pre-miRNA Information
pre-miRNA hsa-mir-6132   
Genomic Coordinates chr7: 117020211 - 117020319
Description Homo sapiens miR-6132 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6132
Sequence 21| AGCAGGGCUGGGGAUUGCA |39
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1272646274 4 dbSNP
rs1211969145 8 dbSNP
rs1310278496 11 dbSNP
rs1044115534 13 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HSPB6   
Synonyms HEL55, Hsp20, PPP1R91
Description heat shock protein family B (small) member 6
Transcript NM_144617   
Expression
Putative miRNA Targets on HSPB6
3'UTR of HSPB6
(miRNA target sites are highlighted)
>HSPB6|NM_144617|3'UTR
   1 GAGGGGGCTGGGCCGCGCCCGCACCCCGGGAGCCTCCTCAGGCTCCCTCTATTAAAGCCGATCTGACTCCGCCCAGCCAG
  81 ATGTCCCGAGTGCGCCAAGGACTGTCCTCTCACCCACTCCTGGATTCTGCCCTGACCTCCATCCTGGACACTGCCTTGAT
 161 AACATAGACCCTTCCACTGACACCCTCGCTCTCACACCCCCTCCAGCTTTCCGACCCCACACCGACAACTCCCCGGCTTC
 241 CAGACCCTACCAGCACTACCCTAACCCTCAGCCGACAGTCTCAGCCCCACCGACCCACTTTCTTGGCATATAGCCCCACT
 321 TAAGACCCCTCCTCTACTTCCTTCTGAGTCCTCTACAAAGACATCCGGGTACTACATTTCCATCCCTTCCCTATTTTGAC
 401 ACCAAATTATGGTGTAGACAGCCCTCCCCCAACCCCAGGCCAGTCAGGCACAATCCCCCCACCCCCCAAACGTCCTGGAC
 481 TGCACAGACCTCCCACTCCAGACCATCCAGGCCTGGTTCCCAAGACCCGATCCTTCCCCTGCAACCAGACAGTCTACAAC
 561 TGCCCCCTCCAGCCCATTTTCTGCCGTGAAACCCCAGCCAGCCACACCAGACTCTGGAACCCTTTTTCGACTGCCCCAAC
 641 TCTTGGACACCAGGCCAACTAGAACACCCAACACCAAACTGTACAGACTCTCCCACCCCAACCTCCCCAGACTCTGCACG
 721 GATGTCCTAGGCCCCCTCCCCAACTCTAACCAGACCCCATCCCCCTAAGTCCCTTTGTCTTGACCCCCAAGTCTTCAACC
 801 AGATATCCTCGGCAACCCACCTCCCACCCTCCTCCTCTTCTCCTTCAAGACCCAACTGAGCACCCGCTCTGATTCCCCAC
 881 AGCCTTTCTCCCTGCCACCACTCCCTTAGTCTTTCCCAGGCTTACTCTCCCAATAAATGTGCTAGAGCTCTGCCAAAAAA
 961 AAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acgUUA---GGGGUCGGGACGa 5'
             |||   |:  |||:|||| 
Target 5' ataAATGTGCTAGAGCTCTGCc 3'
933 - 954 132.00 -13.10
2
miRNA  3' acGUUAGG-----GGUCGGGACga 5'
            || |||     :| ||||||  
Target 5' ccCACTCCTGGATTCTGCCCTGac 3'
113 - 136 129.00 -14.50
3
miRNA  3' acGUUAGGGGUCGGGACGa 5'
            |:||||::  |||||| 
Target 5' ccCGATCCTT-CCCCTGCa 3'
526 - 543 128.00 -18.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24306565 16 COSMIC
COSN30612414 44 COSMIC
COSN31522510 54 COSMIC
COSN16128197 158 COSMIC
COSN29624765 165 COSMIC
COSN26636570 189 COSMIC
COSN31544602 191 COSMIC
COSN21833889 241 COSMIC
COSN31611442 273 COSMIC
COSN31536850 287 COSMIC
COSN31590715 348 COSMIC
COSN20079581 443 COSMIC
COSN25752322 497 COSMIC
COSN25127866 692 COSMIC
COSN31537996 943 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1343075193 2 dbSNP
rs11549030 5 dbSNP
rs1442460841 6 dbSNP
rs1355859344 8 dbSNP
rs1326606674 17 dbSNP
rs1409111027 19 dbSNP
rs1406761837 20 dbSNP
rs573650486 21 dbSNP
rs1468333924 24 dbSNP
rs948120700 25 dbSNP
rs1178055832 27 dbSNP
rs1314701656 28 dbSNP
rs1471288925 35 dbSNP
rs1231328031 36 dbSNP
rs915786699 39 dbSNP
rs747183197 41 dbSNP
rs1462011195 42 dbSNP
rs1265599157 43 dbSNP
rs1202300059 45 dbSNP
rs1320868570 49 dbSNP
rs935930556 50 dbSNP
rs143062937 58 dbSNP
rs1223786218 59 dbSNP
rs1375111022 60 dbSNP
rs1234885034 68 dbSNP
rs1277358670 69 dbSNP
rs758747030 71 dbSNP
rs749062434 72 dbSNP
rs977131048 74 dbSNP
rs1338693245 75 dbSNP
rs932312452 81 dbSNP
rs1180472690 84 dbSNP
