miRTarBase - #MIRT571336


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pre-miRNA Information
pre-miRNA hsa-mir-6509   
Genomic Coordinates chr7: 135206994 - 135207078
Description Homo sapiens miR-6509 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6509-3p
Sequence 52| UUCCACUGCCACUACCUAAUUU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778601614 1 dbSNP
rs754554776 3 dbSNP
rs767798995 3 dbSNP
rs145322812 4 dbSNP
rs773941257 5 dbSNP
rs768273593 9 dbSNP
rs984565062 12 dbSNP
rs748872915 13 dbSNP
rs774861125 14 dbSNP
rs13241975 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RABGEF1   
Synonyms RABEX5, RAP1, rabex-5
Description RAB guanine nucleotide exchange factor 1
Transcript NM_014504   
Expression
Putative miRNA Targets on RABGEF1
3'UTR of RABGEF1
(miRNA target sites are highlighted)		 
>RABGEF1|NM_014504|3'UTR
   1 TCACAATTTAGTGGAGAGTATTTATTTGAGCCTAAATTGTAGGTAGCCCTTACTACACTCAACTGATTGGGATCTAGAAT
  81 GTAACTAAATTGCTTATAAATGTCAGAGCATTTTTTAAAGGTACAGTATATGGGGATTGTTTCGTTTTTCCTAGCAGGGG
 161 AACCTTAGTTAATAATAAAATACTACTTATTTGAGTTACTGATACAGATTCATTTAAGGCTTGTGTGCAAATTTTGTCTC
 241 AATCTTTTTTCCCTCCATGATTTTCCTATGTGCTTCCTCTGGCATTCACTGTGGTTTTGGTAAATAATTGCCTTTTAAAG
 321 GATTAAACAAATGAATGCTACAAAGTGTATGTTCAAGAAAATTAAATGGTACCACTCTTCCACAGTTTGGAATAATTTTA
 401 TAATTGTAAAGATAGAAATTATATTGATAAGTAAATATGTAAAATTGTAAATATGTAAAAAAAAGAATGGTGTCTGCTGT
 481 GCATGGCATTTTATATGTTAATTTTTTAGTTTAAAATGAAGTATATTGAATGTTTGCCTTTAGCACCATTTTATTTGGTT
 561 TGTCCCACTAAAATGACTCGAGAAGTGTTTAGACAAACTCCCCTTAAGATGTGCACTCCATCTTTAAGAACGTGTTAGCC
 641 TTAACTTTGAGGTTCTATATAGTCAGAGACTATGACACCACTAAGGTTCAGAATAAAGTTTAGGCCACATAAAATTGCTG
 721 TTTAATGTAGTCGATGGAAGACTTTAAACTATGCTTCTAGCTTATTTTTCCCTCATTCATTCAGCAAATCTCTATTGAGT
 801 TCTTCAGTGAGAAGGAGCAGGCACTGGGCCTGGAATGGAAGGCGGGAATGAATGGGCCTCTGATGGTGAGAGGTGACGGG
 881 GTCCCTCAGCTGTGAGATGCAAGGGGCGCCTTGCAGCCTCCATAATATACATTTGACTTTGCAAACGTCTAGACATGTTT
 961 TCTGAACCTTTTTCAGGACATTTCAACCTCGGGACTATTCATATTAGTGGCCTGAGAGGTGTTTGTTGTGGGGCCACCCT
1041 GTGCATGGTAGAATGTTCAGCAGCATTCCTGCCATCCATATCCATTAGGTGCCAGTAGCACCCCCGCTAGAGCTGTGAAA
1121 AATTCTCTCCAGACATAGTCAGATGTCTCCTGGGGCCATATCACCCCTCCGTTAAGAACCACTGATGTCTTTTACAAACC
1201 AGGAGTTATCCTCCTGGTGGTTAATATGGTGTAACCAAAGAATCTTGCACTCAATGCACAGTGTGATGTTAACTAAAACG
1281 AGTTAAATATTTAGGAGGCTTGACAGCTACCTGCATTGTAGAACCTTTTCTTATCTCAGTGGAACCTTCTATAACCTAAA
1361 TATACCATTGATGATTCTTCTTCCATTCAGTGACATCCACAGATTATGCAGCTATACTTGTGAAATCGTGCATGAGGCCC
1441 CAGGGCACCGTTCTAGAACAACGTCACTTCACACAGGCAGCTGAGAAAGGTTCTCTTGCTTTTCCAGTATCTTCCTAAGG
1521 ATGGAGCCCAAAATTGCAGAGCAGTAACTTTGGAATAAAACCAGGGTGGGTATAAAACTTCTTATTCTTAAATTTACATA
1601 TAAGATCTATTAAGCTTGACACATCTGTGTCATCACGCACTGAAGACAGGAAGCAGTTCACTGAGTCAGCTGGTTCCCAA
1681 GCTCGCACAGAAGGTGATAAGTTACTATCAAATGCCAGTGAGAATCTTCTTATAGAATAACCTGGGCCCAAGTGATTTTA
1761 GTACAAAACTTGCCCTTCTTTGGTTTAATTTTCTATGTGCTTTTAGGTGTGAATCCAGATATGCGGTCTTAATTCCTTTG
