miRTarBase - #MIRT570698


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pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol FBXO41   
Synonyms FBX41
Description F-box protein 41
Transcript NM_001080410   
Expression
Putative miRNA Targets on FBXO41
3'UTR of FBXO41
(miRNA target sites are highlighted)		 
>FBXO41|NM_001080410|3'UTR
   1 CCCGGGTAGGGGGCGGCAGGGCCCCTGCCAGCCCCACACCAGGGCACTCTCTTTGGACCTCAGAGGGACCCTGGTTTGGA
  81 CTAGACCTTTGGAGGCCGAGTGTTATCCCTGGCTTCTGGAGGGGGACTGTCAAGTCTCCTGTCCTCCTCCTGGAGCAGCA
 161 GAGCAACAGGCCTGACCCAGGGCACTGCCTCCCCAGTACAGGGGCTTGGACAGAAGCTGCCCTCCGACCCCCACCCTACC
 241 CCGGCTGGAGTAGCCTCTGGCACAGCCAGTGAGGAGCTGTCACCACCAGCGCCTGGTGTCATCACCTGGAGGATCTGCAA
 321 TAACCACCCAGTGGCTCCTCAGCTGTTCTGGCTGGCCTCTCCTTCCTGAGGCCCAGCCTCCTGGTCAGGAGCATCTGGGG
 401 CCCCAAGCCAATGGGGGCTCCACAAGGCAGCTCAGACTTGGCAAGGAGGGCTCTTCTCCTCAACCTTGCTGCAGCCTTCT
 481 GGGGGCACCCCTTCAGACAGCCTGCCCAGGCTGTGGATCCACATTTCCTGGGGGTACCACAGCCAGACCTAGGGGCCTGG
 561 GCACGTGGTCAGCCAAAAGCTGGGGGCAGCAGTACAGTGGGGTAGTGGGGGTGGGTTTGGAAAGGAAACAGTCACCCAGA
 641 ACTTCTCCCCAGGATGAGACCACCCTTCCAAGGTGGGGGATTGCCAGGGGGAGAAAACTTATTTATTGCTGTAAGACAGG
 721 ACCCCTCCTCCCAACCTCATACCCCACCGCACACCAGAGCTAAATTCAAAGCTGAAAGGCGCACGTTTCTATACCTACAT
 801 TCATTCCTGAGGGACCCTCCAGAGGGTCAAGGTCCCAGCCCCAGGCAGCCCTGTCACAGTGAGAAGTAGTTCCTGTCCTT
 881 AAGGAATTTCCTTCTAATCCAGGTGCTTGGGCAGGAACCCGATGGCCTTCGGGTCACCAAGGCTGTCTGGGAGGGAGGCA
 961 CAGGGCCGCCCTCTGTGCTGAGGCCGTGGAGGAAGCCAGGAGGAGGGTGGCTTGCTTTGCTTCCTTGTCTAATTAGCTTG
1041 CTTGAAGATGTGGCCTTGGCAGGGAGCCAGACCCATGGGGCCAAGGAAGAGGAAGAGCATCCTCAATAGACTCACTCCCC
1121 CTTCCTTGGTCTCCACGGGCCCCGTGGACTGAGGGCTGCATTGGGGTCTTCTGCCTAGGGGAAGTGCTGGACCTGAGCTG
1201 GAGCCACTTGGCTTAGAAGCCACAGGATTCACTTTTCACTGGCCTTTGCAGTCCCCAAAGGATCAGGTCTCAGAACCAAG
1281 GCTCCAAAGGCTGAGGTCTCCCCAGTTCCTCCTCTCAGAACTCCCACAGTAGCTCAGAGGCCGGGGGTCCTGCCAACTTT
1361 CATTTGGAAAGTTCTTTCGAACATCTAAACTAGATCTATCTTAGGGTTTCTTTCTCTCCTAGATAGGATCAGCTCCCAGC
1441 CCTAGCCATTAGGCTGCTGGTCCTGGCGGGGGATGGGGTCCCCTCGTTACCCAGTCCTTCCCAGGGACCCAACTTCCTAA
1521 CACAACCTGGCTTGGACATGAAGACCCTCCCCCAGGTTACCTTGTAAAGAGTCCTCCAGAGCTGGGATCCCATGGGCGCA
1601 GCAGCACACCCAGCTCCCATGGCGTCACTCCCTAGCTCTGTCCCAGCTTTTGCTATCATTGCTGACTTTTCCTCCTGTGG
1681 CTCATTCTGTCCCTGCCCTTTGAAAACCTAAAATACCAAGGGTGTCATGCTGGCAACTCCCTGCCCAGTCCTGCACAAAG
1761 CCTTGGCTGTGTGTGGCACCCCTTGCCTCCTACCCCAGAGCAGCTGGCTCCATTGGCTTCTCCCTGCACCAGCCCTGTCC
1841 TCAGGGGTCAGGAAAAAGCAGCACAGCTTTCTTTCCTCTCCTCCAGAGGCCTGGAAGGGAGGTGGAGGTCCAGTAAGGGC
1921 CTGGCTGCCTTGGATTTCTTGGTCCTGCCTTGCCAACTGCACCCTGTAGCTCCTGCTCCCTGTGACCCCAGAACCAGAGG
2001 TGCTGCCTTCCCTGTCTCCTAGACAAAGCACAAAGGGATGCCCTGCTTGGCTTGAGCCTGCCCAACTGAAGGATTTTCTC
2081 TGCCCCAGGGACCTTCCATCCCTGAATACAAGGCTCTAGGCAACTTCTCTCTGGGTGGTACACACTAGAATGCCTGGCAT
2161 TAGCCCTAGAAAGGAGGTTGGGGTGTATGGGTAGTGAGCTAGGGTGGGAGAAAGGTGGTGCTGAAAGGACAGATGCTAGT
2241 TGTAGTTTCACTCACTCATTCATTCATTAGTGCAACAGTACTGAGCACCACCTGCACTAGAGGCAGAGGGGTGAACAAGA
2321 TACCCTTCTGCCTGGGGGGACGTCCACTTCCCATGGGTTTGGCTATTTCCAGGAAAGCCCCTCAGTCCTCCACCCTGTTC
2401 TGGCTGTGTGTGAAGGATGTGTGTGAGCAGGCCCAATCCTTTGCAGCAAGAATGAGAGGTCAGAGTATTCCATTGCACAC
2481 GCACCCTGGGGCTGACAGACTTGTGCCCCCTAGCCTTCATGCATGCCCAAGCACTGGCAGCTTTGCAGCCCCTGCCCCAC
2561 CAGCCCCTTGACGCTCTTCTTTTGTTCTCTCCTCGGGGATGAGCTCTGCTGCTGAGTAGGGAGCTTTTGCTTGCTGGGAG
2641 GCTCTATGCATGGATTTTTTTGGTGACCATACAGCTAGGGCTGAGGATGGGAACAGGGACAGAGGGCCTGGCTATCCCTA
2721 GAAGCACTTCATCCATCTTTACCCACCCAAACGGGATCCCTTCACATCTCATACCCAGTAAGATGCAAGAAAGGAATATC
2801 TGAGAGCAAGCAGCCCTGCTCCAGGGGCCCCAGGTATGTGTAGAGGCCCAGTGGGGGTGGCCACTTGGTGTTTCTACCAC
