miRTarBase - #MIRT569801


—
pre-miRNA Information
pre-miRNA hsa-mir-3937   
Genomic Coordinates chrX: 39661216 - 39661321
Description Homo sapiens miR-3937 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3937
Sequence 61| ACAGGCGGCUGUAGCAAUGGGGG |83
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1430604115 6 dbSNP
rs776622162 7 dbSNP
rs1283731816 11 dbSNP
rs1029784871 13 dbSNP
rs750525479 20 dbSNP
rs956488517 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol IGDCC3   
Synonyms HsT18880, PUNC
Description immunoglobulin superfamily DCC subclass member 3
Transcript NM_004884   
Expression
Putative miRNA Targets on IGDCC3
3'UTR of IGDCC3
(miRNA target sites are highlighted)		 
>IGDCC3|NM_004884|3'UTR
   1 CCAGTGTCTGGCAGGCTCCAGAGGGTGGACGGAGCGGGGCCCATTCTCAGGTCAAAAGCAAGATTTCTACTGTCATGTGG
  81 GATTTGGATGGTCCTGGGGGCTCCCCAGCATTTCTATCCTGACTGCCTCTTGGGTTGTCAAAACCCAAGGCAGCCTTGAC
 161 AGGGACCCCCCGGCCCTAACACCCATCAGGAGTTGGAGCAGTTCCTGCAGGAGCCTGTTCCTTCCCTGGGCTGACGCCCC
 241 CTTGCCTCTGCCTGGTACCCACATGACTTGGAACTGAACTAACATTTTTCTTTAAAAAGCAAAACTTAAAAAAAAAAAAA
 321 AAGAGGAGAGAGATAGAGGAAGGTGAATTAGACTCCAAAAGATGACCCTGCTGTAGCTGGGCCCTGACACTGTCACCCTC
 401 CACCGACTTTGTTTTCTCAGGATGGATTTTTGCTGTTTTGGCTCTCAGCACCTACCTCAGCCGGAATGAATGTCCTGGGG
 481 GGCAGTGGGGCGGTGGCCTCAGCCCCCTTACCCCACAGAGCCCGAATGCACTCCTACCTCAAGTCCCCTTGCTGGGGACC
 561 CCCTCTCCCTTCCCACACTGTTGTCCAGAGTAAAAAAAAAAAAAAAAAAAAAAGCACTTCCCCGTTTCCAGGTGTGAAAG
 641 AAAAAAAAAAGCACTTCCCCATTTCCAGATGTGAAAGAAAATGTCTACCTCAAGGCTCGCTGGCTCTGTGGGCTGTGTTG
 721 TCACTGGACCTGCCTCCCCGCCCCTCCTGCCCACAGCCCACCTACCTCTCCTGCAGAGGAGAGGCCAGAGGTTGGGCCAC
 801 CAAGGGGAACTCTTGTGGCCTACAGAAATAGAAATGGATTGGGCAGAGAAAAAATGTGAAAGCAGCCAAAAATGAGAGGA
 881 AATTTGTTCCTTGAAGTATAAATTGTCCAAACGAGCCACCTCCCAGCACACCGCCTGTCCCCGTCTTGTCTGTCCACTCC
 961 CATTTTGAGCCAGCCCATCCTTGATGGGGATGCCCATGAGGAACCTGGGCTTGGGAGGGTGGCATCAGCTGGCCGCCTGC
1041 CTCCTGTCCTGCAGGCCCGGCCCCTGGAATGTACCATGTGTGGGATGGGTGTGTGGGAGGGTGAGGGGGTGTGGGTGTCC
1121 CCTGCAGAGGCGCCCCAGCCTCAGGCACCCAGCCAGCCTGATCCACCCCTCGACAGGGGAGCATCCACTGTCAGCAGCCA
1201 TGGCCGGAAGCTATTTTTATACAAGGTGTGTTAAGGGTTATGTTCTTGTGACTTTTTGTTACTCTTTTCTGTTGTGTTGT
1281 TCTTTGAACTACTTAGTTAAAGAAGAAGAAAAGAAAACCAAGGAAACAAATACCTATTTTTGGTTATACTCAGAAACATT
1361 TTTTTAAATAGCAGAAGAAAAACTTTTTTTAAAGAAAAAAGATAAGTGTATTCCTTAAGAATGAGACCATAAATATCCCT
1441 GACCCCCAATCCTCTAGGGACACCTCCACCCTGAACTTTAGTTAATTAGCTGAAGAAGATAGAATTTGTGGTGTTTTCCT
1521 AGAAAACTAGAGCTGTGTCCGCGTGGACTTGGGGAAGGGTAGTCCCTTCCCTTCTCCCAAATGATGTGTGGATGCCCAGG
1601 GCTCCACAAAGCTCCAAGGCAGTGCCCCCTCTGTTCCCAAAGCAGCTTCTCTCGGGAGCCTCCCTCTCCCTTGGGAAGGG
1681 TGCGGCTGGGGCAGGAGGGGGCTGGGGGGCCACCTGGCCTTACTTGGGTTTTGTCACACTCTGCTCATTTTGACTGAATA
1761 AAAGTCCTGTTGCCAAAGTGAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGGGUAACGAUGUCGGCGGACa 5'
            ||||  || ||| ||||||| 