1841 GAAATACACAGTTCGTTTAGTTACTGTACACTCTGTTTGTTCAATAAACTGCATATCAACTTCCCACAAAAGCTGACTTT
1921 TTTGGGTCTCTTACATATAAAGTAGGTTATTGAGTTGATTTTTTTGGAGGTATCTCATATTGGTCGAATTCTTCTGGTAT
2001 GGACTCTTGCCTTATATAGAGGCTTCTATTTCTCTTAAGTCAGCATCAATACAACGGCCGGAGTTTCTGTTTTTGCAATA
2081 AGAAGATGTTGGTATTTTATGTAGGGTAAATGTGACTGGAATACACCTTTGGAACGGAATTCTTTATCAATAAAGTTTCA
2161 CAATCCGTCCCTCTTCCAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuAAUCCAUCACCGUCACCUu 5'
             ||   || |  ||||||| 
Target 5' cctTTTCTTA-TCTCAGTGGAa 3'
 1324 - 1344 142.00 -11.50
2 
miRNA  3' uuuaauccaucaccGUCACCUu 5'
                        :|||||| 
Target 5' ------tcacaattTAGTGGAg 3'
 1 - 16 124.00 -9.10
3 
miRNA  3' uuUAAUCCAUCACCGUCAC-CUu 5'
            | ||   | || ||||| || 
Target 5' ttACTATCAAATGCCAGTGAGAa 3'
 1702 - 1724 120.00 -8.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30147863 3 COSMIC
COSN28866614 22 COSMIC
COSN8034162 25 COSMIC
COSN30461251 49 COSMIC
COSN30460969 50 COSMIC
COSN30131937 58 COSMIC
COSN30104345 89 COSMIC
COSN20104306 107 COSMIC
COSN27638675 383 COSMIC
COSN26555155 446 COSMIC
COSN31552135 463 COSMIC
COSN16128225 527 COSMIC
COSN26551506 586 COSMIC
COSN31569033 604 COSMIC
COSN30540475 630 COSMIC
COSN4922145 683 COSMIC
COSN2231942 754 COSMIC
COSN31962792 843 COSMIC
COSN16148068 1462 COSMIC
COSN6889015 1828 COSMIC
COSN26216936 1984 COSMIC
COSN8305821 2075 COSMIC
COSN8517484 2120 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs556811828 7 dbSNP
rs1362787829 9 dbSNP
rs367574940 14 dbSNP
rs776176843 15 dbSNP
rs1184154470 17 dbSNP
rs761256606 19 dbSNP
rs146288300 23 dbSNP
rs1300215807 39 dbSNP
rs1177698341 40 dbSNP
rs1408789284 41 dbSNP
rs773094696 44 dbSNP
rs1297935040 45 dbSNP
rs762923163 49 dbSNP
rs1391601857 52 dbSNP
rs1469463368 56 dbSNP
rs556276307 58 dbSNP
rs746966622 66 dbSNP
rs1214904854 72 dbSNP
rs542556114 75 dbSNP
rs1288207492 77 dbSNP
rs770257583 81 dbSNP
rs555373818 82 dbSNP
rs1440011429 97 dbSNP
rs1351691776 103 dbSNP
rs56400761 105 dbSNP
rs371472510 106 dbSNP
rs397817016 107 dbSNP
rs147038500 108 dbSNP
rs1304229358 109 dbSNP
rs144768966 109 dbSNP
rs1440105517 123 dbSNP
rs1348005792 124 dbSNP
rs1459107226 130 dbSNP
rs868510655 130 dbSNP
rs1383954264 136 dbSNP
rs1156513122 141 dbSNP
rs1455280963 142 dbSNP
rs572073813 143 dbSNP
rs1192419270 154 dbSNP
rs1454226235 161 dbSNP
rs1245431410 164 dbSNP
rs892337313 174 dbSNP
rs1448007993 175 dbSNP
rs541082357 180 dbSNP
rs1395096999 182 dbSNP
rs1350267470 185 dbSNP
rs1304289565 196 dbSNP
rs1233568532 206 dbSNP
rs865778001 210 dbSNP
rs1445251395 213 dbSNP
rs1333891502 214 dbSNP
rs1378118293 215 dbSNP
rs1245786910 222 dbSNP
rs564068800 225 dbSNP
rs1323784047 229 dbSNP
rs1325680358 230 dbSNP
rs1296092127 241 dbSNP
rs1436223400 242 dbSNP
rs1024917847 245 dbSNP
rs1172492067 252 dbSNP
rs969730901 256 dbSNP
rs544892091 258 dbSNP
rs897301543 267 dbSNP
rs1204880146 288 dbSNP
rs1486777063 290 dbSNP