rs1468157569 86 dbSNP
rs1405192310 88 dbSNP
rs780027094 90 dbSNP
rs1402483512 91 dbSNP
rs756031781 93 dbSNP
rs1158193340 95 dbSNP
rs1445663811 101 dbSNP
rs955183707 103 dbSNP
rs750343113 106 dbSNP
rs922277516 107 dbSNP
rs989883233 120 dbSNP
rs1258798958 128 dbSNP
rs1182065864 132 dbSNP
rs1461266103 135 dbSNP
rs1190632844 138 dbSNP
rs571618832 143 dbSNP
rs963785723 145 dbSNP
rs1318174381 146 dbSNP
rs775724242 147 dbSNP
rs1238968121 148 dbSNP
rs751128090 153 dbSNP
rs1316913078 155 dbSNP
rs1450107875 156 dbSNP
rs763713538 162 dbSNP
rs748825335 165 dbSNP
rs1289327684 169 dbSNP
rs779789974 171 dbSNP
rs981256447 172 dbSNP
rs1343481402 177 dbSNP
rs762629966 179 dbSNP
rs1396350390 185 dbSNP
rs1441567864 188 dbSNP
rs149052927 191 dbSNP
rs1022857093 195 dbSNP
rs1297786533 197 dbSNP
rs370292442 200 dbSNP
rs951611601 201 dbSNP
rs1026288991 205 dbSNP
rs1444336624 211 dbSNP
rs1420909190 212 dbSNP
rs991915216 213 dbSNP
rs1486599201 214 dbSNP
rs1239847675 216 dbSNP
rs952038875 218 dbSNP
rs1003786289 223 dbSNP
rs554528232 234 dbSNP
rs1408735408 235 dbSNP
rs906552073 243 dbSNP
rs190135278 251 dbSNP
rs1472072834 252 dbSNP
rs897910588 259 dbSNP
rs1012322839 273 dbSNP
rs1462932234 274 dbSNP
rs1245823979 280 dbSNP
rs893859924 286 dbSNP
rs1054221925 287 dbSNP
rs1432769553 325 dbSNP
rs935814933 327 dbSNP
rs1008991593 332 dbSNP
rs1399643567 334 dbSNP
rs1276461973 335 dbSNP
rs1447103757 335 dbSNP
rs1239860435 336 dbSNP
rs1285704223 341 dbSNP
rs1289584139 344 dbSNP
rs1320477122 350 dbSNP
rs1218502786 361 dbSNP
rs1226090770 362 dbSNP
rs903111498 365 dbSNP
rs1358708183 367 dbSNP
rs1242211734 376 dbSNP
rs1487639508 380 dbSNP
rs1190873080 383 dbSNP
rs889385354 387 dbSNP
rs1315625984 395 dbSNP
rs1475319352 415 dbSNP
rs1164002840 419 dbSNP
rs137940999 421 dbSNP
rs1050660947 422 dbSNP
rs1247978445 425 dbSNP
rs1362678378 427 dbSNP
rs985127967 431 dbSNP
rs953280226 437 dbSNP
rs1430216320 439 dbSNP
rs1419244478 451 dbSNP
rs1296403367 454 dbSNP
rs932318411 458 dbSNP
rs1415585811 459 dbSNP
rs1283999880 460 dbSNP
rs1320412836 460 dbSNP
rs1029112773 461 dbSNP
rs1422808787 462 dbSNP
rs571906073 464 dbSNP
rs1054529461 466 dbSNP
rs1353601299 473 dbSNP
rs1213889589 475 dbSNP
rs1281805647 478 dbSNP
rs1485811721 485 dbSNP
rs540472813 487 dbSNP
rs1388660287 494 dbSNP
rs550100049 496 dbSNP
rs1471001148 498 dbSNP
rs1177562330 510 dbSNP
rs1379673973 520 dbSNP
rs1486015827 529 dbSNP
rs924341726 537 dbSNP
rs1377307674 544 dbSNP
rs1435589327 545 dbSNP
rs1333683192 546 dbSNP
rs1357645395 550 dbSNP
rs1444889305 552 dbSNP
rs1243470592 553 dbSNP
rs1280482615 560 dbSNP
rs1218811184 561 dbSNP
rs1376867339 564 dbSNP
rs1490041193 566 dbSNP
rs997129988 568 dbSNP
rs1292411027 574 dbSNP
rs762851078 585 dbSNP
rs933903307 586 dbSNP
rs867395643 591 dbSNP
rs1205014223 593 dbSNP
rs796908971 597 dbSNP
rs1437777636 598 dbSNP
rs1362977255 601 dbSNP
rs1195363108 607 dbSNP
rs1396976395 610 dbSNP
rs775220917 612 dbSNP
rs1272141599 621 dbSNP
rs942433916 624 dbSNP
rs866994188 628 dbSNP
rs765719966 629 dbSNP
rs1364978158 635 dbSNP
rs1304305376 636 dbSNP
rs1445230297 638 dbSNP
rs1427068762 640 dbSNP
rs538385175 641 dbSNP
rs567660573 648 dbSNP
rs1231959380 650 dbSNP
rs1353240058 681 dbSNP
rs1272545569 683 dbSNP
rs1214752015 687 dbSNP
rs1170253287 693 dbSNP
