pre-miRNA Information
pre-miRNA hsa-mir-500b   
Genomic Coordinates chrX: 50010672 - 50010750
Description Homo sapiens miR-500b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-500b-3p
Sequence 51| GCACCCAGGCAAGGAUUCUG |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs782140253 8 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PCSK9   
Synonyms FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Description proprotein convertase subtilisin/kexin type 9
Transcript NM_174936   
Expression
Putative miRNA Targets on PCSK9
3'UTR of PCSK9
(miRNA target sites are highlighted)
>PCSK9|NM_174936|3'UTR
   1 CAGCCCCATCCCAGGATGGGTGTCTGGGGAGGGTCAAGGGCTGGGGCTGAGCTTTAAAATGGTTCCGACTTGTCCCTCTC
  81 TCAGCCCTCCATGGCCTGGCACGAGGGGATGGGGATGCTTCCGCCTTTCCGGGGCTGCTGGCCTGGCCCTTGAGTGGGGC
 161 AGCCTCCTTGCCTGGAACTCACTCACTCTGGGTGCCTCCTCCCCAGGTGGAGGTGCCAGGAAGCTCCCTCCCTCACTGTG
 241 GGGCATTTCACCATTCAAACAGGTCGAGCTGTGCTCGGGTGCTGCCAGCTGCTCCCAATGTGCCGATGTCCGTGGGCAGA
 321 ATGACTTTTATTGAGCTCTTGTTCCGTGCCAGGCATTCAATCCTCAGGTCTCCACCAAGGAGGCAGGATTCTTCCCATGG
 401 ATAGGGGAGGGGGCGGTAGGGGCTGCAGGGACAAACATCGTTGGGGGGTGAGTGTGAAAGGTGCTGATGGCCCTCATCTC
 481 CAGCTAACTGTGGAGAAGCCCCTGGGGGCTCCCTGATTAATGGAGGCTTAGCTTTCTGGATGGCATCTAGCCAGAGGCTG
 561 GAGACAGGTGCGCCCCTGGTGGTCACAGGCTGTGCCTTGGTTTCCTGAGCCACCTTTACTCTGCTCTATGCCAGGCTGTG
 641 CTAGCAACACCCAAAGGTGGCCTGCGGGGAGCCATCACCTAGGACTGACTCGGCAGTGTGCAGTGGTGCATGCACTGTCT
 721 CAGCCAACCCGCTCCACTACCCGGCAGGGTACACATTCGCACCCCTACTTCACAGAGGAAGAAACCTGGAACCAGAGGGG
 801 GCGTGCCTGCCAAGCTCACACAGCAGGAACTGAGCCAGAAACGCAGATTGGGCTGGCTCTGAAGCCAAGCCTCTTCTTAC
 881 TTCACCCGGCTGGGCTCCTCATTTTTACGGGTAACAGTGAGGCTGGGAAGGGGAACACAGACCAGGAAGCTCGGTGAGTG
 961 ATGGCAGAACGATGCCTGCAGGCATGGAACTTTTTCCGTTATCACCCAGGCCTGATTCACTGGCCTGGCGGAGATGCTTC
1041 TAAGGCATGGTCGGGGGAGAGGGCCAACAACTGTCCCTCCTTGAGCACCAGCCCCACCCAAGCAAGCAGACATTTATCTT
1121 TTGGGTCTGTCCTCTCTGTTGCCTTTTTACAGCCAACTTTTCTAGACCTGTTTTGCTTTTGTAACTTGAAGATATTTATT
1201 CTGGGTTTTGTAGCATTTTTATTAATATGGTGACTTTTTAAAATAAAAACAAACAAACGTTGTCCTAACAAAAAAAAAAA
1281 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guCUU-AG-GAACG-GACCCACg 5'
            ||| || ||  | ||||||| 
Target 5' tgGAACTCACTCACTCTGGGTGc 3'
173 - 195 150.00 -18.10
2
miRNA  3' gucUUAGGAA-CGGACCCAcg 5'
             :|| :||  :||||||  
Target 5' gaaGATATTTATTCTGGGTtt 3'
1188 - 1208 129.00 -10.44
3
miRNA  3' gucuUAGGAACGGACCCACg 5'
              ||||  |  |||||| 
Target 5' ccccATCCCAGGATGGGTGt 3'
4 - 23 124.00 -13.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
297710 29 ClinVar
297711 59 ClinVar
265950 76 ClinVar
297712 79 ClinVar
297713 91 ClinVar
297714 123 ClinVar
297715 153 ClinVar
297716 172 ClinVar
873731 180 ClinVar
297717 208 ClinVar
297718 233 ClinVar
297719 235 ClinVar
873732 266 ClinVar
297720 275 ClinVar
874691 277 ClinVar
297721 346 ClinVar
874692 369 ClinVar
297722 405 ClinVar
297723 405 ClinVar
297724 415 ClinVar
297725 427 ClinVar
297726 443 ClinVar
297727 445 ClinVar
297728 465 ClinVar
297729 471 ClinVar
297730 489 ClinVar
297731 510 ClinVar