2881 CCCCTGCCATCCAGTCTGGCCCCAGTACCTACCTGGGAGGTTGGTGTACTTGGCTTAAGTACTTCATGCTTTATTCAGGC
2961 TGCTTCCCCACAGCACCGGCAGGAAATGAAGGTGCACTTATATGCATCCCTGCAGGAATAAAGAGTGGGTGGCCTGCCCA
3041 GCCCAGCACCACAGCCTTTCCCCAGCCAGGAGAGACCACCTAAGGATCAAGGCAGCTCCTGTTTTCTTGGTTCTGTGACA
3121 CTCGAGTCTGAGCCAGCCCCTCAGGAATTGCCTCAAAAGAGAAAAACAAAAAAAAGTCCTCCTTCCCAAGGCCTGCTACT
3201 CCAAGGTTTGGCTCCATCCCTTGCCTTTGGGTCCTGCCTATTTCCCCACTCCTGGTCTCTTATCTTTGGGGCCACCAGTG
3281 GGGAGTCACCCGGGCCCCAATCCCTCTAAGGCGCTAAGTTGAAGGAGGCCTTCCCAGAGTGACTATTGGTGCCAAAGTCC
3361 CAGTTCCTGTTGGACTTGGGGTAAAAACAGGAGATGGTGAGTGGGTGTAAGGCCCAAATGCCCAGAGAAGTTAACTCGAA
3441 CCCATGGGACCTGTCCCAGCCTGTCAGTCCCTGATGAGTGTAACTTCCTTCCCCTGGGGGCCTGGCCCTTCTCTCCAACC
3521 CAGTGGCCATGCTTTCTCACCCAGCCTTGTGCCCGGCCTGCATTTCTGTATATATTGCTGTGTATTGTGTGTATGTATGT
3601 ATTCCTGGACAAGTGTGTTCATCTGCAGCCCTTGCCTGAGGATAAGGTTTAGGATTGGGTAAAGATCAGAATACCAGGGC
3681 CAGCTAAGGCAACGACTCCCTCCCCAAACCCTTGGGACCTCAGCCAGTCCCAAGGCTGCCCTGACAATCAGGCAGGCTCC
3761 CCACCGTGAGGCCAAGCCTCCTCTGCCACTGCCAGCATGGCCCAAGGGAGGCTTGGCCTTGGGCTTGCCAGCCTCAGCTC
3841 TGCCCTGACAAGGGTCTTGTATCCAGGGCAGAGGCCTGAGGTGACCCAGGCTTGCTTTGTGGCTGATGCCAGCAGGCTTG
3921 GTTCTAGTGGGCACCACTGGTGGGCAACCTCCATAACTGGCCCTTAGGCCCTACCTTCCTACACAGCTAGGCTATAATGG
4001 GCCTGAGTGAGAGGGTAGCTTCCCCAGCCCCAAGCACAGGCAGAGGGGTGGAGAGCAATTTTTGGTTTTATTTTTGTTTC
4081 TGAAGTGGTGCCTGTACCTCCAGCCCCCAGGGGGCCTTCCCTGGCCACACTTCTCTGCCCCACCCAGGCATCGCCATCCC
4161 AGCACTTTGCTCCATGTCACCCGTAAGATGCCCTTTGCTGAATGTACCTGAGTGTATGTATTTAAAAGGACTCACATGGG
4241 CATCAGAGAATTTATGGCTCTGTATCCAATAAAAAAGATGGTGAAACTGGTCTATCTGCCAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaaCGUAG-AUAGGUUUGGAa 5'
              |:| |  | |||:|||| 
Target 5' ggggGTACCACAGCCAGACCTa 3'
 530 - 551 133.00 -11.90
2 
miRNA  3' auaacGUAGAUAGGUUUGGAa 5'
               |:|  : ||||:||| 
Target 5' cccacCGTGAGGCCAAGCCTc 3'
 3760 - 3780 132.00 -11.60
3 
miRNA  3' auaacguaGAUAGGUUUGGaa 5'
                  ||  |||||||  
Target 5' acgactccCTCCCCAAACCct 3'
 3692 - 3712 129.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30127906 8 COSMIC
COSN27106459 71 COSMIC
COSN28753200 97 COSMIC
COSN31485554 197 COSMIC
COSN31531972 227 COSMIC
COSN9386337 328 COSMIC
COSN1853819 403 COSMIC
COSN27301727 411 COSMIC
COSN25511828 501 COSMIC
COSN21155769 572 COSMIC
COSN27878464 614 COSMIC
COSN7082662 1068 COSMIC
COSN20090557 2091 COSMIC
COSN9386336 2133 COSMIC
COSN30172923 2199 COSMIC
COSN31513539 2278 COSMIC
COSN22047592 2601 COSMIC
COSN22446766 2658 COSMIC
COSN27030288 3167 COSMIC
COSN31526440 3292 COSMIC
COSN31534481 3878 COSMIC
COSN28198325 3889 COSMIC
COSN31541353 3903 COSMIC
COSN30158338 3912 COSMIC
COSN30163273 3928 COSMIC
COSN30175394 4182 COSMIC
COSN31563293 4235 COSMIC
rs1045902 3053 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1005066392 1 dbSNP
rs767121287 3 dbSNP
rs1172860345 4 dbSNP
rs761196272 4 dbSNP
rs1480258570 6 dbSNP
rs959109134 7 dbSNP
rs138268745 8 dbSNP
rs768245332 14 dbSNP
rs370166126 15 dbSNP
rs775195418 16 dbSNP
rs1222032468 17 dbSNP
rs1357299600 19 dbSNP
rs769732247 21 dbSNP
rs1224473994 27 dbSNP
rs1003280425 29 dbSNP
rs1278347549 31 dbSNP
rs1280476345 36 dbSNP
rs1438990108 39 dbSNP
rs536316404 40 dbSNP
rs1381622573 41 dbSNP
rs780991069 42 dbSNP
rs1422372529 43 dbSNP
rs1362129123 44 dbSNP
rs1159189380 48 dbSNP
rs1418041413 49 dbSNP
rs1248408053 52 dbSNP
rs1186137302 61 dbSNP
rs1453209135 63 dbSNP
rs1196733628 65 dbSNP
rs1245882778 70 dbSNP
rs1200451280 73 dbSNP
rs1188492115 78 dbSNP