rs1257208477 697 dbSNP
rs1456230801 697 dbSNP
rs1429472306 698 dbSNP
rs1421287580 703 dbSNP
rs1196747802 704 dbSNP
rs34514071 711 dbSNP
rs1450942974 712 dbSNP
rs759986841 714 dbSNP
rs1479830714 716 dbSNP
rs1423359114 719 dbSNP
rs951554669 720 dbSNP
rs1025792660 724 dbSNP
rs1464452469 733 dbSNP
rs1268913806 737 dbSNP
rs1386669874 740 dbSNP
rs1321043196 742 dbSNP
rs982811361 750 dbSNP
rs1201540490 752 dbSNP
rs1431024510 754 dbSNP
rs1277257423 757 dbSNP
rs970998444 761 dbSNP
rs549421285 762 dbSNP
rs545863304 767 dbSNP
rs1234960189 771 dbSNP
rs776736053 784 dbSNP
rs1205041467 797 dbSNP
rs1355596370 804 dbSNP
rs771044163 810 dbSNP
rs527703570 811 dbSNP
rs1012164378 820 dbSNP
rs893912134 823 dbSNP
rs1308969005 834 dbSNP
rs1194471969 837 dbSNP
rs1262813071 845 dbSNP
rs1275402871 845 dbSNP
rs1190558475 851 dbSNP
rs915831989 852 dbSNP
rs991386663 855 dbSNP
rs1161909597 861 dbSNP
rs747215370 864 dbSNP
rs563771464 865 dbSNP
rs560090812 866 dbSNP
rs1338020666 869 dbSNP
rs1416201560 885 dbSNP
rs1313187980 896 dbSNP
rs920644887 897 dbSNP
rs551295145 904 dbSNP
rs1262489636 905 dbSNP
rs962115031 914 dbSNP
rs1217499932 915 dbSNP
rs773487464 915 dbSNP
rs533047061 916 dbSNP
rs933934889 921 dbSNP
rs1257314957 923 dbSNP
rs901055656 926 dbSNP
rs1356580026 930 dbSNP
rs1366111840 933 dbSNP
rs1173837351 937 dbSNP
rs1440814602 938 dbSNP
rs187186022 943 dbSNP
rs558290758 945 dbSNP
rs1039390373 947 dbSNP
rs1436215286 950 dbSNP
rs1302997397 952 dbSNP
rs111468214 955 dbSNP
rs1178027822 956 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acguuaggggucGGGACGa 5'
                      |||||| 
Target 5' ------uccuucCCCUGCa 3'
1 - 13
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000592984.1 | 3UTR | UCCUUCCCCUGCAACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6132 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT067294 NECAP1 NECAP endocytosis associated 1 2 10
MIRT100110 ABT1 activator of basal transcription 1 2 8
MIRT358583 CANX calnexin 2 2
MIRT445247 SEMA5A semaphorin 5A 2 2
MIRT445764 CCND3 cyclin D3 2 2
MIRT452388 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452829 FAM131B family with sequence similarity 131 member B 2 2
MIRT453450 GLG1 golgi glycoprotein 1 2 2
MIRT455435 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT460629 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461607 DPH2 DPH2 homolog 2 2
MIRT461989 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT464258 VCL vinculin 2 2
MIRT465713 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT466475 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT467119 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 4
MIRT468299 SFT2D2 SFT2 domain containing 2 2 2
MIRT469696 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT469904 PTRF caveolae associated protein 1 2 2
MIRT470015 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT471385 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471409 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471719 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473608 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT476328 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT479448 CDK6 cyclin dependent kinase 6 2 2
MIRT482032 AMER1 APC membrane recruitment protein 1 2 2
