pre-miRNA Information | |
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pre-miRNA | hsa-mir-3120 |
Genomic Coordinates | chr1: 172138808 - 172138888 |
Description | Homo sapiens miR-3120 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-3120-5p | |||||||||||||||||||||
Sequence | 13| CCUGUCUGUGCCUGCUGUACA |33 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||
Editing Events in miRNAs |
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DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | HSPB6 | ||||||||||||||||||||
Synonyms | HEL55, Hsp20, PPP1R91 | ||||||||||||||||||||
Description | heat shock protein family B (small) member 6 | ||||||||||||||||||||
Transcript | NM_144617 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on HSPB6 | |||||||||||||||||||||
3'UTR of HSPB6 (miRNA target sites are highlighted) |
>HSPB6|NM_144617|3'UTR 1 GAGGGGGCTGGGCCGCGCCCGCACCCCGGGAGCCTCCTCAGGCTCCCTCTATTAAAGCCGATCTGACTCCGCCCAGCCAG 81 ATGTCCCGAGTGCGCCAAGGACTGTCCTCTCACCCACTCCTGGATTCTGCCCTGACCTCCATCCTGGACACTGCCTTGAT 161 AACATAGACCCTTCCACTGACACCCTCGCTCTCACACCCCCTCCAGCTTTCCGACCCCACACCGACAACTCCCCGGCTTC 241 CAGACCCTACCAGCACTACCCTAACCCTCAGCCGACAGTCTCAGCCCCACCGACCCACTTTCTTGGCATATAGCCCCACT 321 TAAGACCCCTCCTCTACTTCCTTCTGAGTCCTCTACAAAGACATCCGGGTACTACATTTCCATCCCTTCCCTATTTTGAC 401 ACCAAATTATGGTGTAGACAGCCCTCCCCCAACCCCAGGCCAGTCAGGCACAATCCCCCCACCCCCCAAACGTCCTGGAC 481 TGCACAGACCTCCCACTCCAGACCATCCAGGCCTGGTTCCCAAGACCCGATCCTTCCCCTGCAACCAGACAGTCTACAAC 561 TGCCCCCTCCAGCCCATTTTCTGCCGTGAAACCCCAGCCAGCCACACCAGACTCTGGAACCCTTTTTCGACTGCCCCAAC 641 TCTTGGACACCAGGCCAACTAGAACACCCAACACCAAACTGTACAGACTCTCCCACCCCAACCTCCCCAGACTCTGCACG 721 GATGTCCTAGGCCCCCTCCCCAACTCTAACCAGACCCCATCCCCCTAAGTCCCTTTGTCTTGACCCCCAAGTCTTCAACC 801 AGATATCCTCGGCAACCCACCTCCCACCCTCCTCCTCTTCTCCTTCAAGACCCAACTGAGCACCCGCTCTGATTCCCCAC 881 AGCCTTTCTCCCTGCCACCACTCCCTTAGTCTTTCCCAGGCTTACTCTCCCAATAAATGTGCTAGAGCTCTGCCAAAAAA 961 AAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545213 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000592984.1 | 3UTR | UCCUUCCCCUGCAACCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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134 hsa-miR-3120-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT096972 | BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | ![]() |
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2 | 2 | ||||||
MIRT442624 | LOX | lysyl oxidase | ![]() |
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2 | 2 | ||||||
MIRT473438 | MDM4 | MDM4, p53 regulator | ![]() |
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2 | 2 | ||||||
MIRT490011 | KIFC2 | kinesin family member C2 | ![]() |
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2 | 2 | ||||||
MIRT496449 | N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT496752 | TGIF2 | TGFB induced factor homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT497721 | CYP1A1 | cytochrome P450 family 1 subfamily A member 1 | ![]() |
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2 | 2 | ||||||
MIRT498287 | PADI3 | peptidyl arginine deiminase 3 | ![]() |
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2 | 2 | ||||||
MIRT503195 | ACVR1B | activin A receptor type 1B | ![]() |
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2 | 4 | ||||||
MIRT504760 | TEP1 | telomerase associated protein 1 | ![]() |
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2 | 4 | ||||||
MIRT517810 | UGDH | UDP-glucose 6-dehydrogenase | ![]() |
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2 | 6 | ||||||
MIRT519686 | ZNF622 | zinc finger protein 622 | ![]() |
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2 | 4 | ||||||
MIRT520263 | URGCP | upregulator of cell proliferation | ![]() |
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2 | 2 | ||||||
MIRT523051 | ICMT | isoprenylcysteine carboxyl methyltransferase | ![]() |
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2 | 2 | ||||||
MIRT525601 | OLR1 | oxidized low density lipoprotein receptor 1 | ![]() |
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2 | 4 | ||||||
MIRT526995 | ARL8B | ADP ribosylation factor like GTPase 8B | ![]() |
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2 | 2 | ||||||
MIRT528699 | TRAF3IP2 | TRAF3 interacting protein 2 | ![]() |
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2 | 4 | ||||||
MIRT533142 | WNT10A | Wnt family member 10A | ![]() |
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2 | 2 | ||||||
MIRT537618 | ERI1 | exoribonuclease 1 | ![]() |
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2 | 2 | ||||||
MIRT539707 | EIF3H | eukaryotic translation initiation factor 3 subunit H | ![]() |
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2 | 2 | ||||||
MIRT539752 | CNBP | CCHC-type zinc finger nucleic acid binding protein | ![]() |
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2 | 2 | ||||||