rs768538831 303 dbSNP
rs35526468 307 dbSNP
rs1210421331 310 dbSNP
rs370106458 316 dbSNP
rs116386978 320 dbSNP
rs1275167260 323 dbSNP
rs1215137753 325 dbSNP
rs1338612335 327 dbSNP
rs541276541 327 dbSNP
rs1458151674 331 dbSNP
rs1006886567 348 dbSNP
rs878993841 354 dbSNP
rs11552461 374 dbSNP
rs1020001713 399 dbSNP
rs1253788118 410 dbSNP
rs1445318903 412 dbSNP
rs919317285 414 dbSNP
rs796556666 420 dbSNP
rs1422311886 422 dbSNP
rs563229309 424 dbSNP
rs988058341 426 dbSNP
rs1168996449 429 dbSNP
rs1476422776 433 dbSNP
rs910697002 446 dbSNP
rs1172187415 449 dbSNP
rs943626103 452 dbSNP
rs988696636 453 dbSNP
rs1043253658 455 dbSNP
rs1452522234 456 dbSNP
rs1020156513 463 dbSNP
rs1381744145 464 dbSNP
rs1256144509 466 dbSNP
rs903562150 481 dbSNP
rs529116200 482 dbSNP
rs978544086 483 dbSNP
rs1295050669 490 dbSNP
rs927055683 491 dbSNP
rs1375010566 492 dbSNP
rs1298252088 494 dbSNP
rs1440763395 511 dbSNP
rs1316146246 537 dbSNP
rs1397488242 556 dbSNP
rs180683961 572 dbSNP
rs1258776333 578 dbSNP
rs892194341 578 dbSNP
rs1463449429 579 dbSNP
rs1419096757 586 dbSNP
rs185076386 589 dbSNP
rs1422317012 590 dbSNP
rs527693692 595 dbSNP
rs916876858 601 dbSNP
rs547859687 602 dbSNP
rs1037233720 614 dbSNP
rs1245458055 616 dbSNP
rs1236397127 619 dbSNP
rs1409037448 630 dbSNP
rs904992962 631 dbSNP
rs1182094738 635 dbSNP
rs1318373362 639 dbSNP
rs1002158696 642 dbSNP
rs373320816 650 dbSNP
rs1307340584 652 dbSNP
rs1222848566 654 dbSNP
rs1374071579 658 dbSNP
rs1304965121 661 dbSNP
rs897353665 665 dbSNP
rs931479807 667 dbSNP
rs567205703 670 dbSNP
rs1456763478 677 dbSNP
rs1048993410 680 dbSNP
rs1064795 685 dbSNP
rs1007348412 696 dbSNP
rs1378568020 708 dbSNP
rs1414429395 714 dbSNP
rs987532989 721 dbSNP
rs910719026 727 dbSNP
rs1174513500 728 dbSNP
rs550141265 731 dbSNP
rs1466811194 732 dbSNP
rs1261064599 736 dbSNP
rs1215510937 746 dbSNP
rs1350992146 756 dbSNP
rs1281883061 757 dbSNP
rs1234296478 758 dbSNP
rs964840812 760 dbSNP
rs1301264803 761 dbSNP
rs1288647554 767 dbSNP
rs553132756 769 dbSNP
rs1364583320 770 dbSNP
rs1289765347 771 dbSNP
rs901159915 777 dbSNP
rs151285636 781 dbSNP
rs936368668 783 dbSNP
rs556104336 791 dbSNP
rs1052542617 794 dbSNP
rs865920741 822 dbSNP
rs1196722528 823 dbSNP
rs1020208411 826 dbSNP
rs572059500 828 dbSNP
rs1299026479 835 dbSNP
rs1262200680 842 dbSNP
rs913531026 854 dbSNP
rs1192619053 857 dbSNP
rs968574452 860 dbSNP
rs949167611 865 dbSNP
rs534365582 867 dbSNP
rs749602838 872 dbSNP
rs978599523 875 dbSNP
rs1253718069 876 dbSNP
rs1034557366 877 dbSNP
rs958498960 879 dbSNP
rs1218288451 882 dbSNP
rs1263298454 888 dbSNP
rs1399716519 889 dbSNP
rs992960396 899 dbSNP
rs1315092976 901 dbSNP
rs564673169 901 dbSNP
rs1189985959 904 dbSNP
rs916951909 904 dbSNP
rs188324334 906 dbSNP
rs972998823 908 dbSNP
rs918833392 913 dbSNP
rs1158469488 929 dbSNP
rs748004020 930 dbSNP
rs1048560593 938 dbSNP
rs1188274054 940 dbSNP
rs1358985868 941 dbSNP
