pre-miRNA Information | |
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pre-miRNA | hsa-mir-125b-2 |
Genomic Coordinates | chr21: 16590237 - 16590325 |
Synonyms | MIRN125B2, MIR125B2 |
Description | Homo sapiens miR-125b-2 stem-loop |
Comment | This miRNA sequence is predicted based on homology to a verified miRNA from mouse . |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | |||||||||||||||
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Mature miRNA | hsa-miR-125b-2-3p | ||||||||||||||
Sequence | 54| UCACAAGUCAGGCUCUUGGGAC |75 | ||||||||||||||
Evidence | Experimental | ||||||||||||||
Experiments | Cloned | ||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | JKAMP | ||||||||||||||||||||
Synonyms | C14orf100, C24orf100, CDA06, HSPC213, HSPC327, JAMP | ||||||||||||||||||||
Description | JNK1/MAPK8-associated membrane protein | ||||||||||||||||||||
Transcript | NM_001098625 | ||||||||||||||||||||
Other Transcripts | NM_016475 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on JKAMP | |||||||||||||||||||||
3'UTR of JKAMP (miRNA target sites are highlighted) |
>JKAMP|NM_001098625|3'UTR 1 GTGTAGACATGTGAAATGCCAAAAACCTGAGAAGTGCTCCTAATAAAAAAGTAAATCAATCTTAACAGTGTATGAGAACT 81 ATTCTATCATATATGGGAACAAGATTGTCAGTATATCTTAATGTTTGGGTTTGTCTTTGTTTTGTTTATGGTTAGACTTA 161 CAGACTTGGAAAATGCAAAACTCTGTAATACTCTGTTACACAGGGTAATATTATCTGCTACACTGGAAGGCCGCTAGGAA 241 GCCCTTGCTTCTCTCAACAGTTCAGCTGTTCTTTAGGGCAAAATCATGTTTCTGTGTACCTAGCAATGTGTTCCCATTTT 321 ATTAAGAAAAGCTTTAACACGTGTAATCTGCAGTCCTTAACAGTGGCGTAATTGTACTTACCTGTTGTGTTTCAGTTTGT 401 TTTTCACCTATAATGAATTGTAAAAACAAACATACTTGTGGGGTCTGATAGCAAACATAGAAATGATGTATATTGTTTTT 481 TGTTATCTATTTATTTTCATCAATACAGTATTTTGATGTATTGCAAAAATAGATAATAATTTATATAACAGGTTTTCTGT 561 TTATAGATTGGTTCAAGATTTGTTTGGATTATTGTTCCTGTAAAGAAAACAATAATAAAAAGCTTACCTACATAAAATTT 641 CAATGTTTTGACACTTAATTGTTGTTTGGCACAATAGTATGGAAGTAATTCAAACTGGTAAATAGTTTCCTCTCATATCT 721 CGGGTATATATACATACCATATTTTATTGATCCAGAGATACTTATTTCACTTTGTGACATCTCTGAATTAGGATGCATCT 801 TACAACTGATGGCTTATTAGATTTAATGAAATACAGAAGATACACAGAATAAAAAGGGTTTTCCTGTGGTTGGTTTGTGG 881 TTTGTGATAGGTGTTCTGTGATGTTTATGCTTTGAAGGCCTTAAGACTCATGGTTGCAACCATGGAAGCAAAATGAAATT 961 TTTAGCTCTTAACCTAACAACCTGACCATGTTTATCCATTTTTATTGTTTAGAAGTTTATTTACTGATACTTGGTGGAGG 1041 TTGTGTGAATTAGTTAAATTTTAAATGTTTAAGACTTCTATTAACAGCTGCAAAATATGAAAGTAAGTGCACTCACTTTT 1121 CCTGTAGTAGTCTGTCTTTTGAATTCACAGCAGTTGTATCCTTGAGTTACTTTGTTAATGTATTTTTCTCAGTACATTTA 1201 ACCACTGGGAAATGAACCCTTGTACGAATGTGTTTCTTCTTCTCTGTAGGAATAAAAAATAAATATAAAAATTTTATTTG 1281 TATTGCACACATTTGGGGGGTTATTAGTGTTCATTAAAATTCTGAGTTGCCCAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control
PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545212 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000261247.9 | 3UTR | UAAAAACAAACAUACUUGUGGGGUCUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM545214 | |
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Method / RBP | PAR-CLIP / AGO3 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000261247.9 | 3UTR | UAAAAACAAACAUACUUGUGGGGUCUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT038624 | HN1L | Jupiter microtubule associated homolog 2 | ![]() |
1 | 1 | |||||||
MIRT038625 | KDELC2 | KDEL motif containing 2 | ![]() |
1 | 1 | |||||||
MIRT038626 | ABHD15 | abhydrolase domain containing 15 | ![]() |
1 | 1 | |||||||
MIRT038627 | PPP1R12C | protein phosphatase 1 regulatory subunit 12C | ![]() |
1 | 1 | |||||||
MIRT038628 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | ![]() |
1 | 1 | |||||||
MIRT038629 | ASH2L | ASH2 like histone lysine methyltransferase complex subunit | ![]() |
1 | 1 | |||||||
MIRT038630 | USP22 | ubiquitin specific peptidase 22 | ![]() |
1 | 1 | |||||||
MIRT038631 | CSTB | cystatin B | ![]() |
1 | 1 | |||||||
MIRT038632 | SYT2 | synaptotagmin 2 | ![]() |
1 | 1 | |||||||
MIRT038633 | NDUFS7 | NADH:ubiquinone oxidoreductase core subunit S7 | ![]() |
1 | 1 | |||||||
MIRT038634 | MTA2 | metastasis associated 1 family member 2 | ![]() |
1 | 1 | |||||||
MIRT053086 | IGF1R | insulin like growth factor 1 receptor | ![]() |
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3 | 1 | |||||
MIRT055788 | PLEKHA1 | pleckstrin homology domain containing A1 | ![]() |
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2 | 12 | ||||||
MIRT061248 | AMOTL1 | angiomotin like 1 | ![]() |
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2 | 10 | ||||||
MIRT061649 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 6 | ||||||
MIRT079046 | TNRC6C | trinucleotide repeat containing 6C | ![]() |
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2 | 4 | ||||||
MIRT084583 | BCL2L11 | BCL2 like 11 | ![]() |