rs757420604 79 dbSNP
rs879415931 85 dbSNP
rs1164250147 90 dbSNP
rs565617439 94 dbSNP
rs80319113 97 dbSNP
rs559200824 98 dbSNP
rs531969229 106 dbSNP
rs1346149491 107 dbSNP
rs893158272 121 dbSNP
rs765105355 123 dbSNP
rs759473513 134 dbSNP
rs1227246390 152 dbSNP
rs1315113871 155 dbSNP
rs1357899179 156 dbSNP
rs935190323 172 dbSNP
rs1207986207 182 dbSNP
rs756124881 189 dbSNP
rs564585221 197 dbSNP
rs1289132850 199 dbSNP
rs1447527956 201 dbSNP
rs1210290507 203 dbSNP
rs1245995734 204 dbSNP
rs1449037494 205 dbSNP
rs996092514 208 dbSNP
rs372442356 209 dbSNP
rs1238854556 215 dbSNP
rs923857854 219 dbSNP
rs1163169290 222 dbSNP
rs753684556 225 dbSNP
rs944887003 230 dbSNP
rs933241501 232 dbSNP
rs921575520 242 dbSNP
rs140489725 243 dbSNP
rs1416211682 250 dbSNP
rs1337064954 252 dbSNP
rs1403240269 257 dbSNP
rs1341729357 259 dbSNP
rs1241915794 263 dbSNP
rs112137477 282 dbSNP
rs766208278 290 dbSNP
rs1230173348 291 dbSNP
rs1016047855 298 dbSNP
rs1265982787 299 dbSNP
rs983599007 310 dbSNP
rs1464303534 312 dbSNP
rs370061489 317 dbSNP
rs531516004 318 dbSNP
rs561109380 323 dbSNP
rs950897800 327 dbSNP
rs1036342741 328 dbSNP
rs1440919157 344 dbSNP
rs1469499183 355 dbSNP
rs542437515 371 dbSNP
rs930902043 372 dbSNP
rs1473847070 374 dbSNP
rs920298237 378 dbSNP
rs1003091161 383 dbSNP
rs906128568 389 dbSNP
rs534167655 395 dbSNP
rs990488757 396 dbSNP
rs958994434 403 dbSNP
rs1332875948 409 dbSNP
rs1335883058 411 dbSNP
rs866786695 414 dbSNP
rs927712397 417 dbSNP
rs1011563615 428 dbSNP
rs893205265 430 dbSNP
rs1257541631 435 dbSNP
rs1242027645 449 dbSNP
rs1053170738 451 dbSNP
rs1020775391 453 dbSNP
rs147910875 454 dbSNP
rs559877104 458 dbSNP
rs1484117375 462 dbSNP
rs1204114586 472 dbSNP
rs375565432 475 dbSNP
rs1251656354 481 dbSNP
rs1481053416 485 dbSNP
rs1201410802 488 dbSNP
rs1376306982 504 dbSNP
rs902321521 506 dbSNP
rs1464211315 515 dbSNP
rs957981236 520 dbSNP
rs1311853409 522 dbSNP
rs1241544517 523 dbSNP
rs1431163342 534 dbSNP
rs1382748059 549 dbSNP
rs1305652717 552 dbSNP
rs1313527814 553 dbSNP
rs1028161250 561 dbSNP
rs1303112429 564 dbSNP
rs996144937 586 dbSNP
rs480538 592 dbSNP
rs1232806162 599 dbSNP
rs900485694 599 dbSNP
rs1341139789 601 dbSNP
rs541588023 602 dbSNP
rs1317914743 608 dbSNP
rs1052035904 609 dbSNP
rs1040458537 610 dbSNP
rs1008969892 611 dbSNP
rs1490642094 624 dbSNP
rs1212202952 627 dbSNP
rs933228796 631 dbSNP
rs1358419970 637 dbSNP
rs1433035415 638 dbSNP
rs886641118 641 dbSNP
rs1390340409 650 dbSNP
rs1047887869 651 dbSNP
rs930767894 655 dbSNP
rs920855445 661 dbSNP
rs760447370 673 dbSNP
rs937680716 674 dbSNP
rs372281332 676 dbSNP
rs1385957074 681 dbSNP
rs1296034483 687 dbSNP
rs1158342241 689 dbSNP
rs982300295 691 dbSNP
rs941698815 695 dbSNP
rs772914469 698 dbSNP
rs989407422 699 dbSNP
rs1192048098 705 dbSNP
rs1264259415 720 dbSNP
rs1488446423 729 dbSNP
rs1487080994 739 dbSNP
rs1250319387 742 dbSNP
rs1267164614 742 dbSNP
rs908957880 748 dbSNP
rs983231270 749 dbSNP
rs1389010032 752 dbSNP
rs1423950355 755 dbSNP
rs957978658 762 dbSNP
rs1366579207 778 dbSNP
rs559003005 780 dbSNP
rs975235713 781 dbSNP
rs1390623126 783 dbSNP
rs1433130602 784 dbSNP
rs1320216901 785 dbSNP
rs544061982 791 dbSNP
rs1359155009 795 dbSNP
rs771645211 813 dbSNP
rs1321596305 816 dbSNP
rs1240412811 817 dbSNP
rs1035842315 818 dbSNP
rs982031683 821 dbSNP
rs1357159660 830 dbSNP
rs576683967 832 dbSNP
rs1018994519 833 dbSNP
rs1269621012 835 dbSNP
rs555269044 837 dbSNP
rs970323697 841 dbSNP
rs1428929557 843 dbSNP
