146 dbSNP
rs1055088845 149 dbSNP
rs1283693588 151 dbSNP
rs1406524905 153 dbSNP
rs562346271 154 dbSNP
rs1010322312 155 dbSNP
rs1346476145 161 dbSNP
rs1156262728 177 dbSNP
rs1368504323 180 dbSNP
rs529449728 183 dbSNP
rs1202119183 184 dbSNP
rs1268851639 187 dbSNP
rs572081831 187 dbSNP
rs760244637 188 dbSNP
rs1487110173 202 dbSNP
rs1006874567 206 dbSNP
rs1018256933 213 dbSNP
rs1313015534 214 dbSNP
rs1265223750 219 dbSNP
rs963008631 220 dbSNP
rs1343384761 222 dbSNP
rs1282341674 224 dbSNP
rs146589678 226 dbSNP
rs1220970611 233 dbSNP
rs368725715 236 dbSNP
rs1286625335 246 dbSNP
rs566417404 249 dbSNP
rs983279273 255 dbSNP
rs1199805024 260 dbSNP
rs917033397 263 dbSNP
rs1429040306 269 dbSNP
rs1430837379 271 dbSNP
rs1260191553 273 dbSNP
rs971119579 274 dbSNP
rs137877258 275 dbSNP
rs1202026679 285 dbSNP
rs1262312219 286 dbSNP
rs1323020722 286 dbSNP
rs1227828796 288 dbSNP
rs1309238630 307 dbSNP
rs1197778737 309 dbSNP
rs1162643779 316 dbSNP
rs551716737 333 dbSNP
rs1338057971 336 dbSNP
rs960592687 344 dbSNP
rs1246875018 352 dbSNP
rs1299118615 353 dbSNP
rs1463827609 357 dbSNP
rs1478741182 368 dbSNP
rs1170348329 369 dbSNP
rs1387170567 370 dbSNP
rs926993251 372 dbSNP
rs1165583345 376 dbSNP
rs1461057130 391 dbSNP
rs570419545 394 dbSNP
rs1196200070 395 dbSNP
rs1422850566 406 dbSNP
rs1249603541 408 dbSNP
rs1227589043 411 dbSNP
rs1359981157 414 dbSNP
rs1466131809 416 dbSNP
rs185458134 417 dbSNP
rs1381647293 422 dbSNP
rs1307261964 424 dbSNP
rs1393563090 432 dbSNP
rs556178447 437 dbSNP
rs796659190 438 dbSNP
rs1392076072 440 dbSNP
rs73334479 441 dbSNP
rs1161807302 449 dbSNP
rs1444055125 457 dbSNP
rs1364666965 460 dbSNP
rs1323166577 467 dbSNP
rs1051192486 481 dbSNP
rs1204126288 487 dbSNP
rs1490498898 494 dbSNP
rs1293823480 504 dbSNP
rs535263999 509 dbSNP
rs1006946604 510 dbSNP
rs1054201 513 dbSNP
rs1276447524 520 dbSNP
rs1040162079 524 dbSNP
rs898502225 528 dbSNP
rs1288143766 537 dbSNP
rs532254670 537 dbSNP
rs1405910119 544 dbSNP
rs1347980407 549 dbSNP
rs995872185 561 dbSNP
rs554253920 563 dbSNP
rs1385780500 565 dbSNP
rs1160305347 567 dbSNP
rs3735288 578 dbSNP
rs1004744236 590 dbSNP
rs1181242325 598 dbSNP
rs1480620384 600 dbSNP
rs1024165040 603 dbSNP
rs1197209706 610 dbSNP
rs971192968 613 dbSNP
rs539842511 619 dbSNP
rs1348163293 624 dbSNP
rs1267066299 628 dbSNP
rs1224580877 629 dbSNP
rs1326085607 635 dbSNP
rs1281710020 638 dbSNP
rs558229606 641 dbSNP
rs926996802 642 dbSNP
rs1320391390 645 dbSNP
rs1290150978 648 dbSNP
rs1380578950 655 dbSNP
rs1452913979 656 dbSNP
rs957099826 660 dbSNP
rs1191048284 664 dbSNP
rs1431170270 670 dbSNP
rs1261927203 671 dbSNP
rs1173943674 673 dbSNP
rs1477671357 674 dbSNP
rs1242611571 676 dbSNP
rs1194749749 679 dbSNP
rs1444776215 682 dbSNP
rs1247093526 683 dbSNP
rs1441077092 686 dbSNP
rs1203916351 689 dbSNP
rs1462324489 690 dbSNP
rs990214922 691 dbSNP
rs1195827071 693 dbSNP
rs1218956084 694 dbSNP
rs1340740093 696 dbSNP
rs913515357 697 dbSNP
rs1225416683 698 dbSNP
rs1364570192 707 dbSNP
rs946282689 708 dbSNP
rs1051262625 709 dbSNP
rs912742706 722 dbSNP
rs942836583 725 dbSNP
rs1039791964 738 dbSNP
rs1420222788 746 dbSNP
rs1163560344 758 dbSNP
rs1474352178 758 dbSNP
rs77878566 759 dbSNP