MIRT539808 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | ![]() |
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2 | 2 | ||||||
MIRT539941 | IFNAR2 | interferon alpha and beta receptor subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT540424 | FAM83F | family with sequence similarity 83 member F | ![]() |
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2 | 2 | ||||||
MIRT540509 | CXCL10 | C-X-C motif chemokine ligand 10 | ![]() |
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2 | 2 | ||||||
MIRT540720 | GUF1 | GUF1 homolog, GTPase | ![]() |
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2 | 2 | ||||||
MIRT541630 | PARP2 | poly(ADP-ribose) polymerase 2 | ![]() |
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2 | 2 | ||||||
MIRT542286 | POLR3K | RNA polymerase III subunit K | ![]() |
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2 | 2 | ||||||
MIRT542456 | AKR7A2 | aldo-keto reductase family 7 member A2 | ![]() |
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2 | 2 | ||||||
MIRT542550 | MRPS10 | mitochondrial ribosomal protein S10 | ![]() |
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2 | 2 | ||||||
MIRT542771 | PPAP2B | phospholipid phosphatase 3 | ![]() |
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2 | 2 | ||||||
MIRT550085 | TRAPPC2 | trafficking protein particle complex 2 | ![]() |
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2 | 2 | ||||||
MIRT551458 | CARKD | NAD(P)HX dehydratase | ![]() |
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2 | 2 | ||||||
MIRT555622 | PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | ![]() |
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2 | 2 | ||||||
MIRT569136 | KATNAL1 | katanin catalytic subunit A1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT572328 | HSPB6 | heat shock protein family B (small) member 6 | ![]() |
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2 | 2 | ||||||
MIRT574607 | LZIC | leucine zipper and CTNNBIP1 domain containing | ![]() |
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2 | 2 | ||||||
MIRT575583 | Mcm8 | minichromosome maintenance 8 homologous recombination repair factor | ![]() |
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2 | 4 | ||||||
MIRT576125 | Hrk | harakiri, BCL2 interacting protein (contains only BH3 domain) | ![]() |
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2 | 5 | ||||||
MIRT576657 | Fam216a | family with sequence similarity 216, member A | ![]() |
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2 | 2 | ||||||
MIRT607222 | ACSM2A | acyl-CoA synthetase medium chain family member 2A | ![]() |
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2 | 4 | ||||||
MIRT607292 | CD300E | CD300e molecule | ![]() |
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2 | 6 | ||||||
MIRT607746 | ANGPT4 | angiopoietin 4 | ![]() |
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2 | 2 | ||||||
MIRT607905 | SPRYD4 | SPRY domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT608159 | HRK | harakiri, BCL2 interacting protein | ![]() |
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2 | 7 | ||||||
MIRT608657 | ABCF3 | ATP binding cassette subfamily F member 3 | ![]() |
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2 | 4 | ||||||
MIRT609115 | ZNF703 | zinc finger protein 703 | ![]() |
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2 | 6 | ||||||
MIRT610231 | ACOT9 | acyl-CoA thioesterase 9 | ![]() |
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2 | 2 | ||||||
MIRT610870 | NUDCD3 | NudC domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT611217 | MC2R | melanocortin 2 receptor | ![]() |
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2 | 2 | ||||||
MIRT614858 | PLEKHA6 | pleckstrin homology domain containing A6 | ![]() |
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2 | 2 | ||||||
MIRT616966 | LMX1A | LIM homeobox transcription factor 1 alpha | ![]() |
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2 | 2 | ||||||
MIRT617258 | GLIPR1L2 | GLI pathogenesis related 1 like 2 | ![]() |
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2 | 2 | ||||||
MIRT618009 | SLC9A3R2 | SLC9A3 regulator 2 | ![]() |
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2 | 2 | ||||||
MIRT619067 | BSND | barttin CLCNK type accessory beta subunit | ![]() |
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2 | 4 | ||||||
MIRT619295 | FAM26E | calcium homeostasis modulator family member 5 | ![]() |
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2 | 2 | ||||||
MIRT619348 | GINM1 | glycoprotein integral membrane 1 | ![]() |
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2 | 2 | ||||||
MIRT619362 | CFHR5 | complement factor H related 5 | ![]() |
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2 | 2 | ||||||