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2 | 8 | ||||||
MIRT093523 | GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | ![]() |
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2 | 2 | ||||||
MIRT097383 | LHFPL2 | LHFPL tetraspan subfamily member 2 | ![]() |
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2 | 4 | ||||||
MIRT098030 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT186262 | TCEB3 | elongin A | ![]() |
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2 | 2 | ||||||
MIRT187284 | DAZAP2 | DAZ associated protein 2 | ![]() |
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2 | 10 | ||||||
MIRT361113 | LRRC1 | leucine rich repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT443585 | FAM84B | family with sequence similarity 84 member B | ![]() |
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2 | 2 | ||||||
MIRT452249 | TRAM1 | translocation associated membrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT476289 | GMFB | glia maturation factor beta | ![]() |
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2 | 8 | ||||||
MIRT483871 | MRPL12 | mitochondrial ribosomal protein L12 | ![]() |
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2 | 2 | ||||||
MIRT484250 | ANK1 | ankyrin 1 | ![]() |
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2 | 2 | ||||||
MIRT499251 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 4 | ||||||
MIRT502270 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | ![]() |
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2 | 4 | ||||||
MIRT504652 | RPL9 | ribosomal protein L9 | ![]() |
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2 | 6 | ||||||
MIRT505210 | UBN2 | ubinuclein 2 | ![]() |
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2 | 6 | ||||||
MIRT512690 | POP1 | POP1 homolog, ribonuclease P/MRP subunit | ![]() |
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2 | 2 | ||||||
MIRT517341 | ZNF529 | zinc finger protein 529 | ![]() |
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2 | 4 | ||||||
MIRT518946 | LSG1 | large 60S subunit nuclear export GTPase 1 | ![]() |
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2 | 2 | ||||||
MIRT520866 | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone | ![]() |
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2 | 2 | ||||||
MIRT521236 | SAR1A | secretion associated Ras related GTPase 1A | ![]() |
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2 | 2 | ||||||
MIRT528324 | GIGYF2 | GRB10 interacting GYF protein 2 | ![]() |
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2 | 2 | ||||||
MIRT533297 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT541024 | WEE1 | WEE1 G2 checkpoint kinase | ![]() |
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2 | 4 | ||||||
MIRT544034 | ERRFI1 | ERBB receptor feedback inhibitor 1 | ![]() |
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2 | 2 | ||||||
MIRT547037 | POGZ | pogo transposable element derived with ZNF domain | ![]() |
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2 | 2 | ||||||
MIRT556102 | MOAP1 | modulator of apoptosis 1 | ![]() |
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2 | 2 | ||||||
MIRT558320 | DR1 | down-regulator of transcription 1 | ![]() |
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2 | 2 | ||||||
MIRT558520 | CSRNP3 | cysteine and serine rich nuclear protein 3 | ![]() |
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2 | 2 | ||||||
MIRT566230 | PTMA | prothymosin, alpha | ![]() |
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2 | 4 | ||||||
MIRT568437 | ARPP19 | cAMP regulated phosphoprotein 19 | ![]() |
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2 | 2 | ||||||
MIRT570584 | OTUD7B | OTU deubiquitinase 7B | ![]() |
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2 | 2 | ||||||
MIRT571384 | JKAMP | JNK1/MAPK8-associated membrane protein | ![]() |
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2 | 2 | ||||||
MIRT572798 | SIGLEC14 | sialic acid binding Ig like lectin 14 | ![]() |
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2 | 2 | ||||||
MIRT573864 | C9orf78 | chromosome 9 open reading frame 78 | ![]() |
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2 | 2 | ||||||
MIRT609930 | SLC38A1 | solute carrier family 38 member 1 | ![]() |
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2 | 4 | ||||||
MIRT610437 | CSMD2 | CUB and Sushi multiple domains 2 | ![]() |
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2 | 2 | ||||||