297732 537 ClinVar
297733 549 ClinVar
297734 572 ClinVar
297735 615 ClinVar
876637 667 ClinVar
297736 760 ClinVar
297737 786 ClinVar
297738 804 ClinVar
873786 844 ClinVar
297739 847 ClinVar
297740 850 ClinVar
988770 864 ClinVar
873787 888 ClinVar
297741 951 ClinVar
988769 981 ClinVar
297742 1053 ClinVar
297743 1086 ClinVar
874742 1094 ClinVar
297744 1151 ClinVar
297745 1155 ClinVar
297746 1169 ClinVar
297747 1230 ClinVar
297748 1247 ClinVar
COSN30470396 15 COSMIC
COSN31536775 48 COSMIC
COSN20073458 131 COSMIC
COSN8474416 274 COSMIC
COSN5373596 396 COSMIC
COSN6460342 572 COSMIC
COSN25765832 680 COSMIC
COSN32057306 872 COSMIC
COSN7224152 1086 COSMIC
COSN23998310 1163 COSMIC
COSN10050369 1241 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1169441514 2 dbSNP
rs1419917238 5 dbSNP
rs1442996382 6 dbSNP
rs768204124 7 dbSNP
rs773818469 9 dbSNP
rs1366938062 15 dbSNP
rs553095640 21 dbSNP
rs1405021769 23 dbSNP
rs1302206576 26 dbSNP
rs189293781 29 dbSNP
rs771949878 30 dbSNP
rs1015416657 38 dbSNP
rs970494615 41 dbSNP
rs1340440495 45 dbSNP
rs773075461 50 dbSNP
rs760320200 51 dbSNP
rs1410050717 58 dbSNP
rs886046437 59 dbSNP
rs1159122739 60 dbSNP
rs962100203 63 dbSNP
rs994959013 67 dbSNP
rs764673359 68 dbSNP
rs28362287 76 dbSNP
rs1403962635 78 dbSNP
rs757944328 79 dbSNP
rs779641062 82 dbSNP
rs1490414204 88 dbSNP
rs549317206 91 dbSNP
rs936619529 103 dbSNP
rs1450296241 108 dbSNP
rs1286923206 114 dbSNP
rs953422561 115 dbSNP
rs989327370 119 dbSNP
rs751118819 123 dbSNP
rs1286548447 124 dbSNP
rs565851054 130 dbSNP
rs912152944 131 dbSNP
rs72646531 132 dbSNP
rs1302838439 134 dbSNP
rs1213804355 135 dbSNP
rs534769041 136 dbSNP
rs557810558 142 dbSNP
rs1346786994 148 dbSNP
rs890219404 150 dbSNP
rs886046438 153 dbSNP
rs988303907 157 dbSNP
rs557622245 172 dbSNP
rs1428146812 175 dbSNP
rs1189141189 187 dbSNP
rs1198998812 191 dbSNP
rs1477223169 202 dbSNP
rs1244220160 207 dbSNP
rs780774423 208 dbSNP
rs1446937027 213 dbSNP
rs898800751 217 dbSNP
rs145330737 233 dbSNP
rs182138201 235 dbSNP
rs1282847200 244 dbSNP
rs187366792 253 dbSNP
rs886644283 259 dbSNP
rs1270561772 263 dbSNP
rs1014422575 265 dbSNP
rs368297335 266 dbSNP
rs937695786 267 dbSNP
rs886046439 275 dbSNP
rs372350423 278 dbSNP
rs1469841199 279 dbSNP
rs1404765851 285 dbSNP
rs1056749858 289 dbSNP
rs1173464893 292 dbSNP
rs769628328 305 dbSNP
rs777645981 306 dbSNP
rs561634446 307 dbSNP
rs980569920 312 dbSNP
rs1367014114 313 dbSNP
rs1033025408 316 dbSNP
rs1439751801 318 dbSNP
rs957586588 330 dbSNP
rs989397020 332 dbSNP
rs1309484550 336 dbSNP
rs1274058525 338 dbSNP
rs1439130943 339 dbSNP
rs1004125446 342 dbSNP
rs17111555 346 dbSNP
rs770857069 347 dbSNP
rs1453319369 353 dbSNP
rs1381332915 363 dbSNP
rs1300577017 368 dbSNP
rs151125363 369 dbSNP
rs911692292 374 dbSNP
rs1169369738 376 dbSNP
rs564160446 381 dbSNP
rs1429475339 388 dbSNP
rs1388739206 395 dbSNP
rs886046440 405 dbSNP
rs1165967560 408 dbSNP
rs1027742048 413 dbSNP
rs953466707 414 dbSNP
rs13376071 415 dbSNP
rs1018994107 416 dbSNP
rs1233643654 426 dbSNP