MIRT619541 | PIWIL2 | piwi like RNA-mediated gene silencing 2 | ![]() |
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2 | 2 | ||||||
MIRT619782 | NRIP2 | nuclear receptor interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT619994 | NPAP1 | nuclear pore associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT621030 | CDC14B | cell division cycle 14B | ![]() |
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2 | 2 | ||||||
MIRT622033 | STAT5A | signal transducer and activator of transcription 5A | ![]() |
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2 | 2 | ||||||
MIRT622728 | PITPNM3 | PITPNM family member 3 | ![]() |
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2 | 2 | ||||||
MIRT623144 | NAV2 | neuron navigator 2 | ![]() |
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2 | 2 | ||||||
MIRT623600 | IPO9 | importin 9 | ![]() |
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2 | 2 | ||||||
MIRT624608 | B3GALT5 | beta-1,3-galactosyltransferase 5 | ![]() |
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2 | 2 | ||||||
MIRT624905 | CTCFL | CCCTC-binding factor like | ![]() |
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2 | 2 | ||||||
MIRT625030 | SPC24 | SPC24, NDC80 kinetochore complex component | ![]() |
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2 | 2 | ||||||
MIRT625688 | MCM8 | minichromosome maintenance 8 homologous recombination repair factor | ![]() |
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2 | 5 | ||||||
MIRT626531 | EMCN | endomucin | ![]() |
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2 | 2 | ||||||
MIRT627204 | ZDHHC20 | zinc finger DHHC-type containing 20 | ![]() |
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2 | 2 | ||||||
MIRT628033 | LSAMP | limbic system-associated membrane protein | ![]() |
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2 | 2 | ||||||
MIRT628203 | FREM2 | FRAS1 related extracellular matrix protein 2 | ![]() |
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2 | 2 | ||||||
MIRT631012 | LINS | lines homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT633195 | HSPE1-MOB4 | HSPE1-MOB4 readthrough | ![]() |
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2 | 2 | ||||||
MIRT633890 | CACNG8 | calcium voltage-gated channel auxiliary subunit gamma 8 | ![]() |
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2 | 2 | ||||||
MIRT634023 | MOB4 | MOB family member 4, phocein | ![]() |
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2 | 2 | ||||||
MIRT634416 | PLCXD3 | phosphatidylinositol specific phospholipase C X domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT636866 | ARSE | arylsulfatase E (chondrodysplasia punctata 1) | ![]() |
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2 | 2 | ||||||
MIRT642527 | ANKRD9 | ankyrin repeat domain 9 | ![]() |
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2 | 2 | ||||||
MIRT645408 | FAM110A | family with sequence similarity 110 member A | ![]() |
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2 | 2 | ||||||
MIRT645635 | SYTL4 | synaptotagmin like 4 | ![]() |
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2 | 2 | ||||||
MIRT646013 | TNFAIP8L2 | TNF alpha induced protein 8 like 2 | ![]() |
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2 | 2 | ||||||
MIRT646686 | ASGR2 | asialoglycoprotein receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT652838 | TACO1 | translational activator of cytochrome c oxidase I | ![]() |
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2 | 2 | ||||||
MIRT655156 | PHF21B | PHD finger protein 21B | ![]() |
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2 | 2 | ||||||
MIRT658491 | EXOC7 | exocyst complex component 7 | ![]() |
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2 | 2 | ||||||
MIRT659398 | CORO2A | coronin 2A | ![]() |
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2 | 2 | ||||||
MIRT666825 | PRCP | prolylcarboxypeptidase | ![]() |
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2 | 2 | ||||||
MIRT666866 | POU2F2 | POU class 2 homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT668224 | GABRA1 | gamma-aminobutyric acid type A receptor alpha1 subunit | ![]() |
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2 | 2 | ||||||
MIRT673288 | PDE3A | phosphodiesterase 3A | ![]() |
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2 | 2 | ||||||
MIRT673878 | KLF2 | Kruppel like factor 2 | ![]() |
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2 | 2 | ||||||
MIRT681721 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT682406 | PARD6B | par-6 family cell polarity regulator beta | ![]() |
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2 | 2 | ||||||
MIRT684109 | MCM10 | minichromosome maintenance 10 replication initiation factor | ![]() |
