miRTarBase - #MIRT569608


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pre-miRNA Information
pre-miRNA hsa-mir-6132   
Genomic Coordinates chr7: 117020211 - 117020319
Description Homo sapiens miR-6132 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6132
Sequence 21| AGCAGGGCUGGGGAUUGCA |39
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1272646274 4 dbSNP
rs1211969145 8 dbSNP
rs1310278496 11 dbSNP
rs1044115534 13 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TRIM29   
Synonyms ATDC
Description tripartite motif containing 29
Transcript NM_012101   
Expression
Putative miRNA Targets on TRIM29
3'UTR of TRIM29
(miRNA target sites are highlighted)		 
>TRIM29|NM_012101|3'UTR
   1 GCTCCTGGCGGAAGGAACGAGGCGCCACACCCCTGCTCTTCCTCCTGACCCTGCTGCTCTTGCCTTCTAAGCTACTGTGC
  81 TTGTCTGGGTGGGAGGGAGCCTGGTCCTGCACCTGCCCTCTGCAGCCCTCTGCCAGCCTCTTGGGGGCAGTTCCGGCCTC
 161 TCCGACTTCCCCACTGGCCACACTCCATTCAGACTCCTTTCCTGCCTTGTGACCTCAGATGGTCACCATCATTCCTGTGC
 241 TCAGAGGCCAACCCATCACAGGGGTGAGATAGGTTGGGGCCTGCCCTAACCCGCCAGCCTCCTCCTCTCGGGCTGGATCT
 321 GGGGGCTAGCAGTGAGTACCCGCATGGTATCAGCCTGCCTCTCCCGCCCACGCCCTGCTGTCTCCAGGCCTATAGACGTT
 401 TCTCTCCAAGGCCCTATCCCCCAATGTTGTCAGCAGATGCCTGGACAGCACAGCCACCCATCTCCCATTCACATGGCCCA
 481 CCTCCTGCTTCCCAGAGGACTGGCCCTACGTGCTCTCTCTCGTCCTACCTATCAATGCCCAGCATGGCAGAACCTGCAGC
 561 CCTTGGCCACTGCAGATGGAAACCTCTCAGTGTCTTGACATCACCCTACCCAGGCGGTGGGTCTCCACCACAGCCACTTT
 641 GAGTCTGTGGTCCCTGGAGGGTGGCTTCTCCTGACTGGCAGGATGACCTTAGCCAAGATATTCCTCTGTTCCCTCTGCTG
 721 AGATAAAGAATTCCCTTAACATGATATAATCCACCCATGCAAATAGCTACTGGCCCAGCTACCATTTACCATTTGCCTAC
 801 AGAATTTCATTCAGTCTACACTTTGGCATTCTCTCTGGCGATGGAGTGTGGCTGGGCTGACCGCAAAAGGTGCCTTACAC
 881 ACTGCCCCCACCCTCAGCCGTTGCCCCATCAGAGGCTGCCTCCTCCTTCTGATTACCCCCCATGTTGCATATCAGGGTGC
 961 TCAAGGATTGGAGAGGAGACAAAACCAGGAGCAGCACAGTGGGGACATCTCCCGTCTCAACAGCCCCAGGCCTATGGGGG
1041 CTCTGGAAGGATGGGCCAGCTTGCAGGGGTTGGGGAGGGAGACATCCAGCTTGGGCTTTCCCCTTTGGAATAAACCATTG
1121 GTCTGTCAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acguuagGGGU-CGGGACGa 5'
                 |||| ||||||| 
Target 5' tctcccgCCCACGCCCTGCt 3'
 360 - 379 152.00 -21.80
2 
miRNA  3' acguuagGGGUCGGGACGa 5'
                 ||::|:||||| 
Target 5' gagggagCCTGGTCCTGCa 3'
 93 - 111 136.00 -17.60
3 
miRNA  3' acGUUAGGGGUCGG-GACGa 5'
            ||: ||:::||| |||| 
Target 5' tgCAGCCCTTGGCCACTGCa 3'
 555 - 574 129.00 -22.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30449431 7 COSMIC
COSN13305972 10 COSMIC
COSN28854005 14 COSMIC
COSN31590587 14 COSMIC
COSN30135462 24 COSMIC
COSN30492746 27 COSMIC
COSN28755689 32 COSMIC
COSN31498587 33 COSMIC
COSN30514369 50 COSMIC
COSN30182884 56 COSMIC
COSN30519953 88 COSMIC
COSN30104164 95 COSMIC
COSN30104155 96 COSMIC
COSN31561867 125 COSMIC
COSN24312626 133 COSMIC
COSN30540482 133 COSMIC
COSN24312625 134 COSMIC
COSN30169285 154 COSMIC
COSN20077526 277 COSMIC
COSN1127683 297 COSMIC
COSN5823788 607 COSMIC
COSN27528005 697 COSMIC
COSN31960701 1013 COSMIC
COSN23671994 1056 COSMIC
COSN31571837 1059 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1337413845 2 dbSNP
rs1392092622 4 dbSNP
rs745809428 7 dbSNP
rs187156970 9 dbSNP
rs141454834 10 dbSNP
rs1171470567 11 dbSNP
rs781299417 12 dbSNP
rs755185348 18 dbSNP
rs751754730 19 dbSNP
rs766742343 21 dbSNP
rs758695501 23 dbSNP
rs750773934 24 dbSNP
rs573667356 25 dbSNP
rs1251378088 26 dbSNP
rs988217451 28 dbSNP
rs757541258 30 dbSNP
rs762352222 30 dbSNP
rs201391224 32 dbSNP
rs1455649821 36 dbSNP
rs763614704 37 dbSNP