rs1009273597 845 dbSNP
rs536426462 848 dbSNP
rs1483376830 850 dbSNP
rs1400450132 853 dbSNP
rs1253491134 860 dbSNP
rs1423153421 861 dbSNP
rs566300073 864 dbSNP
rs1364653995 867 dbSNP
rs886439101 869 dbSNP
rs1023663928 872 dbSNP
rs1011531027 874 dbSNP
rs761243156 875 dbSNP
rs1406965244 877 dbSNP
rs1026766469 888 dbSNP
rs1158165052 891 dbSNP
rs371085709 894 dbSNP
rs1359890160 895 dbSNP
rs995086353 901 dbSNP
rs1301110408 910 dbSNP
rs1378594230 911 dbSNP
rs1410973266 920 dbSNP
rs1031640859 923 dbSNP
rs998856594 930 dbSNP
rs553448027 933 dbSNP
rs184920102 934 dbSNP
rs1051575982 936 dbSNP
rs570867909 949 dbSNP
rs1482681102 950 dbSNP
rs906245759 951 dbSNP
rs1253811895 957 dbSNP
rs1471570216 960 dbSNP
rs144590210 967 dbSNP
rs748248023 968 dbSNP
rs941667535 970 dbSNP
rs1416356681 985 dbSNP
rs531366427 986 dbSNP
rs1047449598 1002 dbSNP
rs929012900 1004 dbSNP
rs936569863 1006 dbSNP
rs1349131684 1007 dbSNP
rs1409774022 1009 dbSNP
rs142350495 1010 dbSNP
rs1370233575 1013 dbSNP
rs1220593283 1023 dbSNP
rs567060468 1026 dbSNP
rs1346717875 1050 dbSNP
rs1205167279 1066 dbSNP
rs1276191825 1067 dbSNP
rs981617126 1078 dbSNP
rs749850826 1080 dbSNP
rs965187216 1084 dbSNP
rs1352266998 1088 dbSNP
rs916158386 1090 dbSNP
rs990329173 1094 dbSNP
rs957621509 1105 dbSNP
rs549300706 1106 dbSNP
rs1170513802 1113 dbSNP
rs1368848096 1117 dbSNP
rs1031609708 1121 dbSNP
rs147839957 1125 dbSNP
rs1324856579 1129 dbSNP
rs955470415 1135 dbSNP
rs1351969565 1137 dbSNP
rs1030182750 1139 dbSNP
rs997355491 1142 dbSNP
rs75729698 1143 dbSNP
rs1369730780 1144 dbSNP
rs548325412 1144 dbSNP
rs1299147625 1149 dbSNP
rs1339500058 1158 dbSNP
rs1213909496 1160 dbSNP
rs899383847 1161 dbSNP
rs1453265214 1166 dbSNP
rs1006100136 1174 dbSNP
rs1219064915 1178 dbSNP
rs1350449297 1180 dbSNP
rs887710262 1184 dbSNP
rs1190796509 1189 dbSNP
rs1388397753 1194 dbSNP
rs1328084513 1210 dbSNP
rs532670533 1216 dbSNP
rs1033937004 1225 dbSNP
rs1002330761 1231 dbSNP
rs1416505021 1239 dbSNP
rs906693518 1244 dbSNP
rs1047031570 1249 dbSNP
rs1047417975 1255 dbSNP
rs928989044 1256 dbSNP
rs758346598 1261 dbSNP
rs928403295 1276 dbSNP
rs1362603787 1285 dbSNP
rs1429335981 1297 dbSNP
rs1423545338 1303 dbSNP
rs180905963 1304 dbSNP
rs1053428766 1305 dbSNP
rs1272280994 1316 dbSNP
rs1329693622 1320 dbSNP
rs775297383 1337 dbSNP
rs1246354117 1346 dbSNP
rs1446642032 1352 dbSNP
rs56262012 1359 dbSNP
rs781581407 1364 dbSNP
rs1197301286 1378 dbSNP
rs921140952 1379 dbSNP
rs1459151696 1396 dbSNP
rs59113407 1400 dbSNP
rs957588872 1406 dbSNP
rs753415183 1412 dbSNP
rs943991340 1414 dbSNP
rs1203308098 1419 dbSNP
rs924894200 1421 dbSNP
rs142222652 1422 dbSNP
rs1341788956 1430 dbSNP
rs1445729796 1435 dbSNP
rs955596958 1436 dbSNP
rs543352770 1450 dbSNP
rs1351047570 1467 dbSNP
rs572257855 1468 dbSNP
rs997302861 1470 dbSNP
rs1350163846 1481 dbSNP
rs964161442 1486 dbSNP
rs1017422743 1512 dbSNP
rs1033716206 1517 dbSNP
rs1006089986 1518 dbSNP
rs887677616 1521 dbSNP
rs1444407668 1526 dbSNP
rs1401875885 1528 dbSNP
rs111779907 1533 dbSNP
rs1180413614 1538 dbSNP
rs1026276692 1542 dbSNP
rs1002446607 1553 dbSNP
rs993172108 1555 dbSNP
rs1357120813 1557 dbSNP
rs746846005 1569 dbSNP
rs906828901 1580 dbSNP
rs1177780799 1581 dbSNP
rs553953749 1582 dbSNP
rs1371045464 1593 dbSNP
rs1434188211 1597 dbSNP
rs1010164136 1598 dbSNP
rs892181937 1610 dbSNP
rs777944652 1611 dbSNP
rs1234227824 1616 dbSNP
rs4852915 1623 dbSNP
rs763832520 1624 dbSNP
rs1210206621 1654 dbSNP
rs1000609667 1656 dbSNP