rs886046441 427 dbSNP
rs966264807 429 dbSNP
rs550300315 431 dbSNP
rs920299564 433 dbSNP
rs1293694184 436 dbSNP
rs563834186 440 dbSNP
rs573180793 441 dbSNP
rs914045128 442 dbSNP
rs1222515081 443 dbSNP
rs72646533 443 dbSNP
rs28362288 445 dbSNP
rs28362289 453 dbSNP
rs979554949 462 dbSNP
rs886046442 465 dbSNP
rs886046443 471 dbSNP
rs886046444 489 dbSNP
rs1180452405 490 dbSNP
rs1368383810 496 dbSNP
rs1014473482 497 dbSNP
rs1380812866 499 dbSNP
rs548989313 501 dbSNP
rs72646534 504 dbSNP
rs886046445 510 dbSNP
rs1408838170 513 dbSNP
rs1181662275 515 dbSNP
rs757196482 517 dbSNP
rs1482202058 519 dbSNP
rs1271407639 526 dbSNP
rs1222935691 532 dbSNP
rs72646535 537 dbSNP
rs772321046 537 dbSNP
rs886046446 549 dbSNP
rs1241134346 552 dbSNP
rs1316935150 555 dbSNP
rs1287174692 571 dbSNP
rs662145 572 dbSNP
rs1346996430 573 dbSNP
rs1033492730 577 dbSNP
rs1405905466 580 dbSNP
rs957428111 584 dbSNP
rs1356970840 585 dbSNP
rs1056131446 593 dbSNP
rs17111557 615 dbSNP
rs1158516051 617 dbSNP
rs1354350207 619 dbSNP
rs1440442645 620 dbSNP
rs551502518 621 dbSNP
rs1334000029 627 dbSNP
rs1200471738 630 dbSNP
rs1432348106 638 dbSNP
rs1378291136 642 dbSNP
rs764587283 645 dbSNP
rs1486154074 648 dbSNP
rs966616937 654 dbSNP
rs571711835 655 dbSNP
rs1358480437 658 dbSNP
rs1229137487 665 dbSNP
rs1330828556 666 dbSNP
rs777232480 666 dbSNP
rs762427407 667 dbSNP
rs911759536 668 dbSNP
rs765744739 674 dbSNP
rs1200264462 676 dbSNP
rs1238787072 677 dbSNP
rs1320535734 679 dbSNP
rs539259897 688 dbSNP
rs1181614039 692 dbSNP
rs974559716 694 dbSNP
rs1465740717 696 dbSNP
rs751077328 697 dbSNP
rs930343330 698 dbSNP
rs1428959332 699 dbSNP
rs1247317753 708 dbSNP
rs889202048 710 dbSNP
rs373867523 714 dbSNP
rs907513439 719 dbSNP
rs1199462488 721 dbSNP
rs950291623 722 dbSNP
rs1252763163 730 dbSNP
rs1018945396 731 dbSNP
rs1452557623 732 dbSNP
rs901858718 733 dbSNP
rs1002102713 738 dbSNP
rs1433558568 739 dbSNP
rs1009801394 740 dbSNP
rs1021222541 742 dbSNP
rs1385006046 743 dbSNP
rs1054595868 746 dbSNP
rs1334927598 750 dbSNP
rs1395589163 754 dbSNP
rs968588765 759 dbSNP
rs886046447 760 dbSNP
rs1034304126 764 dbSNP
rs28362290 765 dbSNP
rs1389352615 775 dbSNP
rs991882624 776 dbSNP
rs879886207 777 dbSNP
rs939691598 779 dbSNP
rs1166585213 784 dbSNP
rs886046448 786 dbSNP
rs113241059 797 dbSNP
rs1220297401 798 dbSNP
rs955364172 803 dbSNP
rs529378080 804 dbSNP
rs1440246792 810 dbSNP
rs1252197284 815 dbSNP
rs931260736 828 dbSNP
rs748386411 830 dbSNP
rs1196052013 831 dbSNP
rs1343261076 836 dbSNP
rs1049560093 840 dbSNP
rs889645684 841 dbSNP
rs943439922 843 dbSNP
rs28362291 844 dbSNP
rs1191839538 845 dbSNP
rs901807760 846 dbSNP
rs886046449 847 dbSNP
rs72646536 849 dbSNP
rs28362292 850 dbSNP
rs1193851604 858 dbSNP
rs951792188 874 dbSNP
rs1469571787 876 dbSNP
rs1171392767 877 dbSNP
rs796694326 881 dbSNP
rs756500786 888 dbSNP
rs1001548344 889 dbSNP
rs981756165 893 dbSNP
rs1182014730 895 dbSNP
rs1033840761 897 dbSNP
rs1249247736 898 dbSNP
rs959823691 909 dbSNP
rs1055053262 910 dbSNP
rs1491002124 912 dbSNP