rs1376323366 38 dbSNP
rs1036267596 45 dbSNP
rs760262685 49 dbSNP
rs775221035 50 dbSNP
rs1184828812 62 dbSNP
rs1389822408 63 dbSNP
rs564624110 64 dbSNP
rs987856352 67 dbSNP
rs1414195609 71 dbSNP
rs1319632913 76 dbSNP
rs1289478485 77 dbSNP
rs1428088884 79 dbSNP
rs1319342210 82 dbSNP
rs1236062358 83 dbSNP
rs953419084 89 dbSNP
rs1028853594 90 dbSNP
rs970307538 100 dbSNP
rs1021845188 112 dbSNP
rs1307721683 116 dbSNP
rs1011600986 126 dbSNP
rs994737835 128 dbSNP
rs891770283 132 dbSNP
rs1393060171 133 dbSNP
rs1053234482 134 dbSNP
rs1456305353 137 dbSNP
rs997990723 138 dbSNP
rs901715023 139 dbSNP
rs1039271353 148 dbSNP
rs943171272 154 dbSNP
rs148329788 155 dbSNP
rs899001756 163 dbSNP
rs1014744126 164 dbSNP
rs1004725516 169 dbSNP
rs1182778324 170 dbSNP
rs1048937901 174 dbSNP
rs929003497 177 dbSNP
rs1473480960 182 dbSNP
rs1394589251 204 dbSNP
rs1323552941 218 dbSNP
rs765180165 227 dbSNP
rs1330130943 236 dbSNP
rs1056899969 243 dbSNP
rs1249336791 244 dbSNP
rs147241809 246 dbSNP
rs559240625 260 dbSNP
rs1291511454 262 dbSNP
rs1335629183 263 dbSNP
rs1215621416 264 dbSNP
rs1271550273 265 dbSNP
rs1207577307 269 dbSNP
rs1182739028 276 dbSNP
rs1234973429 279 dbSNP
rs926360245 286 dbSNP
rs905554199 291 dbSNP
rs1045322482 292 dbSNP
rs776365343 293 dbSNP
rs1162139297 299 dbSNP
rs915506403 302 dbSNP
rs988271528 309 dbSNP
rs539598309 310 dbSNP
rs935534995 312 dbSNP
rs1288118253 313 dbSNP
rs1330408168 323 dbSNP
rs1333775697 324 dbSNP
rs1408987034 326 dbSNP
rs1293895789 330 dbSNP
rs1437557617 331 dbSNP
rs911937620 332 dbSNP
rs987603305 334 dbSNP
rs1036560364 338 dbSNP
rs990385735 341 dbSNP
rs1321786143 342 dbSNP
rs1282522525 343 dbSNP
rs1355657886 344 dbSNP
rs112336766 351 dbSNP
rs1028990837 353 dbSNP
rs1275371608 355 dbSNP
rs746451868 359 dbSNP
rs115405985 365 dbSNP
rs963229524 366 dbSNP
rs1014796537 371 dbSNP
rs1186369115 372 dbSNP
rs1005099562 373 dbSNP
rs541320676 389 dbSNP
rs1017648491 390 dbSNP
rs771679809 392 dbSNP
rs895661647 397 dbSNP
rs143864244 398 dbSNP
rs568036897 404 dbSNP
rs1428926976 412 dbSNP
rs1001314524 413 dbSNP
rs1313294113 415 dbSNP
rs550142665 417 dbSNP
rs905522781 418 dbSNP
rs1340014373 421 dbSNP
rs538126872 424 dbSNP
rs1011251386 444 dbSNP
rs1272192413 446 dbSNP
rs1340258237 451 dbSNP
rs1227900077 455 dbSNP
rs894041765 466 dbSNP
rs897527060 482 dbSNP
rs11540608 486 dbSNP
rs756415398 492 dbSNP
rs1327714816 495 dbSNP
rs1199253124 496 dbSNP
rs935485366 502 dbSNP
rs1284119654 509 dbSNP
rs912087626 510 dbSNP
rs1347543890 518 dbSNP
rs1448523638 519 dbSNP
rs866490033 521 dbSNP
rs570612553 522 dbSNP
rs1432622727 523 dbSNP
rs1302249100 528 dbSNP
rs980486634 538 dbSNP
rs1382884203 545 dbSNP
rs1320399583 553 dbSNP
rs1366112852 554 dbSNP
rs1363065877 555 dbSNP
rs948892707 559 dbSNP
rs1304362069 563 dbSNP
rs922027425 569 dbSNP
rs1322650286 610 dbSNP
rs973337303 613 dbSNP
rs138923304 616 dbSNP
rs1245679026 617 dbSNP
rs527469288 619 dbSNP
rs983414155 624 dbSNP
rs114964114 630 dbSNP
rs1158240069 631 dbSNP
rs1254474751 632 dbSNP
rs139149872 632 dbSNP
rs1414873450 641 dbSNP
rs1452393121 641 dbSNP
rs1175047254 644 dbSNP
rs960122310 670 dbSNP
rs748554316 677 dbSNP
rs559815948 679 dbSNP
rs781515277 680 dbSNP
rs1456774321 682 dbSNP
rs1326902531 683 dbSNP
rs1007581594 686 dbSNP
rs1453423100 698 dbSNP
rs1301053462 701 dbSNP
rs1248193877 704 dbSNP
rs115146023 722 dbSNP
rs1463129552 731 dbSNP
rs1241812274 733 dbSNP
rs1481581297 740 dbSNP
rs753472233 741 dbSNP
rs562007282 746 dbSNP