rs1389017127 764 dbSNP
rs576494397 766 dbSNP
rs1462393429 769 dbSNP
rs760089307 771 dbSNP
rs1240857540 772 dbSNP
rs1209904883 773 dbSNP
rs1438744809 778 dbSNP
rs1275786730 784 dbSNP
rs1194595032 794 dbSNP
rs995551633 796 dbSNP
rs1296543930 804 dbSNP
rs1047489223 811 dbSNP
rs1360032756 817 dbSNP
rs887084767 821 dbSNP
rs1330559876 825 dbSNP
rs1400639182 826 dbSNP
rs1369818308 828 dbSNP
rs1004817799 829 dbSNP
rs1445885390 832 dbSNP
rs1411263453 833 dbSNP
rs1234996429 836 dbSNP
rs544161865 836 dbSNP
rs1001772445 844 dbSNP
rs1034136706 849 dbSNP
rs1293101408 853 dbSNP
rs35340467 853 dbSNP
rs562222545 854 dbSNP
rs1358905251 858 dbSNP
rs1023988013 859 dbSNP
rs1214051743 866 dbSNP
rs1284840214 871 dbSNP
rs957335015 872 dbSNP
rs989855330 873 dbSNP
rs1019925468 874 dbSNP
rs1488347067 878 dbSNP
rs1218120778 879 dbSNP
rs1347622374 880 dbSNP
rs1163418319 884 dbSNP
rs1254006531 888 dbSNP
rs1400960565 889 dbSNP
rs1180525434 902 dbSNP
rs1409681115 902 dbSNP
rs1472467435 904 dbSNP
rs1441717401 919 dbSNP
rs1489984060 920 dbSNP
rs574200238 925 dbSNP
rs1188157060 926 dbSNP
rs1319003387 933 dbSNP
rs966986535 945 dbSNP
rs1226416256 947 dbSNP
rs1328207019 949 dbSNP
rs1370015531 961 dbSNP
rs1406734380 964 dbSNP
rs111913918 968 dbSNP
rs560204570 976 dbSNP
rs912772488 980 dbSNP
rs1379875350 982 dbSNP
rs942919646 990 dbSNP
rs1420387398 993 dbSNP
rs975976294 998 dbSNP
rs1178982846 999 dbSNP
rs1431969882 1003 dbSNP
rs1425053057 1006 dbSNP
rs866365132 1011 dbSNP
rs1400139616 1017 dbSNP
rs1486885677 1018 dbSNP
rs931409184 1021 dbSNP
rs1047114654 1024 dbSNP
rs887115838 1025 dbSNP
rs1263557993 1027 dbSNP
rs1335413830 1031 dbSNP
rs1310413012 1037 dbSNP
rs1300500983 1039 dbSNP
rs949326803 1048 dbSNP
rs1238369143 1051 dbSNP
rs1433946284 1061 dbSNP
rs1045719014 1062 dbSNP
rs1339159237 1066 dbSNP
rs1464830968 1067 dbSNP
rs772415453 1071 dbSNP
rs1353896931 1072 dbSNP
rs1388402878 1073 dbSNP
rs1187955569 1083 dbSNP
rs1445524319 1083 dbSNP
rs1202037864 1088 dbSNP
rs1245170151 1088 dbSNP
rs1482146182 1089 dbSNP
rs1255138011 1090 dbSNP
rs1205143504 1091 dbSNP
rs1001404577 1095 dbSNP
rs1034578718 1099 dbSNP
rs1253802069 1110 dbSNP
rs1383124492 1113 dbSNP
rs1316713176 1115 dbSNP
rs1394709187 1125 dbSNP
rs8772 1127 dbSNP
rs1201011668 1135 dbSNP
rs1011754344 1141 dbSNP
rs1019956548 1146 dbSNP
rs1369226401 1152 dbSNP
rs967018510 1154 dbSNP
rs551855687 1159 dbSNP
rs1425381166 1163 dbSNP
rs563780775 1164 dbSNP
rs1019856210 1165 dbSNP
rs1177706310 1166 dbSNP
rs1255255980 1167 dbSNP
rs1177521597 1169 dbSNP
rs113634843 1177 dbSNP
rs1237814320 1179 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cguCGGUCG---AGAUGGGGGCGGu 5'
             |||:||   ||  :||||||| 
Target 5' ---GCCGGCCCGUCCUUCCCCGCCc 3'
1 - 22
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 PAR-CLIP data was present in ERX177604. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_6 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000382361.3 | 3UTR | CCGUCCUUCCCCGCCCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000382361.3 | 3UTR | GCCGGCCCGUCCUUCCCCGCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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