Target 5' ctCCCA--GC-ACA-CCGCCTGt 3'
 920 - 938 159.00 -25.90
2 
miRNA  3' ggggGUA-ACGAUGUCGGCGGACa 5'
              |||  |||  :|||||||| 
Target 5' gtggCATCAGCT--GGCCGCCTGc 3'
 1019 - 1040 155.00 -19.60
3 
miRNA  3' ggGGGUAACGAUGUCGGCGGACa 5'
            ||| ||||  |  |:||||| 
Target 5' gcCCCCTTGC--C-TCTGCCTGg 3'
 236 - 255 140.00 -24.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30527353 27 COSMIC
COSN30521649 28 COSMIC
COSN26979681 30 COSMIC
COSN13633565 31 COSMIC
COSN30475862 32 COSMIC
COSN1179035 36 COSMIC
COSN31607695 41 COSMIC
COSN20042243 54 COSMIC
COSN31570468 60 COSMIC
COSN31571420 74 COSMIC
COSN26979683 90 COSMIC
COSN31498248 93 COSMIC
COSN31495419 94 COSMIC
COSN31509869 99 COSMIC
COSN30475392 105 COSMIC
COSN30480110 107 COSMIC
COSN31958474 118 COSMIC
COSN30504628 123 COSMIC
COSN508725 130 COSMIC
COSN27382480 308 COSMIC
COSN29832692 396 COSMIC
COSN31517492 405 COSMIC
COSN31594168 422 COSMIC
COSN30168279 446 COSMIC
COSN26464702 500 COSMIC
COSN26574193 529 COSMIC
COSN26641672 555 COSMIC
COSN8590245 592 COSMIC
COSN31485217 673 COSMIC
COSN31486421 736 COSMIC
COSN1682392 737 COSMIC
COSN2520660 740 COSMIC
COSN31549774 778 COSMIC
COSN26564317 785 COSMIC
COSN30544616 798 COSMIC
COSN31484365 983 COSMIC
COSN32063819 1005 COSMIC
COSN31551532 1010 COSMIC
COSN20856761 1125 COSMIC
COSN24094113 1132 COSMIC
COSN31545268 1190 COSMIC
COSN31587985 1240 COSMIC
COSN8749476 1274 COSMIC
COSN16427671 1386 COSMIC
COSN5756007 1563 COSMIC
COSN6278169 1576 COSMIC
COSN26585382 1659 COSMIC
COSN8175773 1684 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1282683454 2 dbSNP
rs368951705 5 dbSNP
rs746616128 14 dbSNP
rs1449270692 21 dbSNP
rs1216179552 22 dbSNP
rs985288436 27 dbSNP
rs201323718 30 dbSNP
rs758106277 31 dbSNP
rs745874407 35 dbSNP
rs778710245 36 dbSNP
rs1208838580 38 dbSNP
rs757162017 39 dbSNP
rs1281349251 40 dbSNP
rs186443623 42 dbSNP
rs753937830 48 dbSNP
rs1366410048 57 dbSNP
rs1330194582 58 dbSNP
rs373242020 64 dbSNP
rs760417011 69 dbSNP
rs1419350268 79 dbSNP
rs774985518 81 dbSNP
rs144745548 85 dbSNP
rs555522760 96 dbSNP
rs771707851 99 dbSNP
rs1175553961 103 dbSNP
rs985085982 106 dbSNP
rs11853777 109 dbSNP
rs1332434489 112 dbSNP
rs773651680 115 dbSNP
rs956115207 118 dbSNP
rs1172327866 121 dbSNP
rs1441547318 122 dbSNP
rs1238900894 130 dbSNP
rs1282450330 134 dbSNP
rs907246300 135 dbSNP
rs552718554 138 dbSNP
rs1199450292 139 dbSNP
rs1253554800 146 dbSNP
rs118001444 148 dbSNP
rs1000264556 154 dbSNP
rs904304640 158 dbSNP
rs1247830721 160 dbSNP
rs1448086843 167 dbSNP
rs1257971560 169 dbSNP
rs1022706432 170 dbSNP
rs1012647689 171 dbSNP
rs550854147 172 dbSNP
rs8031105 181 dbSNP
rs1170908645 182 dbSNP
rs1387352618 190 dbSNP
rs1242232381 193 dbSNP
rs1353756003 195 dbSNP
rs1307930971 196 dbSNP
rs1057001367 199 dbSNP
rs533319467 200 dbSNP