rs1001682389 747 dbSNP
rs1242090271 749 dbSNP
rs1211416607 752 dbSNP
rs969757625 754 dbSNP
rs1274702635 755 dbSNP
rs1021404684 757 dbSNP
rs1190219341 769 dbSNP
rs1250996962 773 dbSNP
rs1420589699 774 dbSNP
rs181198953 777 dbSNP
rs897740459 786 dbSNP
rs891498794 792 dbSNP
rs1396738468 795 dbSNP
rs1053098027 825 dbSNP
rs904842664 833 dbSNP
rs1044858080 834 dbSNP
rs1226318724 839 dbSNP
rs142280957 840 dbSNP
rs1350373611 843 dbSNP
rs1234390039 846 dbSNP
rs890612595 848 dbSNP
rs766608765 853 dbSNP
rs1294617538 861 dbSNP
rs1051903987 862 dbSNP
rs932153450 863 dbSNP
rs921996521 873 dbSNP
rs758690108 876 dbSNP
rs1481528515 881 dbSNP
rs543747646 885 dbSNP
rs1202736338 890 dbSNP
rs763679802 890 dbSNP
rs1360759355 893 dbSNP
rs1251043487 895 dbSNP
rs55716758 899 dbSNP
rs924873991 900 dbSNP
rs765560808 905 dbSNP
rs907902062 918 dbSNP
rs761474397 925 dbSNP
rs983770006 935 dbSNP
rs369030313 936 dbSNP
rs928547324 939 dbSNP
rs1306594663 943 dbSNP
rs1183022876 949 dbSNP
rs1415947579 956 dbSNP
rs979937567 958 dbSNP
rs1315279826 959 dbSNP
rs1027658988 962 dbSNP
rs188544059 971 dbSNP
rs961874631 973 dbSNP
rs1236175561 976 dbSNP
rs1210648839 977 dbSNP
rs969894823 980 dbSNP
rs1308863804 985 dbSNP
rs776503988 985 dbSNP
rs1003441568 996 dbSNP
rs1021373637 1007 dbSNP
rs763911357 1013 dbSNP
rs760703943 1014 dbSNP
rs1307057379 1016 dbSNP
rs138009441 1021 dbSNP
rs1230039054 1027 dbSNP
rs893561594 1030 dbSNP
rs114375048 1033 dbSNP
rs1031370568 1034 dbSNP
rs1181319459 1035 dbSNP
rs1413982330 1040 dbSNP
rs1008317146 1050 dbSNP
rs1370917920 1059 dbSNP
rs1262466734 1065 dbSNP
rs934854497 1069 dbSNP
rs1451580808 1070 dbSNP
rs924786731 1074 dbSNP
rs1041065122 1076 dbSNP
rs1309534953 1078 dbSNP
rs184261394 1083 dbSNP
rs910772622 1094 dbSNP
rs1357907891 1103 dbSNP
rs986099552 1104 dbSNP
rs535537853 1118 dbSNP
rs868259173 1121 dbSNP
rs996271071 1127 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acguuagGGGU-CGGGACGa 5'
                 |||| ||||||| 
Target 5' --ucccgCCCACGCCCUGC- 3'
 		1 - 17
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000341846.5 | 3UTR | UCCCGCCCACGCCCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6132 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT067294 NECAP1 NECAP endocytosis associated 1 2 10
MIRT100110 ABT1 activator of basal transcription 1 2 8
MIRT358583 CANX calnexin 2 2
MIRT445247 SEMA5A semaphorin 5A 2 2
MIRT445764 CCND3 cyclin D3 2 2
MIRT452388 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452829 FAM131B family with sequence similarity 131 member B 2 2
MIRT453450 GLG1 golgi glycoprotein 1 2 2
MIRT455435 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT460629 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461607 DPH2 DPH2 homolog 2 2
MIRT461989 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT464258 VCL vinculin 2 2
MIRT465713 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT466475 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT467119 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 4
MIRT468299 SFT2D2 SFT2 domain containing 2 2 2
MIRT469696 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT469904 PTRF caveolae associated protein 1 2 2
MIRT470015 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT471385 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471409 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471719 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473608 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT476328 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT479448 CDK6 cyclin dependent kinase 6 2 2