MIRT614407 | MURC | caveolae associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT618625 | GREB1 | growth regulation by estrogen in breast cancer 1 | ![]() |
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2 | 2 | ||||||
MIRT620605 | SAP30 | Sin3A associated protein 30 | ![]() |
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2 | 2 | ||||||
MIRT635313 | FAM179A | TOG array regulator of axonemal microtubules 2 | ![]() |
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2 | 2 | ||||||
MIRT635918 | GLTSCR2 | NOP53 ribosome biogenesis factor | ![]() |
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2 | 2 | ||||||
MIRT638507 | MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | ![]() |
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2 | 2 | ||||||
MIRT640597 | TM9SF4 | transmembrane 9 superfamily member 4 | ![]() |
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2 | 2 | ||||||
MIRT644066 | IQCE | IQ motif containing E | ![]() |
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2 | 2 | ||||||
MIRT648287 | TRAPPC2L | trafficking protein particle complex 2 like | ![]() |
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2 | 2 | ||||||
MIRT653089 | SSR3 | signal sequence receptor subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT654651 | PTAFR | platelet activating factor receptor | ![]() |
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2 | 2 | ||||||
MIRT658084 | FOXR2 | forkhead box R2 | ![]() |
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2 | 2 | ||||||
MIRT665306 | ZBTB37 | zinc finger and BTB domain containing 37 | ![]() |
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2 | 2 | ||||||
MIRT665974 | SYTL4 | synaptotagmin like 4 | ![]() |
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2 | 2 | ||||||
MIRT674905 | RASSF9 | Ras association domain family member 9 | ![]() |
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2 | 2 | ||||||
MIRT680085 | THAP1 | THAP domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT681487 | DIP2A | disco interacting protein 2 homolog A | ![]() |
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2 | 2 | ||||||
MIRT691243 | DFNB59 | pejvakin | ![]() |
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2 | 2 | ||||||
MIRT692361 | AGTRAP | angiotensin II receptor associated protein | ![]() |
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2 | 2 | ||||||
MIRT693034 | MB21D1 | Mab-21 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT694478 | LRTOMT | leucine rich transmembrane and O-methyltransferase domain containing | ![]() |
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2 | 2 | ||||||
MIRT696069 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 2 | ||||||
MIRT696579 | TTC21B | tetratricopeptide repeat domain 21B | ![]() |
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2 | 2 | ||||||
MIRT696759 | MTFMT | mitochondrial methionyl-tRNA formyltransferase | ![]() |
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2 | 2 | ||||||
MIRT697306 | ZNF652 | zinc finger protein 652 | ![]() |
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2 | 2 | ||||||
MIRT698736 | STX12 | syntaxin 12 | ![]() |
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2 | 2 | ||||||
MIRT701055 | PARP2 | poly(ADP-ribose) polymerase 2 | ![]() |
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2 | 2 | ||||||
MIRT701197 | OTUD3 | OTU deubiquitinase 3 | ![]() |
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2 | 2 | ||||||
MIRT701334 | NSD1 | nuclear receptor binding SET domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT703617 | FBXO45 | F-box protein 45 | ![]() |
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2 | 2 | ||||||
MIRT708893 | ZNF780A | zinc finger protein 780A | ![]() |
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2 | 2 | ||||||
MIRT711621 | DGKH | diacylglycerol kinase eta | ![]() |
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2 | 2 | ||||||
MIRT713744 | TMEM81 | transmembrane protein 81 | ![]() |
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2 | 2 | ||||||
MIRT715060 | TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT719711 | CD101 | CD101 molecule | ![]() |
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2 | 2 | ||||||
MIRT720293 | DLGAP3 | DLG associated protein 3 | ![]() |
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2 | 2 | ||||||
MIRT722605 | CCDC152 | coiled-coil domain containing 152 | ![]() |
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2 | 2 | ||||||
MIRT724565 | ACSBG1 | acyl-CoA synthetase bubblegum family member 1 | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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