rs572031454 945 dbSNP
rs1253498219 946 dbSNP
rs1421780463 948 dbSNP
rs1481912516 949 dbSNP
rs942826452 950 dbSNP
rs1298970886 951 dbSNP
rs1041505929 971 dbSNP
rs1295480029 974 dbSNP
rs577695871 975 dbSNP
rs1340057312 979 dbSNP
rs1434491052 980 dbSNP
rs1393155109 987 dbSNP
rs1276676613 989 dbSNP
rs75039203 996 dbSNP
rs1219707756 1003 dbSNP
rs1010231508 1004 dbSNP
rs1419785504 1006 dbSNP
rs1041705937 1010 dbSNP
rs1472261894 1016 dbSNP
rs1366289194 1018 dbSNP
rs1308302767 1023 dbSNP
rs1351171731 1027 dbSNP
rs904442958 1030 dbSNP
rs62465660 1031 dbSNP
rs1450681591 1038 dbSNP
rs373149667 1063 dbSNP
rs1456789508 1074 dbSNP
rs1275479339 1075 dbSNP
rs1218811307 1091 dbSNP
rs1355929553 1099 dbSNP
rs1282702200 1101 dbSNP
rs1241415323 1102 dbSNP
rs563117888 1104 dbSNP
rs1396507119 1108 dbSNP
rs958773308 1109 dbSNP
rs112908224 1112 dbSNP
rs1489115232 1116 dbSNP
rs1388300032 1121 dbSNP
rs1024007065 1128 dbSNP
rs1453980625 1132 dbSNP
rs1379182967 1134 dbSNP
rs961721417 1148 dbSNP
rs773815765 1152 dbSNP
rs1438391014 1156 dbSNP
rs1441860802 1157 dbSNP
rs775793835 1158 dbSNP
rs1200184284 1159 dbSNP
rs1451462885 1166 dbSNP
rs140498015 1169 dbSNP
rs116038845 1170 dbSNP
rs1354630661 1171 dbSNP
rs1285400721 1172 dbSNP
rs181147939 1179 dbSNP
rs1325657994 1180 dbSNP
rs1435630258 1185 dbSNP
rs1329186579 1186 dbSNP
rs1319989235 1188 dbSNP
rs185592345 1194 dbSNP
rs1359430252 1198 dbSNP
rs984752253 1201 dbSNP
rs1350503859 1215 dbSNP
rs761244789 1216 dbSNP
rs547502779 1218 dbSNP
rs1395157065 1223 dbSNP
rs558250257 1225 dbSNP
rs1041167632 1228 dbSNP
rs922687936 1230 dbSNP
rs1441578153 1234 dbSNP
rs1195695917 1249 dbSNP
rs926093637 1253 dbSNP
rs1262809921 1260 dbSNP
rs1214714764 1261 dbSNP
rs764646351 1278 dbSNP
rs1279400285 1279 dbSNP
rs1218603909 1288 dbSNP
rs1342739942 1297 dbSNP
rs754182124 1314 dbSNP
rs956307152 1317 dbSNP
rs533240276 1334 dbSNP
rs1448804826 1340 dbSNP
rs989044835 1344 dbSNP
rs191714111 1345 dbSNP
rs570221432 1350 dbSNP
rs536094839 1361 dbSNP
rs1359258790 1364 dbSNP
rs1279903978 1367 dbSNP
rs560731904 1373 dbSNP
rs1226225180 1375 dbSNP
rs1291438693 1376 dbSNP
rs1478390603 1379 dbSNP
rs1423313820 1381 dbSNP
rs1321740100 1383 dbSNP
rs1198579476 1390 dbSNP
rs767094176 1403 dbSNP
rs926347883 1405 dbSNP
rs1238158651 1406 dbSNP
rs549694693 1410 dbSNP
rs1000146758 1427 dbSNP
rs1275104007 1432 dbSNP
rs1219166416 1448 dbSNP
rs150148487 1449 dbSNP
rs1276014764 1455 dbSNP
rs1237233704 1458 dbSNP
rs929221177 1460 dbSNP
rs775107000 1461 dbSNP
rs1165171312 1462 dbSNP
rs762207761 1471 dbSNP
rs1465106798 1491 dbSNP
rs1014496631 1503 dbSNP
rs1398099118 1506 dbSNP
rs534592980 1508 dbSNP
rs775563784 1512 dbSNP
rs557431518 1514 dbSNP
rs1355766089 1521 dbSNP
rs577592251 1525 dbSNP
rs1018132654 1526 dbSNP
rs536703324 1527 dbSNP
rs1168937116 1529 dbSNP
rs1425788691 1532 dbSNP
rs1445383917 1537 dbSNP
rs993185851 1544 dbSNP
rs1414732688 1555 dbSNP