MIRT482032 AMER1 APC membrane recruitment protein 1 2 2
MIRT482360 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT484661 HOXD3 homeobox D3 2 4
MIRT486828 NDOR1 NADPH dependent diflavin oxidoreductase 1 2 2
MIRT487069 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487196 NFASC neurofascin 2 4
MIRT487448 TFAP2B transcription factor AP-2 beta 2 4
MIRT487517 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT487640 BRSK2 BR serine/threonine kinase 2 2 4
MIRT487755 SKI SKI proto-oncogene 2 4
MIRT489944 CPLX1 complexin 1 2 2
MIRT491101 MSI1 musashi RNA binding protein 1 2 4
MIRT491181 LAMA5 laminin subunit alpha 5 2 2
MIRT492355 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493918 FAM127B retrotransposon Gag like 8A 2 4
MIRT493932 FAM127A retrotransposon Gag like 8C 2 4
MIRT494679 ARID3A AT-rich interaction domain 3A 2 2
MIRT494814 AKAP11 A-kinase anchoring protein 11 2 2
MIRT494835 ADCY9 adenylate cyclase 9 2 2
MIRT495455 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT496962 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT526228 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT531028 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT557110 HOXA3 homeobox A3 2 2
MIRT560514 POGK pogo transposable element derived with KRAB domain 2 2
MIRT567753 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT569608 TRIM29 tripartite motif containing 29 2 2
MIRT570242 CPNE5 copine 5 2 2
MIRT572327 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT572373 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575024 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT576146 Hmox1 heme oxygenase 1 2 2
MIRT612443 SMOC2 SPARC related modular calcium binding 2 2 2
MIRT615404 VDAC2 voltage dependent anion channel 2 2 2
MIRT629114 CYCS cytochrome c, somatic 2 2
MIRT631362 FOXI2 forkhead box I2 2 2
MIRT639322 THBD thrombomodulin 2 2
MIRT643797 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT669687 ABLIM1 actin binding LIM protein 1 2 2
MIRT670595 LLGL1 LLGL1, scribble cell polarity complex component 2 4
MIRT691190 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT691688 FLOT2 flotillin 2 2 2
MIRT697127 OTUD5 OTU deubiquitinase 5 2 2
MIRT700814 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701248 NUP35 nucleoporin 35 2 2
MIRT702362 KLHL15 kelch like family member 15 2 2
MIRT703325 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT706060 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT710475 CDH5 cadherin 5 2 2
MIRT713018 SLC4A2 solute carrier family 4 member 2 2 2
MIRT716427 RAB15 RAB15, member RAS oncogene family 2 2
MIRT718093 ABHD12 abhydrolase domain containing 12 2 2
MIRT718542 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719122 CACFD1 calcium channel flower domain containing 1 2 2
MIRT721393 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT736283 CDC42 cell division cycle 42 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6132 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6132 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6132 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-6132 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6132 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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