pre-miRNA Information | |
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pre-miRNA | hsa-mir-497 |
Genomic Coordinates | chr17: 7017911 - 7018022 |
Synonyms | MIRN497, hsa-mir-497, MIR497 |
Description | Homo sapiens miR-497 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-497-3p | ||||||||||||||||||||||||||||
Sequence | 64| CAAACCACACUGUGGUGUUAGA |85 | ||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||
Experiments | Cloned | ||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | THYN1 | ||||||||||||||||||||
Synonyms | HSPC144, MDS012, MY105, THY28, THY28KD | ||||||||||||||||||||
Description | thymocyte nuclear protein 1 | ||||||||||||||||||||
Transcript | NM_001037304 | ||||||||||||||||||||
Other Transcripts | NM_001037305 , NM_014174 , NM_199297 , NM_199298 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on THYN1 | |||||||||||||||||||||
3'UTR of THYN1 (miRNA target sites are highlighted) |
>THYN1|NM_001037304|3'UTR 1 GCCTGGAGGAAAAGGAACCAAGTTAACTGAGATACTGCTGCTGGAATGGGCGAGACATTGCTGCAAAGAAGTCAAGCTTT 81 TTTCAGACAAAAGGTGTGAGGGGGCTTGCTTGGTATGCTTACCTGGGCTTGTGTACCTCAGTGGTTTTTGTGTACTTTTT 161 TCAATAAAATATCAAAGTTGAAGAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545215 | |
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Method / RBP | PAR-CLIP / AGO4 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000352327.5 | 3UTR | GCUUGUGUACCUCAGUGGUUUUUGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT092955 | CYP2U1 | cytochrome P450 family 2 subfamily U member 1 | ![]() |
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2 | 4 | ||||||
MIRT124568 | PRRC2B | proline rich coiled-coil 2B | ![]() |
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2 | 2 | ||||||
MIRT125196 | EIF1AX | eukaryotic translation initiation factor 1A, X-linked | ![]() |
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2 | 4 | ||||||
MIRT147296 | KPNA2 | karyopherin subunit alpha 2 | ![]() |
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2 | 8 | ||||||
MIRT163999 | KIAA1109 | KIAA1109 | ![]() |
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2 | 4 | ||||||
MIRT252495 | NWD1 | NACHT and WD repeat domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT357969 | GRPEL2 | GrpE like 2, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT443007 | TRIOBP | TRIO and F-actin binding protein | ![]() |
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2 | 2 | ||||||
MIRT443524 | NETO1 | neuropilin and tolloid like 1 | ![]() |
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2 | 2 | ||||||
MIRT443573 | EVX2 | even-skipped homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT443656 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT460670 | KRT10 | keratin 10 | ![]() |
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2 | 8 | ||||||
MIRT464761 | UBE2N | ubiquitin conjugating enzyme E2 N | ![]() |
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2 | 2 | ||||||
MIRT465032 | LINC00598 | long intergenic non-protein coding RNA 598 | ![]() |
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2 | 2 | ||||||
MIRT465040 | TTC39C | tetratricopeptide repeat domain 39C | ![]() |
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2 | 2 | ||||||
MIRT468667 | SEC62 | SEC62 homolog, preprotein translocation factor | ![]() |
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2 | 2 | ||||||
MIRT473694 | MAPK8 | mitogen-activated protein kinase 8 | ![]() |
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2 | 4 | ||||||
MIRT477618 | EFNA3 | ephrin A3 | ![]() |
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2 | 2 | ||||||
MIRT480506 | C11orf57 | chromosome 11 open reading frame 57 | ![]() |
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2 | 2 | ||||||
MIRT480592 | BUB3 | BUB3, mitotic checkpoint protein | ![]() |
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2 | 2 | ||||||
MIRT486915 | ZNF398 | zinc finger protein 398 | ![]() |
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2 | 6 | ||||||
MIRT487770 | ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | ![]() |
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2 | 16 | ||||||
MIRT493265 | MDFIC | MyoD family inhibitor domain containing | ![]() |
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2 | 2 | ||||||
MIRT495271 | SLC1A2 | solute carrier family 1 member 2 | ![]() |
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2 | 4 | ||||||
MIRT495309 | CHST12 | carbohydrate sulfotransferase 12 | ![]() |