MIRT482360 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT484661 HOXD3 homeobox D3 2 4
MIRT486828 NDOR1 NADPH dependent diflavin oxidoreductase 1 2 2
MIRT487069 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487196 NFASC neurofascin 2 4
MIRT487448 TFAP2B transcription factor AP-2 beta 2 4
MIRT487517 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT487640 BRSK2 BR serine/threonine kinase 2 2 4
MIRT487755 SKI SKI proto-oncogene 2 4
MIRT489944 CPLX1 complexin 1 2 2
MIRT491101 MSI1 musashi RNA binding protein 1 2 4
MIRT491181 LAMA5 laminin subunit alpha 5 2 2
MIRT492355 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493918 FAM127B retrotransposon Gag like 8A 2 4
MIRT493932 FAM127A retrotransposon Gag like 8C 2 4
MIRT494679 ARID3A AT-rich interaction domain 3A 2 2
MIRT494814 AKAP11 A-kinase anchoring protein 11 2 2
MIRT494835 ADCY9 adenylate cyclase 9 2 2
MIRT495455 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT496962 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT526228 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT531028 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT557110 HOXA3 homeobox A3 2 2
MIRT560514 POGK pogo transposable element derived with KRAB domain 2 2
MIRT567753 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT569608 TRIM29 tripartite motif containing 29 2 2
MIRT570242 CPNE5 copine 5 2 2
MIRT572327 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT572373 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575024 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT576146 Hmox1 heme oxygenase 1 2 2
MIRT612443 SMOC2 SPARC related modular calcium binding 2 2 2
MIRT615404 VDAC2 voltage dependent anion channel 2 2 2
MIRT629114 CYCS cytochrome c, somatic 2 2
MIRT631362 FOXI2 forkhead box I2 2 2
MIRT639322 THBD thrombomodulin 2 2
MIRT643797 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT669687 ABLIM1 actin binding LIM protein 1 2 2
MIRT670595 LLGL1 LLGL1, scribble cell polarity complex component 2 4
MIRT691190 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT691688 FLOT2 flotillin 2 2 2
MIRT697127 OTUD5 OTU deubiquitinase 5 2 2
MIRT700814 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701248 NUP35 nucleoporin 35 2 2
MIRT702362 KLHL15 kelch like family member 15 2 2
MIRT703325 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT706060 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT710475 CDH5 cadherin 5 2 2
MIRT713018 SLC4A2 solute carrier family 4 member 2 2 2
MIRT716427 RAB15 RAB15, member RAS oncogene family 2 2
MIRT718093 ABHD12 abhydrolase domain containing 12 2 2
MIRT718542 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719122 CACFD1 calcium channel flower domain containing 1 2 2
MIRT721393 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT736283 CDC42 cell division cycle 42 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6132 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6132 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6132 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-6132 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6132 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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