rs760740556 1564 dbSNP
rs1000211645 1566 dbSNP
rs1240068431 1567 dbSNP
rs1199247504 1568 dbSNP
rs1457232832 1569 dbSNP
rs1033150397 1571 dbSNP
rs556649590 1580 dbSNP
rs956200884 1583 dbSNP
rs1027292141 1595 dbSNP
rs1311646936 1598 dbSNP
rs989509256 1601 dbSNP
rs951781616 1604 dbSNP
rs1217548939 1608 dbSNP
rs758339585 1616 dbSNP
rs573494058 1619 dbSNP
rs1255584413 1620 dbSNP
rs1374941596 1622 dbSNP
rs984426803 1623 dbSNP
rs377595658 1624 dbSNP
rs1199776752 1626 dbSNP
rs1329750232 1630 dbSNP
rs559201553 1635 dbSNP
rs573089960 1636 dbSNP
rs1164398184 1637 dbSNP
rs977327012 1643 dbSNP
rs1238334519 1644 dbSNP
rs1477610542 1654 dbSNP
rs926254599 1659 dbSNP
rs1179260395 1660 dbSNP
rs751648730 1671 dbSNP
rs946126208 1672 dbSNP
rs937747710 1678 dbSNP
rs1192842279 1682 dbSNP
rs977489447 1683 dbSNP
rs183491561 1684 dbSNP
rs1168374686 1685 dbSNP
rs935998288 1686 dbSNP
rs1318311481 1694 dbSNP
rs1286119056 1700 dbSNP
rs1412613035 1708 dbSNP
rs781317612 1711 dbSNP
rs929151674 1713 dbSNP
rs1055749344 1714 dbSNP
rs28619031 1716 dbSNP
rs1293254732 1717 dbSNP
rs1434584770 1722 dbSNP
rs1398974147 1723 dbSNP
rs949961016 1723 dbSNP
rs1419248128 1726 dbSNP
rs868549956 1730 dbSNP
rs1378515066 1731 dbSNP
rs1178198198 1732 dbSNP
rs1433650189 1735 dbSNP
rs1275792674 1736 dbSNP
rs111823104 1740 dbSNP
rs1189179322 1749 dbSNP
rs944589982 1754 dbSNP
rs1263531907 1757 dbSNP
rs1215441619 1758 dbSNP
rs1341785229 1769 dbSNP
rs897635951 1771 dbSNP
rs993238101 1772 dbSNP
rs1039027715 1773 dbSNP
rs1236101579 1779 dbSNP
rs550287276 1794 dbSNP
rs1217892747 1799 dbSNP
rs887484108 1808 dbSNP
rs1274709123 1813 dbSNP
rs563817917 1815 dbSNP
rs187212173 1822 dbSNP
rs1007642445 1848 dbSNP
rs112627693 1852 dbSNP
rs964662912 1854 dbSNP
rs751685722 1863 dbSNP
rs1173858319 1869 dbSNP
rs1424034057 1872 dbSNP
rs3837081 1872 dbSNP
rs397841220 1872 dbSNP
rs3778911 1883 dbSNP
rs1265451355 1888 dbSNP
rs967521617 1888 dbSNP
rs1024865724 1889 dbSNP
rs1257699249 1892 dbSNP
rs1200470820 1898 dbSNP
rs1482635209 1902 dbSNP
rs1255993747 1903 dbSNP
rs199632155 1904 dbSNP
rs200751177 1905 dbSNP
rs1064801 1906 dbSNP
rs1222188229 1914 dbSNP
rs1320502275 1916 dbSNP
rs762600300 1916 dbSNP
rs1218282761 1921 dbSNP
rs1338617302 1924 dbSNP
rs1314961428 1936 dbSNP
rs1396738839 1939 dbSNP
rs1198247015 1941 dbSNP
rs971691630 1942 dbSNP
rs1377061579 1943 dbSNP
rs1400793372 1943 dbSNP
rs11028 1947 dbSNP
rs1174149911 1951 dbSNP
rs926022433 1957 dbSNP
rs1375796368 1968 dbSNP
rs528749441 1972 dbSNP
rs1187809216 1977 dbSNP
rs1422770001 1978 dbSNP
rs1253430869 1982 dbSNP
rs145563422 1984 dbSNP
rs571118070 1985 dbSNP
rs991903656 1986 dbSNP
rs1295901773 1990 dbSNP
rs1259112021 2012 dbSNP
rs915893289 2017 dbSNP
rs1198347582 2027 dbSNP
rs1060527 2042 dbSNP
rs1267531386 2048 dbSNP
rs556637181 2051 dbSNP
rs567051666 2054 dbSNP
rs1448950553 2055 dbSNP
rs117778448 2058 dbSNP