rs758382886 1668 dbSNP
rs1177334426 1669 dbSNP
rs1203686631 1671 dbSNP
rs1250252897 1677 dbSNP
rs948451800 1678 dbSNP
rs10185970 1682 dbSNP
rs1378934076 1689 dbSNP
rs766298100 1691 dbSNP
rs1203165793 1693 dbSNP
rs1482308784 1694 dbSNP
rs1039373602 1700 dbSNP
rs1390302583 1708 dbSNP
rs943938856 1762 dbSNP
rs1312571012 1767 dbSNP
rs1395484212 1774 dbSNP
rs148703695 1777 dbSNP
rs1237913156 1790 dbSNP
rs1379076400 1794 dbSNP
rs1325317104 1795 dbSNP
rs1309865324 1796 dbSNP
rs1299784635 1798 dbSNP
rs1046864017 1813 dbSNP
rs936195438 1815 dbSNP
rs1298387238 1829 dbSNP
rs1344493925 1835 dbSNP
rs537434398 1838 dbSNP
rs978109885 1855 dbSNP
rs1304235910 1858 dbSNP
rs1466184263 1864 dbSNP
rs568943200 1867 dbSNP
rs934266176 1875 dbSNP
rs919307018 1878 dbSNP
rs973480152 1883 dbSNP
rs1192657448 1885 dbSNP
rs963488140 1891 dbSNP
rs1450851878 1892 dbSNP
rs1167717051 1899 dbSNP
rs1421879139 1901 dbSNP
rs144030217 1902 dbSNP
rs975455555 1908 dbSNP
rs964464606 1913 dbSNP
rs1422136836 1922 dbSNP
rs191315831 1924 dbSNP
rs1025657094 1925 dbSNP
rs1182686354 1932 dbSNP
rs1009699194 1935 dbSNP
rs984621043 1942 dbSNP
rs951894714 1944 dbSNP
rs1026161070 1960 dbSNP
rs1432907620 1967 dbSNP
rs993782698 1973 dbSNP
rs573205990 1976 dbSNP
rs768076200 1977 dbSNP
rs957090692 1982 dbSNP
rs1032507713 1986 dbSNP
rs1247687741 1988 dbSNP
rs907136743 1990 dbSNP
rs186483277 1996 dbSNP
rs1024362156 1997 dbSNP
rs1000557266 2020 dbSNP
rs1334681642 2022 dbSNP
rs1248195693 2031 dbSNP
rs1465977668 2034 dbSNP
rs1243893428 2042 dbSNP
rs1184210308 2043 dbSNP
rs149940949 2049 dbSNP
rs1424298994 2051 dbSNP
rs894210453 2054 dbSNP
rs1460676624 2060 dbSNP
rs1159638601 2061 dbSNP
rs1054172273 2063 dbSNP
rs1391053858 2088 dbSNP
rs1451923060 2092 dbSNP
rs936163266 2093 dbSNP
rs1288339811 2094 dbSNP
rs139178798 2105 dbSNP
rs146216935 2120 dbSNP
rs1292038165 2124 dbSNP
rs891009033 2139 dbSNP
rs1047422621 2148 dbSNP
rs774985302 2161 dbSNP
rs767179611 2162 dbSNP
rs115168378 2171 dbSNP
rs1213267021 2175 dbSNP
rs561088903 2183 dbSNP
rs1483324702 2184 dbSNP
rs975804351 2198 dbSNP
rs1183110226 2201 dbSNP
rs1255235638 2202 dbSNP
rs1474859068 2203 dbSNP
rs763423042 2205 dbSNP
rs1182570518 2206 dbSNP
rs942719519 2214 dbSNP
rs561337280 2229 dbSNP
rs1158738615 2230 dbSNP
rs942071101 2232 dbSNP
rs1467595131 2234 dbSNP
rs1370302487 2247 dbSNP
rs542910529 2257 dbSNP
rs1375329294 2258 dbSNP
rs1165624716 2259 dbSNP
rs1290566443 2259 dbSNP
rs1367242170 2261 dbSNP
rs1221707398 2269 dbSNP
rs1427974319 2269 dbSNP
rs141484749 2270 dbSNP
rs1211569641 2272 dbSNP
rs926708336 2275 dbSNP
rs1485290679 2280 dbSNP
rs560283551 2285 dbSNP
rs949417910 2291 dbSNP
rs1479566958 2308 dbSNP
rs773852296 2309 dbSNP
rs1426050102 2310 dbSNP
rs917964280 2314 dbSNP
rs1209196016 2327 dbSNP
rs1171824171 2333 dbSNP
rs1487485549 2334 dbSNP
rs1267117606 2338 dbSNP
rs951446843 2339 dbSNP
rs3817459 2341 dbSNP
rs577858454 2342 dbSNP
rs1441852109 2347 dbSNP
rs115962334 2350 dbSNP
rs762363455 2355 dbSNP
rs1220028506 2356 dbSNP
rs10193579 2357 dbSNP
rs1323261682 2365 dbSNP
rs1229032833 2374 dbSNP
rs1385425155 2382 dbSNP
rs1012993324 2390 dbSNP
rs757732956 2397 dbSNP
rs958398926 2402 dbSNP
rs1203506233 2404 dbSNP
rs963734843 2406 dbSNP
rs1489571722 2412 dbSNP
rs1032646387 2416 dbSNP
rs1192062209 2418 dbSNP
rs374122630 2424 dbSNP
rs999861418 2425 dbSNP
rs1246996294 2427 dbSNP
rs1450100570 2428 dbSNP
rs1465231093 2431 dbSNP
rs1017986189 2432 dbSNP
rs1421494440 2432 dbSNP
rs902956973 2436 dbSNP