rs558939480 201 dbSNP
rs1364170161 214 dbSNP
rs372914569 217 dbSNP
rs1305527096 222 dbSNP
rs182077173 235 dbSNP
rs527499391 236 dbSNP
rs941352022 255 dbSNP
rs1050136092 257 dbSNP
rs909993239 262 dbSNP
rs1195902017 265 dbSNP
rs1254113072 270 dbSNP
rs561892060 271 dbSNP
rs34795347 272 dbSNP
rs1196798304 274 dbSNP
rs1365580858 279 dbSNP
rs1470583034 285 dbSNP
rs1311546438 292 dbSNP
rs1422082809 293 dbSNP
rs367985325 299 dbSNP
rs922980458 300 dbSNP
rs1158164903 301 dbSNP
rs1395059332 305 dbSNP
rs1468795392 306 dbSNP
rs1370479840 307 dbSNP
rs1336990340 308 dbSNP
rs1188527191 316 dbSNP
rs1326659664 323 dbSNP
rs199843268 323 dbSNP
rs750959404 323 dbSNP
rs76982849 323 dbSNP
rs971818390 323 dbSNP
rs940822466 325 dbSNP
rs1253357259 326 dbSNP
rs1419745733 326 dbSNP
rs909410691 327 dbSNP
rs1166105755 328 dbSNP
rs1409953449 330 dbSNP
rs58134830 334 dbSNP
rs1166772567 336 dbSNP
rs959028439 338 dbSNP
rs376184556 339 dbSNP
rs1049816106 343 dbSNP
rs1022580550 344 dbSNP
rs932707773 345 dbSNP
rs922467260 348 dbSNP
rs976951037 350 dbSNP
rs1202908460 352 dbSNP
rs1409843316 358 dbSNP
rs1306900317 362 dbSNP
rs538742285 364 dbSNP
rs1284353088 373 dbSNP
rs1234714074 376 dbSNP
rs1020302899 381 dbSNP
rs570172516 387 dbSNP
rs1253524917 390 dbSNP
rs1481252222 391 dbSNP
rs1204457416 396 dbSNP
rs1355168041 404 dbSNP
rs978449230 405 dbSNP
rs968393927 408 dbSNP
rs1402364840 414 dbSNP
rs1255806118 418 dbSNP
rs1022608556 420 dbSNP
rs1361811969 422 dbSNP
rs1353694472 427 dbSNP
rs1162450216 433 dbSNP
rs780616659 440 dbSNP
rs1012679290 446 dbSNP
rs1032209078 449 dbSNP
rs1392977448 452 dbSNP
rs1164011426 455 dbSNP
rs1472606323 459 dbSNP
rs1001187923 462 dbSNP
rs748660098 463 dbSNP
rs1303063753 465 dbSNP
rs1195633417 466 dbSNP
rs1035235437 471 dbSNP
rs531474126 474 dbSNP
rs1298215184 475 dbSNP
rs781369004 478 dbSNP
rs997160586 483 dbSNP
rs754987148 486 dbSNP
rs1228267510 488 dbSNP
rs1350127484 491 dbSNP
rs897434186 491 dbSNP
rs1037671325 492 dbSNP
rs1208847711 496 dbSNP
rs1179864269 497 dbSNP
rs901526378 500 dbSNP
rs1449902204 503 dbSNP
rs1187843016 516 dbSNP
rs1005734786 523 dbSNP
rs1271654111 524 dbSNP
rs940458152 527 dbSNP
rs888458085 529 dbSNP
rs1358164498 531 dbSNP
rs909379558 533 dbSNP
rs747058593 537 dbSNP
rs1049192889 539 dbSNP
rs1366350569 543 dbSNP
rs1434900700 546 dbSNP
rs866128338 547 dbSNP
rs1270060710 548 dbSNP
rs1373833542 556 dbSNP
rs1219838581 557 dbSNP
rs1310561310 559 dbSNP
rs1429279931 560 dbSNP
rs1261596732 564 dbSNP
rs937513299 564 dbSNP
rs1207887223 566 dbSNP
rs1246057531 572 dbSNP
rs1455547877 574 dbSNP
rs1191224850 577 dbSNP
rs1423815509 580 dbSNP
rs1324341024 586 dbSNP
rs1461093014 588 dbSNP
rs1329637415 590 dbSNP
rs1463148024 591 dbSNP
rs1160823554 592 dbSNP
rs34065363 592 dbSNP
rs79338561 592 dbSNP
rs1178435987 593 dbSNP