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2 | 2 | ||||||
MIRT684423 | TUFT1 | tuftelin 1 | ![]() |
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2 | 2 | ||||||
MIRT684684 | OR7D2 | olfactory receptor family 7 subfamily D member 2 | ![]() |
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2 | 2 | ||||||
MIRT686638 | TMEM184C | transmembrane protein 184C | ![]() |
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2 | 2 | ||||||
MIRT689457 | NXN | nucleoredoxin | ![]() |
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2 | 2 | ||||||
MIRT689627 | NAA30 | N(alpha)-acetyltransferase 30, NatC catalytic subunit | ![]() |
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2 | 2 | ||||||
MIRT690773 | PLA2G2C | phospholipase A2 group IIC | ![]() |
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2 | 2 | ||||||
MIRT690822 | SGSM2 | small G protein signaling modulator 2 | ![]() |
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2 | 2 | ||||||
MIRT693669 | MXRA7 | matrix remodeling associated 7 | ![]() |
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2 | 2 | ||||||
MIRT695553 | CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin | ![]() |
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2 | 2 | ||||||
MIRT695872 | C19orf52 | translocase of inner mitochondrial membrane 29 | ![]() |
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2 | 2 | ||||||
MIRT698160 | TNFRSF13C | TNF receptor superfamily member 13C | ![]() |
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2 | 2 | ||||||
MIRT699933 | RUFY2 | RUN and FYVE domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT708639 | UBE2W | ubiquitin conjugating enzyme E2 W | ![]() |
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2 | 2 | ||||||
MIRT710816 | RAB11FIP4 | RAB11 family interacting protein 4 | ![]() |
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2 | 2 | ||||||
MIRT711242 | TRAT1 | T-cell receptor associated transmembrane adaptor 1 | ![]() |
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2 | 2 | ||||||
MIRT711542 | MSH3 | mutS homolog 3 | ![]() |
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2 | 2 | ||||||
MIRT711749 | DTX1 | deltex E3 ubiquitin ligase 1 | ![]() |
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2 | 2 | ||||||
MIRT712303 | PGM2L1 | phosphoglucomutase 2 like 1 | ![]() |
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2 | 2 | ||||||
MIRT712922 | RPF2 | ribosome production factor 2 homolog | ![]() |
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2 | 2 | ||||||
MIRT714027 | SYDE2 | synapse defective Rho GTPase homolog 2 | ![]() |
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2 | 2 | ||||||
MIRT714768 | TERF1 | telomeric repeat binding factor 1 | ![]() |
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2 | 2 | ||||||
MIRT714844 | ADAMTS17 | ADAM metallopeptidase with thrombospondin type 1 motif 17 | ![]() |
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2 | 2 | ||||||
MIRT715223 | NPVF | neuropeptide VF precursor | ![]() |
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2 | 2 | ||||||
MIRT716110 | GMPS | guanine monophosphate synthase | ![]() |
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2 | 2 | ||||||
MIRT716174 | FAM71F2 | family with sequence similarity 71 member F2 | ![]() |
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2 | 2 | ||||||
MIRT716383 | C6orf223 | chromosome 6 open reading frame 223 | ![]() |
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2 | 2 | ||||||
MIRT716527 | KSR2 | kinase suppressor of ras 2 | ![]() |
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2 | 2 | ||||||
MIRT716962 | P2RY6 | pyrimidinergic receptor P2Y6 | ![]() |
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2 | 2 | ||||||
MIRT717605 | DSTYK | dual serine/threonine and tyrosine protein kinase | ![]() |
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2 | 2 | ||||||
MIRT717696 | PTGS1 | prostaglandin-endoperoxide synthase 1 | ![]() |
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2 | 2 | ||||||
MIRT721360 | ENTHD1 | ENTH domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT721381 | MACC1 | MACC1, MET transcriptional regulator | ![]() |
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2 | 2 | ||||||
MIRT721935 | RASSF2 | Ras association domain family member 2 | ![]() |
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2 | 2 | ||||||
MIRT722094 | SUSD1 | sushi domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT722837 | C17orf102 | chromosome 17 open reading frame 102 | ![]() |
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2 | 2 | ||||||
MIRT722990 | TOR1A | torsin family 1 member A | ![]() |
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2 | 2 | ||||||
MIRT724174 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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