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2 | 2 | ||||||
MIRT496681 | DPP6 | dipeptidyl peptidase like 6 | ![]() |
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2 | 4 | ||||||
MIRT496891 | FOXP1 | forkhead box P1 | ![]() |
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2 | 2 | ||||||
MIRT497330 | IRF4 | interferon regulatory factor 4 | ![]() |
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2 | 2 | ||||||
MIRT498272 | KIAA1644 | KIAA1644 | ![]() |
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2 | 2 | ||||||
MIRT498634 | CHD4 | chromodomain helicase DNA binding protein 4 | ![]() |
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2 | 10 | ||||||
MIRT500581 | USP53 | ubiquitin specific peptidase 53 | ![]() |
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2 | 2 | ||||||
MIRT500751 | TMPPE | transmembrane protein with metallophosphoesterase domain | ![]() |
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2 | 6 | ||||||
MIRT509668 | ZNF354B | zinc finger protein 354B | ![]() |
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2 | 10 | ||||||
MIRT510919 | PSMA2 | proteasome subunit alpha 2 | ![]() |
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2 | 4 | ||||||
MIRT519118 | CEP76 | centrosomal protein 76 | ![]() |
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2 | 2 | ||||||
MIRT526193 | ABCG2 | ATP binding cassette subfamily G member 2 (Junior blood group) | ![]() |
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2 | 2 | ||||||
MIRT526746 | HLA-DOB | major histocompatibility complex, class II, DO beta | ![]() |
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2 | 2 | ||||||
MIRT527270 | FBLN2 | fibulin 2 | ![]() |
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2 | 2 | ||||||
MIRT528198 | PLEKHM2 | pleckstrin homology and RUN domain containing M2 | ![]() |
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2 | 2 | ||||||
MIRT528330 | TBC1D22B | TBC1 domain family member 22B | ![]() |
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2 | 2 | ||||||
MIRT530346 | GABRB3 | gamma-aminobutyric acid type A receptor beta3 subunit | ![]() |
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2 | 2 | ||||||
MIRT533627 | TMX3 | thioredoxin related transmembrane protein 3 | ![]() |
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2 | 2 | ||||||
MIRT533738 | TMEM200C | transmembrane protein 200C | ![]() |
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2 | 2 | ||||||
MIRT533779 | TMEM133 | transmembrane protein 133 | ![]() |
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2 | 2 | ||||||
MIRT534317 | SKIDA1 | SKI/DACH domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT538438 | COG5 | component of oligomeric golgi complex 5 | ![]() |
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2 | 2 | ||||||
MIRT539156 | AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | ![]() |
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2 | 2 | ||||||
MIRT539474 | ADARB2 | adenosine deaminase, RNA specific B2 (inactive) | ![]() |
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2 | 2 | ||||||
MIRT539620 | SHISA9 | shisa family member 9 | ![]() |
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2 | 2 | ||||||
MIRT539650 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | ![]() |
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2 | 2 | ||||||
MIRT540346 | OPHN1 | oligophrenin 1 | ![]() |
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2 | 2 | ||||||
MIRT540412 | PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | ![]() |
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2 | 2 | ||||||
MIRT541200 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | ![]() |
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2 | 2 | ||||||
MIRT541395 | CDC27 | cell division cycle 27 | ![]() |
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2 | 2 | ||||||
MIRT546443 | SNX5 | sorting nexin 5 | ![]() |
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2 | 2 | ||||||
MIRT547369 | MSI2 | musashi RNA binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT553288 | TSPAN3 | tetraspanin 3 | ![]() |
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2 | 2 | ||||||
MIRT554402 | SERP1 | stress associated endoplasmic reticulum protein 1 | ![]() |
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2 | 2 | ||||||
MIRT557822 | FOXN2 | forkhead box N2 | ![]() |
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2 | 2 | ||||||
MIRT568530 | ANP32E | acidic nuclear phosphoprotein 32 family member E | ![]() |