rs1042247427 2441 dbSNP
rs770363372 2465 dbSNP
rs1173114261 2468 dbSNP
rs1409922604 2473 dbSNP
rs573519173 2479 dbSNP
rs1352021086 2480 dbSNP
rs890781680 2481 dbSNP
rs1369805489 2484 dbSNP
rs901421107 2486 dbSNP
rs114850087 2494 dbSNP
rs994475276 2496 dbSNP
rs1337310032 2501 dbSNP
rs1213957774 2503 dbSNP
rs942940607 2514 dbSNP
rs1290325730 2523 dbSNP
rs898436052 2528 dbSNP
rs909846078 2531 dbSNP
rs181788129 2536 dbSNP
rs930016201 2537 dbSNP
rs1190540945 2551 dbSNP
rs1240484491 2556 dbSNP
rs1269456110 2557 dbSNP
rs746254014 2572 dbSNP
rs937167198 2573 dbSNP
rs1456941263 2574 dbSNP
rs1164665010 2575 dbSNP
rs1393225240 2582 dbSNP
rs918707720 2594 dbSNP
rs972289638 2595 dbSNP
rs1255545823 2604 dbSNP
rs971293880 2611 dbSNP
rs1200177241 2633 dbSNP
rs1318201283 2637 dbSNP
rs1429924920 2639 dbSNP
rs917145676 2641 dbSNP
rs949530580 2642 dbSNP
rs1357295332 2647 dbSNP
rs917897987 2650 dbSNP
rs988182095 2658 dbSNP
rs1330063077 2659 dbSNP
rs1333188348 2660 dbSNP
rs1282236712 2662 dbSNP
rs138990179 2662 dbSNP
rs190170875 2662 dbSNP
rs373465384 2662 dbSNP
rs925550258 2670 dbSNP
rs186104262 2678 dbSNP
rs979535051 2680 dbSNP
rs181798707 2681 dbSNP
rs1187619579 2683 dbSNP
rs1387809183 2685 dbSNP
rs1032613840 2691 dbSNP
rs986945914 2694 dbSNP
rs1160000732 2695 dbSNP
rs1382342244 2698 dbSNP
rs1399545896 2707 dbSNP
rs781651864 2710 dbSNP
rs1333486254 2715 dbSNP
rs563349732 2721 dbSNP
rs955176667 2724 dbSNP
rs1159705815 2726 dbSNP
rs1401834267 2733 dbSNP
rs747308049 2740 dbSNP
rs1025711110 2747 dbSNP
rs1292417498 2753 dbSNP
rs545069996 2759 dbSNP
rs1171029066 2763 dbSNP
rs868120485 2782 dbSNP
rs138528309 2790 dbSNP
rs993862454 2792 dbSNP
rs1379094162 2796 dbSNP
rs777846944 2797 dbSNP
rs898383656 2805 dbSNP
rs1016865093 2807 dbSNP
rs1199517268 2818 dbSNP
rs1219845791 2819 dbSNP
rs1001492977 2827 dbSNP
rs557959200 2829 dbSNP
rs1210845847 2831 dbSNP
rs1020073638 2832 dbSNP
rs998754662 2833 dbSNP
rs1468421775 2834 dbSNP
rs901309101 2843 dbSNP
rs1206487868 2844 dbSNP
rs758572063 2852 dbSNP
rs1439863539 2854 dbSNP
rs752654926 2855 dbSNP
rs896587082 2857 dbSNP
rs1052834710 2858 dbSNP
rs1173695208 2860 dbSNP
rs1396406630 2867 dbSNP
rs1432784119 2878 dbSNP
rs935341630 2880 dbSNP
rs1277562914 2885 dbSNP
rs1007126098 2889 dbSNP
rs1043952061 2892 dbSNP
rs374446963 2894 dbSNP
rs549960500 2900 dbSNP
rs531842046 2901 dbSNP
rs942986406 2912 dbSNP
rs1305679265 2917 dbSNP
rs561091528 2920 dbSNP
rs1218 2924 dbSNP
rs1342126039 2936 dbSNP
rs955273493 2938 dbSNP
rs918352265 2946 dbSNP
rs1193949288 2953 dbSNP
rs1436835570 2953 dbSNP
rs1254317606 2963 dbSNP
rs1048414196 2965 dbSNP
rs1172475795 2967 dbSNP
rs1375388117 2968 dbSNP
rs1312076159 2969 dbSNP
rs929983617 2973 dbSNP
rs527716076 2977 dbSNP
rs755996649 2978 dbSNP
rs1001439570 2993 dbSNP
rs1404123914 2996 dbSNP
rs527533967 2998 dbSNP
rs145952641 3000 dbSNP
rs1046508779 3001 dbSNP
rs1440213601 3008 dbSNP
rs1418844094 3012 dbSNP
rs545341305 3016 dbSNP
rs1160380399 3025 dbSNP
rs1470205008 3034 dbSNP
rs1251103150 3038 dbSNP
rs1357569674 3045 dbSNP
rs1215953722 3049 dbSNP
rs917047938 3052 dbSNP
rs1045902 3053 dbSNP
rs1192407811 3060 dbSNP
rs1261879894 3061 dbSNP
rs896526981 3070 dbSNP
rs1184995448 3071 dbSNP
rs958584529 3072 dbSNP
rs1372446349 3074 dbSNP
rs1166868850 3076 dbSNP
rs1461711079 3076 dbSNP
rs1443753172 3078 dbSNP
rs563110065 3085 dbSNP
rs1256390163 3091 dbSNP
rs925899168 3105 dbSNP
rs1289495826 3109 dbSNP
rs376088114 3115 dbSNP
rs142003815 3116 dbSNP