rs552716267 2059 dbSNP
rs1304663869 2067 dbSNP
rs1048844940 2073 dbSNP
rs1463929136 2077 dbSNP
rs887524328 2092 dbSNP
rs191967044 2096 dbSNP
rs944640474 2108 dbSNP
rs1353374027 2109 dbSNP
rs1007287181 2111 dbSNP
rs1224464281 2121 dbSNP
rs1017701593 2130 dbSNP
rs921976886 2132 dbSNP
rs1060528 2134 dbSNP
rs1265325226 2135 dbSNP
rs998461466 2137 dbSNP
rs891892809 2138 dbSNP
rs1029917750 2144 dbSNP
rs1436475185 2145 dbSNP
rs1269891230 2149 dbSNP
rs1200851018 2151 dbSNP
rs1210684901 2162 dbSNP
rs1289691453 2165 dbSNP
rs1395473956 2166 dbSNP
rs1438781930 2167 dbSNP
rs1354495130 2171 dbSNP
rs1308495361 2178 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuuaauccaucaccGUCACCUu 5'
                        ||||||| 
Target 5' ----------aucuCAGUGGAa 3'
 		1 - 12
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000284957.5 | 3UTR | AUCUCAGUGGAACCUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000284957.5 | 3UTR | AUCUCAGUGGAACCUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055374 PDCD4 programmed cell death 4 2 4
MIRT378341 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT444668 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446953 CD248 CD248 molecule 2 2
MIRT460332 CAMK4 calcium/calmodulin dependent protein kinase IV 2 6
MIRT464078 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464586 UBN2 ubinuclein 2 2 2
MIRT468482 SESN3 sestrin 3 2 2
MIRT468962 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT475455 HSPA8 heat shock protein family A (Hsp70) member 8 2 2
MIRT482403 ADRB1 adrenoceptor beta 1 2 10
MIRT486992 ZFAND2B zinc finger AN1-type containing 2B 2 2
MIRT489397 TUBB2A tubulin beta 2A class IIa 2 2
MIRT526319 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526560 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526732 ZNF138 zinc finger protein 138 2 8
MIRT531581 STXBP5L syntaxin binding protein 5 like 2 2
MIRT532011 NOX5 NADPH oxidase 5 2 2
MIRT533407 TXLNG taxilin gamma 2 2
MIRT533436 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533866 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT539254 ANKRD50 ankyrin repeat domain 50 2 2
MIRT541451 C15orf48 chromosome 15 open reading frame 48 2 2
MIRT566794 MIER3 MIER family member 3 2 2
MIRT569294 SURF6 surfeit 6 2 2
MIRT571336 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT572802 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT572813 MYO1C myosin IC 2 2
MIRT574219 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT607259 GRAMD1B GRAM domain containing 1B 2 4
MIRT609307 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT615459 REPS1 RALBP1 associated Eps domain containing 1 2 2
MIRT616861 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT619415 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT619652 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT625325 TNFRSF13B TNF receptor superfamily member 13B 2 2