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2 | 2 | ||||||
MIRT569508 | THYN1 | thymocyte nuclear protein 1 | ![]() |
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2 | 2 | ||||||
MIRT570707 | FAM69A | family with sequence similarity 69 member A | ![]() |
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2 | 2 | ||||||
MIRT608376 | PIWIL2 | piwi like RNA-mediated gene silencing 2 | ![]() |
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2 | 2 | ||||||
MIRT608483 | NKTR | natural killer cell triggering receptor | ![]() |
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2 | 6 | ||||||
MIRT613533 | TRA2B | transformer 2 beta homolog | ![]() |
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2 | 2 | ||||||
MIRT616601 | ELP2 | elongator acetyltransferase complex subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT618166 | DUSP18 | dual specificity phosphatase 18 | ![]() |
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2 | 2 | ||||||
MIRT632059 | CEP135 | centrosomal protein 135 | ![]() |
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2 | 2 | ||||||
MIRT647379 | ZDHHC23 | zinc finger DHHC-type containing 23 | ![]() |
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2 | 2 | ||||||
MIRT648366 | POTED | POTE ankyrin domain family member D | ![]() |
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2 | 2 | ||||||
MIRT651075 | ZNF518B | zinc finger protein 518B | ![]() |
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2 | 4 | ||||||
MIRT653618 | SLC30A4 | solute carrier family 30 member 4 | ![]() |
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2 | 2 | ||||||
MIRT653636 | SLC30A1 | solute carrier family 30 member 1 | ![]() |
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2 | 2 | ||||||
MIRT654895 | POU2F1 | POU class 2 homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT656232 | MFSD6 | major facilitator superfamily domain containing 6 | ![]() |
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2 | 2 | ||||||
MIRT659880 | CAPRIN1 | cell cycle associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT660526 | ARL4C | ADP ribosylation factor like GTPase 4C | ![]() |
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2 | 2 | ||||||
MIRT666286 | SLC30A3 | solute carrier family 30 member 3 | ![]() |
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2 | 2 | ||||||
MIRT686808 | SNX2 | sorting nexin 2 | ![]() |
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2 | 4 | ||||||
MIRT695302 | TK1 | thymidine kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT699737 | SERINC3 | serine incorporator 3 | ![]() |
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2 | 2 | ||||||
MIRT700794 | PIAS2 | protein inhibitor of activated STAT 2 | ![]() |
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2 | 2 | ||||||
MIRT712270 | PPP1CB | protein phosphatase 1 catalytic subunit beta | ![]() |
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2 | 2 | ||||||
MIRT712617 | KNSTRN | kinetochore localized astrin/SPAG5 binding protein | ![]() |
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2 | 2 | ||||||
MIRT714264 | RPL10A | ribosomal protein L10a | ![]() |
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2 | 2 | ||||||
MIRT715072 | TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT715386 | TADA3 | transcriptional adaptor 3 | ![]() |
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2 | 2 | ||||||
MIRT716397 | NPAS1 | neuronal PAS domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT725328 | NFASC | neurofascin | ![]() |
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2 | 2 | ||||||
MIRT725503 | GANAB | glucosidase II alpha subunit | ![]() |
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2 | 2 | ||||||
MIRT732913 | IRAK2 | interleukin 1 receptor associated kinase 2 | ![]() |
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3 | 0 | |||||
MIRT734890 | SMAD3 | SMAD family member 3 | ![]() |
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3 | 0 | |||||
MIRT737328 | LINC02476 | long intergenic non-protein coding RNA 2476 | ![]() |
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3 | 0 | |||||
MIRT737544 | MALAT1 | metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) | ![]() |
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4 | 0 | ||||
MIRT755545 | PAK1 | p21 (RAC1) activated kinase 1 | 3 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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