rs967107490 3123 dbSNP
rs1235477237 3124 dbSNP
rs756988578 3124 dbSNP
rs1241432936 3126 dbSNP
rs1355756670 3130 dbSNP
rs751290298 3144 dbSNP
rs1212726528 3159 dbSNP
rs1282460115 3159 dbSNP
rs1450259079 3161 dbSNP
rs1341349952 3167 dbSNP
rs1043733987 3171 dbSNP
rs1486594349 3171 dbSNP
rs11691842 3175 dbSNP
rs1051667839 3176 dbSNP
rs554756290 3176 dbSNP
rs752901190 3176 dbSNP
rs1415452806 3178 dbSNP
rs762534388 3179 dbSNP
rs75523515 3183 dbSNP
rs1347197280 3190 dbSNP
rs1451634960 3196 dbSNP
rs1401173076 3202 dbSNP
rs533753522 3215 dbSNP
rs1417212091 3238 dbSNP
rs1355295185 3240 dbSNP
rs962481810 3240 dbSNP
rs1232286751 3244 dbSNP
rs1307183124 3245 dbSNP
rs1412489647 3251 dbSNP
rs572913988 3253 dbSNP
rs1007093342 3257 dbSNP
rs1418204198 3262 dbSNP
rs1485942424 3262 dbSNP
rs1255121519 3264 dbSNP
rs1485191094 3266 dbSNP
rs969933094 3267 dbSNP
rs558078443 3268 dbSNP
rs539746009 3272 dbSNP
rs994160080 3274 dbSNP
rs955895087 3285 dbSNP
rs1031954218 3288 dbSNP
rs1451578050 3291 dbSNP
rs568918201 3292 dbSNP
rs1375386418 3294 dbSNP
rs1443336129 3298 dbSNP
rs903969290 3303 dbSNP
rs1375041134 3306 dbSNP
rs1046831846 3307 dbSNP
rs949472516 3312 dbSNP
rs1022226109 3313 dbSNP
rs895231589 3315 dbSNP
rs1235873189 3319 dbSNP
rs148175787 3322 dbSNP
rs889997937 3325 dbSNP
rs1051352000 3328 dbSNP
rs1216969899 3329 dbSNP
rs1217337175 3337 dbSNP
rs1176908088 3343 dbSNP
rs1253689101 3344 dbSNP
rs1455598246 3345 dbSNP
rs1171885320 3349 dbSNP
rs1394958527 3354 dbSNP
rs1172948162 3359 dbSNP
rs1411065220 3359 dbSNP
rs1353193354 3360 dbSNP
rs934271744 3370 dbSNP
rs937217262 3372 dbSNP
rs925867866 3375 dbSNP
rs1371289216 3381 dbSNP
rs1431162839 3383 dbSNP
rs1300647824 3392 dbSNP
rs143752262 3394 dbSNP
rs1037226893 3395 dbSNP
rs1274851011 3403 dbSNP
rs189516133 3404 dbSNP
rs912874492 3405 dbSNP
rs73946817 3406 dbSNP
rs1191803864 3413 dbSNP
rs1394499599 3414 dbSNP
rs1476025587 3421 dbSNP
rs549107896 3427 dbSNP
rs1169544967 3430 dbSNP
rs55693343 3437 dbSNP
rs1018061131 3438 dbSNP
rs1187520784 3441 dbSNP
rs1166146414 3450 dbSNP
rs550654882 3463 dbSNP
rs952889246 3471 dbSNP
rs1027163518 3474 dbSNP
rs551620787 3476 dbSNP
rs1323270423 3479 dbSNP
rs533463577 3480 dbSNP
rs1348858684 3483 dbSNP
rs897416788 3499 dbSNP
rs1245549250 3509 dbSNP
rs1359784747 3511 dbSNP
rs1024943992 3519 dbSNP
rs1217738835 3520 dbSNP
rs183675694 3523 dbSNP
rs1468977480 3524 dbSNP
rs1337188377 3533 dbSNP
rs1212130936 3538 dbSNP
rs1289228417 3540 dbSNP
rs895210818 3541 dbSNP
rs1197023654 3553 dbSNP
rs1218050329 3554 dbSNP
rs1240827259 3558 dbSNP
rs1475385324 3560 dbSNP
rs1189062937 3587 dbSNP
rs1320326914 3589 dbSNP
rs192428146 3591 dbSNP
rs11548978 3593 dbSNP
rs1412636331 3593 dbSNP
rs571619716 3593 dbSNP
rs189779184 3594 dbSNP
rs1343341682 3595 dbSNP
rs1366555532 3597 dbSNP
rs1313259095 3599 dbSNP
rs1357199219 3602 dbSNP
rs1404855346 3603 dbSNP
rs904328471 3606 dbSNP
rs1231245471 3612 dbSNP
rs1022340561 3613 dbSNP
rs771388541 3614 dbSNP
rs1006970936 3617 dbSNP
rs528404916 3621 dbSNP
rs1488229961 3626 dbSNP
rs1212307616 3632 dbSNP
rs913169055 3638 dbSNP
rs1438459076 3646 dbSNP
rs1303703019 3647 dbSNP
rs1484861534 3652 dbSNP
rs1187286822 3653 dbSNP
rs1236494531 3655 dbSNP
rs1371132186 3657 dbSNP
rs1030105942 3661 dbSNP
rs998429946 3663 dbSNP
rs1419009506 3664 dbSNP
rs1402093875 3678 dbSNP
rs1451870306 3681 dbSNP
rs1377204956 3685 dbSNP
rs572827731 3693 dbSNP
rs752453950 3694 dbSNP
rs1037173094 3699 dbSNP
rs943741210 3708 dbSNP