rs1487215667 593 dbSNP
rs1412174390 604 dbSNP
rs1472078962 609 dbSNP
rs1156555430 610 dbSNP
rs1173105689 612 dbSNP
rs1465882070 613 dbSNP
rs1164237370 614 dbSNP
rs1226761240 614 dbSNP
rs1308742550 614 dbSNP
rs1323475608 614 dbSNP
rs1348654516 614 dbSNP
rs1406378082 614 dbSNP
rs1444399384 614 dbSNP
rs1491054957 614 dbSNP
rs72360618 614 dbSNP
rs764110008 614 dbSNP
rs1422611209 615 dbSNP
rs796499867 615 dbSNP
rs1251870426 619 dbSNP
rs960212361 623 dbSNP
rs1179555930 624 dbSNP
rs1259264737 633 dbSNP
rs1473294135 634 dbSNP
rs1166035467 635 dbSNP
rs1478995117 640 dbSNP
rs374122839 641 dbSNP
rs80025624 641 dbSNP
rs1169823182 645 dbSNP
rs1197625786 647 dbSNP
rs79905208 650 dbSNP
rs1310286858 651 dbSNP
rs1314998230 651 dbSNP
rs76029683 651 dbSNP
rs1341299799 654 dbSNP
rs1466847294 657 dbSNP
rs1448409826 659 dbSNP
rs1283404707 661 dbSNP
rs1376755495 661 dbSNP
rs545483587 662 dbSNP
rs922674249 670 dbSNP
rs1275338286 674 dbSNP
rs1239557580 675 dbSNP
rs1240537461 682 dbSNP
rs1340841040 687 dbSNP
rs1040914099 689 dbSNP
rs934472750 691 dbSNP
rs971352393 696 dbSNP
rs1280231354 698 dbSNP
rs1442668475 699 dbSNP
rs1187238016 706 dbSNP
rs913263134 709 dbSNP
rs988848241 714 dbSNP
rs1451770018 726 dbSNP
rs1026242270 728 dbSNP
rs993701012 735 dbSNP
rs957491074 737 dbSNP
rs1390171297 739 dbSNP
rs536806030 740 dbSNP
rs1175612581 741 dbSNP
rs376003219 742 dbSNP
rs978688155 744 dbSNP
rs1272772950 750 dbSNP
rs968589517 751 dbSNP
rs781624728 754 dbSNP
rs1338472651 755 dbSNP
rs576742304 759 dbSNP
rs1298164236 761 dbSNP
rs564637747 762 dbSNP
rs185447489 769 dbSNP
rs901503379 771 dbSNP
rs1345166058 781 dbSNP
rs1199501615 782 dbSNP
rs1036072149 791 dbSNP
rs1466524954 794 dbSNP
rs1003737313 798 dbSNP
rs887491392 801 dbSNP
rs1049299431 805 dbSNP
rs1201038358 809 dbSNP
rs1378254122 810 dbSNP
rs750235404 812 dbSNP
rs1171033578 813 dbSNP
rs1447821046 813 dbSNP
rs1387423569 820 dbSNP
rs927478260 831 dbSNP
rs1045966887 838 dbSNP
rs1416096017 839 dbSNP
rs1425858007 841 dbSNP
rs1015683279 850 dbSNP
rs913232046 855 dbSNP
rs138857541 865 dbSNP
rs888656975 867 dbSNP
rs926028140 867 dbSNP
rs985964972 878 dbSNP
rs1229340159 880 dbSNP
rs1457082769 886 dbSNP
rs1232636969 889 dbSNP
rs1202951009 895 dbSNP
rs62014996 901 dbSNP
rs111862391 902 dbSNP
rs1451042975 903 dbSNP
rs372490848 905 dbSNP
rs1196866223 909 dbSNP
rs1414404590 910 dbSNP
rs901283117 912 dbSNP
rs1029277983 913 dbSNP
rs1234237821 920 dbSNP
rs765025209 932 dbSNP
rs528009820 933 dbSNP
rs1241105117 937 dbSNP
rs934736059 941 dbSNP
rs903023821 943 dbSNP
rs1351906278 948 dbSNP
rs535646356 960 dbSNP
rs1296227467 963 dbSNP
rs1287394594 969 dbSNP
rs1042873140 986 dbSNP
rs1247451499 990 dbSNP
rs576139252 991 dbSNP
rs887459314 999 dbSNP
rs1356291243 1001 dbSNP
rs1208099599 1007 dbSNP
rs1254035246 1008 dbSNP
