pre-miRNA Information | |
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pre-miRNA | hsa-mir-3171 |
Genomic Coordinates | chr14: 27633205 - 27633278 |
Description | Homo sapiens miR-3171 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||
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Mature miRNA | hsa-miR-3171 | ||||||||||||||||||
Sequence | 10| AGAUGUAUGGAAUCUGUAUAUAUC |33 | ||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SYT9 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | synaptotagmin 9 | ||||||||||||||||||||
Transcript | NM_175733 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SYT9 | |||||||||||||||||||||
3'UTR of SYT9 (miRNA target sites are highlighted) |
>SYT9|NM_175733|3'UTR 1 CCATGGGTAAGAGGACTGCTTGTGCCAAGGACAAAATAGGACAACCATCTCACAAAGATCTTAAGTAACTTTTTCCATCC 81 AGCAACATCCAGACGATTTCAGTGACCAAATGCTCAGCTGTAACCACAGCACTAACTGGCCTTCTTTCCAGATTGGGTTT 161 GGTGAACCTGAATGGTCCAGCCACCTTCTGCAGGTGGCCCAAGGTGATGTGCTGCAGGGAAGCATGTCTCTCATGCCAAG 241 AACCAAGATCGGACTATGAACAAAAACAAATGATAGATATAGTGACAGTACCAAGAGTACCAGGACTCAATGTTTCATAT 321 GAAGCCCTTGGTGATGAGGACATAGCATCTGCCCTGGAAATCGTTATTCCAACATAATATTATTTTCTAGAATGCCCTGG 401 AAGGACAGAATATTTAAAAATATATCCAGGTGCTAAATAGGCAGCAGATCTCAATTCACACATGACTACCTTTGAGCTAA 481 TGACTGTCTCCAGAAAATAACTGTGCCCCAAGAAGTGCTCCAGATTTGCAAGGAATAGCCCCAAGAGAATACCAAGACAA 561 GCAGGCTGTTCCCTGGAAAAAATCTAATGCAAGGAGGGCTAGTTCACAGCAAATTCACTGCCTCCTCCCATGCACGTGGT 641 AGAGAGTACCAGTATCAACATGGCCCTGTTTTCTGCTAAAACCAGATTTTGAGGAATCAGAGACCCCCAACACTACTCAC 721 TCAGTAGCTAGCAGCCCCTTCCTTTCAACTGGGAGTGTTATTAGAATGAAAAGTAATTAGTTAGAAGGGCATACATCTCA 801 GTGGCATGAGCATTGTGGAATATCCTTTCCTAGGCACATTCGTCCACTAAGGGAACAGCCTCAGAAACTGGTACAGCAAT 881 GGGTGAGATGAGATCATGGAGAGAGAACACAGCCATCCCCTATAGAAAGGCACAGCTTTTGGGCTTCTCTGGCCTGAATG 961 CCTTCTGGGGTATTTCCATATGCAACAGCCCAGAGTCATAGCCTTGGGCAACCACACATAGAGGTTTCCTTCTCACTTCA 1041 GACACATACATCACTTTCACACCACTTGGGGATGGAAATACCTACAAGAGTGAAGGTCAAGGGCCCTCCCCAGGCATCTC 1121 ATTCATTACTCAGCTTCCTTCCTGACCAAGTCTGCCAACCAATGGCCAGCTATGCGCCTCATCCTCATTGCTTCTGCCTC 1201 CACGTAAATGAAACCAAAGGCCTCAGCATATCCTGGGAGGACTGGGGGCTGTTACCTAATGGTCCTCTCTGTCCCATTAT 1281 AGGTGCAAGGCACCCCATCCACACATTTGCACCACTACTCCAAGATAGTATTTTTCTTTTCACACAATCTCTTTACAGCA 1361 GAATCCAGAGTTGGATTGTAGTTTACCTTCCTGGAAAGCTCATTATCTCTGTTTGAATTAACATTTCAGCATGGAACTAA 1441 CTGGGCGGAGGAAGGATCGTTATACGTCTTCAGAAAGTTCTCATTGCCCCAGCTGCCTAGTACTATACAAGAAGCTCTAC 1521 TTTGATGGCAGATCTAAGAAGGCTATAGGCCTTTGTTTGTAGGAAGCAGTGTCATTACATTCAAGCTTCACTTCTCTGAT 1601 TGGCTTCCAACCACTGGGATTCAAAGAGAATCCAAGGTTCTGCCTATGTCTGATGACATAAGGAAAACTTGGCTTCCTCT 1681 GCTCAAGGTTCCCCTCTGCTCATCCCTCCTCATTCAGACATCCTCCACCATACCAGTGTTTAGAAGCAAAACATGAAGGG 1761 CTAGCGCCACCAGGATAGTTAGCAGAAATATTGTCTGTAAAGCTAGGCAGATGAGCCCAGAAGAATGGTCCCAGAGAAAG 1841 CAGACTGGCTCCAATAGATATCAGGCAGCAATCCCAATAAATTCTGACATGTCCTTGGCAATGGAAGCCTGGGTTGGAGA 1921 TCCTGAGGCAGCTGTGCCTACTGTTCCCCACCTCAGAAGCTTCCTGCCCAGAGAGCCAGCAGCCTTGGGATACTAATGAG 2001 GATGCAACTGGCTTATTGGTATGAAATAGAAGGTGGCTTTGTAGGGGCAAGCAGGCAAAGAGTACTATCCACATGGCAGG 2081 CAGGTGGCTTTGTGTCTGGAAAGCTTTGCCTAGCCAGTACAGCTGTGAGCAGAGGCTGGTTATAAATTTGAACTCCCTCA 2161 GCCCATTTGCAACTCTGCCTCTGTTCTCTTGCATTCTGTTTGGTTGCCCTTTAGTTTCCTAGTAAATGCTCCTTTTGAAA 2241 AACTC Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control
PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545212 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000318881.6 | 3UTR | UCUCACUUCAGACACAUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM545214 | |
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Method / RBP | PAR-CLIP / AGO3 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000318881.6 | 3UTR | UCUCACUUCAGACACAUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||
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37 hsa-miR-3171 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT117345 | MAPRE2 | microtubule associated protein RP/EB family member 2 | 2 | 2 | ||||||||
MIRT152426 | ARID3A | AT-rich interaction domain 3A | 2 | 2 | ||||||||
MIRT227670 | SET | SET nuclear proto-oncogene | 2 | 2 | ||||||||
MIRT293606 | PVR | poliovirus receptor | 2 | 2 | ||||||||
MIRT442923 | TFDP2 | transcription factor Dp-2 | 2 | 2 | ||||||||
MIRT447007 | RSF1 | remodeling and spacing factor 1 | 2 | 2 | ||||||||
MIRT450195 | ZHX3 | zinc fingers and homeoboxes 3 | 2 | 2 | ||||||||
MIRT450883 | COL4A5 | collagen type IV alpha 5 chain | 2 | 2 | ||||||||
MIRT459707 | ZNF641 | zinc finger protein 641 | 2 | 2 | ||||||||
MIRT467111 | SRI | sorcin | 2 | 2 | ||||||||
MIRT468271 | SFXN1 | sideroflexin 1 | 2 | 2 | ||||||||
MIRT484168 | WDR82P1 | WD repeat domain 82 pseudogene 1 | 2 | 8 | ||||||||
MIRT502274 | H3F3B | H3 histone family member 3B | 2 | 4 | ||||||||
MIRT504190 | FAM127B | retrotransposon Gag like 8A | 2 | 2 | ||||||||
MIRT507718 | CMPK1 | cytidine/uridine monophosphate kinase 1 | 2 | 6 | ||||||||
MIRT513852 | JARID2 | jumonji and AT-rich interaction domain containing 2 | 2 | 8 | ||||||||
MIRT521900 | PIAS1 | protein inhibitor of activated STAT 1 | 2 | 2 | ||||||||
MIRT525975 | SPA17 | sperm autoantigenic protein 17 | 2 | 2 | ||||||||
MIRT534599 | RORA | RAR related orphan receptor A | 2 | 2 | ||||||||
MIRT537572 | ESYT2 | extended synaptotagmin 2 | 2 | 2 | ||||||||
MIRT539261 | ANKRD44 | ankyrin repeat domain 44 | 2 | 2 | ||||||||
MIRT544214 | SRSF11 | serine and arginine rich splicing factor 11 | 2 | 4 | ||||||||
MIRT553877 | SUPT7L | SPT7 like, STAGA complex gamma subunit | 2 | 4 | ||||||||
MIRT564547 | CCDC80 | coiled-coil domain containing 80 | 2 | 2 | ||||||||
MIRT571228 | SYT9 | synaptotagmin 9 | 2 | 2 | ||||||||
MIRT572016 | H3F3C | H3 histone family member 3C | 2 | 2 | ||||||||
MIRT613116 | EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | 2 | 2 | ||||||||
MIRT629028 | MMP16 | matrix metallopeptidase 16 | 2 | 4 | ||||||||
MIRT635228 | CD59 | CD59 molecule (CD59 blood group) | 2 | 2 | ||||||||
MIRT641493 | POLA2 | DNA polymerase alpha 2, accessory subunit | 2 | 2 | ||||||||
MIRT648008 | ZNF431 | zinc finger protein 431 | 2 | 2 | ||||||||
MIRT697344 | ZNF544 | zinc finger protein 544 | 2 | 2 | ||||||||
MIRT700991 | PDE3A | phosphodiesterase 3A | 2 | 2 | ||||||||
MIRT704714 | CHD9 | chromodomain helicase DNA binding protein 9 | 2 | 2 | ||||||||
MIRT705320 | ATP2A2 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | 2 | 2 | ||||||||
MIRT705387 | ATP1B3 | ATPase Na+/K+ transporting subunit beta 3 | 2 | 2 | ||||||||
MIRT715811 | NUDT7 | nudix hydrolase 7 | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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