rs1423486557 3711 dbSNP
rs773489186 3719 dbSNP
rs910965075 3733 dbSNP
rs1277846924 3742 dbSNP
rs1353145492 3746 dbSNP
rs1193473123 3753 dbSNP
rs888156253 3758 dbSNP
rs772128331 3765 dbSNP
rs748250171 3766 dbSNP
rs1200187891 3772 dbSNP
rs764968217 3774 dbSNP
rs1251742616 3778 dbSNP
rs1438042743 3785 dbSNP
rs952442584 3792 dbSNP
rs1235995356 3798 dbSNP
rs1459097405 3799 dbSNP
rs1438473483 3813 dbSNP
rs557795859 3816 dbSNP
rs920066215 3823 dbSNP
rs948507538 3824 dbSNP
rs1171745497 3827 dbSNP
rs567553614 3831 dbSNP
rs1397025213 3833 dbSNP
rs1209667246 3848 dbSNP
rs1327028232 3859 dbSNP
rs77927812 3860 dbSNP
rs1276208117 3863 dbSNP
rs1236172724 3864 dbSNP
rs992926042 3865 dbSNP
rs934570338 3869 dbSNP
rs924540554 3876 dbSNP
rs1305748310 3881 dbSNP
rs961634893 3886 dbSNP
rs557002497 3889 dbSNP
rs11548977 3905 dbSNP
rs1378464167 3908 dbSNP
rs767127113 3937 dbSNP
rs1194444615 3939 dbSNP
rs568211739 3953 dbSNP
rs1357824197 3960 dbSNP
rs1213753442 3961 dbSNP
rs954293710 3965 dbSNP
rs1431361025 3966 dbSNP
rs1029641927 3967 dbSNP
rs1373586199 3976 dbSNP
rs998607615 3982 dbSNP
rs1435669286 3985 dbSNP
rs959334066 4007 dbSNP
rs745863181 4008 dbSNP
rs1380235535 4009 dbSNP
rs1328001836 4012 dbSNP
rs1386298750 4014 dbSNP
rs372957611 4014 dbSNP
rs961615491 4014 dbSNP
rs1296841418 4015 dbSNP
rs1328741566 4017 dbSNP
rs1225641563 4028 dbSNP
rs1278024490 4033 dbSNP
rs539636775 4045 dbSNP
rs1000884341 4048 dbSNP
rs1233591005 4050 dbSNP
rs1274488168 4053 dbSNP
rs1487183983 4058 dbSNP
rs903961218 4063 dbSNP
rs1208728064 4064 dbSNP
rs1251312721 4065 dbSNP
rs552326487 4066 dbSNP
rs184943024 4071 dbSNP
rs1191208151 4072 dbSNP
rs1422704507 4076 dbSNP
rs888607645 4087 dbSNP
rs1044611628 4088 dbSNP
rs1366942984 4095 dbSNP
rs1457439024 4097 dbSNP
rs1364246173 4104 dbSNP
rs775268093 4116 dbSNP
rs1010510828 4126 dbSNP
rs781102202 4130 dbSNP
rs757078099 4131 dbSNP
rs1297963548 4133 dbSNP
rs534037105 4135 dbSNP
rs934325279 4137 dbSNP
rs1294672516 4139 dbSNP
rs1374103509 4141 dbSNP
rs1243369730 4144 dbSNP
rs1285302870 4146 dbSNP
rs891709939 4152 dbSNP
rs751251978 4153 dbSNP
rs566497507 4154 dbSNP
rs1041393773 4156 dbSNP
rs1237850014 4160 dbSNP
rs943975512 4182 dbSNP
rs865812163 4183 dbSNP
rs1159891800 4184 dbSNP
rs1365682149 4193 dbSNP
rs917347286 4194 dbSNP
rs1158506038 4198 dbSNP
rs1049440241 4200 dbSNP
rs1416963014 4204 dbSNP
rs1227203882 4207 dbSNP
rs1301481724 4212 dbSNP
rs986388616 4213 dbSNP
rs931019453 4215 dbSNP
rs551385520 4216 dbSNP
rs1336957569 4217 dbSNP
rs772104249 4222 dbSNP
rs954127431 4230 dbSNP
rs376163944 4231 dbSNP
rs1191239609 4246 dbSNP
rs1348534952 4248 dbSNP
rs1212730056 4251 dbSNP
rs1254072130 4258 dbSNP
rs1483047751 4259 dbSNP
rs1304158382 4271 dbSNP
rs1178051438 4281 dbSNP
rs533200987 4287 dbSNP
rs976739565 4291 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auaacguAGAUA-GGUUUGGAa 5'
                 |||:| || : ||| 
Target 5' -----auUCUGUCCCUGCCCUu 3'
 		1 - 17
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auaacguAGAUA-GGUUUGGAa 5'
                 |||:| || : ||| 
Target 5' -----auUCUGUCCCUGCCCUu 3'
 		1 - 17
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A PAR-CLIP data was present in SRX1760632. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_C ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000295133.5 | 3UTR | AUUCUGUCCCUGCCCUUUGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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