rs947327307 1009 dbSNP
rs556574665 1012 dbSNP
rs1449885217 1017 dbSNP
rs1181708588 1023 dbSNP
rs1249970110 1031 dbSNP
rs564851217 1034 dbSNP
rs938327597 1035 dbSNP
rs1312158068 1045 dbSNP
rs928297409 1051 dbSNP
rs972236947 1058 dbSNP
rs539472279 1059 dbSNP
rs1418148558 1061 dbSNP
rs1306956317 1067 dbSNP
rs1405419327 1069 dbSNP
rs1398106642 1075 dbSNP
rs1183256129 1079 dbSNP
rs1015715809 1080 dbSNP
rs984249272 1081 dbSNP
rs952997594 1084 dbSNP
rs1340292418 1089 dbSNP
rs1473953726 1090 dbSNP
rs7174072 1091 dbSNP
rs1210765590 1092 dbSNP
rs541021133 1099 dbSNP
rs1204525810 1102 dbSNP
rs1272677349 1107 dbSNP
rs997086796 1109 dbSNP
rs775714877 1110 dbSNP
rs1001718497 1111 dbSNP
rs1256558542 1111 dbSNP
rs1423078439 1112 dbSNP
rs901185256 1116 dbSNP
rs1005630471 1118 dbSNP
rs1181674147 1119 dbSNP
rs547459293 1120 dbSNP
rs1019577489 1121 dbSNP
rs561150822 1123 dbSNP
rs999348522 1126 dbSNP
rs1316426877 1131 dbSNP
rs889901842 1132 dbSNP
rs1230273343 1137 dbSNP
rs142758622 1146 dbSNP
rs1303121043 1152 dbSNP
rs950222287 1157 dbSNP
rs1292504072 1165 dbSNP
rs892010687 1169 dbSNP
rs1300355952 1171 dbSNP
rs568352142 1172 dbSNP
rs1053311205 1176 dbSNP
rs1295536219 1177 dbSNP
rs151025558 1177 dbSNP
rs1314061511 1180 dbSNP
rs548413636 1182 dbSNP
rs1042946242 1183 dbSNP
rs543087758 1185 dbSNP
rs1255687422 1189 dbSNP
rs531485793 1202 dbSNP
rs75872181 1205 dbSNP
rs572484774 1206 dbSNP
rs1418986958 1207 dbSNP
rs922715226 1213 dbSNP
rs1187760317 1222 dbSNP
rs553542335 1224 dbSNP
rs1416749099 1233 dbSNP
rs374742796 1237 dbSNP
rs975882455 1242 dbSNP
rs1376725256 1245 dbSNP
rs938583711 1248 dbSNP
rs138497444 1258 dbSNP
rs560118519 1259 dbSNP
rs180809392 1260 dbSNP
rs531305672 1261 dbSNP
rs951733939 1262 dbSNP
rs758946564 1263 dbSNP
rs1485561769 1264 dbSNP
rs1259062332 1271 dbSNP
rs752213810 1274 dbSNP
rs1027766952 1277 dbSNP
rs908956085 1291 dbSNP
rs772332022 1293 dbSNP
rs984278614 1299 dbSNP
rs1221419212 1300 dbSNP
rs1321698098 1300 dbSNP
rs562558042 1302 dbSNP
rs1208012501 1305 dbSNP
rs1465218496 1305 dbSNP
rs1240349456 1311 dbSNP
rs754964386 1311 dbSNP
rs1489139575 1313 dbSNP
rs905569824 1318 dbSNP
rs767290349 1325 dbSNP
rs1231292977 1326 dbSNP
rs1479271678 1327 dbSNP
rs1413134629 1331 dbSNP
rs1024016838 1333 dbSNP
rs1014344698 1336 dbSNP
rs1352135195 1339 dbSNP
rs1278693385 1342 dbSNP
rs891979753 1344 dbSNP
rs1053279842 1346 dbSNP
rs1381599273 1352 dbSNP
rs936279007 1355 dbSNP
rs904522241 1358 dbSNP
rs1281997053 1359 dbSNP
rs34483447 1366 dbSNP
rs1221614457 1368 dbSNP
rs1245595258 1376 dbSNP
rs1050154455 1382 dbSNP
rs572448371 1384 dbSNP
rs1183882708 1391 dbSNP
rs1252177292 1391 dbSNP
rs932678866 1391 dbSNP
rs952901329 1391 dbSNP
rs1359223675 1394 dbSNP
rs1416535985 1394 dbSNP
rs1041169549 1401 dbSNP
rs1436741235 1402 dbSNP