MIRT638980 ARFIP2 ADP ribosylation factor interacting protein 2 2 2
MIRT639458 ZNF429 zinc finger protein 429 2 2
MIRT640550 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT641473 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642720 ATXN3 ataxin 3 2 2
MIRT643048 SMN1 survival of motor neuron 1, telomeric 2 2
MIRT644921 SMN2 survival of motor neuron 2, centromeric 2 2
MIRT645875 ZNF275 zinc finger protein 275 2 2
MIRT649824 LIPG lipase G, endothelial type 2 2
MIRT649851 GYS2 glycogen synthase 2 2 2
MIRT649972 TRAFD1 TRAF-type zinc finger domain containing 1 2 2
MIRT650675 ZNF259 ZPR1 zinc finger 1 1
MIRT651319 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT652876 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT652881 SYVN1 synoviolin 1 2 2
MIRT654144 RPAP2 RNA polymerase II associated protein 2 2 2
MIRT657080 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657181 INO80C INO80 complex subunit C 2 2
MIRT657830 GJD3 gap junction protein delta 3 2 2
MIRT657897 GDF7 growth differentiation factor 7 2 2
MIRT659631 CDKN2AIP CDKN2A interacting protein 2 2
MIRT663115 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT664739 METTL16 methyltransferase like 16 2 2
MIRT667551 LRAT lecithin retinol acyltransferase 2 2
MIRT668552 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT682893 XIAP X-linked inhibitor of apoptosis 2 2
MIRT683092 PRRG4 proline rich and Gla domain 4 2 2
MIRT683102 TIMM10B translocase of inner mitochondrial membrane 10B 2 2
MIRT697648 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT709158 ZNF419 zinc finger protein 419 2 2
MIRT713220 RCAN2 regulator of calcineurin 2 2 2
MIRT713277 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT715008 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT715051 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT715696 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT717250 TMEM246 transmembrane protein 246 2 2
MIRT717322 PGK1 phosphoglycerate kinase 1 2 2
MIRT717587 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT718122 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718418 CALN1 calneuron 1 2 2
MIRT718750 ZNF490 zinc finger protein 490 2 2
MIRT720048 PPP1R3F protein phosphatase 1 regulatory subunit 3F 2 2
MIRT721497 THRB thyroid hormone receptor beta 2 2
MIRT722531 EPRS glutamyl-prolyl-tRNA synthetase 2 2
MIRT723279 KRTAP21-2 keratin associated protein 21-2 2 2
MIRT724813 MSX2 msh homeobox 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6509-3p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6509-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6509-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6509-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6509-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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