rs1164749490 1404 dbSNP
rs1363773070 1404 dbSNP
rs944505622 1419 dbSNP
rs1393347522 1438 dbSNP
rs759248888 1440 dbSNP
rs907739233 1444 dbSNP
rs1441154122 1447 dbSNP
rs639812 1450 dbSNP
rs1228798050 1461 dbSNP
rs1291023415 1463 dbSNP
rs573470121 1473 dbSNP
rs1426273362 1475 dbSNP
rs1274852251 1482 dbSNP
rs1202052664 1485 dbSNP
rs1439440448 1485 dbSNP
rs542022915 1499 dbSNP
rs555422249 1502 dbSNP
rs1473362693 1511 dbSNP
rs1428494193 1518 dbSNP
rs1383926666 1522 dbSNP
rs1451342027 1525 dbSNP
rs1169332645 1532 dbSNP
rs1370147214 1536 dbSNP
rs1408399911 1538 dbSNP
rs920525349 1541 dbSNP
rs976079161 1542 dbSNP
rs1448570517 1543 dbSNP
rs56835863 1545 dbSNP
rs1380521737 1549 dbSNP
rs1252550507 1550 dbSNP
rs1212064630 1551 dbSNP
rs1020074010 1558 dbSNP
rs1297653743 1559 dbSNP
rs1319671624 1574 dbSNP
rs78635979 1577 dbSNP
rs1023982719 1580 dbSNP
rs1013981284 1588 dbSNP
rs1443284062 1595 dbSNP
rs1251719724 1596 dbSNP
rs1226557946 1598 dbSNP
rs770252674 1603 dbSNP
rs956194010 1609 dbSNP
rs1305761263 1620 dbSNP
rs1189826654 1622 dbSNP
rs1372557260 1628 dbSNP
rs967485632 1630 dbSNP
rs1219244324 1636 dbSNP
rs556399039 1638 dbSNP
rs189671228 1642 dbSNP
rs1050025422 1645 dbSNP
rs894324692 1646 dbSNP
rs1403685973 1651 dbSNP
rs997229918 1653 dbSNP
rs1055596154 1654 dbSNP
rs1003205482 1655 dbSNP
rs11856970 1665 dbSNP
rs1036471711 1682 dbSNP
rs940354779 1683 dbSNP
rs908859880 1684 dbSNP
rs1048810698 1685 dbSNP
rs1299139008 1692 dbSNP
rs1445289650 1693 dbSNP
rs930499839 1698 dbSNP
rs777023478 1706 dbSNP
rs920476568 1710 dbSNP
rs931699143 1710 dbSNP
rs540115580 1724 dbSNP
rs970109837 1728 dbSNP
rs975607295 1739 dbSNP
rs1371912362 1752 dbSNP
rs1458676641 1754 dbSNP
rs1159725158 1755 dbSNP
rs1178890862 1760 dbSNP
rs1454717855 1764 dbSNP
rs1394593177 1770 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5 PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177607. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_9 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000327987.4 | 3UTR | CACACCGCCUGUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000327987.4 | 3UTR | CACACCGCCUGUCCCCGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000327987.4 | 3UTR | ACACCGCCUGUCCCCGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
Click to see details
Click to see details
40 hsa-miR-3937 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT332487 CD81 CD81 molecule 2 2
MIRT441327 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 4
MIRT454032 EIF3CL eukaryotic translation initiation factor 3 subunit C like 2 2
MIRT458086 EIF3C eukaryotic translation initiation factor 3 subunit C 2 2
MIRT460785 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT463150 ZNF385A zinc finger protein 385A 2 4
MIRT467162 SREBF2 sterol regulatory element binding transcription factor 2 2 2
MIRT469618 RAI1 retinoic acid induced 1 2 4
MIRT472258 NFIC nuclear factor I C 2 2
MIRT487587 FAM83H family with sequence similarity 83 member H 2 4
MIRT489302 B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 2 4
MIRT489741 GNAI2 G protein subunit alpha i2 2 4
MIRT490038 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490767 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491750 SEMA3F semaphorin 3F 2 2
MIRT492690 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT504843 RRP36 ribosomal RNA processing 36 2 4
MIRT510116 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT525313 FANCA Fanconi anemia complementation group A 2 4
MIRT569801 IGDCC3 immunoglobulin superfamily DCC subclass member 3 2 2
MIRT570224 SLC27A1 solute carrier family 27 member 1 2 2
MIRT629378 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT633104 CBX5 chromobox 5 2 2
MIRT645036 ATAD3C ATPase family, AAA domain containing 3C 2 2
MIRT660973 ABI2 abl interactor 2 2 2
MIRT671225 CLSTN1 calsyntenin 1 2 2
MIRT672046 SMTNL2 smoothelin like 2 2 2
MIRT677314 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT678290 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT693477 ZNF707 zinc finger protein 707 2 2
MIRT693576 PIGR polymeric immunoglobulin receptor 2 2
MIRT696832 PLLP plasmolipin 2 2
MIRT700149 RNF115 ring finger protein 115 2 2
MIRT703760 FAM118A family with sequence similarity 118 member A 2 2
MIRT705798 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT709105 SEPT4 septin 4 2 2
MIRT710235 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT711422 EPHA4 EPH receptor A4 2 2
MIRT712529 CYTH2 cytohesin 2 2 2
MIRT714081 ZNF532 zinc finger protein 532 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3937 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3937 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3937 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3937 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3937 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-3937 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3937 Taxane/Cisplatin/Fluorouracil sensitive High Hypopharyngeal Squamous Cell Carcinoma tissue
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (A2780)
hsa-mir-3937 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3937 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-3937 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3937 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3937 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3937 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3937 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-3937 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission